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The map label for this gene is gcvPA [H]

Identifier: 78224344

GI number: 78224344

Start: 3548739

End: 3550085

Strand: Reverse

Name: gcvPA [H]

Synonym: Gmet_3153

Alternate gene names: 78224344

Gene position: 3550085-3548739 (Counterclockwise)

Preceding gene: 78224345

Following gene: 78224343

Centisome position: 88.81

GC content: 67.04

Gene sequence:

>1347_bases
ATGAGCACTGCCAGCTACTGCCCCAACACGCCAGAGGAGGTACGGGAGATGCTGGCCGCCATGGGCGCGGCGAGCATCGA
CGACCTGTTCCAGCCGATTCCGCCGGGGTTGCGGGCCCGCTCCTTTGATCTCCCTGCGGGGATGTCCGAGTTCGAGATGC
TCCGCCGGTTCGAGCACCTGGCCGGGAAGAACGCCCAGCACCTCGCACACTTTGTCGGCGGCGGCTACTACGACCACCTG
ATCCCGGCCGTGGTGGACCACCTTTCGGGGCGGGCCGAATTCTACACCGCCTACACCCCGTACCAGCCCGAATGCTCCCA
GGGGACCCTCCAGGCCCTCTTCGAGTACCAGACCGCCATCTGCCGCCTCACCGGCATGGAGGTCTCCAACGCCTCCCTCT
ACGACGGCGGCACGGCCCTGGCTGAGGCGGCCATGATGGCCCTGCGGATCACGGGGCGAAACCGCCTCGTCATCGACGGG
GCCGTGAACCCCTTTCACCGGGAGGTCGTCAGGACCTACCTGGCCAACCTGGACGTGGAGCTGGTGGAGATCGGGCCCAA
GCTCGGCATGGAGGACGACCTGCGGCTCCGGGCCGCCATCGACGACGCCACTGCCGCGGTCCTCGTCCAGAACCCCAACT
TCTTCGGGAGCGTGAGCGACTTCCGCAAGCTGGCTGCCGACGCCCATGCCGCCGGGGCGCTCCTGGTGGTCTCCGCCTAC
CCGGTGGCCCTGGGGCTCATCGAGAGCCCCGGCGCCATGGGGGCCGATGTCGTGGTGGGGGACGGCCAGAGCCTTGGCAA
CCCCCTCTCCTTCGGGGGGCCCTCCTTCGGCTTCATCGCCAGCCGCAAGGAGTACATCCGCAACTTGCCGGGCCGGATCA
TCGGCGAGACCGTGGACAAAAAGGGACAACGGGGCTTCGTCCTCACCCTTCAGGCCCGTGAACAGCACATCAAGCGCCAC
AAGGCCACCTCCAACATCTGCAGCAACCAGAGCCTCTGCGCCCTGCGGGGGCTCATCTTTCTCTCCAGTCTCGGCGCCCA
GGGGTTTGCGGAGCTGGCGCGGCTCAACTACGATAAGGCCGAGTACGCGAAAAAGGTCCTCGGCTCCCTCTCTGGGGTCG
AGGTGATGAACGGCGGTGCCACCTTCAACGAGTTCACCGTCTGTCTCCCCACGATCGCCGAGGAGGTGGTCACGGCGCTC
CTGCGGAAAGGGGTCGCCGCCGGTGTTCCCCTGAGCCCCTACTATCCGGAGATGGAGCGGTGCATGGTGGTGACCGTGAC
CGAGAAGCGGACCCGGGAGGAGATCGACACCCTGGCCCGGCACCTGGAGGGTATCCTATGCAGCTGA

Upstream 100 bases:

>100_bases
AGGACGCCGGCTGGATGGCAATTATGGACATGGAGGATCCGGCCGAGCTCCAGAAGCTCATGACCCGCGACCAGTATGAC
GAGTACGTGAGGAGCCTCGG

Downstream 100 bases:

>100_bases
TCTATGAGAAATCGGTCCCGGGCCGAAGGGGAGTGCGCCTCCCGGCCAGTGACGTCCCCGCTGCCCCGGAGCTTCCGGCG
GCGCTTCGCCGGAAGGAGCC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSTASYCPNTPEEVREMLAAMGAASIDDLFQPIPPGLRARSFDLPAGMSEFEMLRRFEHLAGKNAQHLAHFVGGGYYDHL
IPAVVDHLSGRAEFYTAYTPYQPECSQGTLQALFEYQTAICRLTGMEVSNASLYDGGTALAEAAMMALRITGRNRLVIDG
AVNPFHREVVRTYLANLDVELVEIGPKLGMEDDLRLRAAIDDATAAVLVQNPNFFGSVSDFRKLAADAHAAGALLVVSAY
PVALGLIESPGAMGADVVVGDGQSLGNPLSFGGPSFGFIASRKEYIRNLPGRIIGETVDKKGQRGFVLTLQAREQHIKRH
KATSNICSNQSLCALRGLIFLSSLGAQGFAELARLNYDKAEYAKKVLGSLSGVEVMNGGATFNEFTVCLPTIAEEVVTAL
LRKGVAAGVPLSPYYPEMERCMVVTVTEKRTREEIDTLARHLEGILCS

Sequences:

>Translated_448_residues
MSTASYCPNTPEEVREMLAAMGAASIDDLFQPIPPGLRARSFDLPAGMSEFEMLRRFEHLAGKNAQHLAHFVGGGYYDHL
IPAVVDHLSGRAEFYTAYTPYQPECSQGTLQALFEYQTAICRLTGMEVSNASLYDGGTALAEAAMMALRITGRNRLVIDG
AVNPFHREVVRTYLANLDVELVEIGPKLGMEDDLRLRAAIDDATAAVLVQNPNFFGSVSDFRKLAADAHAAGALLVVSAY
PVALGLIESPGAMGADVVVGDGQSLGNPLSFGGPSFGFIASRKEYIRNLPGRIIGETVDKKGQRGFVLTLQAREQHIKRH
KATSNICSNQSLCALRGLIFLSSLGAQGFAELARLNYDKAEYAKKVLGSLSGVEVMNGGATFNEFTVCLPTIAEEVVTAL
LRKGVAAGVPLSPYYPEMERCMVVTVTEKRTREEIDTLARHLEGILCS
>Mature_447_residues
STASYCPNTPEEVREMLAAMGAASIDDLFQPIPPGLRARSFDLPAGMSEFEMLRRFEHLAGKNAQHLAHFVGGGYYDHLI
PAVVDHLSGRAEFYTAYTPYQPECSQGTLQALFEYQTAICRLTGMEVSNASLYDGGTALAEAAMMALRITGRNRLVIDGA
VNPFHREVVRTYLANLDVELVEIGPKLGMEDDLRLRAAIDDATAAVLVQNPNFFGSVSDFRKLAADAHAAGALLVVSAYP
VALGLIESPGAMGADVVVGDGQSLGNPLSFGGPSFGFIASRKEYIRNLPGRIIGETVDKKGQRGFVLTLQAREQHIKRHK
ATSNICSNQSLCALRGLIFLSSLGAQGFAELARLNYDKAEYAKKVLGSLSGVEVMNGGATFNEFTVCLPTIAEEVVTALL
RKGVAAGVPLSPYYPEMERCMVVTVTEKRTREEIDTLARHLEGILCS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=346, Percent_Identity=37.8612716763006, Blast_Score=221, Evalue=9e-58,
Organism=Escherichia coli, GI1789269, Length=345, Percent_Identity=34.7826086956522, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17535605, Length=350, Percent_Identity=39.1428571428571, Blast_Score=232, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6323843, Length=360, Percent_Identity=36.6666666666667, Blast_Score=227, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24645648, Length=369, Percent_Identity=38.2113821138211, Blast_Score=229, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 48371; Mature: 48240

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTASYCPNTPEEVREMLAAMGAASIDDLFQPIPPGLRARSFDLPAGMSEFEMLRRFEHL
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AGKNAQHLAHFVGGGYYDHLIPAVVDHLSGRAEFYTAYTPYQPECSQGTLQALFEYQTAI
HCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
CRLTGMEVSNASLYDGGTALAEAAMMALRITGRNRLVIDGAVNPFHREVVRTYLANLDVE
HHHCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHHHCCCEE
LVEIGPKLGMEDDLRLRAAIDDATAAVLVQNPNFFGSVSDFRKLAADAHAAGALLVVSAY
EEEECCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEHH
PVALGLIESPGAMGADVVVGDGQSLGNPLSFGGPSFGFIASRKEYIRNLPGRIIGETVDK
HHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHC
KGQRGFVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFLSSLGAQGFAELARLNYDKA
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHH
EYAKKVLGSLSGVEVMNGGATFNEFTVCLPTIAEEVVTALLRKGVAAGVPLSPYYPEMER
HHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
CMVVTVTEKRTREEIDTLARHLEGILCS
EEEEEECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STASYCPNTPEEVREMLAAMGAASIDDLFQPIPPGLRARSFDLPAGMSEFEMLRRFEHL
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AGKNAQHLAHFVGGGYYDHLIPAVVDHLSGRAEFYTAYTPYQPECSQGTLQALFEYQTAI
HCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
CRLTGMEVSNASLYDGGTALAEAAMMALRITGRNRLVIDGAVNPFHREVVRTYLANLDVE
HHHCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHHHCCCEE
LVEIGPKLGMEDDLRLRAAIDDATAAVLVQNPNFFGSVSDFRKLAADAHAAGALLVVSAY
EEEECCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEHH
PVALGLIESPGAMGADVVVGDGQSLGNPLSFGGPSFGFIASRKEYIRNLPGRIIGETVDK
HHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHC
KGQRGFVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFLSSLGAQGFAELARLNYDKA
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHH
EYAKKVLGSLSGVEVMNGGATFNEFTVCLPTIAEEVVTALLRKGVAAGVPLSPYYPEMER
HHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
CMVVTVTEKRTREEIDTLARHLEGILCS
EEEEEECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA