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The map label for this gene is hemN [H]

Identifier: 78355583

GI number: 78355583

Start: 545682

End: 547418

Strand: Reverse

Name: hemN [H]

Synonym: Dde_0536

Alternate gene names: 78355583

Gene position: 547418-545682 (Counterclockwise)

Preceding gene: 304570596

Following gene: 78355582

Centisome position: 14.68

GC content: 61.95

Gene sequence:

>1737_bases
ATGCTTTCACTGCTACAGGATACGGCTCGAACGGGCCGTATCCGTAGCCCGCAGAGGCGGGTTCGACATGGTTACCTCCA
CCCTGCTGTATTCCCGCAAACAGCAGCACGAGCGCATCGCCGCGCTGGGCAGCGACCTGTGCGGCGACGGCAGGCTGCGT
TTTCTGTACCGCGACTTCCGGGAAGGCTGGCAGCAGGGCATAGAGACTTCCAAAGCGTGGGGCATATACCGGCAGCAGTA
CTGCGGCTGCCTGTACAGCGAAACCGAACGGTACGCCCGCGAACTGAAAAACGCCGGTGCGCAGGTGCCGCAACAGACCG
CCGGCACGCCCTGCTGCGCAGAAGGTACAGAAAAACAGGCAGAACAGGCCGACGCCACCCCCGCAGCCGACAATGCAGGC
AGATAAGACATACTGTGCCGCAACGCGGCGCGGCACACGCCGCATGCGCTGACCGCAACCGCCCGCAGCCCGCGCGGTAT
CCGCAACCACCGGGCGGCGAAGCAGAAAGACAGACCCGCGCGGCCGTTCACCGCCGGACATCCGGAGCCTTTGTGCTGCT
GTATATTCATGTGCCCTTCTGCCGCAGCAAATGCGGCTACTGCGCTTTCCATTCCGTCCCTGTGGCCGCCGCGGGACCGG
ACGGCATGCAACAGTATCTTGATGCGCTGCTGCGCGAGATAGCCCTGTGGGGCGACCGGCTGGGTAACAGAGCGGTGCAT
ACCGTTTTTTTCGGCGGGGGCACGCCCAGTCTGCTGCCGGAAAAAGCGGTGGCCGTCATCATGGACAGGCTGCGACGCGC
GTTCGACATACAGAACGGGGCCGAAATCAGCTTTGAGGCAAATCCCGAATCCGTCTCCGCCTACGGGTATCTTGACACCC
TTTTCAAATGCGGCATCAACAGACTGAGCCTGGGAGTGCAGAGCCTGAACAACGACGGTCTGCGCGTACTGGGGCGGCCC
CACAAGGCGCGCGAAGCCGTAAATGCCTTCCGTCTGGCGCGTCAGGCAGGCTTTGGCAACATCAATCTGGACATGATATG
GGGGCTGCCATCGCAGCGGCTCAAGCTGTGGCTTGACGAGCTGAAAGCAGTAACAGAGCTCAAGCCCGACCATCTGTCAT
GCTACGGACTCACGCTGGAAGAAGGTACCCCGCTGGAACAGGCATGTCTGCAGGGGCGGCACACACTGCCCGACGAGCAG
GAACAGGCCCGCATGTTCATCTACGGTGCGGAATTTCTGGAATCGCGGGGCTATATGCAGTACGAAATTTCCAACTTCGC
CCGCATGGGATTTCAGTGCAGGCACAATCTGGGCTACTGGGAAGGCGCCGAATATCTGGGCATGGGGCCTTCGGCGGTTT
CCACGCTGTCCGGCAGACGCTGGGAAAACCCGCACGGGCTGCAGGAGTATGCCCGCCGCACAGCCGAGGGTACGCTGGGG
CACGATGCCGCGGCACTCACCCCGCTGGAGCGGGCCGAAGAACTTATCATGCTGCGTCTGCGCACGGCACGCGGCCTGCG
CGTGAAAGCATACCGCGACCTTACCGGACGCGATTTTCTGCGCGAGCACAAACAGCTGGTGCACGCCCTGCACCGCAACA
GGCTGGTACGCATCAGCAACGGGTATCTGCGCTTGACCAGAAACGGCATGCTGGTATCGAATACCATTCTGGAAAACATC
TTTGCCACTCTGCCCGAAGAAACGCCGCACAAGCTGTCCGCAGCACAGGAACCGTAG

Upstream 100 bases:

>100_bases
TGGATGTGGCTCACAGGCTGGGGGTCAAAGTGATATACTTTGACCGTGAATATGACCCGCAGGCATGGATGCGCGAAATC
GCTTTCCGTGAAGCGAACAG

Downstream 100 bases:

>100_bases
CGGCCTGCTCTTCAGCAACACGCACGCAGCTGCAGGAACGCCATGAAACCAGCTCTTCTCGGCAACCATGCTCCCCGCGG
CGTCATTCTCGCCCTGCAGC

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MLSLLQDTARTGRIRSPQRRVRHGYLHPAVFPQTAARAHRRAGQRPVRRRQAAFSVPRLPGRLAAGHRDFQSVGHIPAAV
LRLPVQRNRTVRPRTEKRRCAGAATDRRHALLRRRYRKTGRTGRRHPRSRQCRQIRHTVPQRGAAHAACADRNRPQPARY
PQPPGGEAERQTRAAVHRRTSGAFVLLYIHVPFCRSKCGYCAFHSVPVAAAGPDGMQQYLDALLREIALWGDRLGNRAVH
TVFFGGGTPSLLPEKAVAVIMDRLRRAFDIQNGAEISFEANPESVSAYGYLDTLFKCGINRLSLGVQSLNNDGLRVLGRP
HKAREAVNAFRLARQAGFGNINLDMIWGLPSQRLKLWLDELKAVTELKPDHLSCYGLTLEEGTPLEQACLQGRHTLPDEQ
EQARMFIYGAEFLESRGYMQYEISNFARMGFQCRHNLGYWEGAEYLGMGPSAVSTLSGRRWENPHGLQEYARRTAEGTLG
HDAAALTPLERAEELIMLRLRTARGLRVKAYRDLTGRDFLREHKQLVHALHRNRLVRISNGYLRLTRNGMLVSNTILENI
FATLPEETPHKLSAAQEP

Sequences:

>Translated_578_residues
MLSLLQDTARTGRIRSPQRRVRHGYLHPAVFPQTAARAHRRAGQRPVRRRQAAFSVPRLPGRLAAGHRDFQSVGHIPAAV
LRLPVQRNRTVRPRTEKRRCAGAATDRRHALLRRRYRKTGRTGRRHPRSRQCRQIRHTVPQRGAAHAACADRNRPQPARY
PQPPGGEAERQTRAAVHRRTSGAFVLLYIHVPFCRSKCGYCAFHSVPVAAAGPDGMQQYLDALLREIALWGDRLGNRAVH
TVFFGGGTPSLLPEKAVAVIMDRLRRAFDIQNGAEISFEANPESVSAYGYLDTLFKCGINRLSLGVQSLNNDGLRVLGRP
HKAREAVNAFRLARQAGFGNINLDMIWGLPSQRLKLWLDELKAVTELKPDHLSCYGLTLEEGTPLEQACLQGRHTLPDEQ
EQARMFIYGAEFLESRGYMQYEISNFARMGFQCRHNLGYWEGAEYLGMGPSAVSTLSGRRWENPHGLQEYARRTAEGTLG
HDAAALTPLERAEELIMLRLRTARGLRVKAYRDLTGRDFLREHKQLVHALHRNRLVRISNGYLRLTRNGMLVSNTILENI
FATLPEETPHKLSAAQEP
>Mature_578_residues
MLSLLQDTARTGRIRSPQRRVRHGYLHPAVFPQTAARAHRRAGQRPVRRRQAAFSVPRLPGRLAAGHRDFQSVGHIPAAV
LRLPVQRNRTVRPRTEKRRCAGAATDRRHALLRRRYRKTGRTGRRHPRSRQCRQIRHTVPQRGAAHAACADRNRPQPARY
PQPPGGEAERQTRAAVHRRTSGAFVLLYIHVPFCRSKCGYCAFHSVPVAAAGPDGMQQYLDALLREIALWGDRLGNRAVH
TVFFGGGTPSLLPEKAVAVIMDRLRRAFDIQNGAEISFEANPESVSAYGYLDTLFKCGINRLSLGVQSLNNDGLRVLGRP
HKAREAVNAFRLARQAGFGNINLDMIWGLPSQRLKLWLDELKAVTELKPDHLSCYGLTLEEGTPLEQACLQGRHTLPDEQ
EQARMFIYGAEFLESRGYMQYEISNFARMGFQCRHNLGYWEGAEYLGMGPSAVSTLSGRRWENPHGLQEYARRTAEGTLG
HDAAALTPLERAEELIMLRLRTARGLRVKAYRDLTGRDFLREHKQLVHALHRNRLVRISNGYLRLTRNGMLVSNTILENI
FATLPEETPHKLSAAQEP

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=266, Percent_Identity=37.9699248120301, Blast_Score=176, Evalue=5e-44,
Organism=Escherichia coli, GI1789325, Length=395, Percent_Identity=35.1898734177215, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082341, Length=386, Percent_Identity=29.0155440414508, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 65294; Mature: 65294

Theoretical pI: Translated: 11.37; Mature: 11.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLLQDTARTGRIRSPQRRVRHGYLHPAVFPQTAARAHRRAGQRPVRRRQAAFSVPRLP
CCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GRLAAGHRDFQSVGHIPAAVLRLPVQRNRTVRPRTEKRRCAGAATDRRHALLRRRYRKTG
CHHHCCCHHHHHHCCHHHHHHHCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHC
RTGRRHPRSRQCRQIRHTVPQRGAAHAACADRNRPQPARYPQPPGGEAERQTRAAVHRRT
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
SGAFVLLYIHVPFCRSKCGYCAFHSVPVAAAGPDGMQQYLDALLREIALWGDRLGNRAVH
CCCEEEEEEECCHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
TVFFGGGTPSLLPEKAVAVIMDRLRRAFDIQNGAEISFEANPESVSAYGYLDTLFKCGIN
EEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCH
RLSLGVQSLNNDGLRVLGRPHKAREAVNAFRLARQAGFGNINLDMIWGLPSQRLKLWLDE
HHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
LKAVTELKPDHLSCYGLTLEEGTPLEQACLQGRHTLPDEQEQARMFIYGAEFLESRGYMQ
HHHHHHCCCCCEEEEEEEECCCCCHHHHHHCCCCCCCCCHHHCEEEEEEHHHHHHCCCEE
YEISNFARMGFQCRHNLGYWEGAEYLGMGPSAVSTLSGRRWENPHGLQEYARRTAEGTLG
EHHHHHHHHCHHHHCCCCCCCCCHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCC
HDAAALTPLERAEELIMLRLRTARGLRVKAYRDLTGRDFLREHKQLVHALHRNRLVRISN
CCHHHHCHHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHCCEEEEEC
GYLRLTRNGMLVSNTILENIFATLPEETPHKLSAAQEP
CEEEEECCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLSLLQDTARTGRIRSPQRRVRHGYLHPAVFPQTAARAHRRAGQRPVRRRQAAFSVPRLP
CCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GRLAAGHRDFQSVGHIPAAVLRLPVQRNRTVRPRTEKRRCAGAATDRRHALLRRRYRKTG
CHHHCCCHHHHHHCCHHHHHHHCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHC
RTGRRHPRSRQCRQIRHTVPQRGAAHAACADRNRPQPARYPQPPGGEAERQTRAAVHRRT
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
SGAFVLLYIHVPFCRSKCGYCAFHSVPVAAAGPDGMQQYLDALLREIALWGDRLGNRAVH
CCCEEEEEEECCHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
TVFFGGGTPSLLPEKAVAVIMDRLRRAFDIQNGAEISFEANPESVSAYGYLDTLFKCGIN
EEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCH
RLSLGVQSLNNDGLRVLGRPHKAREAVNAFRLARQAGFGNINLDMIWGLPSQRLKLWLDE
HHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
LKAVTELKPDHLSCYGLTLEEGTPLEQACLQGRHTLPDEQEQARMFIYGAEFLESRGYMQ
HHHHHHCCCCCEEEEEEEECCCCCHHHHHHCCCCCCCCCHHHCEEEEEEHHHHHHCCCEE
YEISNFARMGFQCRHNLGYWEGAEYLGMGPSAVSTLSGRRWENPHGLQEYARRTAEGTLG
EHHHHHHHHCHHHHCCCCCCCCCHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCC
HDAAALTPLERAEELIMLRLRTARGLRVKAYRDLTGRDFLREHKQLVHALHRNRLVRISN
CCHHHHCHHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHCCEEEEEC
GYLRLTRNGMLVSNTILENIFATLPEETPHKLSAAQEP
CEEEEECCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]