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The map label for this gene is zraS [H]

Identifier: 78355157

GI number: 78355157

Start: 101732

End: 103510

Strand: Reverse

Name: zraS [H]

Synonym: Dde_0110

Alternate gene names: 78355157

Gene position: 103510-101732 (Counterclockwise)

Preceding gene: 78355164

Following gene: 78355156

Centisome position: 2.77

GC content: 60.26

Gene sequence:

>1779_bases
ATGCACTTCAGAAAAAAACATTCTCTTCCCGGGCCGTTTGCCTCGCCGTGGCTGGTTATCGGCGCGGCGGTCATTCTGGG
CGTGGTGGTTGTGGCACTTTCAGTGCGCAACATCACCCGTTCGGAACAATACATGGCCAATATCCTGCTGGAAAAAGGCG
GATCGCTTATCAAGGCATTTGAGGCCGGAGCACGAACGGGCATGCGCGGCAGCGCGTTCCGCCTGCAGGTGCTGCTGGAA
GAAATGGCCGATCAGCCGGATATTGATTTCATTGCCCTGACAGACAGGGAAGGCAATATTGTGGCCCACAGCAACAACGA
ACAGGTAGGCAAACGGCTTTTCGGCGCCGAGGTGACCACCGACCTGCTGCGGCCTGACACACGCCCGAGGTGGAGCATTT
TCGGGCAGGCCGGTAAACGATACTTTGTGGTCTACCGTGAATTTGCACCGCTGCAGGGCCGCCATGCCCGCAGGGGACAC
ATGATGCCGCACATGCGCAACCACGCGTGGGATAACTGGCAGCAGCCGGACGGCCCGCCGCCCATCATTTTTGTCGGGTT
CGACGTTCAGCCGTTCGAGGACGCCCGCAGACAGGACAAACAGCACACCATGACCATGGCAGCCATAGTGCTGCTGTTGG
GGGTTGCGGGTTTCATATCGCTTATCTGGGCACAGAATGTCCGCCGCGCACGCAAAGAGCTGGAAAGCACACAGGCCCTG
TCGGATGAGATTGTTTCCAATCTCCCCGAAGGTCTGGTGGTGCTGGATGCCGCCGGAGATGTTTCTTTCATGAACAATGC
GGCCCGCGCCATGCTGGGAGACGGTACCGCCGCTCACGATGCGCACGAAGCAGCCGCAAGCTGCCCGCCGCTGCCGCCGG
TACTCATGCATGCCGTACGCCAGCTGGACACCCAGCACATACTGAGCGGCAGAGAAACGGTGCTTTCCGGCACCGGAGGC
CCTGTCCCCGTCAGTGTTACCGGTGCGTGCATAACAGGCGAAGACGGTTCGCTGATGGGCAAACTGCTGCTGCTGCACGA
CCTGAGCGAAGTGCGCAGACTGGAAGAAGAAGTACGCAGGCGCGAAAAGCTGGCAGCCATAGGCAGTCTGGCTGCGGGGG
TGGCTCACGAAATACGCAATCCGCTCAGCTCCATCAAAGGCTATGCCACCTATTTCGGCACCCGCTTTGCCGAAGGCAGC
GAAGACCGCGATGCCGCCCGGATCATGGTGCAGGAGGTGGACAGGCTCAACCGCGTCATTTCCGACCTTATCGGTCTGGC
CCGCCCGTCGGACCTGTCTTTAAAGCCCAGCAGACCGGAATCGCTGGCAGAAAACGTGCTCCGCCTTATCCGGCAGGATG
CCGCGGGCAAAAACATAGACTTGCGGTTCGCCGCGGCGGACGACCTGCCGCAGGCAGTGCTCGACCCCGACAGAGTGACG
CAGGCGCTGCTGAATGTCTGCCTTAACGCACTGGATGCCATGGAAAGCGGCGGCGTACTGACGCTGAGCGTTGACACCGA
CAGTACCTCTTCCGAAGGCCGCAGGCTGCTGCGGTTCAAGGTGCGTGACACGGGCTGCGGCATAACGCCCGAAACCCTGA
GCACCATGTTTGACCCGTATTTCACCACCAAAAGTCAGGGAACGGGGCTCGGGCTGGCCATTGTGCACAAAATAGTGGAG
GCCCACGGCGGCGAAATAGCCGTGCAGTCTTCCGTAGGCAGCGGAACGGAAATATCTCTCATTCTGCCGCTTGAACCGCA
ACGCAACGCGAACAGCTGA

Upstream 100 bases:

>100_bases
GTACAGTGAAAGTCAGTGTATAAAAAACATACACCTTTGAGAAAAAGCACTGTATAAAAAATAGACGCTGTACAAATATT
GAACACGCAAGGTGACGGCA

Downstream 100 bases:

>100_bases
CCCGGCGGCGCGTCAAAGGAACAGCCATGACAAACGCTCCTACCATATTGATAGTGGATGATGATCAGGCGCACAGAACC
ATGCTGCGCACCATGCTGCG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MHFRKKHSLPGPFASPWLVIGAAVILGVVVVALSVRNITRSEQYMANILLEKGGSLIKAFEAGARTGMRGSAFRLQVLLE
EMADQPDIDFIALTDREGNIVAHSNNEQVGKRLFGAEVTTDLLRPDTRPRWSIFGQAGKRYFVVYREFAPLQGRHARRGH
MMPHMRNHAWDNWQQPDGPPPIIFVGFDVQPFEDARRQDKQHTMTMAAIVLLLGVAGFISLIWAQNVRRARKELESTQAL
SDEIVSNLPEGLVVLDAAGDVSFMNNAARAMLGDGTAAHDAHEAAASCPPLPPVLMHAVRQLDTQHILSGRETVLSGTGG
PVPVSVTGACITGEDGSLMGKLLLLHDLSEVRRLEEEVRRREKLAAIGSLAAGVAHEIRNPLSSIKGYATYFGTRFAEGS
EDRDAARIMVQEVDRLNRVISDLIGLARPSDLSLKPSRPESLAENVLRLIRQDAAGKNIDLRFAAADDLPQAVLDPDRVT
QALLNVCLNALDAMESGGVLTLSVDTDSTSSEGRRLLRFKVRDTGCGITPETLSTMFDPYFTTKSQGTGLGLAIVHKIVE
AHGGEIAVQSSVGSGTEISLILPLEPQRNANS

Sequences:

>Translated_592_residues
MHFRKKHSLPGPFASPWLVIGAAVILGVVVVALSVRNITRSEQYMANILLEKGGSLIKAFEAGARTGMRGSAFRLQVLLE
EMADQPDIDFIALTDREGNIVAHSNNEQVGKRLFGAEVTTDLLRPDTRPRWSIFGQAGKRYFVVYREFAPLQGRHARRGH
MMPHMRNHAWDNWQQPDGPPPIIFVGFDVQPFEDARRQDKQHTMTMAAIVLLLGVAGFISLIWAQNVRRARKELESTQAL
SDEIVSNLPEGLVVLDAAGDVSFMNNAARAMLGDGTAAHDAHEAAASCPPLPPVLMHAVRQLDTQHILSGRETVLSGTGG
PVPVSVTGACITGEDGSLMGKLLLLHDLSEVRRLEEEVRRREKLAAIGSLAAGVAHEIRNPLSSIKGYATYFGTRFAEGS
EDRDAARIMVQEVDRLNRVISDLIGLARPSDLSLKPSRPESLAENVLRLIRQDAAGKNIDLRFAAADDLPQAVLDPDRVT
QALLNVCLNALDAMESGGVLTLSVDTDSTSSEGRRLLRFKVRDTGCGITPETLSTMFDPYFTTKSQGTGLGLAIVHKIVE
AHGGEIAVQSSVGSGTEISLILPLEPQRNANS
>Mature_592_residues
MHFRKKHSLPGPFASPWLVIGAAVILGVVVVALSVRNITRSEQYMANILLEKGGSLIKAFEAGARTGMRGSAFRLQVLLE
EMADQPDIDFIALTDREGNIVAHSNNEQVGKRLFGAEVTTDLLRPDTRPRWSIFGQAGKRYFVVYREFAPLQGRHARRGH
MMPHMRNHAWDNWQQPDGPPPIIFVGFDVQPFEDARRQDKQHTMTMAAIVLLLGVAGFISLIWAQNVRRARKELESTQAL
SDEIVSNLPEGLVVLDAAGDVSFMNNAARAMLGDGTAAHDAHEAAASCPPLPPVLMHAVRQLDTQHILSGRETVLSGTGG
PVPVSVTGACITGEDGSLMGKLLLLHDLSEVRRLEEEVRRREKLAAIGSLAAGVAHEIRNPLSSIKGYATYFGTRFAEGS
EDRDAARIMVQEVDRLNRVISDLIGLARPSDLSLKPSRPESLAENVLRLIRQDAAGKNIDLRFAAADDLPQAVLDPDRVT
QALLNVCLNALDAMESGGVLTLSVDTDSTSSEGRRLLRFKVRDTGCGITPETLSTMFDPYFTTKSQGTGLGLAIVHKIVE
AHGGEIAVQSSVGSGTEISLILPLEPQRNANS

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=49.1525423728814, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788549, Length=377, Percent_Identity=30.2387267904509, Blast_Score=182, Evalue=7e-47,
Organism=Escherichia coli, GI1790300, Length=369, Percent_Identity=27.10027100271, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI87081816, Length=228, Percent_Identity=32.0175438596491, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693157, Length=372, Percent_Identity=26.8817204301075, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786783, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786600, Length=256, Percent_Identity=24.609375, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI48994928, Length=252, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=27.8761061946903, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=27.3469387755102, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=27.3127753303965, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=24.609375, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=27.1111111111111, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64345; Mature: 64345

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFRKKHSLPGPFASPWLVIGAAVILGVVVVALSVRNITRSEQYMANILLEKGGSLIKAF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EAGARTGMRGSAFRLQVLLEEMADQPDIDFIALTDREGNIVAHSNNEQVGKRLFGAEVTT
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHH
DLLRPDTRPRWSIFGQAGKRYFVVYREFAPLQGRHARRGHMMPHMRNHAWDNWQQPDGPP
HHHCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCC
PIIFVGFDVQPFEDARRQDKQHTMTMAAIVLLLGVAGFISLIWAQNVRRARKELESTQAL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDEIVSNLPEGLVVLDAAGDVSFMNNAARAMLGDGTAAHDAHEAAASCPPLPPVLMHAVR
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHH
QLDTQHILSGRETVLSGTGGPVPVSVTGACITGEDGSLMGKLLLLHDLSEVRRLEEEVRR
HHHHHHHHCCCHHEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
REKLAAIGSLAAGVAHEIRNPLSSIKGYATYFGTRFAEGSEDRDAARIMVQEVDRLNRVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
SDLIGLARPSDLSLKPSRPESLAENVLRLIRQDAAGKNIDLRFAAADDLPQAVLDPDRVT
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHH
QALLNVCLNALDAMESGGVLTLSVDTDSTSSEGRRLLRFKVRDTGCGITPETLSTMFDPY
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCEEEEEEEECCCCCCCHHHHHHHHCCC
FTTKSQGTGLGLAIVHKIVEAHGGEIAVQSSVGSGTEISLILPLEPQRNANS
CCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MHFRKKHSLPGPFASPWLVIGAAVILGVVVVALSVRNITRSEQYMANILLEKGGSLIKAF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EAGARTGMRGSAFRLQVLLEEMADQPDIDFIALTDREGNIVAHSNNEQVGKRLFGAEVTT
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHH
DLLRPDTRPRWSIFGQAGKRYFVVYREFAPLQGRHARRGHMMPHMRNHAWDNWQQPDGPP
HHHCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCC
PIIFVGFDVQPFEDARRQDKQHTMTMAAIVLLLGVAGFISLIWAQNVRRARKELESTQAL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDEIVSNLPEGLVVLDAAGDVSFMNNAARAMLGDGTAAHDAHEAAASCPPLPPVLMHAVR
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHH
QLDTQHILSGRETVLSGTGGPVPVSVTGACITGEDGSLMGKLLLLHDLSEVRRLEEEVRR
HHHHHHHHCCCHHEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
REKLAAIGSLAAGVAHEIRNPLSSIKGYATYFGTRFAEGSEDRDAARIMVQEVDRLNRVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
SDLIGLARPSDLSLKPSRPESLAENVLRLIRQDAAGKNIDLRFAAADDLPQAVLDPDRVT
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHH
QALLNVCLNALDAMESGGVLTLSVDTDSTSSEGRRLLRFKVRDTGCGITPETLSTMFDPY
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCEEEEEEEECCCCCCCHHHHHHHHCCC
FTTKSQGTGLGLAIVHKIVEAHGGEIAVQSSVGSGTEISLILPLEPQRNANS
CCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]