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The map label for this gene is murB

Identifier: 78356091

GI number: 78356091

Start: 1072806

End: 1073705

Strand: Direct

Name: murB

Synonym: Dde_1044

Alternate gene names: 78356091

Gene position: 1072806-1073705 (Clockwise)

Preceding gene: 78356090

Following gene: 78356092

Centisome position: 28.76

GC content: 59.67

Gene sequence:

>900_bases
GTGAAGCCCGTGATACTTTCTGGTCCGGTGCTGAAAGAGCGCACCACACTCCGGCTGGGCGGACAGGCCCTTGCCGAAGT
GCGTCTGGACGACATGCATGCCTTTGACGGGCTGCCGCGGGTGCTGGAACGTCTGGGAGGCACTCCGGCTGTGCTGGGGC
GCGGCAGTAACATACTGGCCCGCGACGGAGAATTGCCGCTGGTGATAATCAACCCCGCGCTGAAAGCAGAGCCGGAAGCA
TGGGCAGACCCGCAGGCAGAAGACCGTGTGCTGGTGCGTGTTGCTGCGGGAGTCCGGTTGCCGGTGTTGCTGGGCAGACT
GGCGGCACAGGGGCTTTCGGGACTGGAAGGTCTGGCGGGGGTGCCCGGAACCGTGGGCGGAGCCGTAGCCATGAACGCCG
GATCGTACGGCAACGACATGGGCTCGGTGCTGTCTTCCGTCGAAATTTTTTCTGCCGGTACCGGCATGATCTGCGTGCCG
CGGTCGCAGTGCCGCTGTGAATACAGGCATTTTTCGGTTCCTGCTGCCGGAGGATGGTTTGTGGTGGCTGCCGTGACGTT
GCAACTGCGCAGGAGCACTGCCACTGCAGTACGTGATGCAATGCGCAGCAATGCGCTGCTGAAAAAGAAGACACAGCCCG
TGACGGAACACAGCGCCGGATGCGTTTTTAAAAATCCCGCTGATGGGATAAGTGCCGGCAGACTGCTGGACCAGTGCGGA
TTCAGAGGGCGCGGAAAGGGCGGTATGGCTTTTTCGTCACTGCATGCAAATTTTCTTGTCAACAAAGCACAGGGTACGTC
AGACGATGCAATGGATCTGATAAATGACGCCCGGCATGCTGTTGAGAGAGCCACAGGGCATTATCTTGAGCTGGAAGTGA
AAATCTGGCCATGGCAGTAA

Upstream 100 bases:

>100_bases
CACTGCCGGAAACGCTCCGGCCGGGTGATCTTTTTCTTACTCTTGGCGCCGGCAGCATCTGGACGGTGGGACAGTTTTAT
CTGGACGGGGAATAACAGCT

Downstream 100 bases:

>100_bases
AGCGTTCAACGAATAAACGCGAGTCTGCACCTCGCAGGAGTAATAATAGTTACAGGCGCAAAAAAAAGGTTTTCAAATCT
CCTGAACTTCCGTCAGGATG

Product: UDP-N-acetylmuramate dehydrogenase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKPVILSGPVLKERTTLRLGGQALAEVRLDDMHAFDGLPRVLERLGGTPAVLGRGSNILARDGELPLVIINPALKAEPEA
WADPQAEDRVLVRVAAGVRLPVLLGRLAAQGLSGLEGLAGVPGTVGGAVAMNAGSYGNDMGSVLSSVEIFSAGTGMICVP
RSQCRCEYRHFSVPAAGGWFVVAAVTLQLRRSTATAVRDAMRSNALLKKKTQPVTEHSAGCVFKNPADGISAGRLLDQCG
FRGRGKGGMAFSSLHANFLVNKAQGTSDDAMDLINDARHAVERATGHYLELEVKIWPWQ

Sequences:

>Translated_299_residues
MKPVILSGPVLKERTTLRLGGQALAEVRLDDMHAFDGLPRVLERLGGTPAVLGRGSNILARDGELPLVIINPALKAEPEA
WADPQAEDRVLVRVAAGVRLPVLLGRLAAQGLSGLEGLAGVPGTVGGAVAMNAGSYGNDMGSVLSSVEIFSAGTGMICVP
RSQCRCEYRHFSVPAAGGWFVVAAVTLQLRRSTATAVRDAMRSNALLKKKTQPVTEHSAGCVFKNPADGISAGRLLDQCG
FRGRGKGGMAFSSLHANFLVNKAQGTSDDAMDLINDARHAVERATGHYLELEVKIWPWQ
>Mature_299_residues
MKPVILSGPVLKERTTLRLGGQALAEVRLDDMHAFDGLPRVLERLGGTPAVLGRGSNILARDGELPLVIINPALKAEPEA
WADPQAEDRVLVRVAAGVRLPVLLGRLAAQGLSGLEGLAGVPGTVGGAVAMNAGSYGNDMGSVLSSVEIFSAGTGMICVP
RSQCRCEYRHFSVPAAGGWFVVAAVTLQLRRSTATAVRDAMRSNALLKKKTQPVTEHSAGCVFKNPADGISAGRLLDQCG
FRGRGKGGMAFSSLHANFLVNKAQGTSDDAMDLINDARHAVERATGHYLELEVKIWPWQ

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=299, Percent_Identity=28.7625418060201, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_DESDG (Q313Q1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387540.1
- ProteinModelPortal:   Q313Q1
- SMR:   Q313Q1
- STRING:   Q313Q1
- GeneID:   3755469
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1044
- NMPDR:   fig|207559.3.peg.873
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   LESSKIP
- ProtClustDB:   CLSK705825
- BioCyc:   DDES207559:DDE_1044-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 31611; Mature: 31611

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 169-169 ACT_SITE 221-221 ACT_SITE 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVILSGPVLKERTTLRLGGQALAEVRLDDMHAFDGLPRVLERLGGTPAVLGRGSNILA
CCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCEEE
RDGELPLVIINPALKAEPEAWADPQAEDRVLVRVAAGVRLPVLLGRLAAQGLSGLEGLAG
ECCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHCCC
VPGTVGGAVAMNAGSYGNDMGSVLSSVEIFSAGTGMICVPRSQCRCEYRHFSVPAAGGWF
CCCCCCCEEEECCCCCCCHHHHHHHHHHHEECCCCEEEECCHHHCEEHHEECCCCCCCHH
VVAAVTLQLRRSTATAVRDAMRSNALLKKKTQPVTEHSAGCVFKNPADGISAGRLLDQCG
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHCC
FRGRGKGGMAFSSLHANFLVNKAQGTSDDAMDLINDARHAVERATGHYLELEVKIWPWQ
CCCCCCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCC
>Mature Secondary Structure
MKPVILSGPVLKERTTLRLGGQALAEVRLDDMHAFDGLPRVLERLGGTPAVLGRGSNILA
CCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCEEE
RDGELPLVIINPALKAEPEAWADPQAEDRVLVRVAAGVRLPVLLGRLAAQGLSGLEGLAG
ECCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHCCC
VPGTVGGAVAMNAGSYGNDMGSVLSSVEIFSAGTGMICVPRSQCRCEYRHFSVPAAGGWF
CCCCCCCEEEECCCCCCCHHHHHHHHHHHEECCCCEEEECCHHHCEEHHEECCCCCCCHH
VVAAVTLQLRRSTATAVRDAMRSNALLKKKTQPVTEHSAGCVFKNPADGISAGRLLDQCG
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHCC
FRGRGKGGMAFSSLHANFLVNKAQGTSDDAMDLINDARHAVERATGHYLELEVKIWPWQ
CCCCCCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA