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The map label for this gene is acdA [H]

Identifier: 78224497

GI number: 78224497

Start: 3720361

End: 3721503

Strand: Reverse

Name: acdA [H]

Synonym: Gmet_3306

Alternate gene names: 78224497

Gene position: 3721503-3720361 (Counterclockwise)

Preceding gene: 78224498

Following gene: 78224496

Centisome position: 93.1

GC content: 63.78

Gene sequence:

>1143_bases
ATGAAACATCTTACCGAAGAACAGAAACTGACGCTGGACATGGTGCGCGACGTGGCGACCCGCGAGATCGCGCCCCGGGC
GCTGGAACTCGACGAGAAATCGCTCTTTCCGGAGTACGCCCGTGACCTCTTTGCCAAGCTGGGTCTCCTCAACCCGCTCC
TCCCCGCTGCATACGGGGGCACGGAGATGGGGGTCCTGACCCTGGCCCTGATTCTCGAGGAGCTGGGCCGCGTCTGCGCC
TCCACCGCTCTCCTCCTCATCGCCCAGACCGATGGCATGCTGCCGATCATCCACGGGGGGAGTCCGGAGCTGAAGGAGCG
CTACCTGCGCCGGTTTGCGGGTGAATCCACTCTGCTGACGGCCCTGGCCGCCACCGAGCCGGCCGCCGGTTCCGACCTCC
TTGCCATGAAAACCCGGGCGGTGCGCCAAGGCGACAAGTATGTCATCAACGGCCAGAAGTGCTTCATCACCAACGGCTCG
GTGGCTGACGTCATCGTCGTGTATGCCTACACCGATCCGGAGAAGGGGTCCAAGGGTATCAGCGCCTTTGTCGTGGAGAA
GGGGACCCCGGGACTCGTCTACGGCCGCAACGAATCGAAGATGGGGATGCGCGGCTCCATCAACTCCGAGCTCTTTTTCG
AGAACATGGAGGTCCCGGCGGAAAACATCATCGGCGCTGAAGGGACCGGCTTTGCCAACCTCATGCAGACCCTCTCCACC
AACCGAGTCTTCTGCGCGGCCCAGGCCGTCGGCATCGCCCAGGGTGCGCTGGACATAGCCGTCAGACACACCCAGGACCG
GGTGCAGTTCGGCAAGCCCATCGCCCACCTCGCGCCGGTTCAGTTCATGGTCGCCGACATGGCGACGGCCGTGGAAGCCT
CGCGGCTGTTGACCCGGAAGGCGGCGGAACTGCTCGATGATGGGGATAAGAAGGCGGTGCTCTACGGCAGCATGGCCAAG
ACTATGGCGAGCGACACTGCCATGCGGGTGACCACCGATGCCGTGCAGGTGCTCGGCGGCTCCGGCTACATGAAGGAAAA
CGGCGTGGAGCGGATGATGCGGGACGCCAAGCTGACCCAGATCTACACCGGCACCAATCAGATAACCCGCATGGTGACGG
GGAGGGCCCTGTTGTTCCCGTAA

Upstream 100 bases:

>100_bases
AACCAGATCCAGCGGCTGGTCATCGCCCGGGAGATCCTGAAAGAGGCCGCTTGAATCCCGGAAAGCGTGAATTTTCGCAC
TGATAAAAGGAGATATCCCC

Downstream 100 bases:

>100_bases
AGGGTAACAACAGGAATGTATCGTGACATCAGGCAGATAGCCTTAAGAGCGGAGAAAGAGAATGGCTAGGACAAATGTGA
TGATCGCCGAGACCTTTCCG

Product: Acyl-CoA dehydrogenase-like

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKHLTEEQKLTLDMVRDVATREIAPRALELDEKSLFPEYARDLFAKLGLLNPLLPAAYGGTEMGVLTLALILEELGRVCA
STALLLIAQTDGMLPIIHGGSPELKERYLRRFAGESTLLTALAATEPAAGSDLLAMKTRAVRQGDKYVINGQKCFITNGS
VADVIVVYAYTDPEKGSKGISAFVVEKGTPGLVYGRNESKMGMRGSINSELFFENMEVPAENIIGAEGTGFANLMQTLST
NRVFCAAQAVGIAQGALDIAVRHTQDRVQFGKPIAHLAPVQFMVADMATAVEASRLLTRKAAELLDDGDKKAVLYGSMAK
TMASDTAMRVTTDAVQVLGGSGYMKENGVERMMRDAKLTQIYTGTNQITRMVTGRALLFP

Sequences:

>Translated_380_residues
MKHLTEEQKLTLDMVRDVATREIAPRALELDEKSLFPEYARDLFAKLGLLNPLLPAAYGGTEMGVLTLALILEELGRVCA
STALLLIAQTDGMLPIIHGGSPELKERYLRRFAGESTLLTALAATEPAAGSDLLAMKTRAVRQGDKYVINGQKCFITNGS
VADVIVVYAYTDPEKGSKGISAFVVEKGTPGLVYGRNESKMGMRGSINSELFFENMEVPAENIIGAEGTGFANLMQTLST
NRVFCAAQAVGIAQGALDIAVRHTQDRVQFGKPIAHLAPVQFMVADMATAVEASRLLTRKAAELLDDGDKKAVLYGSMAK
TMASDTAMRVTTDAVQVLGGSGYMKENGVERMMRDAKLTQIYTGTNQITRMVTGRALLFP
>Mature_380_residues
MKHLTEEQKLTLDMVRDVATREIAPRALELDEKSLFPEYARDLFAKLGLLNPLLPAAYGGTEMGVLTLALILEELGRVCA
STALLLIAQTDGMLPIIHGGSPELKERYLRRFAGESTLLTALAATEPAAGSDLLAMKTRAVRQGDKYVINGQKCFITNGS
VADVIVVYAYTDPEKGSKGISAFVVEKGTPGLVYGRNESKMGMRGSINSELFFENMEVPAENIIGAEGTGFANLMQTLST
NRVFCAAQAVGIAQGALDIAVRHTQDRVQFGKPIAHLAPVQFMVADMATAVEASRLLTRKAAELLDDGDKKAVLYGSMAK
TMASDTAMRVTTDAVQVLGGSGYMKENGVERMMRDAKLTQIYTGTNQITRMVTGRALLFP

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=41.3793103448276, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=39.8936170212766, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=39.8936170212766, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4501859, Length=369, Percent_Identity=37.3983739837398, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI226958412, Length=387, Percent_Identity=36.1757105943152, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=35.9580052493438, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI226958414, Length=350, Percent_Identity=37.1428571428571, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI76496475, Length=379, Percent_Identity=32.9815303430079, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4557235, Length=379, Percent_Identity=32.9815303430079, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=31.496062992126, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=32.3287671232877, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=30.9895833333333, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI7669494, Length=369, Percent_Identity=30.6233062330623, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI38505218, Length=335, Percent_Identity=28.3582089552239, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI48976061, Length=310, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI211971008, Length=310, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=33.8501291989664, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=29.5514511873351, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082384, Length=317, Percent_Identity=26.813880126183, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=39.5778364116095, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=39.7905759162304, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=38.9473684210526, Blast_Score=253, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI17538396, Length=388, Percent_Identity=37.6288659793814, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=369, Percent_Identity=33.8753387533875, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17506239, Length=367, Percent_Identity=34.8773841961853, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=368, Percent_Identity=33.695652173913, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71985184, Length=385, Percent_Identity=33.7662337662338, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=37.0503597122302, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=32.3529411764706, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=360, Percent_Identity=32.2222222222222, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=31.0541310541311, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=334, Percent_Identity=32.3353293413174, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=220, Percent_Identity=36.3636363636364, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=28.4595300261097, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=30.0429184549356, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562446, Length=299, Percent_Identity=28.4280936454849, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531913, Length=171, Percent_Identity=26.9005847953216, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=42.7055702917772, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=38.9920424403183, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24646207, Length=379, Percent_Identity=38.2585751978892, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI21355753, Length=392, Percent_Identity=37.7551020408163, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=35.3887399463807, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI281363737, Length=385, Percent_Identity=33.2467532467532, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI19920834, Length=384, Percent_Identity=28.3854166666667, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 40991; Mature: 40991

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLTEEQKLTLDMVRDVATREIAPRALELDEKSLFPEYARDLFAKLGLLNPLLPAAYGG
CCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHHCCC
TEMGVLTLALILEELGRVCASTALLLIAQTDGMLPIIHGGSPELKERYLRRFAGESTLLT
CHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCHHHHH
ALAATEPAAGSDLLAMKTRAVRQGDKYVINGQKCFITNGSVADVIVVYAYTDPEKGSKGI
HHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEEEEEEECCCCCCCCCC
SAFVVEKGTPGLVYGRNESKMGMRGSINSELFFENMEVPAENIIGAEGTGFANLMQTLST
EEEEEECCCCCEEECCCCCCCCCCCCCCCHHEEECCCCCHHHCCCCCCCCHHHHHHHHCC
NRVFCAAQAVGIAQGALDIAVRHTQDRVQFGKPIAHLAPVQFMVADMATAVEASRLLTRK
CCEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAELLDDGDKKAVLYGSMAKTMASDTAMRVTTDAVQVLGGSGYMKENGVERMMRDAKLTQ
HHHHHCCCCCCEEEEHHHHHHHHCCCHHEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHE
IYTGTNQITRMVTGRALLFP
EECCHHHHHHHHCCCEECCC
>Mature Secondary Structure
MKHLTEEQKLTLDMVRDVATREIAPRALELDEKSLFPEYARDLFAKLGLLNPLLPAAYGG
CCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHHCCC
TEMGVLTLALILEELGRVCASTALLLIAQTDGMLPIIHGGSPELKERYLRRFAGESTLLT
CHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCHHHHH
ALAATEPAAGSDLLAMKTRAVRQGDKYVINGQKCFITNGSVADVIVVYAYTDPEKGSKGI
HHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEEEEEEECCCCCCCCCC
SAFVVEKGTPGLVYGRNESKMGMRGSINSELFFENMEVPAENIIGAEGTGFANLMQTLST
EEEEEECCCCCEEECCCCCCCCCCCCCCCHHEEECCCCCHHHCCCCCCCCHHHHHHHHCC
NRVFCAAQAVGIAQGALDIAVRHTQDRVQFGKPIAHLAPVQFMVADMATAVEASRLLTRK
CCEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAELLDDGDKKAVLYGSMAKTMASDTAMRVTTDAVQVLGGSGYMKENGVERMMRDAKLTQ
HHHHHCCCCCCEEEEHHHHHHHHCCCHHEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHE
IYTGTNQITRMVTGRALLFP
EECCHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]