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The map label for this gene is uppS [H]

Identifier: 78356173

GI number: 78356173

Start: 1157141

End: 1157872

Strand: Reverse

Name: uppS [H]

Synonym: Dde_1126

Alternate gene names: 78356173

Gene position: 1157872-1157141 (Counterclockwise)

Preceding gene: 78356174

Following gene: 78356172

Centisome position: 31.04

GC content: 60.79

Gene sequence:

>732_bases
TTGACCCAACCGAAGACGCCCCAGGAACGGAGTCTGCCCGCACATATTGCCATCATTATGGACGGCAACGGCAGGTGGGC
AACGGCCAGAGGGCTTTCGCGCAGCGAAGGGCACAAAGCCGGAAGCCGCGCTGTCCGCACGGTGGTCACCCGCTGCCGCG
AGCTGGGCATCAGCCATCTGACTCTTTACGCGTTTTCGCAGGAAAACTGGGGACGGCCCAAAAAAGAAGTGGGGTTCCTC
TTTGATCTGCTGGTCAGCTTTCTGCGTGATGAACTGCCCGCCATGGAGCGCGAGAACATCCGCCTTTCCGTCTTCGGCGA
TATAAGCGCACTGCCCATGGCCGCCCGCAAGGCGCTGGATCACGCCATGGCCCGCACGGCCCGCAACACGGCTCTGCATC
TGAATCTGGCGCTCAACTATTCCGGCAGAGCAGACATTGTGCAGGCCTGCCGCAGACTCATGGCCGCAGGCACCTCGGAG
CAGGATGTCACGGAAGAGCTTTTCAGCAGCTTTCTGTGGACAGCCGGCCAGCCGGACCCCGACCTTGTAATCCGCACCAG
CGGAGAAATCAGGCTTTCTAACTTTCTGCTGTACCAGAGCGCCTACAGCGAACTTTATTTCACCGACATTGCATGGCCCG
ACTTCGGCAGCGAACAGCTGGACGAGGCGCTGCACGCCTATGCCATGCGCAGCCGCCGTTTCGGCCGGACCGAGGAGCAG
AAACAGTCATGA

Upstream 100 bases:

>100_bases
CCGCAGCAGGCAGCTGCGGCCTTGACCCCTATCGGCTTAGGGGGTACAAGATACTGTTTTCATTACAACAACATACACAT
ACATTTCAAGGAGTTACCCC

Downstream 100 bases:

>100_bases
TCAGTTCGCACCGCAAACGCATACTCACCTCGCTCATTCTGCTACCTGTTCTGGCGGGCGCTCTGTTCATGGGCGGCTGG
TTTCTTTTTGCACTCATTCT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTQPKTPQERSLPAHIAIIMDGNGRWATARGLSRSEGHKAGSRAVRTVVTRCRELGISHLTLYAFSQENWGRPKKEVGFL
FDLLVSFLRDELPAMERENIRLSVFGDISALPMAARKALDHAMARTARNTALHLNLALNYSGRADIVQACRRLMAAGTSE
QDVTEELFSSFLWTAGQPDPDLVIRTSGEIRLSNFLLYQSAYSELYFTDIAWPDFGSEQLDEALHAYAMRSRRFGRTEEQ
KQS

Sequences:

>Translated_243_residues
MTQPKTPQERSLPAHIAIIMDGNGRWATARGLSRSEGHKAGSRAVRTVVTRCRELGISHLTLYAFSQENWGRPKKEVGFL
FDLLVSFLRDELPAMERENIRLSVFGDISALPMAARKALDHAMARTARNTALHLNLALNYSGRADIVQACRRLMAAGTSE
QDVTEELFSSFLWTAGQPDPDLVIRTSGEIRLSNFLLYQSAYSELYFTDIAWPDFGSEQLDEALHAYAMRSRRFGRTEEQ
KQS
>Mature_242_residues
TQPKTPQERSLPAHIAIIMDGNGRWATARGLSRSEGHKAGSRAVRTVVTRCRELGISHLTLYAFSQENWGRPKKEVGFLF
DLLVSFLRDELPAMERENIRLSVFGDISALPMAARKALDHAMARTARNTALHLNLALNYSGRADIVQACRRLMAAGTSEQ
DVTEELFSSFLWTAGQPDPDLVIRTSGEIRLSNFLLYQSAYSELYFTDIAWPDFGSEQLDEALHAYAMRSRRFGRTEEQK
QS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=226, Percent_Identity=37.1681415929204, Blast_Score=150, Evalue=7e-37,
Organism=Homo sapiens, GI45580738, Length=226, Percent_Identity=37.1681415929204, Blast_Score=150, Evalue=7e-37,
Organism=Escherichia coli, GI1786371, Length=246, Percent_Identity=47.1544715447154, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=32, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=211, Percent_Identity=33.175355450237, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=29.7674418604651, Blast_Score=95, Evalue=9e-21,
Organism=Drosophila melanogaster, GI18857969, Length=208, Percent_Identity=37.5, Blast_Score=150, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27367; Mature: 27236

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPKTPQERSLPAHIAIIMDGNGRWATARGLSRSEGHKAGSRAVRTVVTRCRELGISHL
CCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
TLYAFSQENWGRPKKEVGFLFDLLVSFLRDELPAMERENIRLSVFGDISALPMAARKALD
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
HAMARTARNTALHLNLALNYSGRADIVQACRRLMAAGTSEQDVTEELFSSFLWTAGQPDP
HHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
DLVIRTSGEIRLSNFLLYQSAYSELYFTDIAWPDFGSEQLDEALHAYAMRSRRFGRTEEQ
CEEEECCCCEEHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
KQS
HCC
>Mature Secondary Structure 
TQPKTPQERSLPAHIAIIMDGNGRWATARGLSRSEGHKAGSRAVRTVVTRCRELGISHL
CCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
TLYAFSQENWGRPKKEVGFLFDLLVSFLRDELPAMERENIRLSVFGDISALPMAARKALD
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
HAMARTARNTALHLNLALNYSGRADIVQACRRLMAAGTSEQDVTEELFSSFLWTAGQPDP
HHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
DLVIRTSGEIRLSNFLLYQSAYSELYFTDIAWPDFGSEQLDEALHAYAMRSRRFGRTEEQ
CEEEECCCCEEHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
KQS
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]