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The map label for this gene is uvrC

Identifier: 78224419

GI number: 78224419

Start: 3633756

End: 3635600

Strand: Direct

Name: uvrC

Synonym: Gmet_3228

Alternate gene names: 78224419

Gene position: 3633756-3635600 (Clockwise)

Preceding gene: 78224416

Following gene: 78224422

Centisome position: 90.9

GC content: 63.25

Gene sequence:

>1845_bases
ATGTTCGACAAATCTCGCCTGAACACCCTCCCCGAATCCCCCGGCGTCTACCTCATGAAAGGGTCAGACGGCACCATCCT
CTACGTGGGGAAGGCCAAGAGCCTCAGGAAACGGGTTCGCTCCTACTTCGGCGCTGCCGGTGAATCCCGCTACCACATCC
GGTTCCTCGTGGCCCGGGTGGCGGAAGTGGAGGTCATTGTCACCGACACCGAGAAAGAGGCTCTCATCCTCGAGAACACT
CTCATCAAGAAGCATCGCCCCCGTTATAACCTGGACCTGCGGGACGACAAGACCTACTTCTCGCTCCGCATGGACATGAA
CGAGGAGTTCCCCCGACTCACCATCATCCGGAAGGTGCGCCAGGACGGAGCCCGCTATTTCGGCCCCTATTCATCGGCCG
CTTCGGCCCGCGAAGCCCTTAAGCAGCTCTACCGGCTCTTTCCCCTGCGCCACTACCCCCTTGAAACCTGCCGCCGGCGC
CGGCGCCCCTGCCTCTTCTACCAGCTTAGGCAGTGCTCGGCTCCGTGTCACGGCCTCATCTCACCCGAGGAATACCAGGG
CCTCGTCCAGGGGGCCGCCCTCTTTCTGGACGGGAAGAACCGTGACCTTCTGAAGACCTACCGGGAACGGATGGCATCCG
CGGCAGCGAACGAGCGCTACGAGGAGGCGGCCCGCTACCGGGACCTCATCCGCGCCATCGAGGTAACGGTGGAAAAACAG
AAAATGGTGACCACGGGAGGAGATGCCGACGTTCTCGGCATACACCGGGAAGGGAGCTCCCTCTCCCTCGCCCTCCTCTT
CATCAGGGGAGGGCGTCTCATCGGCAGCCGCAGCTACCTTCTCGCCTGGGAACTGGAGGACGAGGAGGCCGTTTCGTCAT
TCCTCAACGACTACTACAGCCGGGAGGTCTTCATCCCCGACGAGGTGCTTGTTCCGCTGCCCGTGGCCGACAGCGCGGCA
CTGGCGGAACTTCTCTCCGAGCGGCGGGGCAAGCGGACAAGCGTAGCGCACCCCCAACGGGGAACAAAGGCCGGTCTGGT
CAAACTCGCGGGGAAGAACGCCGAGGCGGCCCTTCGGGAGAAGCAGAAACGGGAGGAAGGAGCGGAAGCGGTCCTGACGG
AACTGAAGGAACGGCTCCACCTGCGGAACCTCCCCCGCTGCATCGAGTGCTATGACATATCGAACATCCAGGGGACCTAC
CCAGTGGGAAGCAGGGTCTCGTTCCGTGACGGCAAGGCGGACAAGGGAGGCTATCGCCACTACCGGATCAAGACGGTCGC
CGGCGCCGACGACTTCGCCATGATGCACGAGGTCCTCTCACGCCGGTTCAGGGACAGCCCGGCCAAGGACGAACATCCCG
ACCTGATTGTGGTTGACGGCGGCATCGGACAGTTGAACATCCTGACCGCCGTTCTCCGGGAGTTGCAGGTGGAGGATGTG
GATGCCGCCTCCTTGGCCAAGAGCCGGGTGGAACGGGACATGGCGGCGGAAGAGCTGACACGGAGCACCGAGCGGGTCTT
CCTCCCGGGCCGCAAAAACCCGGTGATCCTCCGCCAGAACAGCGCGCCACTCCTCCTCCTGGCACGGATCCGCGACGAGG
CCCACCGCTTCGCCATCACCTACCACCAGAAACTGCGGGGAAAAGACACCATCCGGTCGATCCTCGACACCATTCCAGGA
ATCGGGCCGAAACGGCGGAAGGAACTTCTGCGGCAATTCGGAAGCCTGCGGCGAATACGGGAAGCGAGTCGGGATGAGCT
GGCCGCCACCCCGACCATTCCGCCGACCCTAGCCGAGAGCATCTGGAAATCTCTCCACGAAAACGACGAAGGCGACACCC
CCTGA

Upstream 100 bases:

>100_bases
GCGAGGCCCCGTAACTACGCGAAAAACGGCCATACAAAACTTTGAATTCCGGGGTCCCGACCCTCTTTTCAACGGAGCCC
TCACTCGGTATACTGGCCCC

Downstream 100 bases:

>100_bases
AAGGGATGCCGCCTTCGGGCGCTCCAGTGGAAACTCCCCCTATTTTTCGGCCAGGAGCTTCTTGATGAGGGTTTCCATGT
TCTTGAGGGTGGCGTCCGAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MFDKSRLNTLPESPGVYLMKGSDGTILYVGKAKSLRKRVRSYFGAAGESRYHIRFLVARVAEVEVIVTDTEKEALILENT
LIKKHRPRYNLDLRDDKTYFSLRMDMNEEFPRLTIIRKVRQDGARYFGPYSSAASAREALKQLYRLFPLRHYPLETCRRR
RRPCLFYQLRQCSAPCHGLISPEEYQGLVQGAALFLDGKNRDLLKTYRERMASAAANERYEEAARYRDLIRAIEVTVEKQ
KMVTTGGDADVLGIHREGSSLSLALLFIRGGRLIGSRSYLLAWELEDEEAVSSFLNDYYSREVFIPDEVLVPLPVADSAA
LAELLSERRGKRTSVAHPQRGTKAGLVKLAGKNAEAALREKQKREEGAEAVLTELKERLHLRNLPRCIECYDISNIQGTY
PVGSRVSFRDGKADKGGYRHYRIKTVAGADDFAMMHEVLSRRFRDSPAKDEHPDLIVVDGGIGQLNILTAVLRELQVEDV
DAASLAKSRVERDMAAEELTRSTERVFLPGRKNPVILRQNSAPLLLLARIRDEAHRFAITYHQKLRGKDTIRSILDTIPG
IGPKRRKELLRQFGSLRRIREASRDELAATPTIPPTLAESIWKSLHENDEGDTP

Sequences:

>Translated_614_residues
MFDKSRLNTLPESPGVYLMKGSDGTILYVGKAKSLRKRVRSYFGAAGESRYHIRFLVARVAEVEVIVTDTEKEALILENT
LIKKHRPRYNLDLRDDKTYFSLRMDMNEEFPRLTIIRKVRQDGARYFGPYSSAASAREALKQLYRLFPLRHYPLETCRRR
RRPCLFYQLRQCSAPCHGLISPEEYQGLVQGAALFLDGKNRDLLKTYRERMASAAANERYEEAARYRDLIRAIEVTVEKQ
KMVTTGGDADVLGIHREGSSLSLALLFIRGGRLIGSRSYLLAWELEDEEAVSSFLNDYYSREVFIPDEVLVPLPVADSAA
LAELLSERRGKRTSVAHPQRGTKAGLVKLAGKNAEAALREKQKREEGAEAVLTELKERLHLRNLPRCIECYDISNIQGTY
PVGSRVSFRDGKADKGGYRHYRIKTVAGADDFAMMHEVLSRRFRDSPAKDEHPDLIVVDGGIGQLNILTAVLRELQVEDV
DAASLAKSRVERDMAAEELTRSTERVFLPGRKNPVILRQNSAPLLLLARIRDEAHRFAITYHQKLRGKDTIRSILDTIPG
IGPKRRKELLRQFGSLRRIREASRDELAATPTIPPTLAESIWKSLHENDEGDTP
>Mature_614_residues
MFDKSRLNTLPESPGVYLMKGSDGTILYVGKAKSLRKRVRSYFGAAGESRYHIRFLVARVAEVEVIVTDTEKEALILENT
LIKKHRPRYNLDLRDDKTYFSLRMDMNEEFPRLTIIRKVRQDGARYFGPYSSAASAREALKQLYRLFPLRHYPLETCRRR
RRPCLFYQLRQCSAPCHGLISPEEYQGLVQGAALFLDGKNRDLLKTYRERMASAAANERYEEAARYRDLIRAIEVTVEKQ
KMVTTGGDADVLGIHREGSSLSLALLFIRGGRLIGSRSYLLAWELEDEEAVSSFLNDYYSREVFIPDEVLVPLPVADSAA
LAELLSERRGKRTSVAHPQRGTKAGLVKLAGKNAEAALREKQKREEGAEAVLTELKERLHLRNLPRCIECYDISNIQGTY
PVGSRVSFRDGKADKGGYRHYRIKTVAGADDFAMMHEVLSRRFRDSPAKDEHPDLIVVDGGIGQLNILTAVLRELQVEDV
DAASLAKSRVERDMAAEELTRSTERVFLPGRKNPVILRQNSAPLLLLARIRDEAHRFAITYHQKLRGKDTIRSILDTIPG
IGPKRRKELLRQFGSLRRIREASRDELAATPTIPPTLAESIWKSLHENDEGDTP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=612, Percent_Identity=38.8888888888889, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI1788037, Length=193, Percent_Identity=32.1243523316062, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_GEOMG (Q39QN3)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386166.1
- HSSP:   P07992
- ProteinModelPortal:   Q39QN3
- STRING:   Q39QN3
- GeneID:   3740944
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3228
- NMPDR:   fig|269799.3.peg.2462
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q39QN3
- ProtClustDB:   PRK00558
- BioCyc:   GMET269799:GMET_3228-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69720; Mature: 69720

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKSRLNTLPESPGVYLMKGSDGTILYVGKAKSLRKRVRSYFGAAGESRYHIRFLVARV
CCCCHHCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AEVEVIVTDTEKEALILENTLIKKHRPRYNLDLRDDKTYFSLRMDMNEEFPRLTIIRKVR
HEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
QDGARYFGPYSSAASAREALKQLYRLFPLRHYPLETCRRRRRPCLFYQLRQCSAPCHGLI
HCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCC
SPEEYQGLVQGAALFLDGKNRDLLKTYRERMASAAANERYEEAARYRDLIRAIEVTVEKQ
CHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMVTTGGDADVLGIHREGSSLSLALLFIRGGRLIGSRSYLLAWELEDEEAVSSFLNDYYS
HEEECCCCCCEEEEECCCCCCEEEEEEEECCEEECCCCEEEEEECCCHHHHHHHHHHHHC
REVFIPDEVLVPLPVADSAALAELLSERRGKRTSVAHPQRGTKAGLVKLAGKNAEAALRE
CEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHH
KQKREEGAEAVLTELKERLHLRNLPRCIECYDISNIQGTYPVGSRVSFRDGKADKGGYRH
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEHEECCCCCCCCCCCCEEECCCCCCCCCCCEE
YRIKTVAGADDFAMMHEVLSRRFRDSPAKDEHPDLIVVDGGIGQLNILTAVLRELQVEDV
EEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
DAASLAKSRVERDMAAEELTRSTERVFLPGRKNPVILRQNSAPLLLLARIRDEAHRFAIT
CHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEHHHHHHHHHEEEE
YHQKLRGKDTIRSILDTIPGIGPKRRKELLRQFGSLRRIREASRDELAATPTIPPTLAES
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHH
IWKSLHENDEGDTP
HHHHHHCCCCCCCC
>Mature Secondary Structure
MFDKSRLNTLPESPGVYLMKGSDGTILYVGKAKSLRKRVRSYFGAAGESRYHIRFLVARV
CCCCHHCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AEVEVIVTDTEKEALILENTLIKKHRPRYNLDLRDDKTYFSLRMDMNEEFPRLTIIRKVR
HEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
QDGARYFGPYSSAASAREALKQLYRLFPLRHYPLETCRRRRRPCLFYQLRQCSAPCHGLI
HCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCC
SPEEYQGLVQGAALFLDGKNRDLLKTYRERMASAAANERYEEAARYRDLIRAIEVTVEKQ
CHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMVTTGGDADVLGIHREGSSLSLALLFIRGGRLIGSRSYLLAWELEDEEAVSSFLNDYYS
HEEECCCCCCEEEEECCCCCCEEEEEEEECCEEECCCCEEEEEECCCHHHHHHHHHHHHC
REVFIPDEVLVPLPVADSAALAELLSERRGKRTSVAHPQRGTKAGLVKLAGKNAEAALRE
CEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHH
KQKREEGAEAVLTELKERLHLRNLPRCIECYDISNIQGTYPVGSRVSFRDGKADKGGYRH
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEHEECCCCCCCCCCCCEEECCCCCCCCCCCEE
YRIKTVAGADDFAMMHEVLSRRFRDSPAKDEHPDLIVVDGGIGQLNILTAVLRELQVEDV
EEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
DAASLAKSRVERDMAAEELTRSTERVFLPGRKNPVILRQNSAPLLLLARIRDEAHRFAIT
CHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEHHHHHHHHHEEEE
YHQKLRGKDTIRSILDTIPGIGPKRRKELLRQFGSLRRIREASRDELAATPTIPPTLAES
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHH
IWKSLHENDEGDTP
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA