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The map label for this gene is penA [H]

Identifier: 78356083

GI number: 78356083

Start: 1061864

End: 1063891

Strand: Direct

Name: penA [H]

Synonym: Dde_1036

Alternate gene names: 78356083

Gene position: 1061864-1063891 (Clockwise)

Preceding gene: 78356082

Following gene: 78356084

Centisome position: 28.47

GC content: 62.23

Gene sequence:

>2028_bases
GTGTTGAAAAGCAGAACTGCCGCGAACAAAAAGCTGAAGCGCCAGCCGAAAGCCGTACCCGCCAGTCCTCCAAAGGACAG
AAGCGGTATACGGCTTGTGTCCGTTGCGGCGGTTTTTGCACTGCTGTGGGCGGGGCTGTGGGCCCGCGCATGGTATGTCC
AGCTCATTGACGGTCCCCGGCTGGCGGCTATGGCCAGCAGACAGCATCATGCCACAGAACTGGTCACGGGCCAGCGCGGC
GATATTCTGGACAGAAACGGACTTGTGCTTGCACGCAGTGCCGATTTCAAATCTGTTTTTGTACGCCCCGTGGAAGTGGC
CGACCGCAGAGAAGCCGCCCGCATGCTGGCTAATGCGCTGGGCAGAACCTATGCGGAAATGCTGACCAAGGTCTCGCGCC
GCAGTTCTTTTGTGTGGGTGGCCCGCGAAGTGGATGACAAGGCCGCGGCGCGCATCCGCCGTGCCGGTGTGCCGGGCGTT
TATCTGACCACGGAATACAGCCGCCTGTATCCTTACCGTCAGCTTGCCGGCAGGCTGCTGGGGTTTGTGGGTACCGATGA
CAAGGGGCTGGAAGGGCTGGAACTGGCTTTTGACGAGTATCTGACCGGTCAGAGCACCAGACAGGTGGTGCAGCGTGATG
CGGCGGGACGGCGTCTGTATATGGACGGTGCGGGCTTTGCCGAAGGGCTGAAAGGCAAAACCCTGCGGCTGACGCTGGAT
GCCCAGATACAGTTTTTTGCAGAAGATGCACTGGCTGCCGCGGTGCGCCGTTATGAGGGGGCCTGGGGCGGTTGTCTGGT
GGTGGACGTGCCCACGGGCGACATTCTGGCCTGGGCGGAGTACCCGCCGTTCAACCCCAACGCCTACAAAGGCTATGCGC
CCTCCATGTGGCGTAACCGGCTGGCCATGGATGCGCTGGAACCCGGTTCCACCGTAAAGCCTTTTCTGATTGCCGCGGCC
ATGGAAGACGGGCTGGTGCAGCCGGACAGTCTTTTCTTCTGCGAAAACGGCCGTTGGAAGCTGCACGATGTGACCATCCG
CGATACCAAGCGGCATCAGTGGCTTACCGTGGATAAAGTGCTGCGTTACTCCAGCAACATCGGCATGGCCAAGATAGGGT
TGGAGATGGGCGCCGCCAGATACTACGACTACCTTGACAGACTGGGGTTCGGCAGGCGTCCCGACGTGCCGCTGCCCGGC
GAGGGGCGCGGTATAATCCGGTCGCCGGGTGAATGGCGCGAAGTAGATCTGGCTGCCGCGTCGTTCGGTCAGGGGTTTGC
CGTCACAGGAGCTCAGCTGGCCAAAGCGTATCTGGCTCTGGCCAACGGCGGCGTAACCAGACCGCTGCGGCTGGTGGACG
ACGGCGGGCAGAACCAGCCCCGTGGAGAGAGAATTTTTTCGGAGCAGACGTCAGCCGCGGTGCTGGCCATGCTGCGCGAG
GTGGTGGAAGGCGACGGAACAGGGCGGCATGCCGATATAGCCGGTCTGGACGTGGGCGGCAAAACCGGCACAGCCCAGAA
AGCCAGCAGAAGCGGCAGCGGCTACGGCGACGAATATGTGGCCTCGTTCGTGGGGCTGGTTCCGGCGCTCAATCCCCGCC
ACATTGTGGTGGTCACAGTGGATAACCCGCGCAAGAGCCACTACGGCAGTGTGGTGGCGGCACCGGTTTTCAAATCTGTT
GTCAGCAGAACGTGGGCCTACCTCGGACTGCTGCCCGAATCTCCGGCGGATGCCGGCGGTCTGGCTTCGGCAGACGCTCC
CGAGGTTTCCGGACGTGTCATGCCTGTTGCCGGTTCCTTCGGGCGGCCTTCGGCCGTTGTGGCCGCCGCGGATGATCTGA
CCGTGGTACCGGATGTGGTGGGGCGCAGCCTGCGCAGCGCCGTGGAAGTTTTTGCCCGTAAGGGTCTTATACCGGAAATT
AAAGGGCACGGGGGCACCGTTGTGCGGCAGCAGCCCGCGGCAGGGTCGCCGTGGCCGGATAATATAACAGAATCACAGTA
CGTACTGTGGGTTATGGAGCAGTCCTGA

Upstream 100 bases:

>100_bases
GGAGAGGGGTGCCGCGCACGGAGCTGAAATTTTCTGAACGGGGGGAGGCCGTACCGGCGGTGCGCAGGCACAGCCGGAGC
ATGAGCAGGAGAAACAGGCG

Downstream 100 bases:

>100_bases
CCATGAAAAGCACACTCTCATTCGACGCGCTTGCCGCAGCGGTGCGCGCCGGACTGCTGAACATCCGTATTGATTCACGG
AAAGTACGGCAGGGCGATGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MLKSRTAANKKLKRQPKAVPASPPKDRSGIRLVSVAAVFALLWAGLWARAWYVQLIDGPRLAAMASRQHHATELVTGQRG
DILDRNGLVLARSADFKSVFVRPVEVADRREAARMLANALGRTYAEMLTKVSRRSSFVWVAREVDDKAAARIRRAGVPGV
YLTTEYSRLYPYRQLAGRLLGFVGTDDKGLEGLELAFDEYLTGQSTRQVVQRDAAGRRLYMDGAGFAEGLKGKTLRLTLD
AQIQFFAEDALAAAVRRYEGAWGGCLVVDVPTGDILAWAEYPPFNPNAYKGYAPSMWRNRLAMDALEPGSTVKPFLIAAA
MEDGLVQPDSLFFCENGRWKLHDVTIRDTKRHQWLTVDKVLRYSSNIGMAKIGLEMGAARYYDYLDRLGFGRRPDVPLPG
EGRGIIRSPGEWREVDLAAASFGQGFAVTGAQLAKAYLALANGGVTRPLRLVDDGGQNQPRGERIFSEQTSAAVLAMLRE
VVEGDGTGRHADIAGLDVGGKTGTAQKASRSGSGYGDEYVASFVGLVPALNPRHIVVVTVDNPRKSHYGSVVAAPVFKSV
VSRTWAYLGLLPESPADAGGLASADAPEVSGRVMPVAGSFGRPSAVVAAADDLTVVPDVVGRSLRSAVEVFARKGLIPEI
KGHGGTVVRQQPAAGSPWPDNITESQYVLWVMEQS

Sequences:

>Translated_675_residues
MLKSRTAANKKLKRQPKAVPASPPKDRSGIRLVSVAAVFALLWAGLWARAWYVQLIDGPRLAAMASRQHHATELVTGQRG
DILDRNGLVLARSADFKSVFVRPVEVADRREAARMLANALGRTYAEMLTKVSRRSSFVWVAREVDDKAAARIRRAGVPGV
YLTTEYSRLYPYRQLAGRLLGFVGTDDKGLEGLELAFDEYLTGQSTRQVVQRDAAGRRLYMDGAGFAEGLKGKTLRLTLD
AQIQFFAEDALAAAVRRYEGAWGGCLVVDVPTGDILAWAEYPPFNPNAYKGYAPSMWRNRLAMDALEPGSTVKPFLIAAA
MEDGLVQPDSLFFCENGRWKLHDVTIRDTKRHQWLTVDKVLRYSSNIGMAKIGLEMGAARYYDYLDRLGFGRRPDVPLPG
EGRGIIRSPGEWREVDLAAASFGQGFAVTGAQLAKAYLALANGGVTRPLRLVDDGGQNQPRGERIFSEQTSAAVLAMLRE
VVEGDGTGRHADIAGLDVGGKTGTAQKASRSGSGYGDEYVASFVGLVPALNPRHIVVVTVDNPRKSHYGSVVAAPVFKSV
VSRTWAYLGLLPESPADAGGLASADAPEVSGRVMPVAGSFGRPSAVVAAADDLTVVPDVVGRSLRSAVEVFARKGLIPEI
KGHGGTVVRQQPAAGSPWPDNITESQYVLWVMEQS
>Mature_675_residues
MLKSRTAANKKLKRQPKAVPASPPKDRSGIRLVSVAAVFALLWAGLWARAWYVQLIDGPRLAAMASRQHHATELVTGQRG
DILDRNGLVLARSADFKSVFVRPVEVADRREAARMLANALGRTYAEMLTKVSRRSSFVWVAREVDDKAAARIRRAGVPGV
YLTTEYSRLYPYRQLAGRLLGFVGTDDKGLEGLELAFDEYLTGQSTRQVVQRDAAGRRLYMDGAGFAEGLKGKTLRLTLD
AQIQFFAEDALAAAVRRYEGAWGGCLVVDVPTGDILAWAEYPPFNPNAYKGYAPSMWRNRLAMDALEPGSTVKPFLIAAA
MEDGLVQPDSLFFCENGRWKLHDVTIRDTKRHQWLTVDKVLRYSSNIGMAKIGLEMGAARYYDYLDRLGFGRRPDVPLPG
EGRGIIRSPGEWREVDLAAASFGQGFAVTGAQLAKAYLALANGGVTRPLRLVDDGGQNQPRGERIFSEQTSAAVLAMLRE
VVEGDGTGRHADIAGLDVGGKTGTAQKASRSGSGYGDEYVASFVGLVPALNPRHIVVVTVDNPRKSHYGSVVAAPVFKSV
VSRTWAYLGLLPESPADAGGLASADAPEVSGRVMPVAGSFGRPSAVVAAADDLTVVPDVVGRSLRSAVEVFARKGLIPEI
KGHGGTVVRQQPAAGSPWPDNITESQYVLWVMEQS

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=553, Percent_Identity=31.8264014466546, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1786854, Length=586, Percent_Identity=23.037542662116, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 73066; Mature: 73066

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSRTAANKKLKRQPKAVPASPPKDRSGIRLVSVAAVFALLWAGLWARAWYVQLIDGPR
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEEEEEECCCC
LAAMASRQHHATELVTGQRGDILDRNGLVLARSADFKSVFVRPVEVADRREAARMLANAL
HHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCHHHEEEHHHHHHHHHHHHHHHHHH
GRTYAEMLTKVSRRSSFVWVAREVDDKAAARIRRAGVPGVYLTTEYSRLYPYRQLAGRLL
HHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHH
GFVGTDDKGLEGLELAFDEYLTGQSTRQVVQRDAAGRRLYMDGAGFAEGLKGKTLRLTLD
EECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCHHCCCCCCEEEEEEE
AQIQFFAEDALAAAVRRYEGAWGGCLVVDVPTGDILAWAEYPPFNPNAYKGYAPSMWRNR
CEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHH
LAMDALEPGSTVKPFLIAAAMEDGLVQPDSLFFCENGRWKLHDVTIRDTKRHQWLTVDKV
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEECCCCCCEEEHHHH
LRYSSNIGMAKIGLEMGAARYYDYLDRLGFGRRPDVPLPGEGRGIIRSPGEWREVDLAAA
HHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHH
SFGQGFAVTGAQLAKAYLALANGGVTRPLRLVDDGGQNQPRGERIFSEQTSAAVLAMLRE
HCCCCEEECHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
VVEGDGTGRHADIAGLDVGGKTGTAQKASRSGSGYGDEYVASFVGLVPALNPRHIVVVTV
HHCCCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEE
DNPRKSHYGSVVAAPVFKSVVSRTWAYLGLLPESPADAGGLASADAPEVSGRVMPVAGSF
CCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
GRPSAVVAAADDLTVVPDVVGRSLRSAVEVFARKGLIPEIKGHGGTVVRQQPAAGSPWPD
CCCCEEEEECCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCC
NITESQYVLWVMEQS
CCCCCEEEEEEEECC
>Mature Secondary Structure
MLKSRTAANKKLKRQPKAVPASPPKDRSGIRLVSVAAVFALLWAGLWARAWYVQLIDGPR
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEEEEEECCCC
LAAMASRQHHATELVTGQRGDILDRNGLVLARSADFKSVFVRPVEVADRREAARMLANAL
HHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCHHHEEEHHHHHHHHHHHHHHHHHH
GRTYAEMLTKVSRRSSFVWVAREVDDKAAARIRRAGVPGVYLTTEYSRLYPYRQLAGRLL
HHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHH
GFVGTDDKGLEGLELAFDEYLTGQSTRQVVQRDAAGRRLYMDGAGFAEGLKGKTLRLTLD
EECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCHHCCCCCCEEEEEEE
AQIQFFAEDALAAAVRRYEGAWGGCLVVDVPTGDILAWAEYPPFNPNAYKGYAPSMWRNR
CEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHH
LAMDALEPGSTVKPFLIAAAMEDGLVQPDSLFFCENGRWKLHDVTIRDTKRHQWLTVDKV
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEECCCCCCEEEHHHH
LRYSSNIGMAKIGLEMGAARYYDYLDRLGFGRRPDVPLPGEGRGIIRSPGEWREVDLAAA
HHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHH
SFGQGFAVTGAQLAKAYLALANGGVTRPLRLVDDGGQNQPRGERIFSEQTSAAVLAMLRE
HCCCCEEECHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
VVEGDGTGRHADIAGLDVGGKTGTAQKASRSGSGYGDEYVASFVGLVPALNPRHIVVVTV
HHCCCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEE
DNPRKSHYGSVVAAPVFKSVVSRTWAYLGLLPESPADAGGLASADAPEVSGRVMPVAGSF
CCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
GRPSAVVAAADDLTVVPDVVGRSLRSAVEVFARKGLIPEIKGHGGTVVRQQPAAGSPWPD
CCCCEEEEECCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCC
NITESQYVLWVMEQS
CCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]