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The map label for this gene is ltaE [H]

Identifier: 78224686

GI number: 78224686

Start: 3931681

End: 3932742

Strand: Reverse

Name: ltaE [H]

Synonym: Gmet_3503

Alternate gene names: 78224686

Gene position: 3932742-3931681 (Counterclockwise)

Preceding gene: 78224694

Following gene: 78224685

Centisome position: 98.38

GC content: 66.48

Gene sequence:

>1062_bases
ATGACAGATGGAGTCGATACGGTCAAAAAATACCAGTTCGCCAGCGACAACTACGCCGGGATCTGTCCCGAGGCCTTGCA
GGCCATGGAGGCCGCCAACAGGGGGTACGCCTGCTCCTACGGCGACGACCCCTGGACGGAGAAGGCGTGCCGGCTCCTGC
GGGACCTCTTCGAGACCGACTGCGAGGTCTTTTTCGTCTTCAACGGCACCGCCGCCAACTCCCTGGCCCTGGCATCCCTC
TGTCACTCCTACAACAGCATCATCTGCCACGAGACCTCCCATGTGGAGACCGACGAGTGCGGAGCCTCCGAATTCTTCTC
CAACGGGACCAAGATCCTCCTCGTCTCCGGCGGGCACGGCAAGGTGGACCTGGAGGCCGTGGAGCACACGGTGAAGCGCC
GCACCGACATCCACTATCCCAAGCCCAAGGCCCTGAGCATCACCCAGGCCACGGAGCTCGGCACCCTCTATTCGGTGGAG
GAGCTTCAGGCCGTGGGGGAGCTGGCCCGGCGCCTCGATCTGAAGCTCCACATGGACGGGGCCCGCTTCGCCAACGCCGT
TGCCACTCTCGGCGCGGCCCCCGCCGAACTCACCTGGAAAGCGGGGGTGGATGTCCTCTGCTTCGGCGGTACCAAAAACG
GCATGGCGGTGGGGGAGGCGATCATCTTCTTCAACCGGGACCTGGCTTCCGAATTCGACTACCGCTGCAAGCAGGCGGGG
CAGCTCGCCTCCAAGATGCGCTTCCTGGCCGCCCCCTGGGTCGGCATGCTGGAAAGCGGCGCCTGGCTCACCCGCGCGGC
CAACGCCAACGCCTGCGCCGCCAGGCTGGAGGCCCGCCTGCGGGAGATTCCCGGCGTGGGAATCCGTTTCCCCCGCCAGG
CCAATTCGGTCTTCGCCGACTTCTCCCCTGAGGTGGCCGCCGCCCTCCAGGAGCGGGGGTGGCACTTCTATTCCTTCATC
GGCTCCGGCGGGGCCCGTTTCATGTGCTCCTGGGAGACCACCGAGGCGGACGTGGATCTCCTGGCGGCCGACCTTTCGGC
CGTCGCCTCGCGCCATGGGTGA

Upstream 100 bases:

>100_bases
GACCGTGGATCCGCGACGGATTCAGGTTTACTATTTTCCCGCGCCCGTATACTCTCTCCCGAAAAGTGCCCGCGTCCGCG
CGGTTCTATGGAGAGTGCCG

Downstream 100 bases:

>100_bases
GGAGTTAGAATTTTTTCTTAAGACGCATTATTTTTATATGCACCCGATACGAGGTTTAGTGATGAGTAATATCAAGCTGT
TACACTGATGTGTTTCAGGG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low specificity L-TA [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTDGVDTVKKYQFASDNYAGICPEALQAMEAANRGYACSYGDDPWTEKACRLLRDLFETDCEVFFVFNGTAANSLALASL
CHSYNSIICHETSHVETDECGASEFFSNGTKILLVSGGHGKVDLEAVEHTVKRRTDIHYPKPKALSITQATELGTLYSVE
ELQAVGELARRLDLKLHMDGARFANAVATLGAAPAELTWKAGVDVLCFGGTKNGMAVGEAIIFFNRDLASEFDYRCKQAG
QLASKMRFLAAPWVGMLESGAWLTRAANANACAARLEARLREIPGVGIRFPRQANSVFADFSPEVAAALQERGWHFYSFI
GSGGARFMCSWETTEADVDLLAADLSAVASRHG

Sequences:

>Translated_353_residues
MTDGVDTVKKYQFASDNYAGICPEALQAMEAANRGYACSYGDDPWTEKACRLLRDLFETDCEVFFVFNGTAANSLALASL
CHSYNSIICHETSHVETDECGASEFFSNGTKILLVSGGHGKVDLEAVEHTVKRRTDIHYPKPKALSITQATELGTLYSVE
ELQAVGELARRLDLKLHMDGARFANAVATLGAAPAELTWKAGVDVLCFGGTKNGMAVGEAIIFFNRDLASEFDYRCKQAG
QLASKMRFLAAPWVGMLESGAWLTRAANANACAARLEARLREIPGVGIRFPRQANSVFADFSPEVAAALQERGWHFYSFI
GSGGARFMCSWETTEADVDLLAADLSAVASRHG
>Mature_352_residues
TDGVDTVKKYQFASDNYAGICPEALQAMEAANRGYACSYGDDPWTEKACRLLRDLFETDCEVFFVFNGTAANSLALASLC
HSYNSIICHETSHVETDECGASEFFSNGTKILLVSGGHGKVDLEAVEHTVKRRTDIHYPKPKALSITQATELGTLYSVEE
LQAVGELARRLDLKLHMDGARFANAVATLGAAPAELTWKAGVDVLCFGGTKNGMAVGEAIIFFNRDLASEFDYRCKQAGQ
LASKMRFLAAPWVGMLESGAWLTRAANANACAARLEARLREIPGVGIRFPRQANSVFADFSPEVAAALQERGWHFYSFIG
SGGARFMCSWETTEADVDLLAADLSAVASRHG

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. Can also act on L-erythro- phenylserine, L-threo-phenylserine, L-beta-3,4- methylenedioxyphenylserine and L-beta-3,4-dihydroxyphenylserine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=287, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193206520, Length=171, Percent_Identity=30.4093567251462, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193206524, Length=171, Percent_Identity=30.4093567251462, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193206522, Length=171, Percent_Identity=30.4093567251462, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 38295; Mature: 38164

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGVDTVKKYQFASDNYAGICPEALQAMEAANRGYACSYGDDPWTEKACRLLRDLFETD
CCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCC
CEVFFVFNGTAANSLALASLCHSYNSIICHETSHVETDECGASEFFSNGTKILLVSGGHG
CEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHCCCCEEEEEECCCC
KVDLEAVEHTVKRRTDIHYPKPKALSITQATELGTLYSVEELQAVGELARRLDLKLHMDG
CEEHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECH
ARFANAVATLGAAPAELTWKAGVDVLCFGGTKNGMAVGEAIIFFNRDLASEFDYRCKQAG
HHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCHHHHEEEEECCHHHHHHHHHHHHHH
QLASKMRFLAAPWVGMLESGAWLTRAANANACAARLEARLREIPGVGIRFPRQANSVFAD
HHHHHHHHHHCCHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEECC
FSPEVAAALQERGWHFYSFIGSGGARFMCSWETTEADVDLLAADLSAVASRHG
CCHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDGVDTVKKYQFASDNYAGICPEALQAMEAANRGYACSYGDDPWTEKACRLLRDLFETD
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCC
CEVFFVFNGTAANSLALASLCHSYNSIICHETSHVETDECGASEFFSNGTKILLVSGGHG
CEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHCCCCEEEEEECCCC
KVDLEAVEHTVKRRTDIHYPKPKALSITQATELGTLYSVEELQAVGELARRLDLKLHMDG
CEEHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECH
ARFANAVATLGAAPAELTWKAGVDVLCFGGTKNGMAVGEAIIFFNRDLASEFDYRCKQAG
HHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCHHHHEEEEECCHHHHHHHHHHHHHH
QLASKMRFLAAPWVGMLESGAWLTRAANANACAARLEARLREIPGVGIRFPRQANSVFAD
HHHHHHHHHHCCHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEECC
FSPEVAAALQERGWHFYSFIGSGGARFMCSWETTEADVDLLAADLSAVASRHG
CCHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9464392 [H]