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The map label for this gene is livM [H]

Identifier: 78355657

GI number: 78355657

Start: 633160

End: 634329

Strand: Reverse

Name: livM [H]

Synonym: Dde_0610

Alternate gene names: 78355657

Gene position: 634329-633160 (Counterclockwise)

Preceding gene: 78355658

Following gene: 78355656

Centisome position: 17.01

GC content: 58.03

Gene sequence:

>1170_bases
ATGGATAAAATCAAGCAATCGTTACTCATCTGCTTCTGGTTCATGTTCATGACATTTCCGCTGGTGGTCATCCGCGTGGA
CACCATCAACGACACCGTGACATGGCGCTGGCTCAACATGGTCTATATCGGCGCGGGCAGTTTCGTGCTTTCCTTTGTGT
GGCGCTGGGCCATGGCCCGCCGCAATTCTAAACGTGCTTCCGGCAGCCCCGCAGCGTCACCTGCCACCGGCATGGTGCAC
AGACTGGGACAGGACAGACGTTTTTCTGCCGCATTCTACTGTGCCGTGCTGGGGCTGGGCATTGTACTGCCCTGGCTTGT
CTCCACCTACCAGACCAACATCATGATCTCGTTCCTGCTCTATGTCATTCTGGGGCTGGGGCTGAACATTGTGGTGGGCG
TGGCGGGCATGCTCTTTCTGGGCTATGCCGCGTTTTACGCCATCGGCGCATACTCGTACGCGCTGCTCAATACCTATTTC
GGCCTGGGATTCTGGACGGTGCTGCCTGTGGGCGGCATTCTGGCCGCGGCAGCCGGCGTTGCGCTGGCTTTTCCCGTGCT
GCGCCTGCGCGGCGACTATCTGGCCATCGTCACGCTGGGTTTCGGCGAAATAGTACGGCTGGTGCTGGAAAACTGGAGCG
ACTTCACGCAAGGGCCCAGCGGCATATCCAACATTCCCCGGCCCTCGCTTTTCGGAGCGGAACTGGGCGTGGCCGAAACC
GGCATCTACATCTACTACATTGTTCTTGTGATGGCTGTGCTTACCGTGGCCGCAGTGCAGCGCATAAAGGATTCGCGCAT
AGGCCGGGCCCTGCAGGCGCTGCGTGAAGATGAAATTGCCTGTCAGGCCATGGGCATAGACAGAGTGAACGTAAAGCTGA
CCGCCTTTGGCGTGGGCACGGCATGGGCCGGTTTTGCCGGCGTCATCTTTGCCGCCAAAACCACCTTCATCAACCCTGCC
AGCTTCACCTTCATGGAATCGGCCATCATTCTTTCCATTGTGGTGCTGGGCGGCATGGGATCGAGGCGCGGCTTTTCTCA
TCCTGCTGCCCGAATACCTGCGCGAATTTGCAGAATACCGCATGCTCATGTTCGCATCGGCCATGGTACTGATGATGGTC
TTCCGTCCGCAGGGGCTGATCACGCCCAAAAAACGCAAGTACGAAATTGA

Upstream 100 bases:

>100_bases
TCTTCAGGCCTTCCGGCATCATGGGCAAAGCTCCGGTCGAAAAGGTGTAACCAGAAGGCGGCGCGCACACGCCCGCCGCG
CTTTTTCAGGATCGCATAGA

Downstream 100 bases:

>100_bases
TGATCCCGAGCTGCACGCCGGTAAAGAAGGAGAGGCCTGATGCCGGTTCTTGAGGTAGATTCCCTTTCAAAAAATTTCGG
CGGACTGCGCGCCCTGAACG

Product: high-affinity branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDKIKQSLLICFWFMFMTFPLVVIRVDTINDTVTWRWLNMVYIGAGSFVLSFVWRWAMARRNSKRASGSPAASPATGMVH
RLGQDRRFSAAFYCAVLGLGIVLPWLVSTYQTNIMISFLLYVILGLGLNIVVGVAGMLFLGYAAFYAIGAYSYALLNTYF
GLGFWTVLPVGGILAAAAGVALAFPVLRLRGDYLAIVTLGFGEIVRLVLENWSDFTQGPSGISNIPRPSLFGAELGVAET
GIYIYYIVLVMAVLTVAAVQRIKDSRIGRALQALREDEIACQAMGIDRVNVKLTAFGVGTAWAGFAGVIFAAKTTFINPA
SFTFMESAIILSIVVLGGMGSRRGFSHPAARIPARICRIPHAHVRIGHGTDDGLPSAGADHAQKTQVRN

Sequences:

>Translated_389_residues
MDKIKQSLLICFWFMFMTFPLVVIRVDTINDTVTWRWLNMVYIGAGSFVLSFVWRWAMARRNSKRASGSPAASPATGMVH
RLGQDRRFSAAFYCAVLGLGIVLPWLVSTYQTNIMISFLLYVILGLGLNIVVGVAGMLFLGYAAFYAIGAYSYALLNTYF
GLGFWTVLPVGGILAAAAGVALAFPVLRLRGDYLAIVTLGFGEIVRLVLENWSDFTQGPSGISNIPRPSLFGAELGVAET
GIYIYYIVLVMAVLTVAAVQRIKDSRIGRALQALREDEIACQAMGIDRVNVKLTAFGVGTAWAGFAGVIFAAKTTFINPA
SFTFMESAIILSIVVLGGMGSRRGFSHPAARIPARICRIPHAHVRIGHGTDDGLPSAGADHAQKTQVRN
>Mature_389_residues
MDKIKQSLLICFWFMFMTFPLVVIRVDTINDTVTWRWLNMVYIGAGSFVLSFVWRWAMARRNSKRASGSPAASPATGMVH
RLGQDRRFSAAFYCAVLGLGIVLPWLVSTYQTNIMISFLLYVILGLGLNIVVGVAGMLFLGYAAFYAIGAYSYALLNTYF
GLGFWTVLPVGGILAAAAGVALAFPVLRLRGDYLAIVTLGFGEIVRLVLENWSDFTQGPSGISNIPRPSLFGAELGVAET
GIYIYYIVLVMAVLTVAAVQRIKDSRIGRALQALREDEIACQAMGIDRVNVKLTAFGVGTAWAGFAGVIFAAKTTFINPA
SFTFMESAIILSIVVLGGMGSRRGFSHPAARIPARICRIPHAHVRIGHGTDDGLPSAGADHAQKTQVRN

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=337, Percent_Identity=47.7744807121662, Blast_Score=258, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 42176; Mature: 42176

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIKQSLLICFWFMFMTFPLVVIRVDTINDTVTWRWLNMVYIGAGSFVLSFVWRWAMAR
CCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHH
RNSKRASGSPAASPATGMVHRLGQDRRFSAAFYCAVLGLGIVLPWLVSTYQTNIMISFLL
CCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVILGLGLNIVVGVAGMLFLGYAAFYAIGAYSYALLNTYFGLGFWTVLPVGGILAAAAGV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAFPVLRLRGDYLAIVTLGFGEIVRLVLENWSDFTQGPSGISNIPRPSLFGAELGVAET
HHHHHHHHHCCCEEEEEEECHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCHHHH
GIYIYYIVLVMAVLTVAAVQRIKDSRIGRALQALREDEIACQAMGIDRVNVKLTAFGVGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCH
AWAGFAGVIFAAKTTFINPASFTFMESAIILSIVVLGGMGSRRGFSHPAARIPARICRIP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
HAHVRIGHGTDDGLPSAGADHAQKTQVRN
HHHEEECCCCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MDKIKQSLLICFWFMFMTFPLVVIRVDTINDTVTWRWLNMVYIGAGSFVLSFVWRWAMAR
CCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHH
RNSKRASGSPAASPATGMVHRLGQDRRFSAAFYCAVLGLGIVLPWLVSTYQTNIMISFLL
CCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVILGLGLNIVVGVAGMLFLGYAAFYAIGAYSYALLNTYFGLGFWTVLPVGGILAAAAGV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAFPVLRLRGDYLAIVTLGFGEIVRLVLENWSDFTQGPSGISNIPRPSLFGAELGVAET
HHHHHHHHHCCCEEEEEEECHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCHHHH
GIYIYYIVLVMAVLTVAAVQRIKDSRIGRALQALREDEIACQAMGIDRVNVKLTAFGVGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCH
AWAGFAGVIFAAKTTFINPASFTFMESAIILSIVVLGGMGSRRGFSHPAARIPARICRIP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
HAHVRIGHGTDDGLPSAGADHAQKTQVRN
HHHEEECCCCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]