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The map label for this gene is hisS

Identifier: 78355058

GI number: 78355058

Start: 10354

End: 11607

Strand: Direct

Name: hisS

Synonym: Dde_0011

Alternate gene names: 78355058

Gene position: 10354-11607 (Clockwise)

Preceding gene: 78355057

Following gene: 78355059

Centisome position: 0.28

GC content: 57.58

Gene sequence:

>1254_bases
ATGAGTAATGTAAAGAAAATAAAGGGTTTTGCAGACCTTTTTTCACCGGAAAGCGACGTGTTCACCTTTATGGAGAATAC
GGCACGCGATGTGTTTTCATCCTATGGCTACGGAGAGTTGCGCACGCCTATTCTTGAGCGCACGGAACTGTTCTGCCGTT
CCATAGGCACGGAAACCGACGTGGTGCAGAAGGAAATGTATACGTTTCCTGACCGGAAAAACCGGTCTCTGACCATGCGG
CCGGAAGCGACAGCCGGAGTGATGCGGGCTTATATCGAAGGTTCGCTGCATAGTCAGGAGCAGGTTTCAAAGCTGTTCAC
GTTTGGTCCCATGTTCCGGTACGAGCGTCCGCAGAAGGGGCGCATGCGGCAGTTTCATCAGATCAACTGCGAATGTCTCG
GCCCGCAGGAACCGTATGCAGACGCGGAAATAATCCTCATGCTGTTGATGTTCCTCAAGCGCATAGGTTTGTCCGGCCTT
GAGCTGCAGATCAATTCACTGGGCTGCCGTGAGTGCCGTCCGCAGTATCATGCGGCACTCAGGGCGTTTCTGGCGTCGCT
TGATACGGCAGAACTGTGTGAAGACTGCCGCAGGCGCATGGAAACAAACCCCCTGCGCGTGCTGGACTGCAAGGTGCCGC
GCTGTAAAGAGCTGACAGCGGATGCTCCGGTGATACTCGACCATACCTGCGATGCCTGTTCGGAGCATCATTCCGTGGTG
CTCGGCATGTTGGAGCGTGCCGGTGTGGTGTATACGGCAAACCCCCGTCTGGTGCGCGGTCTTGATTATTACAACCGCAC
CACATTTGAAGTGGTATGCGGCGAAATAGGTGCACAGTCTTCCGTTGCCGGTGGCGGCCGGTACGACGGTCTTGTGTCGC
AGCTGGGCGGTCCCGATGTGCCGGGCATCGGCTTTGCGTGCGGTATGGAACGTCTGGCGCTGGCGCTGGAGCAGAAGGCG
CAGCGCGAAGTGCCGCGTCCTGATTTTCTGGTGGCAGTGCTGGAACAGGACGGTCTTGAGCGCGGAATGATGCTGGCTGA
GGCCCTGCGCGAAAGCGGGCTGAAAGGTGAAGTCAGCTTTGCCGCCCGCAGCATGAAAAGCCAGATGCGGCAGGCCGGAA
AACGCAATGTACGCAAGGTGCTGCTGCTGGGCGGCAGCGAGATTGCCGACGGTACAGTTACCGTGAAAGACATGGACACC
GGCGGGCAGACGACAATTTCCCTGGACGCAGCACCCGGTGCTGTGGCTGACTGA

Upstream 100 bases:

>100_bases
GGGCTATGGACTACAGAAGGCTGTTTCACCGGTGTGCCGCGCTTTCGTGGCGGTGGTGCAGCACCGTGACAACGTAATTT
GTCTGTATGGATTGCCAGCT

Downstream 100 bases:

>100_bases
TTAACTTTTTTCGACAGTATCTTGGCGGGGTCGGATGCCCGCCGGAAACAGAGGTATACTTCATGAGCGACCAGAATTTG
GACATTCAGCAGGATCACCA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSNVKKIKGFADLFSPESDVFTFMENTARDVFSSYGYGELRTPILERTELFCRSIGTETDVVQKEMYTFPDRKNRSLTMR
PEATAGVMRAYIEGSLHSQEQVSKLFTFGPMFRYERPQKGRMRQFHQINCECLGPQEPYADAEIILMLLMFLKRIGLSGL
ELQINSLGCRECRPQYHAALRAFLASLDTAELCEDCRRRMETNPLRVLDCKVPRCKELTADAPVILDHTCDACSEHHSVV
LGMLERAGVVYTANPRLVRGLDYYNRTTFEVVCGEIGAQSSVAGGGRYDGLVSQLGGPDVPGIGFACGMERLALALEQKA
QREVPRPDFLVAVLEQDGLERGMMLAEALRESGLKGEVSFAARSMKSQMRQAGKRNVRKVLLLGGSEIADGTVTVKDMDT
GGQTTISLDAAPGAVAD

Sequences:

>Translated_417_residues
MSNVKKIKGFADLFSPESDVFTFMENTARDVFSSYGYGELRTPILERTELFCRSIGTETDVVQKEMYTFPDRKNRSLTMR
PEATAGVMRAYIEGSLHSQEQVSKLFTFGPMFRYERPQKGRMRQFHQINCECLGPQEPYADAEIILMLLMFLKRIGLSGL
ELQINSLGCRECRPQYHAALRAFLASLDTAELCEDCRRRMETNPLRVLDCKVPRCKELTADAPVILDHTCDACSEHHSVV
LGMLERAGVVYTANPRLVRGLDYYNRTTFEVVCGEIGAQSSVAGGGRYDGLVSQLGGPDVPGIGFACGMERLALALEQKA
QREVPRPDFLVAVLEQDGLERGMMLAEALRESGLKGEVSFAARSMKSQMRQAGKRNVRKVLLLGGSEIADGTVTVKDMDT
GGQTTISLDAAPGAVAD
>Mature_416_residues
SNVKKIKGFADLFSPESDVFTFMENTARDVFSSYGYGELRTPILERTELFCRSIGTETDVVQKEMYTFPDRKNRSLTMRP
EATAGVMRAYIEGSLHSQEQVSKLFTFGPMFRYERPQKGRMRQFHQINCECLGPQEPYADAEIILMLLMFLKRIGLSGLE
LQINSLGCRECRPQYHAALRAFLASLDTAELCEDCRRRMETNPLRVLDCKVPRCKELTADAPVILDHTCDACSEHHSVVL
GMLERAGVVYTANPRLVRGLDYYNRTTFEVVCGEIGAQSSVAGGGRYDGLVSQLGGPDVPGIGFACGMERLALALEQKAQ
REVPRPDFLVAVLEQDGLERGMMLAEALRESGLKGEVSFAARSMKSQMRQAGKRNVRKVLLLGGSEIADGTVTVKDMDTG
GQTTISLDAAPGAVAD

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15029520, Length=458, Percent_Identity=22.0524017467249, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI6996014, Length=423, Percent_Identity=22.4586288416076, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1788861, Length=415, Percent_Identity=47.4698795180723, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71993693, Length=467, Percent_Identity=23.5546038543897, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993686, Length=466, Percent_Identity=24.0343347639485, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_DESDG (Q317R4)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_386507.1
- ProteinModelPortal:   Q317R4
- SMR:   Q317R4
- STRING:   Q317R4
- GeneID:   3755953
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0011
- NMPDR:   fig|207559.3.peg.517
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   DDES207559:DDE_0011-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 46140; Mature: 46008

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVKKIKGFADLFSPESDVFTFMENTARDVFSSYGYGELRTPILERTELFCRSIGTETD
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCCCHHH
VVQKEMYTFPDRKNRSLTMRPEATAGVMRAYIEGSLHSQEQVSKLFTFGPMFRYERPQKG
HHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCCCCCH
RMRQFHQINCECLGPQEPYADAEIILMLLMFLKRIGLSGLELQINSLGCRECRPQYHAAL
HHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHCCHHHHHHH
RAFLASLDTAELCEDCRRRMETNPLRVLDCKVPRCKELTADAPVILDHTCDACSEHHSVV
HHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCCEEEECCHHHHHHHHHHH
LGMLERAGVVYTANPRLVRGLDYYNRTTFEVVCGEIGAQSSVAGGGRYDGLVSQLGGPDV
HHHHHHCCEEEECCCHHEECCHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCC
PGIGFACGMERLALALEQKAQREVPRPDFLVAVLEQDGLERGMMLAEALRESGLKGEVSF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCHHHHHHHHHHHHHCCCCCHHHH
AARSMKSQMRQAGKRNVRKVLLLGGSEIADGTVTVKDMDTGGQTTISLDAAPGAVAD
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
SNVKKIKGFADLFSPESDVFTFMENTARDVFSSYGYGELRTPILERTELFCRSIGTETD
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCCCHHH
VVQKEMYTFPDRKNRSLTMRPEATAGVMRAYIEGSLHSQEQVSKLFTFGPMFRYERPQKG
HHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCCCCCH
RMRQFHQINCECLGPQEPYADAEIILMLLMFLKRIGLSGLELQINSLGCRECRPQYHAAL
HHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHCCHHHHHHH
RAFLASLDTAELCEDCRRRMETNPLRVLDCKVPRCKELTADAPVILDHTCDACSEHHSVV
HHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCCEEEECCHHHHHHHHHHH
LGMLERAGVVYTANPRLVRGLDYYNRTTFEVVCGEIGAQSSVAGGGRYDGLVSQLGGPDV
HHHHHHCCEEEECCCHHEECCHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCC
PGIGFACGMERLALALEQKAQREVPRPDFLVAVLEQDGLERGMMLAEALRESGLKGEVSF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCHHHHHHHHHHHHHCCCCCHHHH
AARSMKSQMRQAGKRNVRKVLLLGGSEIADGTVTVKDMDTGGQTTISLDAAPGAVAD
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA