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The map label for this gene is macA [H]

Identifier: 78356387

GI number: 78356387

Start: 1358410

End: 1359684

Strand: Reverse

Name: macA [H]

Synonym: Dde_1340

Alternate gene names: 78356387

Gene position: 1359684-1358410 (Counterclockwise)

Preceding gene: 78356388

Following gene: 78356386

Centisome position: 36.45

GC content: 57.96

Gene sequence:

>1275_bases
TTGATCCAACACCCAACACACGGCACCTATATGCGCAAATTCATAGTCATTTCCCTGATGCTTGTCTGTACGGCAGCCGC
CGGCGGCTGGTTTTTCATAAACAAAAAAACAGGGCACGCCGTTGTGATCACCCGCACGCAGGAACTGCGTCCGGGCACCA
TACGCGAAGTGCTTGAAGCCACCGGCATCATCAAGCCAGAAGTGGGAGCCATTGTAAAAACAGGCACCCGCGCCACAGGA
CTCATCCGCAAAATGTACGTCCGGGTGGGCGACAGTGTGCAGAAAGGCGACCTCATTGCCGAAATAGATGACAGAGAGCA
GCAGGCTTCATTAAACGAAGCCAGTGCCAATGTGGAAAAAAGCAAAGCGGAACTGCGGCAGATCGAACTTTCGTACCCGC
TGCGCATTGACGAAGCCGCAGCCCAGCTTAAAGCGGCCAAAGCGGAACTGCGCTTTGCCGAACTGACGCTGCAGCGCACC
CAGCAGCTGGTCACCCAGCATCTTGAAACCCAGAACAAACTGGACGACACCCAGCAGGCTGCCACGGTATCGAGCAACAC
CGTGCGGGCCCGCGAAGCCACTCTGCGCCGCCTCAGGGCGGAATTTGAGCTGGAGCGCACCAAAGCCCGCGAAGCGCTGC
AGCAGGCTCAGGCCGGGCTGGAGTCCGCCCGCATACGCATGTCGTATACCACCATATACAGTCCCATAAACGGCATTGTC
AGCCAGGTGACTGCACAGGAAGGCGAAACGGTTGTGGCCGGACTTGAGGTGGCAAACCTCATCACCGTGCTTGACCCCGA
CAGGCTTGAAATGTGGATATATGTCGATGAAACCGATGTGGGTAAAGTCAGGCCCGGCATGACGACGGAATTCCGTGTGG
ACACCTATCCCGATGCGGTGTTCACCGGCACCGTGGACCAGATATATCCGCAGCCGGAAGTACGTGACAACATTGTGTAC
TATCAGGCGCTGGTCAAACTTGCACCGGAAACATCGCGCAAGCTGCGGCCGGAAATGACCACGCAGTGCAGTGTCATTGT
GCACGAAAAGGACAACGTGCTTGCCCTGCCCAATGCCGCGCTTAAATGGGTAGACGGCAAACAGACGGTGTTTGTACAGC
GCGCCGCGGGCAACGTGGAAAAAGTCTACCCGCAGCTGGGGCTGCGCGGGCTGGACGCCAGTGAAGTCGTAAGCGGGCTG
AATGCCGGAGACATGGTGGCCGTGGATGTAGATCTGGGCAGCGCCCCTGCCGCAAAACGTGGCGGGGCACACTGA

Upstream 100 bases:

>100_bases
AGCATCAACGGCGCCACGGGCTCTGAAACAGGCCGCAACGCCGGATGCGGACAAATATCAGCACTGGATTTATGCAGGCC
CCGAAGGTATACATGCAGCT

Downstream 100 bases:

>100_bases
TGAATGAAACCGCAGCCCCGCTCATCAGCACACGCGGACTTTACCGCACGTTCACACAGGGTGACCTGACCGTGCAGGCC
GTGCGACCGCTTGATATGGA

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIQHPTHGTYMRKFIVISLMLVCTAAAGGWFFINKKTGHAVVITRTQELRPGTIREVLEATGIIKPEVGAIVKTGTRATG
LIRKMYVRVGDSVQKGDLIAEIDDREQQASLNEASANVEKSKAELRQIELSYPLRIDEAAAQLKAAKAELRFAELTLQRT
QQLVTQHLETQNKLDDTQQAATVSSNTVRAREATLRRLRAEFELERTKAREALQQAQAGLESARIRMSYTTIYSPINGIV
SQVTAQEGETVVAGLEVANLITVLDPDRLEMWIYVDETDVGKVRPGMTTEFRVDTYPDAVFTGTVDQIYPQPEVRDNIVY
YQALVKLAPETSRKLRPEMTTQCSVIVHEKDNVLALPNAALKWVDGKQTVFVQRAAGNVEKVYPQLGLRGLDASEVVSGL
NAGDMVAVDVDLGSAPAAKRGGAH

Sequences:

>Translated_424_residues
MIQHPTHGTYMRKFIVISLMLVCTAAAGGWFFINKKTGHAVVITRTQELRPGTIREVLEATGIIKPEVGAIVKTGTRATG
LIRKMYVRVGDSVQKGDLIAEIDDREQQASLNEASANVEKSKAELRQIELSYPLRIDEAAAQLKAAKAELRFAELTLQRT
QQLVTQHLETQNKLDDTQQAATVSSNTVRAREATLRRLRAEFELERTKAREALQQAQAGLESARIRMSYTTIYSPINGIV
SQVTAQEGETVVAGLEVANLITVLDPDRLEMWIYVDETDVGKVRPGMTTEFRVDTYPDAVFTGTVDQIYPQPEVRDNIVY
YQALVKLAPETSRKLRPEMTTQCSVIVHEKDNVLALPNAALKWVDGKQTVFVQRAAGNVEKVYPQLGLRGLDASEVVSGL
NAGDMVAVDVDLGSAPAAKRGGAH
>Mature_424_residues
MIQHPTHGTYMRKFIVISLMLVCTAAAGGWFFINKKTGHAVVITRTQELRPGTIREVLEATGIIKPEVGAIVKTGTRATG
LIRKMYVRVGDSVQKGDLIAEIDDREQQASLNEASANVEKSKAELRQIELSYPLRIDEAAAQLKAAKAELRFAELTLQRT
QQLVTQHLETQNKLDDTQQAATVSSNTVRAREATLRRLRAEFELERTKAREALQQAQAGLESARIRMSYTTIYSPINGIV
SQVTAQEGETVVAGLEVANLITVLDPDRLEMWIYVDETDVGKVRPGMTTEFRVDTYPDAVFTGTVDQIYPQPEVRDNIVY
YQALVKLAPETSRKLRPEMTTQCSVIVHEKDNVLALPNAALKWVDGKQTVFVQRAAGNVEKVYPQLGLRGLDASEVVSGL
NAGDMVAVDVDLGSAPAAKRGGAH

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=400, Percent_Identity=27.5, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 46696; Mature: 46696

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQHPTHGTYMRKFIVISLMLVCTAAAGGWFFINKKTGHAVVITRTQELRPGTIREVLEA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHH
TGIIKPEVGAIVKTGTRATGLIRKMYVRVGDSVQKGDLIAEIDDREQQASLNEASANVEK
HCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCHHH
SKAELRQIELSYPLRIDEAAAQLKAAKAELRFAELTLQRTQQLVTQHLETQNKLDDTQQA
HHHHHHHEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ATVSSNTVRAREATLRRLRAEFELERTKAREALQQAQAGLESARIRMSYTTIYSPINGIV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEHHHHHHHHHHHH
SQVTAQEGETVVAGLEVANLITVLDPDRLEMWIYVDETDVGKVRPGMTTEFRVDTYPDAV
HHHHHCCCCEEEEHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCE
FTGTVDQIYPQPEVRDNIVYYQALVKLAPETSRKLRPEMTTQCSVIVHEKDNVLALPNAA
EECCHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEECCCCEEECCCHH
LKWVDGKQTVFVQRAAGNVEKVYPQLGLRGLDASEVVSGLNAGDMVAVDVDLGSAPAAKR
EEEECCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCC
GGAH
CCCC
>Mature Secondary Structure
MIQHPTHGTYMRKFIVISLMLVCTAAAGGWFFINKKTGHAVVITRTQELRPGTIREVLEA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHH
TGIIKPEVGAIVKTGTRATGLIRKMYVRVGDSVQKGDLIAEIDDREQQASLNEASANVEK
HCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCHHH
SKAELRQIELSYPLRIDEAAAQLKAAKAELRFAELTLQRTQQLVTQHLETQNKLDDTQQA
HHHHHHHEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ATVSSNTVRAREATLRRLRAEFELERTKAREALQQAQAGLESARIRMSYTTIYSPINGIV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEHHHHHHHHHHHH
SQVTAQEGETVVAGLEVANLITVLDPDRLEMWIYVDETDVGKVRPGMTTEFRVDTYPDAV
HHHHHCCCCEEEEHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCE
FTGTVDQIYPQPEVRDNIVYYQALVKLAPETSRKLRPEMTTQCSVIVHEKDNVLALPNAA
EECCHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEECCCCEEECCCHH
LKWVDGKQTVFVQRAAGNVEKVYPQLGLRGLDASEVVSGLNAGDMVAVDVDLGSAPAAKR
EEEECCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCC
GGAH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]