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The map label for this gene is lysS [H]

Identifier: 78356412

GI number: 78356412

Start: 1383393

End: 1384991

Strand: Direct

Name: lysS [H]

Synonym: Dde_1365

Alternate gene names: 78356412

Gene position: 1383393-1384991 (Clockwise)

Preceding gene: 78356411

Following gene: 78356413

Centisome position: 37.09

GC content: 53.16

Gene sequence:

>1599_bases
ATGGAGATATTTCCCTTGAGTAATCAAGAATCCTCAAACCGCAAAAAGATCAAGCTTCCCACCAAGTCCGAGCATTCCGC
TTACTTTATGCCCATGCTTACGAGGCTTGATGAGCGTGACGAACTGAACGAAGTCATCAAGAGCCGTGTTGCCAAGTCCT
GTGACATGATGGACGCAGGGGTGCCCCTGTTTCCCAACAGGTTCAACAAAGAAATTGATGTCGCTGAAATTCAGGCAGGC
TATGAAGGTCTGGAAGCCGAAGAACTGGAAACTCTGGATCAGGAGTTCAGCTGCGCCGGGCGTATCGTGTCCCAGCGTTC
CTTCGGCAAGGTTACCTTTTTCCACCTGCTTGATAAAAGCGGCAAAATGCAGTGCTACGCTTCGCGGGATTCGCTGGGAG
CCGATGCCTACAGCGTTTTTAAAAAATTTGACATAGGCGACATTGTGGGCGTGTGCGGTACGCTGTTCCGCACCAAAACG
GGCGAGCTGACCATACAGTGTTCTTCCGTGCAGCTGCTTACCAAGTCCATCCGCCCCCTGCCGGAAAAGTACCACGGGCT
GAAAGACGTGGAAACCCGCTACCGTCAGCGCTATGTGGACCTGATAGTCACCCCGCGTACCCGCGAGATATTCCGCAAAC
GCGGCCAGATTGTGCGTGAATTCCGCAATTTTATGGAAGAACGCGGGTTCATGGAAGTGGAAACACCCATGATGCAGCCC
ATTCCGGGCGGCGCCACGGCAAAGCCTTTTGTCACGCATCACAATGCGCTTGATATGCAGCTGTACATGCGCATTGCGCC
GGAGCTGTACCTGAAGCGTCTGCTGGTGGGCGGCTTTGAAAAAGTGTTCGAAATCAACCGCAACTTCCGTAACGAAGGGA
TTTCCACCCAACATAATCCCGAATTCACCATGTGTGAGTTTTACTGGGCATATGCCCGCTTTGAAGATCTGATGGATCTG
ACGGAACAGTTGTTTTCGCGTCTGGCGCAAAAGGTCTGCGGCAGCACCGTTATTACCTATCAGGGGCAGGAAGTGGACCT
GACGCCCGGCAAGTGGCAGCGGATGACATTCCATGACTCGCTGGAAAAAGTCGGCGGACACGCGCCGGAATTTTACAACG
ATTACGAAAAGCTGTCCGCATATATCCGCGAACGGGGCGAAAAGGTCATCGAAGGCGAAAAGCTGGGCAAGCTGCAGGCA
AAGCTTTTTGATCTGGATGTGGAATACAAGCTTATCCAGCCGCATTTCATCTATCATTACCCCACTGATATCTCGCCGCT
TTCGCGCCGGAATGATGACAATCCTGACGTGACTGACCGTTTCGAGCTGTTTATAACGGGCAGAGAACTGGCCAATGCGT
TCTCGGAACTGAATGACCCCGTTGACCAGCGCAAGCGTTTTGACGATCAGGTGGCGGAAAAAGAAGCCGGCGATGATGAA
GCGCACTTTATGGATGAAGACTACCTGCGTGCGCTTGAATACGGTATGCCTCCTGCCGCAGGGCAGGGCGTGGGCATTGA
CCGTCTGGTCATGCTGCTCACGGATTCGGCTTCCATCCGCGAGGTTATCCTCTTCCCGCTGCTTAAGCTGGAGAGCTGA

Upstream 100 bases:

>100_bases
AAAAAAATCTTTAAAAACTCACGGGGGGCGGGCTTCCTTGACGGAGCGTCCCAATTGGAATACCCATACCCGATTCAGCG
TTTGCGACCAATTTAAGAGC

Downstream 100 bases:

>100_bases
TCTGAAAACGGCAACAGCAGTCGCCATACCGGGCCGCAGTCAGGCCCGCCAACCGGAAAGGACAAGCCAGCAGCATGCGT
TTTGAGCTGTTTGTTGCGTT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MEIFPLSNQESSNRKKIKLPTKSEHSAYFMPMLTRLDERDELNEVIKSRVAKSCDMMDAGVPLFPNRFNKEIDVAEIQAG
YEGLEAEELETLDQEFSCAGRIVSQRSFGKVTFFHLLDKSGKMQCYASRDSLGADAYSVFKKFDIGDIVGVCGTLFRTKT
GELTIQCSSVQLLTKSIRPLPEKYHGLKDVETRYRQRYVDLIVTPRTREIFRKRGQIVREFRNFMEERGFMEVETPMMQP
IPGGATAKPFVTHHNALDMQLYMRIAPELYLKRLLVGGFEKVFEINRNFRNEGISTQHNPEFTMCEFYWAYARFEDLMDL
TEQLFSRLAQKVCGSTVITYQGQEVDLTPGKWQRMTFHDSLEKVGGHAPEFYNDYEKLSAYIRERGEKVIEGEKLGKLQA
KLFDLDVEYKLIQPHFIYHYPTDISPLSRRNDDNPDVTDRFELFITGRELANAFSELNDPVDQRKRFDDQVAEKEAGDDE
AHFMDEDYLRALEYGMPPAAGQGVGIDRLVMLLTDSASIREVILFPLLKLES

Sequences:

>Translated_532_residues
MEIFPLSNQESSNRKKIKLPTKSEHSAYFMPMLTRLDERDELNEVIKSRVAKSCDMMDAGVPLFPNRFNKEIDVAEIQAG
YEGLEAEELETLDQEFSCAGRIVSQRSFGKVTFFHLLDKSGKMQCYASRDSLGADAYSVFKKFDIGDIVGVCGTLFRTKT
GELTIQCSSVQLLTKSIRPLPEKYHGLKDVETRYRQRYVDLIVTPRTREIFRKRGQIVREFRNFMEERGFMEVETPMMQP
IPGGATAKPFVTHHNALDMQLYMRIAPELYLKRLLVGGFEKVFEINRNFRNEGISTQHNPEFTMCEFYWAYARFEDLMDL
TEQLFSRLAQKVCGSTVITYQGQEVDLTPGKWQRMTFHDSLEKVGGHAPEFYNDYEKLSAYIRERGEKVIEGEKLGKLQA
KLFDLDVEYKLIQPHFIYHYPTDISPLSRRNDDNPDVTDRFELFITGRELANAFSELNDPVDQRKRFDDQVAEKEAGDDE
AHFMDEDYLRALEYGMPPAAGQGVGIDRLVMLLTDSASIREVILFPLLKLES
>Mature_532_residues
MEIFPLSNQESSNRKKIKLPTKSEHSAYFMPMLTRLDERDELNEVIKSRVAKSCDMMDAGVPLFPNRFNKEIDVAEIQAG
YEGLEAEELETLDQEFSCAGRIVSQRSFGKVTFFHLLDKSGKMQCYASRDSLGADAYSVFKKFDIGDIVGVCGTLFRTKT
GELTIQCSSVQLLTKSIRPLPEKYHGLKDVETRYRQRYVDLIVTPRTREIFRKRGQIVREFRNFMEERGFMEVETPMMQP
IPGGATAKPFVTHHNALDMQLYMRIAPELYLKRLLVGGFEKVFEINRNFRNEGISTQHNPEFTMCEFYWAYARFEDLMDL
TEQLFSRLAQKVCGSTVITYQGQEVDLTPGKWQRMTFHDSLEKVGGHAPEFYNDYEKLSAYIRERGEKVIEGEKLGKLQA
KLFDLDVEYKLIQPHFIYHYPTDISPLSRRNDDNPDVTDRFELFITGRELANAFSELNDPVDQRKRFDDQVAEKEAGDDE
AHFMDEDYLRALEYGMPPAAGQGVGIDRLVMLLTDSASIREVILFPLLKLES

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=484, Percent_Identity=43.801652892562, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI194272210, Length=484, Percent_Identity=43.801652892562, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI45439306, Length=348, Percent_Identity=25.5747126436782, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI40789249, Length=250, Percent_Identity=27.2, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789256, Length=495, Percent_Identity=53.1313131313131, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1790571, Length=499, Percent_Identity=51.9038076152305, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI87082379, Length=322, Percent_Identity=30.7453416149068, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1788173, Length=300, Percent_Identity=25, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17535925, Length=493, Percent_Identity=42.393509127789, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17535927, Length=490, Percent_Identity=42.2448979591837, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71994340, Length=490, Percent_Identity=42.2448979591837, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17551876, Length=351, Percent_Identity=22.7920227920228, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566633, Length=225, Percent_Identity=27.1111111111111, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320242, Length=495, Percent_Identity=44.8484848484849, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324256, Length=505, Percent_Identity=32.2772277227723, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6323011, Length=357, Percent_Identity=27.1708683473389, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325153, Length=269, Percent_Identity=26.0223048327138, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640849, Length=485, Percent_Identity=44.5360824742268, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24640851, Length=485, Percent_Identity=44.5360824742268, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI17136276, Length=456, Percent_Identity=23.9035087719298, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24584738, Length=279, Percent_Identity=25.089605734767, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 61413; Mature: 61413

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFPLSNQESSNRKKIKLPTKSEHSAYFMPMLTRLDERDELNEVIKSRVAKSCDMMDAG
CEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCC
VPLFPNRFNKEIDVAEIQAGYEGLEAEELETLDQEFSCAGRIVSQRSFGKVTFFHLLDKS
CCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCC
GKMQCYASRDSLGADAYSVFKKFDIGDIVGVCGTLFRTKTGELTIQCSSVQLLTKSIRPL
CCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCC
PEKYHGLKDVETRYRQRYVDLIVTPRTREIFRKRGQIVREFRNFMEERGFMEVETPMMQP
HHHHCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
IPGGATAKPFVTHHNALDMQLYMRIAPELYLKRLLVGGFEKVFEINRNFRNEGISTQHNP
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EFTMCEFYWAYARFEDLMDLTEQLFSRLAQKVCGSTVITYQGQEVDLTPGKWQRMTFHDS
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEECCCCCCEEHHHHHH
LEKVGGHAPEFYNDYEKLSAYIRERGEKVIEGEKLGKLQAKLFDLDVEYKLIQPHFIYHY
HHHHCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHCCCCEEEEECCEEEEEC
PTDISPLSRRNDDNPDVTDRFELFITGRELANAFSELNDPVDQRKRFDDQVAEKEAGDDE
CCCCCHHHCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCH
AHFMDEDYLRALEYGMPPAAGQGVGIDRLVMLLTDSASIREVILFPLLKLES
HHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEIFPLSNQESSNRKKIKLPTKSEHSAYFMPMLTRLDERDELNEVIKSRVAKSCDMMDAG
CEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCC
VPLFPNRFNKEIDVAEIQAGYEGLEAEELETLDQEFSCAGRIVSQRSFGKVTFFHLLDKS
CCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCC
GKMQCYASRDSLGADAYSVFKKFDIGDIVGVCGTLFRTKTGELTIQCSSVQLLTKSIRPL
CCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCC
PEKYHGLKDVETRYRQRYVDLIVTPRTREIFRKRGQIVREFRNFMEERGFMEVETPMMQP
HHHHCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
IPGGATAKPFVTHHNALDMQLYMRIAPELYLKRLLVGGFEKVFEINRNFRNEGISTQHNP
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EFTMCEFYWAYARFEDLMDLTEQLFSRLAQKVCGSTVITYQGQEVDLTPGKWQRMTFHDS
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEECCCCCCEEHHHHHH
LEKVGGHAPEFYNDYEKLSAYIRERGEKVIEGEKLGKLQAKLFDLDVEYKLIQPHFIYHY
HHHHCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHCCCCEEEEECCEEEEEC
PTDISPLSRRNDDNPDVTDRFELFITGRELANAFSELNDPVDQRKRFDDQVAEKEAGDDE
CCCCCHHHCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCH
AHFMDEDYLRALEYGMPPAAGQGVGIDRLVMLLTDSASIREVILFPLLKLES
HHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA