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The map label for this gene is fmt [H]

Identifier: 78355061

GI number: 78355061

Start: 14185

End: 15174

Strand: Direct

Name: fmt [H]

Synonym: Dde_0014

Alternate gene names: 78355061

Gene position: 14185-15174 (Clockwise)

Preceding gene: 78355060

Following gene: 78355062

Centisome position: 0.38

GC content: 60.3

Gene sequence:

>990_bases
ATGGCAGAAGCGCGCGAAAAACTGAAAATAGTCTACATGGGCACGCCGGATTTTGCGGCGACGGTACTTTCTCATCTGCT
TGCGTGGGAAGACGCCGAGGTGCTTGCTGTGTACACGCAGCCCGACAGGCCCTGCGGCCGCGGGCTGGAATGCCGTCCTT
CCGCTGTGAAGTCGCTGGCTCTGGAACACGGCCTGCCTGTATTCCAGCCGCTTAATTTCAAGGCCGAAGAAGATGTGCGT
CAGCTTGCCGCGCTGCAGCCCGATGTGCTTGTGGTAGCTGCATACGGGCTTATTCTGCCGCAGTGCGTTCTTGATATAGC
ACCGCGGGGTGCGGTGAACGTGCACGCCTCGTTACTGCCGCGGTACCGCGGTGCCGCCCCCATTCAGCGGGCCATCATGA
ACGGTGACGCCGTGACAGGTGTGACCATAATGCAGATGGAGGCCGGTCTGGACAGCGGGCCCATGCTGCTGCAGAGGGCT
ACCGGCATAGGTATTACCGATACGGCGGCAACTATGCATGACGAACTGGCCGATCTGGGCGGCAGGCTGCTGGTAGAAGC
GCTGGGGCGGATGATGAAAGGCGAACTGGTGCCCATGGAACAGAACCATGAGGCTGCCACCCACGCTCCCAAACTGACCA
AGGCCGACGGTGAAATTGTATGGAACCGTCCTGCCCGTGAAGTGGATGCTCATATCCGCGGGGTTCATCCGTGGCCGGGG
GCTTTTTTTGCGCTGCGCCGCGAAGGGCATAAAACATTGCGCGTGGGTATAGAACCCGGCTGCACGGGTGATGCCGTGCC
CGAAGGGGTCAAGCCCGGCACGGTGACAGGTATGGCAGGCGACAGGCTGGCCATTGCCTGTGCTGACAGGTTGTACCTTG
TTTCTTCGCTGCGTCCTGCCAGCCGCAAGCCCATGACTGCTTCTGCTTTTTACTGCGGATATCTGGCCGAATGCACTCTG
GCGGAGTGTGTCGGTCTGGATGAATGCTGA

Upstream 100 bases:

>100_bases
CCATCTGTCTGCAGCACGAAATAGACCATCTGGACGGTACGCTGTTTATCGACAAGATAAGCCGCCTTAAGCGTTCACTC
TATGACAACAAAGTGAAAAA

Downstream 100 bases:

>100_bases
GACCCTGCGTCTGTGGCCGGCTGTGGTCTGCTGCCGTGGCCGGCGACAGCCCTTCTGCAGTGTATGCGGCGGAAACTTCT
TTTCTGCCGGTGTGTTATTT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAEAREKLKIVYMGTPDFAATVLSHLLAWEDAEVLAVYTQPDRPCGRGLECRPSAVKSLALEHGLPVFQPLNFKAEEDVR
QLAALQPDVLVVAAYGLILPQCVLDIAPRGAVNVHASLLPRYRGAAPIQRAIMNGDAVTGVTIMQMEAGLDSGPMLLQRA
TGIGITDTAATMHDELADLGGRLLVEALGRMMKGELVPMEQNHEAATHAPKLTKADGEIVWNRPAREVDAHIRGVHPWPG
AFFALRREGHKTLRVGIEPGCTGDAVPEGVKPGTVTGMAGDRLAIACADRLYLVSSLRPASRKPMTASAFYCGYLAECTL
AECVGLDEC

Sequences:

>Translated_329_residues
MAEAREKLKIVYMGTPDFAATVLSHLLAWEDAEVLAVYTQPDRPCGRGLECRPSAVKSLALEHGLPVFQPLNFKAEEDVR
QLAALQPDVLVVAAYGLILPQCVLDIAPRGAVNVHASLLPRYRGAAPIQRAIMNGDAVTGVTIMQMEAGLDSGPMLLQRA
TGIGITDTAATMHDELADLGGRLLVEALGRMMKGELVPMEQNHEAATHAPKLTKADGEIVWNRPAREVDAHIRGVHPWPG
AFFALRREGHKTLRVGIEPGCTGDAVPEGVKPGTVTGMAGDRLAIACADRLYLVSSLRPASRKPMTASAFYCGYLAECTL
AECVGLDEC
>Mature_328_residues
AEAREKLKIVYMGTPDFAATVLSHLLAWEDAEVLAVYTQPDRPCGRGLECRPSAVKSLALEHGLPVFQPLNFKAEEDVRQ
LAALQPDVLVVAAYGLILPQCVLDIAPRGAVNVHASLLPRYRGAAPIQRAIMNGDAVTGVTIMQMEAGLDSGPMLLQRAT
GIGITDTAATMHDELADLGGRLLVEALGRMMKGELVPMEQNHEAATHAPKLTKADGEIVWNRPAREVDAHIRGVHPWPGA
FFALRREGHKTLRVGIEPGCTGDAVPEGVKPGTVTGMAGDRLAIACADRLYLVSSLRPASRKPMTASAFYCGYLAECTLA
ECVGLDEC

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=332, Percent_Identity=31.0240963855422, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI21614513, Length=333, Percent_Identity=28.5285285285285, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI238814322, Length=283, Percent_Identity=27.5618374558304, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1789683, Length=302, Percent_Identity=43.3774834437086, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788589, Length=283, Percent_Identity=31.8021201413428, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI133930964, Length=255, Percent_Identity=27.0588235294118, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319458, Length=263, Percent_Identity=25.0950570342205, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571984, Length=244, Percent_Identity=34.4262295081967, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45550868, Length=243, Percent_Identity=34.5679012345679, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24585660, Length=242, Percent_Identity=28.5123966942149, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 35249; Mature: 35118

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAREKLKIVYMGTPDFAATVLSHLLAWEDAEVLAVYTQPDRPCGRGLECRPSAVKSLA
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
LEHGLPVFQPLNFKAEEDVRQLAALQPDVLVVAAYGLILPQCVLDIAPRGAVNVHASLLP
HHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
RYRGAAPIQRAIMNGDAVTGVTIMQMEAGLDSGPMLLQRATGIGITDTAATMHDELADLG
HHCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
GRLLVEALGRMMKGELVPMEQNHEAATHAPKLTKADGEIVWNRPAREVDAHIRGVHPWPG
HHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCH
AFFALRREGHKTLRVGIEPGCTGDAVPEGVKPGTVTGMAGDRLAIACADRLYLVSSLRPA
HHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHCCCC
SRKPMTASAFYCGYLAECTLAECVGLDEC
CCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AEAREKLKIVYMGTPDFAATVLSHLLAWEDAEVLAVYTQPDRPCGRGLECRPSAVKSLA
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
LEHGLPVFQPLNFKAEEDVRQLAALQPDVLVVAAYGLILPQCVLDIAPRGAVNVHASLLP
HHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
RYRGAAPIQRAIMNGDAVTGVTIMQMEAGLDSGPMLLQRATGIGITDTAATMHDELADLG
HHCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
GRLLVEALGRMMKGELVPMEQNHEAATHAPKLTKADGEIVWNRPAREVDAHIRGVHPWPG
HHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCH
AFFALRREGHKTLRVGIEPGCTGDAVPEGVKPGTVTGMAGDRLAIACADRLYLVSSLRPA
HHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHCCCC
SRKPMTASAFYCGYLAECTLAECVGLDEC
CCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA