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The map label for this gene is serS

Identifier: 78224711

GI number: 78224711

Start: 3961102

End: 3962373

Strand: Reverse

Name: serS

Synonym: Gmet_3528

Alternate gene names: 78224711

Gene position: 3962373-3961102 (Counterclockwise)

Preceding gene: 78224714

Following gene: 78224710

Centisome position: 99.12

GC content: 62.66

Gene sequence:

>1272_bases
ATGCTTGACCCCAAACACCTGAGGGAAAATTTCGAGTCTGTCGAACAGCGTCTTGCCACCCGTGGCGGCGCGGTGACCTT
GGACCGGTTCCGGGAACTGGACTCCCGTCGCCGGGAACTCCTCCGCGAGGCCGAATCCCTCAAGGCGGTGCGCAACGCCG
CCTCCGAGGAGATCAGCCGGATCAAGGACAAGAGCCAGGCCCAGCCCCGCATCGCCGAGATGCGCGAAGTCTCCGCCAAG
ATCAAGGTTCTCGACGACGACCTCCGGGGGGTCGACGACGACCTCCAGGCGGTCCTCCTGACGATCCCCAATATCCCCCA
CCAATCGGTGCCGGTGGGCGCCTCCGAGGCCGACAACCGGGAGGTGCGGAAATGGGGTGAGCCTCCCCGTTTCGGGTTCA
CCCCCAGGCCCCATTGGGAGATCGGCGAAGGTCTCGGTATCCTCGATTTCGAGCGGGGAGCCAAGCTCACGGGCGCCCGC
TTCACCCTCTACCGCGGTGCTGGTGCCCGGCTTGAGCGGGCGCTTATCAACTTCATGCTCGACCTCCATACGGAGAAGCA
CGGCTACGAGGAAACTCTCCCGCCATTCATGGTCAACCGCGAAAGCATGACCGGCACCGGCCAGCTCCCCAAGTTCGAGG
AGGACCTCTTCCACCTGGACGGCACCGACTACTACCTGATCCCCACCGCCGAGGTGCCGGTGACCAATATCCACCGGGGC
GAGATCCTGAAGGGAAGCGATCTTCCCCTCTCCTACACCGCCTACACCCCCTGCTTCCGGAAGGAGGCTGGCTCCTACGG
CAAGGACGTGCGGGGTCTGATCCGCCAGCACCAGTTCAACAAGGTGGAACTGGTTAAATTCACCCATCCCTCCACCTCCT
ATGCGGAGTTGGAACGGCTTCTGGCCAATGCCGAGGAGGTGCTCCGCCAGCTCGGTCTCCACTACCGGGTGGTGGAGCTT
TGCACCGGCGATATGGGATTCTCGGCCGCCAAGACCTATGATATTGAGGTATGGCTCCCGGCCCAGGATACCTACCGGGA
GATCTCCTCGTGCAGCAACTTCGAGGATTTCCAGGCCCGTCGGGCGTCGATACGCTTCCGTGAGGACGACAAGGCCAAGC
CCGAATTCGCCCATACCCTGAACGGCTCAGGGCTTGCTGTTGGCCGGACCCTGGTTGCCATCCTTGAGAATTACCAGCAG
GAGGATGGTACCGTGGTGATTCCCGAGGTGTTGAGGCCCTACATGGGAGGATGTTCAAGCATCGGCCGTTAG

Upstream 100 bases:

>100_bases
ACCTGGCGCATGGGGACTCCGAGGGGGAAAACGGTTGACTCTTGGGGATACGGATGCTAAGAACTATAGCTTTAATGCCT
GAAAAGTAAAGGACTTATCC

Downstream 100 bases:

>100_bases
ATGCGGTGAAAAAATTAGGTTCTTCAGGGAATTCCGGGGAAGATTAATAAACAACAACGGCAGCACTGCGGTATCTTGAT
GGTTCCCCAACCAAAAAAGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDPKHLRENFESVEQRLATRGGAVTLDRFRELDSRRRELLREAESLKAVRNAASEEISRIKDKSQAQPRIAEMREVSAK
IKVLDDDLRGVDDDLQAVLLTIPNIPHQSVPVGASEADNREVRKWGEPPRFGFTPRPHWEIGEGLGILDFERGAKLTGAR
FTLYRGAGARLERALINFMLDLHTEKHGYEETLPPFMVNRESMTGTGQLPKFEEDLFHLDGTDYYLIPTAEVPVTNIHRG
EILKGSDLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFTHPSTSYAELERLLANAEEVLRQLGLHYRVVEL
CTGDMGFSAAKTYDIEVWLPAQDTYREISSCSNFEDFQARRASIRFREDDKAKPEFAHTLNGSGLAVGRTLVAILENYQQ
EDGTVVIPEVLRPYMGGCSSIGR

Sequences:

