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The map label for this gene is atpB

Identifier: 78224549

GI number: 78224549

Start: 3774852

End: 3775541

Strand: Direct

Name: atpB

Synonym: Gmet_3359

Alternate gene names: 78224549

Gene position: 3774852-3775541 (Clockwise)

Preceding gene: 78224548

Following gene: 78224550

Centisome position: 94.43

GC content: 53.33

Gene sequence:

>690_bases
ATGGTTCATCCGCTGCTGTTCCTGCAGTTCTTCAGAAAGCTCCTCGAACCGCTCCACATTTCGGAAGCGGGAGCTGACGC
CATTGCATACACATGGCTCATTATCGTATTCCTGCTAATCGTTTCGCTTATTGCCACCAAAGCGCTCAAAGCCGTTCCCA
CAGGAATGCAAAACTTCATGGAAGTGGTGGTCGGCGGCATCGAGAATATGGTGGAAGAAACCATGGGAGAGAAAGGACGG
CCCTACTTTCCGCTCATAGCCACCCTTGCCCTCTTCGTTCTCGTATCGAACCTCATCGGCCTCATTCCCGGGTTCTTCCC
GCCAACTGCAAACCTGAATACGACCGCGGCGTGCGCAATTATCGTGTTCCTCTCGACCCACGTGGTCGGGATCAAGAAAC
ACGGATTCCATTACCTTCAGCACTTCATGGGCCCGATCTGGTGGTTGGCACCGCTCATGTTCTTCATTGAGATCATCGGC
CACCTGAGCCGTCCCCTTTCTCTCTCACTGCGTCTTTTCGGCAACATGAACGGCCACGAACTCGTTCTCATGATCTTCTT
CGCCTTGGCGCCGTTCCTCGTGCCGCTGCCGATGATGCTGATGGGGGTTCTCGTATCCTTTATCCAGGCGTTCGTATTCA
TGCTTCTCGCCATGATTTATATTCAGGGCTCTCTCGAAGAGGCTCACTAA

Upstream 100 bases:

>100_bases
TGGAATCGACGTCATAGGCCTTATCATCGGCTTGTCGATATTCGTGGTCGTAATTATAGGACTTTCGATTTATATGTTGC
TTGATAAAGGAGAGTAACTC

Downstream 100 bases:

>100_bases
TTACTCGAATCCTATACTGTTTAGGAGACAACACCCAAAGGGAGGTAGTAAAAGATGGATTTTCTTACGATGTGCATGCT
CGCAGCTGGTTTCGGTATGG

Product: H+-transporting two-sector ATPase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MVHPLLFLQFFRKLLEPLHISEAGADAIAYTWLIIVFLLIVSLIATKALKAVPTGMQNFMEVVVGGIENMVEETMGEKGR
PYFPLIATLALFVLVSNLIGLIPGFFPPTANLNTTAACAIIVFLSTHVVGIKKHGFHYLQHFMGPIWWLAPLMFFIEIIG
HLSRPLSLSLRLFGNMNGHELVLMIFFALAPFLVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEEAH

Sequences:

>Translated_229_residues
MVHPLLFLQFFRKLLEPLHISEAGADAIAYTWLIIVFLLIVSLIATKALKAVPTGMQNFMEVVVGGIENMVEETMGEKGR
PYFPLIATLALFVLVSNLIGLIPGFFPPTANLNTTAACAIIVFLSTHVVGIKKHGFHYLQHFMGPIWWLAPLMFFIEIIG
HLSRPLSLSLRLFGNMNGHELVLMIFFALAPFLVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEEAH
>Mature_229_residues
MVHPLLFLQFFRKLLEPLHISEAGADAIAYTWLIIVFLLIVSLIATKALKAVPTGMQNFMEVVVGGIENMVEETMGEKGR
PYFPLIATLALFVLVSNLIGLIPGFFPPTANLNTTAACAIIVFLSTHVVGIKKHGFHYLQHFMGPIWWLAPLMFFIEIIG
HLSRPLSLSLRLFGNMNGHELVLMIFFALAPFLVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEEAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=164, Percent_Identity=31.7073170731707, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790176, Length=210, Percent_Identity=30, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6226527, Length=212, Percent_Identity=30.6603773584906, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_GEOMG (Q39QA3)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386296.1
- ProteinModelPortal:   Q39QA3
- SMR:   Q39QA3
- STRING:   Q39QA3
- GeneID:   3739103
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3359
- NMPDR:   fig|269799.3.peg.3334
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   LHGQVFL
- PhylomeDB:   Q39QA3
- ProtClustDB:   CLSK924394
- BioCyc:   GMET269799:GMET_3359-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 25527; Mature: 25527

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x154bf194)-; HASH(0x15cf47d0)-; HASH(0x1595d13c)-; HASH(0x160786c8)-; HASH(0x158d72c0)-; HASH(0x160786f8)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHPLLFLQFFRKLLEPLHISEAGADAIAYTWLIIVFLLIVSLIATKALKAVPTGMQNFM
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVVGGIENMVEETMGEKGRPYFPLIATLALFVLVSNLIGLIPGFFPPTANLNTTAACAI
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IVFLSTHVVGIKKHGFHYLQHFMGPIWWLAPLMFFIEIIGHLSRPLSLSLRLFGNMNGHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHH
LVLMIFFALAPFLVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEEAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCH
>Mature Secondary Structure
MVHPLLFLQFFRKLLEPLHISEAGADAIAYTWLIIVFLLIVSLIATKALKAVPTGMQNFM
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVVGGIENMVEETMGEKGRPYFPLIATLALFVLVSNLIGLIPGFFPPTANLNTTAACAI
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IVFLSTHVVGIKKHGFHYLQHFMGPIWWLAPLMFFIEIIGHLSRPLSLSLRLFGNMNGHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHH
LVLMIFFALAPFLVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEEAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA