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The map label for this gene is ttcA [H]

Identifier: 78355291

GI number: 78355291

Start: 228454

End: 229206

Strand: Reverse

Name: ttcA [H]

Synonym: Dde_0244

Alternate gene names: 78355291

Gene position: 229206-228454 (Counterclockwise)

Preceding gene: 78355292

Following gene: 78355290

Centisome position: 6.14

GC content: 55.38

Gene sequence:

>753_bases
ATGGGTAAAGAACAGCTCAACTACGCACAGAAACAATGCATCGCCAGCGCGGGCAAGCTCATGCAGACCACCGGCATGCT
GTACCCCGGCGCCCGGGTCGGGGTGGCGGTATCAGGCGGCATGGACAGCTGGGTACTGCTGCAGGTGCTGCTGTACAGAC
AGCGCATTGTCCCTTTTCACTTTGAAATAATGGCCCTGCATGTCAATCCCGGCTTTGACCCGCAAAGCCATGCCCCGCTG
CTGGAATGGCTGCACCGCAACGGCGTGGCCGGCCATGTGGAACTGACGGACCACGGCCCGCGCGCCCATTCTCCGGAAAA
CAGACGCAACTCGCCGTGCTTTTATTGCGCCATGCTGCGCCGCAAGCACCTTTTTGACCTGTGCGGCAGGTACAACCTGA
CGCATCTGGCCTTCGGCCATAATGCCGACGATCTTGTGGCCACATTTTATATGAATCTGTACGAAGGCGGACGGGTGGAA
GGCATGGGCATGTGCGAAGACTTTTTCGGCGGCATGCTTAAAGTCATCCGGCCGCTGATGCTGGTGGAAAAATCTGTCAT
CCATCGTGCGGTGCGCGCATGGGAACTGCCGCTGTGGACAAACCCCTGTCCTTCGGCTTTCAACTCGCGCCGCAGCGAGG
TCATGGATGAATTTAAAGCCATGTGTAAAAACAACAAAACAATGAAAAGTAATGTTTTCAATGGTTTGATACGCTGGCAG
CTTGACTTGACACGTAAAGTGCAATCAAAGTAA

Upstream 100 bases:

>100_bases
CACTGCACAAACTTGCATCGCACGGCGGAAGCAGGTATCTCACCCCGCGCCGGTCCACGGCACACTCTGCCGTCAGCGGC
ACACAGCGGGGAATCCATAC

Downstream 100 bases:

>100_bases
CTAGTATCGTTGATCCGCCTGTCCTGTTCCGGCGGCACGAACTGACACCATAACCCCCCGGCTATGCTTTTTAACAAATA
CCACATTGTCATCTTCAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MGKEQLNYAQKQCIASAGKLMQTTGMLYPGARVGVAVSGGMDSWVLLQVLLYRQRIVPFHFEIMALHVNPGFDPQSHAPL
LEWLHRNGVAGHVELTDHGPRAHSPENRRNSPCFYCAMLRRKHLFDLCGRYNLTHLAFGHNADDLVATFYMNLYEGGRVE
GMGMCEDFFGGMLKVIRPLMLVEKSVIHRAVRAWELPLWTNPCPSAFNSRRSEVMDEFKAMCKNNKTMKSNVFNGLIRWQ
LDLTRKVQSK

Sequences:

>Translated_250_residues
MGKEQLNYAQKQCIASAGKLMQTTGMLYPGARVGVAVSGGMDSWVLLQVLLYRQRIVPFHFEIMALHVNPGFDPQSHAPL
LEWLHRNGVAGHVELTDHGPRAHSPENRRNSPCFYCAMLRRKHLFDLCGRYNLTHLAFGHNADDLVATFYMNLYEGGRVE
GMGMCEDFFGGMLKVIRPLMLVEKSVIHRAVRAWELPLWTNPCPSAFNSRRSEVMDEFKAMCKNNKTMKSNVFNGLIRWQ
LDLTRKVQSK
>Mature_249_residues
GKEQLNYAQKQCIASAGKLMQTTGMLYPGARVGVAVSGGMDSWVLLQVLLYRQRIVPFHFEIMALHVNPGFDPQSHAPLL
EWLHRNGVAGHVELTDHGPRAHSPENRRNSPCFYCAMLRRKHLFDLCGRYNLTHLAFGHNADDLVATFYMNLYEGGRVEG
MGMCEDFFGGMLKVIRPLMLVEKSVIHRAVRAWELPLWTNPCPSAFNSRRSEVMDEFKAMCKNNKTMKSNVFNGLIRWQL
DLTRKVQSK

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=225, Percent_Identity=32.4444444444444, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=222, Percent_Identity=27.9279279279279, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 28498; Mature: 28366

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKEQLNYAQKQCIASAGKLMQTTGMLYPGARVGVAVSGGMDSWVLLQVLLYRQRIVPFH
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEE
FEIMALHVNPGFDPQSHAPLLEWLHRNGVAGHVELTDHGPRAHSPENRRNSPCFYCAMLR
EEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
RKHLFDLCGRYNLTHLAFGHNADDLVATFYMNLYEGGRVEGMGMCEDFFGGMLKVIRPLM
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LVEKSVIHRAVRAWELPLWTNPCPSAFNSRRSEVMDEFKAMCKNNKTMKSNVFNGLIRWQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LDLTRKVQSK
HHHHHHHCCC
>Mature Secondary Structure 
GKEQLNYAQKQCIASAGKLMQTTGMLYPGARVGVAVSGGMDSWVLLQVLLYRQRIVPFH
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEE
FEIMALHVNPGFDPQSHAPLLEWLHRNGVAGHVELTDHGPRAHSPENRRNSPCFYCAMLR
EEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
RKHLFDLCGRYNLTHLAFGHNADDLVATFYMNLYEGGRVEGMGMCEDFFGGMLKVIRPLM
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LVEKSVIHRAVRAWELPLWTNPCPSAFNSRRSEVMDEFKAMCKNNKTMKSNVFNGLIRWQ
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LDLTRKVQSK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]