>Translated_423_residues
MLDPKHLRENFESVEQRLATRGGAVTLDRFRELDSRRRELLREAESLKAVRNAASEEISRIKDKSQAQPRIAEMREVSAK
IKVLDDDLRGVDDDLQAVLLTIPNIPHQSVPVGASEADNREVRKWGEPPRFGFTPRPHWEIGEGLGILDFERGAKLTGAR
FTLYRGAGARLERALINFMLDLHTEKHGYEETLPPFMVNRESMTGTGQLPKFEEDLFHLDGTDYYLIPTAEVPVTNIHRG
EILKGSDLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFTHPSTSYAELERLLANAEEVLRQLGLHYRVVEL
CTGDMGFSAAKTYDIEVWLPAQDTYREISSCSNFEDFQARRASIRFREDDKAKPEFAHTLNGSGLAVGRTLVAILENYQQ
EDGTVVIPEVLRPYMGGCSSIGR
>Mature_423_residues
MLDPKHLRENFESVEQRLATRGGAVTLDRFRELDSRRRELLREAESLKAVRNAASEEISRIKDKSQAQPRIAEMREVSAK
IKVLDDDLRGVDDDLQAVLLTIPNIPHQSVPVGASEADNREVRKWGEPPRFGFTPRPHWEIGEGLGILDFERGAKLTGAR
FTLYRGAGARLERALINFMLDLHTEKHGYEETLPPFMVNRESMTGTGQLPKFEEDLFHLDGTDYYLIPTAEVPVTNIHRG
EILKGSDLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFTHPSTSYAELERLLANAEEVLRQLGLHYRVVEL
CTGDMGFSAAKTYDIEVWLPAQDTYREISSCSNFEDFQARRASIRFREDDKAKPEFAHTLNGSGLAVGRTLVAILENYQQ
EDGTVVIPEVLRPYMGGCSSIGR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=336, Percent_Identity=36.6071428571429, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI8923421, Length=399, Percent_Identity=33.0827067669173, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI225579074, Length=328, Percent_Identity=36.5853658536585, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=52.093023255814, Blast_Score=450, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17539260, Length=433, Percent_Identity=31.1778290993072, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=387, Percent_Identity=28.4237726098191, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=36.4253393665158, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6321799, Length=379, Percent_Identity=31.6622691292876, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24581334, Length=426, Percent_Identity=32.3943661971831, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17737985, Length=340, Percent_Identity=33.2352941176471, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_GEOMG (Q39PU1)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386458.1
- HSSP:   Q9N0F3
- ProteinModelPortal:   Q39PU1
- SMR:   Q39PU1
- STRING:   Q39PU1
- GeneID:   3739787
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3528
- NMPDR:   fig|269799.3.peg.3496
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q39PU1
- ProtClustDB:   PRK05431
- BioCyc:   GMET269799:GMET_3528-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47867; Mature: 47867

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPKHLRENFESVEQRLATRGGAVTLDRFRELDSRRRELLREAESLKAVRNAASEEISR
CCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKDKSQAQPRIAEMREVSAKIKVLDDDLRGVDDDLQAVLLTIPNIPHQSVPVGASEADNR
HHHHHHCCCHHHHHHHHHHHHEEECCHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
EVRKWGEPPRFGFTPRPHWEIGEGLGILDFERGAKLTGARFTLYRGAGARLERALINFML
HHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
DLHTEKHGYEETLPPFMVNRESMTGTGQLPKFEEDLFHLDGTDYYLIPTAEVPVTNIHRG
HHHHHHCCCHHCCCCCEECCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCC
EILKGSDLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFTHPSTSYAELERL
CEECCCCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
LANAEEVLRQLGLHYRVVELCTGDMGFSAAKTYDIEVWLPAQDTYREISSCSNFEDFQAR
HHHHHHHHHHHCCHHEEHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHH
RASIRFREDDKAKPEFAHTLNGSGLAVGRTLVAILENYQQEDGTVVIPEVLRPYMGGCSS
HHHCEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHCCHHH
IGR
CCC
>Mature Secondary Structure
MLDPKHLRENFESVEQRLATRGGAVTLDRFRELDSRRRELLREAESLKAVRNAASEEISR
CCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKDKSQAQPRIAEMREVSAKIKVLDDDLRGVDDDLQAVLLTIPNIPHQSVPVGASEADNR
HHHHHHCCCHHHHHHHHHHHHEEECCHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
EVRKWGEPPRFGFTPRPHWEIGEGLGILDFERGAKLTGARFTLYRGAGARLERALINFML
HHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
DLHTEKHGYEETLPPFMVNRESMTGTGQLPKFEEDLFHLDGTDYYLIPTAEVPVTNIHRG
HHHHHHCCCHHCCCCCEECCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCC
EILKGSDLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFTHPSTSYAELERL
CEECCCCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
LANAEEVLRQLGLHYRVVELCTGDMGFSAAKTYDIEVWLPAQDTYREISSCSNFEDFQAR
HHHHHHHHHHHCCHHEEHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHH
RASIRFREDDKAKPEFAHTLNGSGLAVGRTLVAILENYQQEDGTVVIPEVLRPYMGGCSS
HHHCEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHCCHHH
IGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA