Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 78224410

GI number: 78224410

Start: 3618425

End: 3620422

Strand: Direct

Name: uvrB [H]

Synonym: Gmet_3219

Alternate gene names: 78224410

Gene position: 3618425-3620422 (Clockwise)

Preceding gene: 78224409

Following gene: 78224411

Centisome position: 90.52

GC content: 63.11

Gene sequence:

>1998_bases
ATGGACCGTTATACCCTGGTAAGTGACTATACTCCCCGCGGAGACCAACCGAGGGCCATCGAGGAACTCAGCGAGGGAAT
CCTCCGGGGCGACCGGCACCAGGTTCTCCTGGGGGTCACCGGCTCGGGGAAGACCTTCACCATGGCGAACGTCATCGCCG
CCACCAACCGTCCCGCCCTGGTCCTGGCCCCCAACAAGACCCTGGCTGCGCAACTCTACGGCGAATTCAAGGAGCTCTTC
CCCCACAACGCCGTGGAGTACTTCGTCTCCTACTACGACTACTATCAGCCCGAAGCCTACATCCCCACCACGGACACCTT
CATCGAGAAGGACTCCTCCATCAACGACGAGATCGACAAACTGCGCCACGCGGCCACCCGCAGCCTCCTGACCCGGCAGG
ACGTGATCATCGTGGCCTCGGTGTCGTGCATCTACGGCATCGGCTCCCCGGCCGAGTATCAGGCAATGCACATCTTCTTT
CACGAGGGAGAGGAGTACGGGCGGGACACCCTGCTGCGCAAGCTCGTGGAGATCCAGTACGAGCGTAACGACATTGATTT
CCATCGGGGAACCTTCCGGGTGCGTGGGGACATCGTGGAGATCTTTCCGGCCCACGAGGACGAGAAGGCGCTGCGGATCG
AATTCTTCGGCGACGCGGTGGAGGCCATCAGCGAGATCGATCCCCTGCGGGGGGTGGCGCACCAGCGGCTTGCCAAATGC
GCCGTCTATCCTGCGTCCCACTACGTGGCCACCCGGGAAACCCTTGAGCGGGCAATCGAAGAAATCAGAGTAGCCCTGCG
GGAGCGAATCCAGTGGTTCCGGGAACGTAACATGCTCGTGGAGGCCCAGCGGCTCGAGCAGCGCACCATGTTCGACCTGG
AAATGATGGAAGAGATGGGGTTCTGCCAGGGAATCGAAAACTACTCCCGCCACTTTGACGGCCGGGCGCCGGGGGAGCCC
CCCTACACACTCCTCGATTATTTCCCGAAGGACTTCCTCCTCTTCGTGGACGAGTCTCACATCACCGTCTCCCAGGTGGG
AGGGATGTACCGGGGGGACCGAAGCCGCAAGGAGACCCTGGTGAATTACGGGTTCCGCCTCCCGTCGGCCCTGGACAACC
GCCCCCTCACCTTCCAGGAGTTCACTGCCCGGCTCAACCAGACGATCTACGTCTCCGCCACCCCCGCCGACTACGAATTG
CAGCAGGCCGGCGGCGTGGTGGTGGAACAGGTGATCCGCCCCACCGGCCTCCTGGACCCGGTCATTGAGGTGAGGCCTGC
CGCAGGCCAGGTGGACGACCTCCTCCACGAAGTCCGGGAGACCGTGGCCCGGGGCGAGCGGGTGCTGGTCACCACCCTCA
CCAAGCGGATGGCCGAGGAACTGACCGACTACTACCGGGACCTGGGGGTACGGGTGCGGTACCTCCACTCGGATATCGAC
ACCATCCAGCGGATGCAGATCATCCGGGACCTGCGCCTCGGCGAGTTCGACGTGCTCGTGGGGATCAACCTCCTGCGGGA
GGGGCTCGACATCCCCGAGGTTTCGCTGGTGGCGATCCTCGATGCCGACAAGGAGGGATTCCTCCGCTCAGCCCGGTCCC
TGATCCAGACCTGTGGCCGGGCCGCCCGCAATGTCAATGGCCGGGTCACCATGTACGCCGACGCGGTAACCGGCTCCATG
GAGGCATGCATCGAAGAGACCGCACGGCGCCGGACGATCCAGGAGGCTTTCAACACCGAGCACAACATCACCCCCCGGAC
GGTGAAAAAGGGGCTCCGCACCATACTCGAATCCATCGAGGAGCGGGACTACTACACCATTCCCCTTGCGGCCGAGCCTC
AAGAAGAATACGTTCCTGCCGATGAGATTCCTAAGCTGGTGAAGCGCCTCCGCAAGGAGATGCTTGCCTCTGCCAAGAAC
CTGGAATTCGAGAAGGCGGCCGAACTCCGTGACCGGATCAAGAACCTGGAGGAGCGGCACCTTCAGCTCCACCCCTGA

Upstream 100 bases:

>100_bases
GGCTCCGCTACCGCTTCCTTCCGAAACATTCGCATAACTCCGGATTTCGTGCGTCCTTTTCCCCGATGCAAACGCGACCC
GTCCATGGTACTATCCCCCC

Downstream 100 bases:

>100_bases
AATGCCGGAGAACGTCATGAAACCACCATCAGTACTGCTCGTCGACGATGAACGCTTTTTTCTCTCCGTGCAGCGGGACT
TTCTCAAGGGCTCCCCGATC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MDRYTLVSDYTPRGDQPRAIEELSEGILRGDRHQVLLGVTGSGKTFTMANVIAATNRPALVLAPNKTLAAQLYGEFKELF
PHNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDKLRHAATRSLLTRQDVIIVASVSCIYGIGSPAEYQAMHIFF
HEGEEYGRDTLLRKLVEIQYERNDIDFHRGTFRVRGDIVEIFPAHEDEKALRIEFFGDAVEAISEIDPLRGVAHQRLAKC
AVYPASHYVATRETLERAIEEIRVALRERIQWFRERNMLVEAQRLEQRTMFDLEMMEEMGFCQGIENYSRHFDGRAPGEP
PYTLLDYFPKDFLLFVDESHITVSQVGGMYRGDRSRKETLVNYGFRLPSALDNRPLTFQEFTARLNQTIYVSATPADYEL
QQAGGVVVEQVIRPTGLLDPVIEVRPAAGQVDDLLHEVRETVARGERVLVTTLTKRMAEELTDYYRDLGVRVRYLHSDID
TIQRMQIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGRAARNVNGRVTMYADAVTGSM
EACIEETARRRTIQEAFNTEHNITPRTVKKGLRTILESIEERDYYTIPLAAEPQEEYVPADEIPKLVKRLRKEMLASAKN
LEFEKAAELRDRIKNLEERHLQLHP

Sequences:

>Translated_665_residues
MDRYTLVSDYTPRGDQPRAIEELSEGILRGDRHQVLLGVTGSGKTFTMANVIAATNRPALVLAPNKTLAAQLYGEFKELF
PHNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDKLRHAATRSLLTRQDVIIVASVSCIYGIGSPAEYQAMHIFF
HEGEEYGRDTLLRKLVEIQYERNDIDFHRGTFRVRGDIVEIFPAHEDEKALRIEFFGDAVEAISEIDPLRGVAHQRLAKC
AVYPASHYVATRETLERAIEEIRVALRERIQWFRERNMLVEAQRLEQRTMFDLEMMEEMGFCQGIENYSRHFDGRAPGEP
PYTLLDYFPKDFLLFVDESHITVSQVGGMYRGDRSRKETLVNYGFRLPSALDNRPLTFQEFTARLNQTIYVSATPADYEL
QQAGGVVVEQVIRPTGLLDPVIEVRPAAGQVDDLLHEVRETVARGERVLVTTLTKRMAEELTDYYRDLGVRVRYLHSDID
TIQRMQIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGRAARNVNGRVTMYADAVTGSM
EACIEETARRRTIQEAFNTEHNITPRTVKKGLRTILESIEERDYYTIPLAAEPQEEYVPADEIPKLVKRLRKEMLASAKN
LEFEKAAELRDRIKNLEERHLQLHP
>Mature_665_residues
MDRYTLVSDYTPRGDQPRAIEELSEGILRGDRHQVLLGVTGSGKTFTMANVIAATNRPALVLAPNKTLAAQLYGEFKELF
PHNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDKLRHAATRSLLTRQDVIIVASVSCIYGIGSPAEYQAMHIFF
HEGEEYGRDTLLRKLVEIQYERNDIDFHRGTFRVRGDIVEIFPAHEDEKALRIEFFGDAVEAISEIDPLRGVAHQRLAKC
AVYPASHYVATRETLERAIEEIRVALRERIQWFRERNMLVEAQRLEQRTMFDLEMMEEMGFCQGIENYSRHFDGRAPGEP
PYTLLDYFPKDFLLFVDESHITVSQVGGMYRGDRSRKETLVNYGFRLPSALDNRPLTFQEFTARLNQTIYVSATPADYEL
QQAGGVVVEQVIRPTGLLDPVIEVRPAAGQVDDLLHEVRETVARGERVLVTTLTKRMAEELTDYYRDLGVRVRYLHSDID
TIQRMQIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGRAARNVNGRVTMYADAVTGSM
EACIEETARRRTIQEAFNTEHNITPRTVKKGLRTILESIEERDYYTIPLAAEPQEEYVPADEIPKLVKRLRKEMLASAKN
LEFEKAAELRDRIKNLEERHLQLHP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=60.5105105105105, Blast_Score=785, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76255; Mature: 76255

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRYTLVSDYTPRGDQPRAIEELSEGILRGDRHQVLLGVTGSGKTFTMANVIAATNRPAL
CCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHCCCCCEE
VLAPNKTLAAQLYGEFKELFPHNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDK
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHH
LRHAATRSLLTRQDVIIVASVSCIYGIGSPAEYQAMHIFFHEGEEYGRDTLLRKLVEIQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEEEECCHHCCHHHHHHHHHHHHH
ERNDIDFHRGTFRVRGDIVEIFPAHEDEKALRIEFFGDAVEAISEIDPLRGVAHQRLAKC
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AVYPASHYVATRETLERAIEEIRVALRERIQWFRERNMLVEAQRLEQRTMFDLEMMEEMG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FCQGIENYSRHFDGRAPGEPPYTLLDYFPKDFLLFVDESHITVSQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCEEHHHHCCCCCCCCHHHHHH
VNYGFRLPSALDNRPLTFQEFTARLNQTIYVSATPADYELQQAGGVVVEQVIRPTGLLDP
HHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCHHHHHCCHHHHHHHCCCCCCCC
VIEVRPAAGQVDDLLHEVRETVARGERVLVTTLTKRMAEELTDYYRDLGVRVRYLHSDID
HHHCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHH
TIQRMQIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
AARNVNGRVTMYADAVTGSMEACIEETARRRTIQEAFNTEHNITPRTVKKGLRTILESIE
HHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ERDYYTIPLAAEPQEEYVPADEIPKLVKRLRKEMLASAKNLEFEKAAELRDRIKNLEERH
CCCCEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
LQLHP
CCCCC
>Mature Secondary Structure
MDRYTLVSDYTPRGDQPRAIEELSEGILRGDRHQVLLGVTGSGKTFTMANVIAATNRPAL
CCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHCCCCCEE
VLAPNKTLAAQLYGEFKELFPHNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDK
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHH
LRHAATRSLLTRQDVIIVASVSCIYGIGSPAEYQAMHIFFHEGEEYGRDTLLRKLVEIQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEEEECCHHCCHHHHHHHHHHHHH
ERNDIDFHRGTFRVRGDIVEIFPAHEDEKALRIEFFGDAVEAISEIDPLRGVAHQRLAKC
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AVYPASHYVATRETLERAIEEIRVALRERIQWFRERNMLVEAQRLEQRTMFDLEMMEEMG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FCQGIENYSRHFDGRAPGEPPYTLLDYFPKDFLLFVDESHITVSQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCEEHHHHCCCCCCCCHHHHHH
VNYGFRLPSALDNRPLTFQEFTARLNQTIYVSATPADYELQQAGGVVVEQVIRPTGLLDP
HHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCHHHHHCCHHHHHHHCCCCCCCC
VIEVRPAAGQVDDLLHEVRETVARGERVLVTTLTKRMAEELTDYYRDLGVRVRYLHSDID
HHHCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHH
TIQRMQIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
AARNVNGRVTMYADAVTGSMEACIEETARRRTIQEAFNTEHNITPRTVKKGLRTILESIE
HHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ERDYYTIPLAAEPQEEYVPADEIPKLVKRLRKEMLASAKNLEFEKAAELRDRIKNLEERH
CCCCEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
LQLHP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA