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The map label for this gene is gcvPB [H]

Identifier: 78224343

GI number: 78224343

Start: 3547303

End: 3548748

Strand: Reverse

Name: gcvPB [H]

Synonym: Gmet_3152

Alternate gene names: 78224343

Gene position: 3548748-3547303 (Counterclockwise)

Preceding gene: 78224344

Following gene: 78224342

Centisome position: 88.78

GC content: 65.49

Gene sequence:

>1446_bases
ATGCAGCTGATCTATGAGAAATCGGTCCCGGGCCGAAGGGGAGTGCGCCTCCCGGCCAGTGACGTCCCCGCTGCCCCGGA
GCTTCCGGCGGCGCTTCGCCGGAAGGAGCCGGCGGCACTCCCCGAGGCGAGCGAGTTGGACGTGGTGCGCCACTTCACGG
GGCTCTCCCGCCGCAACTTCTCGGTGGACACCAATTTTTACCCCCTGGGCTCCTGTACCATGAAGTACAACGCCAAGGTC
CTGGAGGAGGCGGCGCGGCTCTTCGCCCCCTACCATCCCATGGTGCCGCTCCTTCCCCATGGCTCTTCCTTCAGCCAGGG
GTGCCTGGGGCTCGCCTATGAACTGGGGGCGGCCCTCGCCGAGATCACCGGCATGGACGAGGTGACCACCCAACCCCTGG
CCGGCGCCCACGGCGAGATGACCGGCATCATGCTCATCGCCGCCTACCACGAGGCCAAGGGGAACAAGAAGAAGTACGTG
GTGGTCCCCGACTCCTCCCATGGCACCAACCCGGCCTCCGCCACCATGGTGGGATACGAGATCATCACCGTCCCGACGGC
CCCCTACGGCGACATGGACCTGGACAGATTCCGGGAGGTGATGACCGACGAGGTGGCGGCAGTCATGATGACCTGCCCCA
ACACCCTGGGGCTCTTCAACCCCCACATACAGGAGATCTGCGACATCGCCCACGACCACGACGCCCTCATGTACTACGAC
GGCGCCAACCTGAACGCCATCCTCGGCAAGGTCCGCCCCGGCGACGTGGGATTCGATGTGATCCATCTGAACCTTCACAA
GACCTTCGGCACCCCCCACGGCGGGGGCGGTCCCGGGAGCGGCCCGGTCGGGGTGAAGAAGCAACTGGTCCCCTTCCTTC
CCTCTCCCCGGATCGTGAAATACGACGACGGTTGCTACGGGGTCGATGCCCCGGCCCACGGGAGCATCGGCCGTACCTCT
GGCTTCTTCGGCAACTTCGGGGTCATGGCCAAGGCCTTTGCCTACATCACCATGGTGGGCCGCGAGGGGCTCATCCAGGT
GAGCGAGCAGGCGGTCCTGAACGCCAACTACGTGATGCACCGCCTGAAGGACGTGTACGACCTCCCCTATGACCAGACCT
GCATGCACGAGTGCGTCTTCTCGGCGGCCCGGCAGGTGAAGAGCGGCGTCCATGCCATCGACATCGCCAAGTTCCTCATC
GACCGGGGCTACCATCCTCCCACGGTCTACTTCCCGCTCATCGTCAAGGAGGCGATCATGATCGAGCCCACCGAGACCGA
GAGCAAGGAGACCCTGGACGCCTTCATCGCCGTCATGCGCGAGGCGGCGGAACTGGCCGAGTCCGATCCGGCCGCCTTTG
CCGAGATGCCCCGGACCATGCCGGTCACCCGCCTCGACGAGACCAAGGCGGCCCGGGAGCAGAATGTCTGCTACTTTGGC
TGCTGA

Upstream 100 bases:

>100_bases
CCTACTATCCGGAGATGGAGCGGTGCATGGTGGTGACCGTGACCGAGAAGCGGACCCGGGAGGAGATCGACACCCTGGCC
CGGCACCTGGAGGGTATCCT

Downstream 100 bases:

>100_bases
TGGTTCTCCCAACCTGACCCGCTGGCGCCTCGTGGACACCGGCCCCCTGGACGGCCCCGCCAACATGGCGGTGGACGAGG
CGCTTCTTCTCCATTTCGAC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MQLIYEKSVPGRRGVRLPASDVPAAPELPAALRRKEPAALPEASELDVVRHFTGLSRRNFSVDTNFYPLGSCTMKYNAKV
LEEAARLFAPYHPMVPLLPHGSSFSQGCLGLAYELGAALAEITGMDEVTTQPLAGAHGEMTGIMLIAAYHEAKGNKKKYV
VVPDSSHGTNPASATMVGYEIITVPTAPYGDMDLDRFREVMTDEVAAVMMTCPNTLGLFNPHIQEICDIAHDHDALMYYD
GANLNAILGKVRPGDVGFDVIHLNLHKTFGTPHGGGGPGSGPVGVKKQLVPFLPSPRIVKYDDGCYGVDAPAHGSIGRTS
GFFGNFGVMAKAFAYITMVGREGLIQVSEQAVLNANYVMHRLKDVYDLPYDQTCMHECVFSAARQVKSGVHAIDIAKFLI
DRGYHPPTVYFPLIVKEAIMIEPTETESKETLDAFIAVMREAAELAESDPAAFAEMPRTMPVTRLDETKAAREQNVCYFG
C

Sequences:

>Translated_481_residues
MQLIYEKSVPGRRGVRLPASDVPAAPELPAALRRKEPAALPEASELDVVRHFTGLSRRNFSVDTNFYPLGSCTMKYNAKV
LEEAARLFAPYHPMVPLLPHGSSFSQGCLGLAYELGAALAEITGMDEVTTQPLAGAHGEMTGIMLIAAYHEAKGNKKKYV
VVPDSSHGTNPASATMVGYEIITVPTAPYGDMDLDRFREVMTDEVAAVMMTCPNTLGLFNPHIQEICDIAHDHDALMYYD
GANLNAILGKVRPGDVGFDVIHLNLHKTFGTPHGGGGPGSGPVGVKKQLVPFLPSPRIVKYDDGCYGVDAPAHGSIGRTS
GFFGNFGVMAKAFAYITMVGREGLIQVSEQAVLNANYVMHRLKDVYDLPYDQTCMHECVFSAARQVKSGVHAIDIAKFLI
DRGYHPPTVYFPLIVKEAIMIEPTETESKETLDAFIAVMREAAELAESDPAAFAEMPRTMPVTRLDETKAAREQNVCYFG
C
>Mature_481_residues
MQLIYEKSVPGRRGVRLPASDVPAAPELPAALRRKEPAALPEASELDVVRHFTGLSRRNFSVDTNFYPLGSCTMKYNAKV
LEEAARLFAPYHPMVPLLPHGSSFSQGCLGLAYELGAALAEITGMDEVTTQPLAGAHGEMTGIMLIAAYHEAKGNKKKYV
VVPDSSHGTNPASATMVGYEIITVPTAPYGDMDLDRFREVMTDEVAAVMMTCPNTLGLFNPHIQEICDIAHDHDALMYYD
GANLNAILGKVRPGDVGFDVIHLNLHKTFGTPHGGGGPGSGPVGVKKQLVPFLPSPRIVKYDDGCYGVDAPAHGSIGRTS
GFFGNFGVMAKAFAYITMVGREGLIQVSEQAVLNANYVMHRLKDVYDLPYDQTCMHECVFSAARQVKSGVHAIDIAKFLI
DRGYHPPTVYFPLIVKEAIMIEPTETESKETLDAFIAVMREAAELAESDPAAFAEMPRTMPVTRLDETKAAREQNVCYFG
C

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=422, Percent_Identity=40.521327014218, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1789269, Length=430, Percent_Identity=38.8372093023256, Blast_Score=254, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17535605, Length=461, Percent_Identity=37.3101952277657, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI32564013, Length=360, Percent_Identity=40.2777777777778, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=413, Percent_Identity=42.1307506053269, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24645648, Length=420, Percent_Identity=38.8095238095238, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52288; Mature: 52288

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIYEKSVPGRRGVRLPASDVPAAPELPAALRRKEPAALPEASELDVVRHFTGLSRRNF
CCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
SVDTNFYPLGSCTMKYNAKVLEEAARLFAPYHPMVPLLPHGSSFSQGCLGLAYELGAALA
CCCCCEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EITGMDEVTTQPLAGAHGEMTGIMLIAAYHEAKGNKKKYVVVPDSSHGTNPASATMVGYE
HHCCCCHHHCCCCCCCCCCCEEEEEEEEEHHCCCCCEEEEEEECCCCCCCCCCEEEEEEE
IITVPTAPYGDMDLDRFREVMTDEVAAVMMTCPNTLGLFNPHIQEICDIAHDHDALMYYD
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEC
GANLNAILGKVRPGDVGFDVIHLNLHKTFGTPHGGGGPGSGPVGVKKQLVPFLPSPRIVK
CCCCHHHEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEE
YDDGCYGVDAPAHGSIGRTSGFFGNFGVMAKAFAYITMVGREGLIQVSEQAVLNANYVMH
ECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
RLKDVYDLPYDQTCMHECVFSAARQVKSGVHAIDIAKFLIDRGYHPPTVYFPLIVKEAIM
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHEE
IEPTETESKETLDAFIAVMREAAELAESDPAAFAEMPRTMPVTRLDETKAAREQNVCYFG
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEC
C
C
>Mature Secondary Structure
MQLIYEKSVPGRRGVRLPASDVPAAPELPAALRRKEPAALPEASELDVVRHFTGLSRRNF
CCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
SVDTNFYPLGSCTMKYNAKVLEEAARLFAPYHPMVPLLPHGSSFSQGCLGLAYELGAALA
CCCCCEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EITGMDEVTTQPLAGAHGEMTGIMLIAAYHEAKGNKKKYVVVPDSSHGTNPASATMVGYE
HHCCCCHHHCCCCCCCCCCCEEEEEEEEEHHCCCCCEEEEEEECCCCCCCCCCEEEEEEE
IITVPTAPYGDMDLDRFREVMTDEVAAVMMTCPNTLGLFNPHIQEICDIAHDHDALMYYD
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEC
GANLNAILGKVRPGDVGFDVIHLNLHKTFGTPHGGGGPGSGPVGVKKQLVPFLPSPRIVK
CCCCHHHEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEE
YDDGCYGVDAPAHGSIGRTSGFFGNFGVMAKAFAYITMVGREGLIQVSEQAVLNANYVMH
ECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
RLKDVYDLPYDQTCMHECVFSAARQVKSGVHAIDIAKFLIDRGYHPPTVYFPLIVKEAIM
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHEE
IEPTETESKETLDAFIAVMREAAELAESDPAAFAEMPRTMPVTRLDETKAAREQNVCYFG
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEC
C
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]