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The map label for this gene is gcvT [H]

Identifier: 78224346

GI number: 78224346

Start: 3550507

End: 3551595

Strand: Reverse

Name: gcvT [H]

Synonym: Gmet_3155

Alternate gene names: 78224346

Gene position: 3551595-3550507 (Counterclockwise)

Preceding gene: 78224347

Following gene: 78224345

Centisome position: 88.85

GC content: 63.64

Gene sequence:

>1089_bases
ATGGAACCCCTCAAGAACACCCCCCTTTGCGCTGAACACGAGAAGCTGAACGCCCTCATGGCCCCCTTCGGCGGCTGGAA
CATGCCGATCCAGTACGAGGGGATCATTGCCGAGCACCGTTGGTGCCGGGAGAAGGCGGCCCTCTTCGACATCTGCCACA
TGGGAGAGTTTCACTTCAAGGGGGACATTGTCGCCTCGGGGCTTGAAGACGTCTTTACCTTCTCCGTTAAGTCGATCCCG
GTGGGGCGCTCCCGCTACGGGTTCCTCCTGAACGAAAACGGCGGTGTCATTGACGACCTCATCGTCTTCCGCCTGGCCGA
TGACGAGGCCATGGTGGTGGTGAACGCCGCCACCATCGAGAAAGACTTTGCCGCCATCTCTGCCCGGCTCTGCGGCGGGG
AGTTCCGGGATATTTCGGCTGAAACTGGCAAGCTGGACCTCCAGGGGCCCCTCTCCCGCGAGGTCCTTTCCGGCGTCGTT
GGCCCGGAGATTGCCGCCATCCCCTACTTCAAGTTCATCCGGACGAAGGTCCTCGGCGTTGATGCCATCGTGAGCCGCAC
CGGCTACACCGGCGAGTTGGGGTACGAGATCTTCCTTCCGGCGGAAAAGAGCGCGGAGCTCTGGACCCGGTTCCTCTCCG
ACGAGCGGGTGAAGCCCGCCGGCCTCGGCGCCCGGGATGTGCTCCGGCTGGAGATGGGGTACAGCCTCTACGGGAGCGAC
ATCGACGAGGCCACCACCCCCCTTGAGGCGGGGCTTGAGGCCTTCGTCAACTTCGACAAGGCGTTCGTTGGCAAAGAGGC
GCTCCTGAAGCAGCGGGCCGAAGGGGTGAAGCGGCTCAAGGTGGCCTTCGACGTCACTTCCCGCCGTTCCCCCCGCCACG
ACTATGAAATCCACTTCGAGGGGGAGCGGGTCGGCACCGTCACCAGCGGCGTCTTCTCCCCCATGCTCGGTTGCGGCATC
GGCATGGGATACGTGAATCCCTCGGTGGCCACCCTCGGCGCGCCCCTAACCATAACTCACGAGAAGGTGAGCATGGAGGC
GACGGTGGTGGAGCTTCCCTTCTACCGGGGCGGGTCGCTTCGTTCATAA

Upstream 100 bases:

>100_bases
GCTGGTTTTGTGGTGTACAATAGTGTTTTACAAAGCCAGGCAAATCAATTAGAGTCCAGTTTTATGTATCTTGTTTAATT
TCCCCGCCGGAGGACCAGTC

Downstream 100 bases:

>100_bases
GAAATTTTTCGCCGGATACGGATTCTGTTATCAAAATCAAGGAGGGATACATGGAAATCTATTTCACCAAGGAGCACGAG
TGGGTCAAGGTCAAGGAAGG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MEPLKNTPLCAEHEKLNALMAPFGGWNMPIQYEGIIAEHRWCREKAALFDICHMGEFHFKGDIVASGLEDVFTFSVKSIP
VGRSRYGFLLNENGGVIDDLIVFRLADDEAMVVVNAATIEKDFAAISARLCGGEFRDISAETGKLDLQGPLSREVLSGVV
GPEIAAIPYFKFIRTKVLGVDAIVSRTGYTGELGYEIFLPAEKSAELWTRFLSDERVKPAGLGARDVLRLEMGYSLYGSD
IDEATTPLEAGLEAFVNFDKAFVGKEALLKQRAEGVKRLKVAFDVTSRRSPRHDYEIHFEGERVGTVTSGVFSPMLGCGI
GMGYVNPSVATLGAPLTITHEKVSMEATVVELPFYRGGSLRS

Sequences:

>Translated_362_residues
MEPLKNTPLCAEHEKLNALMAPFGGWNMPIQYEGIIAEHRWCREKAALFDICHMGEFHFKGDIVASGLEDVFTFSVKSIP
VGRSRYGFLLNENGGVIDDLIVFRLADDEAMVVVNAATIEKDFAAISARLCGGEFRDISAETGKLDLQGPLSREVLSGVV
GPEIAAIPYFKFIRTKVLGVDAIVSRTGYTGELGYEIFLPAEKSAELWTRFLSDERVKPAGLGARDVLRLEMGYSLYGSD
IDEATTPLEAGLEAFVNFDKAFVGKEALLKQRAEGVKRLKVAFDVTSRRSPRHDYEIHFEGERVGTVTSGVFSPMLGCGI
GMGYVNPSVATLGAPLTITHEKVSMEATVVELPFYRGGSLRS
>Mature_362_residues
MEPLKNTPLCAEHEKLNALMAPFGGWNMPIQYEGIIAEHRWCREKAALFDICHMGEFHFKGDIVASGLEDVFTFSVKSIP
VGRSRYGFLLNENGGVIDDLIVFRLADDEAMVVVNAATIEKDFAAISARLCGGEFRDISAETGKLDLQGPLSREVLSGVV
GPEIAAIPYFKFIRTKVLGVDAIVSRTGYTGELGYEIFLPAEKSAELWTRFLSDERVKPAGLGARDVLRLEMGYSLYGSD
IDEATTPLEAGLEAFVNFDKAFVGKEALLKQRAEGVKRLKVAFDVTSRRSPRHDYEIHFEGERVGTVTSGVFSPMLGCGI
GMGYVNPSVATLGAPLTITHEKVSMEATVVELPFYRGGSLRS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=364, Percent_Identity=33.5164835164835, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI257796258, Length=335, Percent_Identity=34.6268656716418, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI257796256, Length=297, Percent_Identity=34.006734006734, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI257796254, Length=362, Percent_Identity=30.1104972375691, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=27.9761904761905, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI197927446, Length=337, Percent_Identity=28.7833827893175, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI21361378, Length=337, Percent_Identity=28.7833827893175, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI194306651, Length=352, Percent_Identity=25, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789272, Length=369, Percent_Identity=35.230352303523, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17560118, Length=369, Percent_Identity=33.8753387533875, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32563613, Length=319, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71994045, Length=334, Percent_Identity=25.4491017964072, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994052, Length=334, Percent_Identity=25.4491017964072, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320222, Length=362, Percent_Identity=32.3204419889503, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI20129441, Length=372, Percent_Identity=33.8709677419355, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28571104, Length=284, Percent_Identity=28.8732394366197, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20130091, Length=315, Percent_Identity=25.3968253968254, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39643; Mature: 39643

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLKNTPLCAEHEKLNALMAPFGGWNMPIQYEGIIAEHRWCREKAALFDICHMGEFHFK
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCEEHHHHHHHHHHHHHHHHHCCCEEEC
GDIVASGLEDVFTFSVKSIPVGRSRYGFLLNENGGVIDDLIVFRLADDEAMVVVNAATIE
CCHHHCCHHHHHEEEEECCCCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEEEEHHHH
KDFAAISARLCGGEFRDISAETGKLDLQGPLSREVLSGVVGPEIAAIPYFKFIRTKVLGV
HHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
DAIVSRTGYTGELGYEIFLPAEKSAELWTRFLSDERVKPAGLGARDVLRLEMGYSLYGSD
HHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHEEEEECCCEECCCC
IDEATTPLEAGLEAFVNFDKAFVGKEALLKQRAEGVKRLKVAFDVTSRRSPRHDYEIHFE
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEEEEEC
GERVGTVTSGVFSPMLGCGIGMGYVNPSVATLGAPLTITHEKVSMEATVVELPFYRGGSL
CCEECCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCEEEEEEEEEECCCCCCCC
RS
CC
>Mature Secondary Structure
MEPLKNTPLCAEHEKLNALMAPFGGWNMPIQYEGIIAEHRWCREKAALFDICHMGEFHFK
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCEEHHHHHHHHHHHHHHHHHCCCEEEC
GDIVASGLEDVFTFSVKSIPVGRSRYGFLLNENGGVIDDLIVFRLADDEAMVVVNAATIE
CCHHHCCHHHHHEEEEECCCCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEEEEHHHH
KDFAAISARLCGGEFRDISAETGKLDLQGPLSREVLSGVVGPEIAAIPYFKFIRTKVLGV
HHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
DAIVSRTGYTGELGYEIFLPAEKSAELWTRFLSDERVKPAGLGARDVLRLEMGYSLYGSD
HHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHEEEEECCCEECCCC
IDEATTPLEAGLEAFVNFDKAFVGKEALLKQRAEGVKRLKVAFDVTSRRSPRHDYEIHFE
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEEEEEC
GERVGTVTSGVFSPMLGCGIGMGYVNPSVATLGAPLTITHEKVSMEATVVELPFYRGGSL
CCEECCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCEEEEEEEEEECCCCCCCC
RS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA