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The map label for this gene is zraS [H]

Identifier: 78355743

GI number: 78355743

Start: 709531

End: 711243

Strand: Reverse

Name: zraS [H]

Synonym: Dde_0696

Alternate gene names: 78355743

Gene position: 711243-709531 (Counterclockwise)

Preceding gene: 78355745

Following gene: 78355742

Centisome position: 19.07

GC content: 60.3

Gene sequence:

>1713_bases
ATGCAGAAAACCAACGCAATGGGACACAAACTGGCTATCTGGGTTTCGGCCTTTGTGCTGCTGTTCGTCTCTCTGACGCT
GGCGCTGACCTACACGCTGGTATCCCACGGTCTGGAAGCGGCCTACGCCAGACGCTCCAGCCAGTACCTTTCCAGTATTG
TCCGGCAGCACTCCATACAGATCGACAGCTTTCTGCGCGAACGCAGGGCCAACCTCGCCTTTCTGGGCAAGTCGCGCACC
GTGGACGAACTGCGTTCGCACGGTCATCTGGAGTGGCTGCTATGGCGGCTTAACGGACAGTACGAAAATGCCTTTGAGGA
TCTGAGTCTTATCTCTCCGCAGGGAGAAGTGACCGCATACGCCGGACATGAGGGCCTGCTGGGCAGCAATGTATTTGAAG
CCCGCTGGTTCCAGCGGGCCATAGCTAAGCCGTCCTATGTGGGCGACGTGGTTGCCATGCCGGACGGATCCCCCAAGCTG
GTTGTTACACTGCGGCTGGGCAGCGCCAAGGAACCGTGGCTTATCAGCGCCACTCTGCGCATGCAGCTGATGGCCGATCT
GGTCCGCTCCGCCGCGCAGTTCACCGAAGGCGACGTGGCCGTCATCAACCGCGCGGGCGTGCCGCAAAGCGGCCTGAACG
CAAGTCAGGAACAGGGCCGCCCCGTCAGCGCCATGGCCGACAAGCTTTTTGCCATGCATGCCGCATCGGGCAGTGCAGTC
ACCACCTACGAGCAGAACGGCGACCTGTATGCGTTTGCCGACCTGAATGAAGGCCGCTGGCTGCTTGTGTCGCGCACCCC
CAATGCCGCCATACAACAGCCCTTTGCCGCTCCCAAAAAGCAGCTGCTCGACAAGCTGATACTGCTGGCGCTGCTGCTCA
TCGGCGGGGCAGCCATGTTTGTGCACTATGTGACCCGCCAGACCAGACGGCTGGCCGCAGAAAAGGATTCGCTGAACACA
CAGGTCATTGAAGCCAACAGGCTGGGCGCGCTGGGCGAACTGGCGGCGGGAGTGGCGCACGAAATCAACAACCCGCTGGC
CATCATCCGCGAAGAAAGCGGCTGGATTGAAGACGTGCTGGATGACGGTTTTGATAATCCGGAAGCACTGGAAGGCGAAA
TCCGCCGCAGTGTCACGCAGATAAATACCCAGACCCTGCGATGCAGAGACATCACCCACAAGCTGCTTTCGTTTGCGCGC
CGCAGTACCGGCCATGAAGCCTGTGTCGATGTAAACATGCTGCTGCAGGAAATAGTGGGCTTTGCCGAACAGCGCGCCCG
CTACATCAACGTGACCACGCGCATGCGGCTGGACCCCGCCCTGCCCATGCTCTCCGCCAGCCCTTCAGAACTGCAGCAGG
TGTTCATCAATCTGGTGAACAACGCGCTGGACGCCATGGAAGACCGCCGCGACGGCACCCTGACCGTCACCTCGCGCCTG
CAGGGAAACACGGCTGTCATCACCGTAAGCGACACAGGCCAGGGCATACCCGACACCCTGCTGAACAAGATATTCGACCC
GTTCTTCACTACCAAGTCGGTGGGAAAGGGCAACGGTCTCGGTCTTTCCATCTGCCACGGCCTTGTGACCCGTGCAGGCG
GAGATATCCGGGTCCAGAGCGAACTGCATAAGGGAACCACCTTCACCGTCGAGCTGCCCGTCACCCCATGCTCGGCAGAA
CCAACAGGCAACGCAGACAGGAGTATCTCATGA

Upstream 100 bases:

>100_bases
ATCAGCATATTAGAAAAACACATCAGGCCACAGGCACACCCCGTGCACAAGCAGCTGCATTCACGGTCACAACAACGCTG
AAAAACAAGTGGACACTGCC

Downstream 100 bases:

>100_bases
ACGTTTTACTGGTTGATGACGAAGTGGCCTTTGTGGAAGCCCTCGCACGGCGGCTGACCCGCAAGAACATGACCGTGCAC
ACTGTGCACAACGGACCGGA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MQKTNAMGHKLAIWVSAFVLLFVSLTLALTYTLVSHGLEAAYARRSSQYLSSIVRQHSIQIDSFLRERRANLAFLGKSRT
VDELRSHGHLEWLLWRLNGQYENAFEDLSLISPQGEVTAYAGHEGLLGSNVFEARWFQRAIAKPSYVGDVVAMPDGSPKL
VVTLRLGSAKEPWLISATLRMQLMADLVRSAAQFTEGDVAVINRAGVPQSGLNASQEQGRPVSAMADKLFAMHAASGSAV
TTYEQNGDLYAFADLNEGRWLLVSRTPNAAIQQPFAAPKKQLLDKLILLALLLIGGAAMFVHYVTRQTRRLAAEKDSLNT
QVIEANRLGALGELAAGVAHEINNPLAIIREESGWIEDVLDDGFDNPEALEGEIRRSVTQINTQTLRCRDITHKLLSFAR
RSTGHEACVDVNMLLQEIVGFAEQRARYINVTTRMRLDPALPMLSASPSELQQVFINLVNNALDAMEDRRDGTLTVTSRL
QGNTAVITVSDTGQGIPDTLLNKIFDPFFTTKSVGKGNGLGLSICHGLVTRAGGDIRVQSELHKGTTFTVELPVTPCSAE
PTGNADRSIS

Sequences:

>Translated_570_residues
MQKTNAMGHKLAIWVSAFVLLFVSLTLALTYTLVSHGLEAAYARRSSQYLSSIVRQHSIQIDSFLRERRANLAFLGKSRT
VDELRSHGHLEWLLWRLNGQYENAFEDLSLISPQGEVTAYAGHEGLLGSNVFEARWFQRAIAKPSYVGDVVAMPDGSPKL
VVTLRLGSAKEPWLISATLRMQLMADLVRSAAQFTEGDVAVINRAGVPQSGLNASQEQGRPVSAMADKLFAMHAASGSAV
TTYEQNGDLYAFADLNEGRWLLVSRTPNAAIQQPFAAPKKQLLDKLILLALLLIGGAAMFVHYVTRQTRRLAAEKDSLNT
QVIEANRLGALGELAAGVAHEINNPLAIIREESGWIEDVLDDGFDNPEALEGEIRRSVTQINTQTLRCRDITHKLLSFAR
RSTGHEACVDVNMLLQEIVGFAEQRARYINVTTRMRLDPALPMLSASPSELQQVFINLVNNALDAMEDRRDGTLTVTSRL
QGNTAVITVSDTGQGIPDTLLNKIFDPFFTTKSVGKGNGLGLSICHGLVTRAGGDIRVQSELHKGTTFTVELPVTPCSAE
PTGNADRSIS
>Mature_570_residues
MQKTNAMGHKLAIWVSAFVLLFVSLTLALTYTLVSHGLEAAYARRSSQYLSSIVRQHSIQIDSFLRERRANLAFLGKSRT
VDELRSHGHLEWLLWRLNGQYENAFEDLSLISPQGEVTAYAGHEGLLGSNVFEARWFQRAIAKPSYVGDVVAMPDGSPKL
VVTLRLGSAKEPWLISATLRMQLMADLVRSAAQFTEGDVAVINRAGVPQSGLNASQEQGRPVSAMADKLFAMHAASGSAV
TTYEQNGDLYAFADLNEGRWLLVSRTPNAAIQQPFAAPKKQLLDKLILLALLLIGGAAMFVHYVTRQTRRLAAEKDSLNT
QVIEANRLGALGELAAGVAHEINNPLAIIREESGWIEDVLDDGFDNPEALEGEIRRSVTQINTQTLRCRDITHKLLSFAR
RSTGHEACVDVNMLLQEIVGFAEQRARYINVTTRMRLDPALPMLSASPSELQQVFINLVNNALDAMEDRRDGTLTVTSRL
QGNTAVITVSDTGQGIPDTLLNKIFDPFFTTKSVGKGNGLGLSICHGLVTRAGGDIRVQSELHKGTTFTVELPVTPCSAE
PTGNADRSIS

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=318, Percent_Identity=31.1320754716981, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788549, Length=269, Percent_Identity=32.7137546468402, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1790861, Length=318, Percent_Identity=25.4716981132075, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=256, Percent_Identity=30.078125, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI48994928, Length=141, Percent_Identity=35.4609929078014, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=28.2511210762332, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=27.3127753303965, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=25.8928571428571, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=116, Percent_Identity=32.7586206896552, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62330; Mature: 62330

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTNAMGHKLAIWVSAFVLLFVSLTLALTYTLVSHGLEAAYARRSSQYLSSIVRQHSIQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
IDSFLRERRANLAFLGKSRTVDELRSHGHLEWLLWRLNGQYENAFEDLSLISPQGEVTAY
HHHHHHHHCCCEEEECCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEE
AGHEGLLGSNVFEARWFQRAIAKPSYVGDVVAMPDGSPKLVVTLRLGSAKEPWLISATLR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEEEECCCCCCEEEHHHHH
MQLMADLVRSAAQFTEGDVAVINRAGVPQSGLNASQEQGRPVSAMADKLFAMHAASGSAV
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCEE
TTYEQNGDLYAFADLNEGRWLLVSRTPNAAIQQPFAAPKKQLLDKLILLALLLIGGAAMF
EEEECCCCEEEEEECCCCCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHYVTRQTRRLAAEKDSLNTQVIEANRLGALGELAAGVAHEINNPLAIIREESGWIEDVL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
DDGFDNPEALEGEIRRSVTQINTQTLRCRDITHKLLSFARRSTGHEACVDVNMLLQEIVG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FAEQRARYINVTTRMRLDPALPMLSASPSELQQVFINLVNNALDAMEDRRDGTLTVTSRL
HHHHCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
QGNTAVITVSDTGQGIPDTLLNKIFDPFFTTKSVGKGNGLGLSICHGLVTRAGGDIRVQS
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
ELHKGTTFTVELPVTPCSAEPTGNADRSIS
HHCCCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKTNAMGHKLAIWVSAFVLLFVSLTLALTYTLVSHGLEAAYARRSSQYLSSIVRQHSIQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
IDSFLRERRANLAFLGKSRTVDELRSHGHLEWLLWRLNGQYENAFEDLSLISPQGEVTAY
HHHHHHHHCCCEEEECCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEE
AGHEGLLGSNVFEARWFQRAIAKPSYVGDVVAMPDGSPKLVVTLRLGSAKEPWLISATLR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEEEECCCCCCEEEHHHHH
MQLMADLVRSAAQFTEGDVAVINRAGVPQSGLNASQEQGRPVSAMADKLFAMHAASGSAV
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCEE
TTYEQNGDLYAFADLNEGRWLLVSRTPNAAIQQPFAAPKKQLLDKLILLALLLIGGAAMF
EEEECCCCEEEEEECCCCCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHYVTRQTRRLAAEKDSLNTQVIEANRLGALGELAAGVAHEINNPLAIIREESGWIEDVL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
DDGFDNPEALEGEIRRSVTQINTQTLRCRDITHKLLSFARRSTGHEACVDVNMLLQEIVG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FAEQRARYINVTTRMRLDPALPMLSASPSELQQVFINLVNNALDAMEDRRDGTLTVTSRL
HHHHCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
QGNTAVITVSDTGQGIPDTLLNKIFDPFFTTKSVGKGNGLGLSICHGLVTRAGGDIRVQS
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
ELHKGTTFTVELPVTPCSAEPTGNADRSIS
HHCCCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]