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The map label for this gene is thiL [H]

Identifier: 78224404

GI number: 78224404

Start: 3610982

End: 3611971

Strand: Reverse

Name: thiL [H]

Synonym: Gmet_3213

Alternate gene names: 78224404

Gene position: 3611971-3610982 (Counterclockwise)

Preceding gene: 78224405

Following gene: 78224403

Centisome position: 90.36

GC content: 64.55

Gene sequence:

>990_bases
TTGAGACTTAGGGAGATAGGGGAATTCGGCCTCATCGGACGCATATCTTCCCGGGTCGCCGACGGTGCCGGGGTGCGGAT
CGGCATCGGTGACGACGCTGCCGCCACGGAGCCCACGCCGGGGCGGTGGCTCCTCGTTACCTCCGACATGCTTCTGGAGG
GAATCCACTTCGACCTTGCCTTCACCGACCCCTACCGCCTCGGAAGAAAATCCCTGGCGGTGAACCTCTCGGACGTGGCC
GCCATGGGGGGGGAGCCCCGCCATTTCCTTCTTTCCCTTGCCGTCCCTACCGGCGTGACCGTGGAGTTCCTTGACCGGTT
CACCGAGGGGATGCTCGATCTGGCCCGCGAACACGGCGTTACTCTCATCGGCGGCGATACCTGCCGCTCGTCAAATGGTC
TCGTGATATCGGTTACCCTCCACGGCGAGCAGGTTCCGGAACTGGTTGTCCGCCGTGGCGGCGCCCGCCCCGGTGACCAT
GTTTTCGTGACGGGCACCGTTGGCGATTCGGCCCTGGGGCTCGAACTCCTGAGACGGGGTGAGCGTCGGGGATGGGCCGT
GGACCGCCACCTGGACCCCACCCCCCGGGTCCGGGCCGGCCTTGCCCTCGCTGGGGCAAGGCTTCCCAGTGCAATGATCG
ACGTGAGCGATGGCCTTGCCGCCGATCTGGGACACATCCTCGATCTTTCCGGCGTTGGTGCCCGTCTTAAGCTCGACCTT
CTTCCCCTCTCTCCCTCTTTTCGCGAACTCGCTCCCCAGATGACCCCGAATCCCTCCCTTCTCTCCCTGACCGGCGGCGA
GGATTACGAACTCCTGTTTACGGTTCCGGCCGATCGGAGCGAGGAAGTGGCCCCCCTCCTGGTGGAAACCGGTTGTGCCG
CCACCCTCATCGGTGAAATAACCGACGGTAGAGGCCTTGCGGTGGTGGGACCCGATGGCCGCGAGATACCCGTTACCTGC
GGTGGCTACAATCATTTTGCCGTAGCGTGA

Upstream 100 bases:

>100_bases
CCCCTCCCGCCAGCGAGGGGAAGCCGGCAGCCACGGTGAAGGCGCCGCCGCGGCGGGGGATTGCCGCTCCCCGCAAAGGA
GCCATGGCCGGGGCAAAGAG

Downstream 100 bases:

>100_bases
CGCCCGGGGGGGGATTCTTTCGCTTCCCGGAACGGTTCTTGCTGCCAACAACCGACATCTCCCGTGACAATGCAGGGCAT
GAGGCCATGATTTTACCAAC

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MRLREIGEFGLIGRISSRVADGAGVRIGIGDDAAATEPTPGRWLLVTSDMLLEGIHFDLAFTDPYRLGRKSLAVNLSDVA
AMGGEPRHFLLSLAVPTGVTVEFLDRFTEGMLDLAREHGVTLIGGDTCRSSNGLVISVTLHGEQVPELVVRRGGARPGDH
VFVTGTVGDSALGLELLRRGERRGWAVDRHLDPTPRVRAGLALAGARLPSAMIDVSDGLAADLGHILDLSGVGARLKLDL
LPLSPSFRELAPQMTPNPSLLSLTGGEDYELLFTVPADRSEEVAPLLVETGCAATLIGEITDGRGLAVVGPDGREIPVTC
GGYNHFAVA

Sequences:

>Translated_329_residues
MRLREIGEFGLIGRISSRVADGAGVRIGIGDDAAATEPTPGRWLLVTSDMLLEGIHFDLAFTDPYRLGRKSLAVNLSDVA
AMGGEPRHFLLSLAVPTGVTVEFLDRFTEGMLDLAREHGVTLIGGDTCRSSNGLVISVTLHGEQVPELVVRRGGARPGDH
VFVTGTVGDSALGLELLRRGERRGWAVDRHLDPTPRVRAGLALAGARLPSAMIDVSDGLAADLGHILDLSGVGARLKLDL
LPLSPSFRELAPQMTPNPSLLSLTGGEDYELLFTVPADRSEEVAPLLVETGCAATLIGEITDGRGLAVVGPDGREIPVTC
GGYNHFAVA
>Mature_329_residues
MRLREIGEFGLIGRISSRVADGAGVRIGIGDDAAATEPTPGRWLLVTSDMLLEGIHFDLAFTDPYRLGRKSLAVNLSDVA
AMGGEPRHFLLSLAVPTGVTVEFLDRFTEGMLDLAREHGVTLIGGDTCRSSNGLVISVTLHGEQVPELVVRRGGARPGDH
VFVTGTVGDSALGLELLRRGERRGWAVDRHLDPTPRVRAGLALAGARLPSAMIDVSDGLAADLGHILDLSGVGARLKLDL
LPLSPSFRELAPQMTPNPSLLSLTGGEDYELLFTVPADRSEEVAPLLVETGCAATLIGEITDGRGLAVVGPDGREIPVTC
GGYNHFAVA

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=331, Percent_Identity=40.4833836858006, Blast_Score=193, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 34703; Mature: 34703

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLREIGEFGLIGRISSRVADGAGVRIGIGDDAAATEPTPGRWLLVTSDMLLEGIHFDLA
CCCHHCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHCCEEEEEE
FTDPYRLGRKSLAVNLSDVAAMGGEPRHFLLSLAVPTGVTVEFLDRFTEGMLDLAREHGV
ECCHHHCCCHHEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCE
TLIGGDTCRSSNGLVISVTLHGEQVPELVVRRGGARPGDHVFVTGTVGDSALGLELLRRG
EEEECCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCC
ERRGWAVDRHLDPTPRVRAGLALAGARLPSAMIDVSDGLAADLGHILDLSGVGARLKLDL
CCCCEEECCCCCCCCCHHHCEEECCCCCCCEEEECCCCHHHHHHHHEECCCCCCEEEEEE
LPLSPSFRELAPQMTPNPSLLSLTGGEDYELLFTVPADRSEEVAPLLVETGCAATLIGEI
EECCCCHHHHCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCEEEEEEC
TDGRGLAVVGPDGREIPVTCGGYNHFAVA
CCCCEEEEECCCCCEEEEEECCCCEEEEC
>Mature Secondary Structure
MRLREIGEFGLIGRISSRVADGAGVRIGIGDDAAATEPTPGRWLLVTSDMLLEGIHFDLA
CCCHHCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHCCEEEEEE
FTDPYRLGRKSLAVNLSDVAAMGGEPRHFLLSLAVPTGVTVEFLDRFTEGMLDLAREHGV
ECCHHHCCCHHEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCE
TLIGGDTCRSSNGLVISVTLHGEQVPELVVRRGGARPGDHVFVTGTVGDSALGLELLRRG
EEEECCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCC
ERRGWAVDRHLDPTPRVRAGLALAGARLPSAMIDVSDGLAADLGHILDLSGVGARLKLDL
CCCCEEECCCCCCCCCHHHCEEECCCCCCCEEEECCCCHHHHHHHHEECCCCCCEEEEEE
LPLSPSFRELAPQMTPNPSLLSLTGGEDYELLFTVPADRSEEVAPLLVETGCAATLIGEI
EECCCCHHHHCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCEEEEEEC
TDGRGLAVVGPDGREIPVTCGGYNHFAVA
CCCCEEEEECCCCCEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]