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The map label for this gene is lpxD [H]

Identifier: 78356419

GI number: 78356419

Start: 1392322

End: 1393365

Strand: Direct

Name: lpxD [H]

Synonym: Dde_1372

Alternate gene names: 78356419

Gene position: 1392322-1393365 (Clockwise)

Preceding gene: 78356418

Following gene: 78356420

Centisome position: 37.33

GC content: 56.9

Gene sequence:

>1044_bases
ATGCAGAAAACCGTCATGAAGGTTTCGGATATAGCCGGAGCACTGGGGCTGAAGCTCAAAGGTCCGGACCGCGAAATTTC
GGGTGTGAACACGCTTGAAGCGGCAGGACCGGAAGAAATCAGCTTTCTGGCTAATCCGAAATACATTCCCATGCTGGCCG
GTACCCGGGCGGCAGCTGTCATAGTGAGCGAGGAATACGCCGGTCAGGTGGAAACCGCGCTTATCAGCGCCAACCCCTAT
TTTGACTTCGGCCGTACCTTGCATCTGTTTGCCAGACCGCAGGGCAGCTTCAGCGGCATCAGCGATATGGCATACATTCA
TCCGGAAGCGGAAATAGGCGGCGGCTGCACCATTTACCCGCATGTCTACATAGGGGCCAGAGCGCGTATAGGTGAGGGAA
CCACGCTCTTTCCGGGCTGCTATGTAGGGGAAGACTGTGCGGTGGGTGAAAACTGCCTGTTGTACCCCAACGTGACGCTG
ATGGCTGCCACAACCGTGGGTGACGACTGTGTGCTGCATTCCGGAGTTGTTCTGGGGGCCGACGGGTTCGGCTTTGCCCG
TACCGAATACGGGATTCAGAAAATTCCGCAGATAGGCAGGGTGCATGTCGGCAACGATGTGGAAATCGGGGCCAATACCG
CCATAGACCGCGCCGTGCTGGGTGTGACCACCATTGGTGACGGCACCAAGATGGATAATCTGGTTCAGGTGGGGCACAAT
GTCACCATCGGCAACGATTGTCTTATCGTTGCGCAGGTGGGCATTTCCGGCAGCACGCACGTGGGTGACAGAGTGACCAT
GGCCGGTCAGGTGGGGGTTGCCGGACACCTTACCATAGGTGACGATGTGACCGTCGGGCCTAAATCGGGCATAGCCAGAA
GCATAGAGCCGGGCAAGACCATGGGCGGACAGCCTGCGGTTGAGCGCGATGTGTACATGCGTACACTGACGGTGATGCCT
AAACTGCCTGACATGTACAAGCGGCTGAGAAAATTAGAAAAAGAGCTTGAGGCGCTGAAAGGCGAATCAGGCAGGGATAG
CTGA

Upstream 100 bases:

>100_bases
TGTGGTGTACGCCAACCCCGAACTGGACGTAACCGCCGAGGTGATGGTTGAAGTGAACCGCATCTGGCGCGCCGGTGCCA
AAAAGTAGTAAGACGGGCAC

Downstream 100 bases:

>100_bases
TGAACGACAAGGCGAAAAGCATTTTGGATATTCGACAGATTCTGGGACTGCTGCCGCACCGGTATCCTTTTCTGCTGGTG
GACAGAGTGCTCGACTACAC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MQKTVMKVSDIAGALGLKLKGPDREISGVNTLEAAGPEEISFLANPKYIPMLAGTRAAAVIVSEEYAGQVETALISANPY
FDFGRTLHLFARPQGSFSGISDMAYIHPEAEIGGGCTIYPHVYIGARARIGEGTTLFPGCYVGEDCAVGENCLLYPNVTL
MAATTVGDDCVLHSGVVLGADGFGFARTEYGIQKIPQIGRVHVGNDVEIGANTAIDRAVLGVTTIGDGTKMDNLVQVGHN
VTIGNDCLIVAQVGISGSTHVGDRVTMAGQVGVAGHLTIGDDVTVGPKSGIARSIEPGKTMGGQPAVERDVYMRTLTVMP
KLPDMYKRLRKLEKELEALKGESGRDS

Sequences:

>Translated_347_residues
MQKTVMKVSDIAGALGLKLKGPDREISGVNTLEAAGPEEISFLANPKYIPMLAGTRAAAVIVSEEYAGQVETALISANPY
FDFGRTLHLFARPQGSFSGISDMAYIHPEAEIGGGCTIYPHVYIGARARIGEGTTLFPGCYVGEDCAVGENCLLYPNVTL
MAATTVGDDCVLHSGVVLGADGFGFARTEYGIQKIPQIGRVHVGNDVEIGANTAIDRAVLGVTTIGDGTKMDNLVQVGHN
VTIGNDCLIVAQVGISGSTHVGDRVTMAGQVGVAGHLTIGDDVTVGPKSGIARSIEPGKTMGGQPAVERDVYMRTLTVMP
KLPDMYKRLRKLEKELEALKGESGRDS
>Mature_347_residues
MQKTVMKVSDIAGALGLKLKGPDREISGVNTLEAAGPEEISFLANPKYIPMLAGTRAAAVIVSEEYAGQVETALISANPY
FDFGRTLHLFARPQGSFSGISDMAYIHPEAEIGGGCTIYPHVYIGARARIGEGTTLFPGCYVGEDCAVGENCLLYPNVTL
MAATTVGDDCVLHSGVVLGADGFGFARTEYGIQKIPQIGRVHVGNDVEIGANTAIDRAVLGVTTIGDGTKMDNLVQVGHN
VTIGNDCLIVAQVGISGSTHVGDRVTMAGQVGVAGHLTIGDDVTVGPKSGIARSIEPGKTMGGQPAVERDVYMRTLTVMP
KLPDMYKRLRKLEKELEALKGESGRDS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=335, Percent_Identity=34.0298507462687, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1786378, Length=253, Percent_Identity=24.5059288537549, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36494; Mature: 36494

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTVMKVSDIAGALGLKLKGPDREISGVNTLEAAGPEEISFLANPKYIPMLAGTRAAAV
CCCHHHHHHHHHHHHEEEECCCCCCCCCCCEECCCCCCCEEEECCCCEEEEECCCCEEEE
IVSEEYAGQVETALISANPYFDFGRTLHLFARPQGSFSGISDMAYIHPEAEIGGGCTIYP
EEEHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCEEEEC
HVYIGARARIGEGTTLFPGCYVGEDCAVGENCLLYPNVTLMAATTVGDDCVLHSGVVLGA
EEEEECEEECCCCCEECCCCEECCCCCCCCCEEEECCEEEEEEEECCCCEEEECCEEEEC
DGFGFARTEYGIQKIPQIGRVHVGNDVEIGANTAIDRAVLGVTTIGDGTKMDNLVQVGHN
CCCCCHHHHHHHHHCCCCCEEECCCCEEECCCCHHHHHEEEEEECCCCCCHHHHHHHCCC
VTIGNDCLIVAQVGISGSTHVGDRVTMAGQVGVAGHLTIGDDVTVGPKSGIARSIEPGKT
EEECCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCC
MGGQPAVERDVYMRTLTVMPKLPDMYKRLRKLEKELEALKGESGRDS
CCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQKTVMKVSDIAGALGLKLKGPDREISGVNTLEAAGPEEISFLANPKYIPMLAGTRAAAV
CCCHHHHHHHHHHHHEEEECCCCCCCCCCCEECCCCCCCEEEECCCCEEEEECCCCEEEE
IVSEEYAGQVETALISANPYFDFGRTLHLFARPQGSFSGISDMAYIHPEAEIGGGCTIYP
EEEHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCEEEEC
HVYIGARARIGEGTTLFPGCYVGEDCAVGENCLLYPNVTLMAATTVGDDCVLHSGVVLGA
EEEEECEEECCCCCEECCCCEECCCCCCCCCEEEECCEEEEEEEECCCCEEEECCEEEEC
DGFGFARTEYGIQKIPQIGRVHVGNDVEIGANTAIDRAVLGVTTIGDGTKMDNLVQVGHN
CCCCCHHHHHHHHHCCCCCEEECCCCEEECCCCHHHHHEEEEEECCCCCCHHHHHHHCCC
VTIGNDCLIVAQVGISGSTHVGDRVTMAGQVGVAGHLTIGDDVTVGPKSGIARSIEPGKT
EEECCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCC
MGGQPAVERDVYMRTLTVMPKLPDMYKRLRKLEKELEALKGESGRDS
CCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA