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The map label for this gene is aspS

Identifier: 78355059

GI number: 78355059

Start: 11670

End: 13490

Strand: Direct

Name: aspS

Synonym: Dde_0012

Alternate gene names: 78355059

Gene position: 11670-13490 (Clockwise)

Preceding gene: 78355058

Following gene: 78355060

Centisome position: 0.31

GC content: 57.0

Gene sequence:

>1821_bases
ATGAGCGACCAGAATTTGGACATTCAGCAGGATCACCAGAAATATGTGGAGTCTCTTGGCGATTGGGCGCGCACCAATAC
GTGCGGTGAGCTGAATGCCAATGCCATCGGGTCCGAAGTGTGCCTGATGGGCTGGGTTCAGTTTCGCCGTGACCACGGCG
GCCTTATTTTTATCGATCTGCGCGACCGCAGCGGCCTGACACAGGTTGTGTTCAGCCCCGATGTCAGCGTGGACGCGCAT
GAGCGCGCTCACGTGCTGCGTTCCGAATACGTGCTGGCCGTGCGCGGCACTGTGCGTCCACGCCCTGAAGGCATGGTGAA
CCCCAATATGAAGACGGGTGAAGTGGAAGTGTATGTTTCCGAGTGGAAACTGCTGAACACCTCCAAGACTCCTCCGTTTC
AGGTGGAAGACCGCGTTGAGGCCAGCGAAAACCTGCGCCTTGAATACCGCTATCTCGACCTGCGCCGTCCTCGGCTTGCC
CGCAACTTCCAGCTGCGCCACCGTGCCACGCAGGCTATCCGCAATTATCTTGACCAGCTGAACTTTCTGGAAGTGGAAAC
CCCGTATCTCACCAAATCCACTCCTGAAGGTGCCCGTGATTTTCTGGTGCCCAGCCGTATGAATCAGGGAGAATTTTACG
CGCTGCCGCAGTCTCCGCAGATTTTCAAGCAGCTTCTGATGGTGGCCGGTATGGACCGCTATTATCAGATTGTGCGCTGT
TTCCGCGACGAAGACCTGCGTGCCGACCGTCAGCCCGAGTTCACTCAGGTGGATATCGAGATGAGCTTTGTGGACGAAGA
ACGCGTGCAGTCCATGGCGGAAGGATTGATGGCGAGGGTTTTCAAGGAGACTCTGGGCATTGATGTGGCGCTGCCTTTCC
CGCGTATGCCGTATGATCAGGCCATTGCCGAATATGGTCTGGACAAGCCTGACACCCGCTTTGATCTGCGCCTCAAGGAT
GTGACGGATATCCTGCGCGGTTCCGGATTCCGGCTGTTTGCCAAGGCGGAACTGGTCAAAGCCATGCGTGTGCCCGGCGG
TGCCGTGCTTTCGCGCAAGGAAATTGACGACTTCACCGAGTTTGTGAAGGTTTACGGTGCGCAGGGGCTTGCGTGGATAA
AGATTAAGGAAGACGAATGGCAGTCGCCCATTGCCAAGTTCCTTTCCGATGACGAGCGCGCCGCACTTACTACGGAGCTG
GGGCTGGAAACGGGCGATATCGTGTTCTTTCAGGCTGCTTCGCCCGACGTGGTCAATAACTCGCTGGGATACCTGCGTCT
CAAGGTGGCCGACAGGTTCGGGCTTATTCCCGAAAACAGCTACAATTTCCTGTGGGTGACTGATTTTCCCCTGTTTGAAT
ACTCGCCCGAAGATAAGCGCTATGTGGCCTGCCACCATCCTTTCACTGCGCCTCAGGTAGGCCACGAAGAACTGATGGTC
AGCGATCCGGCTAAAGCCCGCGCCCGTGCATATGACCTTGTGCTCAACGGCAACGAAGTGGGCGGCGGATCCATACGCAT
CCACAGTCGCGAAGCACAGGAACACATGTTCCGCGCTCTGGGCTTTGATCCGCAGGAAGCCGAGGAACAGTTCGGTTTTC
TCATGCAGGCGCTGGAACTGGGCGCACCGCCTCATGGCGGCATAGCCTTCGGCATGGACCGTCTGGTTATGCTGCTGGCG
GGCTCCGCATCCATCCGCGATGTCATAGCCTTCCCGAAAACACAGAAGGCAACCTGTCTGATGACGCATGCCCCTGATCA
GGTAGCGGCAAAACAGCTGCGCGAGCTTGGCATCAGACTACGTGAAAAACAGGAAGCGTAA

Upstream 100 bases:

>100_bases
TTTCCCTGGACGCAGCACCCGGTGCTGTGGCTGACTGATTAACTTTTTTCGACAGTATCTTGGCGGGGTCGGATGCCCGC
CGGAAACAGAGGTATACTTC

Downstream 100 bases:

>100_bases
TAACCATGTACGCCCCGGCGGAAAACCGCCGGGGCGTTTTGTACGCTGTGCCGTGTCGCCGGCATATTGAAGTGTTGCCG
CTGCATGCATGCGGGTGTAT

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MSDQNLDIQQDHQKYVESLGDWARTNTCGELNANAIGSEVCLMGWVQFRRDHGGLIFIDLRDRSGLTQVVFSPDVSVDAH
ERAHVLRSEYVLAVRGTVRPRPEGMVNPNMKTGEVEVYVSEWKLLNTSKTPPFQVEDRVEASENLRLEYRYLDLRRPRLA
RNFQLRHRATQAIRNYLDQLNFLEVETPYLTKSTPEGARDFLVPSRMNQGEFYALPQSPQIFKQLLMVAGMDRYYQIVRC
FRDEDLRADRQPEFTQVDIEMSFVDEERVQSMAEGLMARVFKETLGIDVALPFPRMPYDQAIAEYGLDKPDTRFDLRLKD
VTDILRGSGFRLFAKAELVKAMRVPGGAVLSRKEIDDFTEFVKVYGAQGLAWIKIKEDEWQSPIAKFLSDDERAALTTEL
GLETGDIVFFQAASPDVVNNSLGYLRLKVADRFGLIPENSYNFLWVTDFPLFEYSPEDKRYVACHHPFTAPQVGHEELMV
SDPAKARARAYDLVLNGNEVGGGSIRIHSREAQEHMFRALGFDPQEAEEQFGFLMQALELGAPPHGGIAFGMDRLVMLLA
GSASIRDVIAFPKTQKATCLMTHAPDQVAAKQLRELGIRLREKQEA

Sequences:

>Translated_606_residues
MSDQNLDIQQDHQKYVESLGDWARTNTCGELNANAIGSEVCLMGWVQFRRDHGGLIFIDLRDRSGLTQVVFSPDVSVDAH
ERAHVLRSEYVLAVRGTVRPRPEGMVNPNMKTGEVEVYVSEWKLLNTSKTPPFQVEDRVEASENLRLEYRYLDLRRPRLA
RNFQLRHRATQAIRNYLDQLNFLEVETPYLTKSTPEGARDFLVPSRMNQGEFYALPQSPQIFKQLLMVAGMDRYYQIVRC
FRDEDLRADRQPEFTQVDIEMSFVDEERVQSMAEGLMARVFKETLGIDVALPFPRMPYDQAIAEYGLDKPDTRFDLRLKD
VTDILRGSGFRLFAKAELVKAMRVPGGAVLSRKEIDDFTEFVKVYGAQGLAWIKIKEDEWQSPIAKFLSDDERAALTTEL
GLETGDIVFFQAASPDVVNNSLGYLRLKVADRFGLIPENSYNFLWVTDFPLFEYSPEDKRYVACHHPFTAPQVGHEELMV
SDPAKARARAYDLVLNGNEVGGGSIRIHSREAQEHMFRALGFDPQEAEEQFGFLMQALELGAPPHGGIAFGMDRLVMLLA
GSASIRDVIAFPKTQKATCLMTHAPDQVAAKQLRELGIRLREKQEA
>Mature_605_residues
SDQNLDIQQDHQKYVESLGDWARTNTCGELNANAIGSEVCLMGWVQFRRDHGGLIFIDLRDRSGLTQVVFSPDVSVDAHE
RAHVLRSEYVLAVRGTVRPRPEGMVNPNMKTGEVEVYVSEWKLLNTSKTPPFQVEDRVEASENLRLEYRYLDLRRPRLAR
NFQLRHRATQAIRNYLDQLNFLEVETPYLTKSTPEGARDFLVPSRMNQGEFYALPQSPQIFKQLLMVAGMDRYYQIVRCF
RDEDLRADRQPEFTQVDIEMSFVDEERVQSMAEGLMARVFKETLGIDVALPFPRMPYDQAIAEYGLDKPDTRFDLRLKDV
TDILRGSGFRLFAKAELVKAMRVPGGAVLSRKEIDDFTEFVKVYGAQGLAWIKIKEDEWQSPIAKFLSDDERAALTTELG
LETGDIVFFQAASPDVVNNSLGYLRLKVADRFGLIPENSYNFLWVTDFPLFEYSPEDKRYVACHHPFTAPQVGHEELMVS
DPAKARARAYDLVLNGNEVGGGSIRIHSREAQEHMFRALGFDPQEAEEQFGFLMQALELGAPPHGGIAFGMDRLVMLLAG
SASIRDVIAFPKTQKATCLMTHAPDQVAAKQLRELGIRLREKQEA

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI40789249, Length=613, Percent_Identity=43.7194127243067, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI5031815, Length=301, Percent_Identity=28.2392026578073, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI194272210, Length=269, Percent_Identity=28.6245353159851, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI45439306, Length=286, Percent_Identity=25.8741258741259, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI4758762, Length=297, Percent_Identity=24.5791245791246, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788173, Length=592, Percent_Identity=48.8175675675676, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI1789256, Length=319, Percent_Identity=25.705329153605, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1790571, Length=295, Percent_Identity=26.1016949152542, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32566633, Length=597, Percent_Identity=35.8458961474037, Blast_Score=335, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI71994340, Length=173, Percent_Identity=30.0578034682081, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535925, Length=173, Percent_Identity=30.0578034682081, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535927, Length=173, Percent_Identity=30.0578034682081, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71984122, Length=296, Percent_Identity=26.6891891891892, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551876, Length=360, Percent_Identity=24.7222222222222, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325153, Length=636, Percent_Identity=33.8050314465409, Blast_Score=293, Evalue=8e-80,
Organism=Saccharomyces cerevisiae, GI6323011, Length=317, Percent_Identity=28.7066246056782, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321807, Length=266, Percent_Identity=25.9398496240602, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=216, Percent_Identity=31.0185185185185, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584738, Length=603, Percent_Identity=38.3084577114428, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24640849, Length=273, Percent_Identity=27.8388278388278, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640851, Length=273, Percent_Identity=27.8388278388278, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136276, Length=251, Percent_Identity=25.0996015936255, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921528, Length=283, Percent_Identity=28.6219081272085, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYD_DESDG (Q317R3)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_386508.1
- ProteinModelPortal:   Q317R3
- SMR:   Q317R3
- STRING:   Q317R3
- GeneID:   3755954
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0012
- NMPDR:   fig|207559.3.peg.518
- eggNOG:   COG0173
- HOGENOM:   HBG396032
- OMA:   AFPKTQQ
- ProtClustDB:   PRK00476
- BioCyc:   DDES207559:DDE_0012-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00044_B
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:3.30.1360.30
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF5
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00459

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.12

Molecular weight: Translated: 68959; Mature: 68828

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQNLDIQQDHQKYVESLGDWARTNTCGELNANAIGSEVCLMGWVQFRRDHGGLIFIDL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCHHHHHHHHHHHHCCCCCEEEEEE
RDRSGLTQVVFSPDVSVDAHERAHVLRSEYVLAVRGTVRPRPEGMVNPNMKTGEVEVYVS
CCCCCCEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
EWKLLNTSKTPPFQVEDRVEASENLRLEYRYLDLRRPRLARNFQLRHRATQAIRNYLDQL
EEEEECCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
NFLEVETPYLTKSTPEGARDFLVPSRMNQGEFYALPQSPQIFKQLLMVAGMDRYYQIVRC
CEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHH
FRDEDLRADRQPEFTQVDIEMSFVDEERVQSMAEGLMARVFKETLGIDVALPFPRMPYDQ
HCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHH
AIAEYGLDKPDTRFDLRLKDVTDILRGSGFRLFAKAELVKAMRVPGGAVLSRKEIDDFTE
HHHHHCCCCCCCEEEEEHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCEECHHHHHHHHH
FVKVYGAQGLAWIKIKEDEWQSPIAKFLSDDERAALTTELGLETGDIVFFQAASPDVVNN
HHHHHCCCCEEEEEEECHHHHHHHHHHHCCCCHHEEEHHCCCCCCCEEEEECCCCCHHCC
SLGYLRLKVADRFGLIPENSYNFLWVTDFPLFEYSPEDKRYVACHHPFTAPQVGHEELMV
CCCEEEEEEEHHCCCCCCCCCCEEEEECCCCEECCCCCCCEEEEECCCCCCCCCCCCEEE
SDPAKARARAYDLVLNGNEVGGGSIRIHSREAQEHMFRALGFDPQEAEEQFGFLMQALEL
CCCHHHHHEEEEEEEECCEECCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GAPPHGGIAFGMDRLVMLLAGSASIRDVIAFPKTQKATCLMTHAPDQVAAKQLRELGIRL
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHH
REKQEA
HHCCCC
>Mature Secondary Structure 
SDQNLDIQQDHQKYVESLGDWARTNTCGELNANAIGSEVCLMGWVQFRRDHGGLIFIDL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCHHHHHHHHHHHHCCCCCEEEEEE
RDRSGLTQVVFSPDVSVDAHERAHVLRSEYVLAVRGTVRPRPEGMVNPNMKTGEVEVYVS
CCCCCCEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
EWKLLNTSKTPPFQVEDRVEASENLRLEYRYLDLRRPRLARNFQLRHRATQAIRNYLDQL
EEEEECCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
NFLEVETPYLTKSTPEGARDFLVPSRMNQGEFYALPQSPQIFKQLLMVAGMDRYYQIVRC
CEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHH
FRDEDLRADRQPEFTQVDIEMSFVDEERVQSMAEGLMARVFKETLGIDVALPFPRMPYDQ
HCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHH
AIAEYGLDKPDTRFDLRLKDVTDILRGSGFRLFAKAELVKAMRVPGGAVLSRKEIDDFTE
HHHHHCCCCCCCEEEEEHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCEECHHHHHHHHH
FVKVYGAQGLAWIKIKEDEWQSPIAKFLSDDERAALTTELGLETGDIVFFQAASPDVVNN
HHHHHCCCCEEEEEEECHHHHHHHHHHHCCCCHHEEEHHCCCCCCCEEEEECCCCCHHCC
SLGYLRLKVADRFGLIPENSYNFLWVTDFPLFEYSPEDKRYVACHHPFTAPQVGHEELMV
CCCEEEEEEEHHCCCCCCCCCCEEEEECCCCEECCCCCCCEEEEECCCCCCCCCCCCEEE
SDPAKARARAYDLVLNGNEVGGGSIRIHSREAQEHMFRALGFDPQEAEEQFGFLMQALEL
CCCHHHHHEEEEEEEECCEECCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GAPPHGGIAFGMDRLVMLLAGSASIRDVIAFPKTQKATCLMTHAPDQVAAKQLRELGIRL
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHH
REKQEA
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA