Click here to switch to the map view.

The map label for this gene is tdcB [H]

Identifier: 78224264

GI number: 78224264

Start: 3470702

End: 3471910

Strand: Direct

Name: tdcB [H]

Synonym: Gmet_3072

Alternate gene names: 78224264

Gene position: 3470702-3471910 (Clockwise)

Preceding gene: 78224263

Following gene: 78224283

Centisome position: 86.82

GC content: 65.18

Gene sequence:

>1209_bases
ATGCTCCCCTACACCCTGATCCAGGAAGCGTCAGACCGCCTCAAAAAGCGGGTCCGGCGCACCGAGCTGATCCACTCCCA
CCACTTCAGCGAGCGGTTCGGCTTCCCCCTTCTCTTCAAGTGCGAGAACCTCCAGCGGACCGGCGCCTTCAAGATCCGGG
GAGCCCTCAACTTCATGACCTCCCAGCCCCGGGAGGCCCTGACAAAGGGGGTCATCACCGCCTCGGCCGGCAACCACGCC
CAGGGGGTCGCCTTTTCCGCCGACCTCCTGGGGGCGCAGGCCACCGTCTTCATGCCCGAGAGCACCCCGCCCCAGAAGGT
GCAGGCCACCAAGGAGTATGGCGCCGACGTAGTCCTCACCGGCAGGAACTTCGACGAGGCCTATGCCGCCGCAGTCCAGG
CCCAGAAGGAGACCGGCGCCCTCTTCGTGCACCCCTTCGACGATCCCCTGGTCATGGCCGGCCAGGGTACCATCGGCCTC
GAAATCCTCGATGAACTCCCCGACGTCTCAGCCATCCTGGTCCCCATCGGGGGAGGCGGGCTCATCGCCGGCATTGCCAC
GGCGGTAAAGGAGACTCACCCCCACGTGCGGATCATCGGCATCGAATCCAAGGCCGCACCCTCCATGCACTTCTCCCTCA
AGAAGGGAAAGATCGTGGAGGCCCCCCTCACGGTTACCCTTGCCGACGGGATCGCCGTGAAGAAGGTGGGACGGAACACC
TTCCCCATCATCCGGGAACTGGTGGACGACGTGGTGCTCGTGGAGGAAGAGGAGATCGCCCTGGCCATCGTGGGGCTCCT
GGAGCGGACGAAACTCCTCGTGGAAGGGGCTGGAGCCGTGACCCTGGCGGCCCTTCTGAACGGCAAGGCGGGGAAACTGC
CGGGGAAGACGGTCTGCGTCCTCTCCGGCGGAAACATCGACGTGAAGACCATTTCCACCGTGGTGGAGCGGGGCCTTGTG
GCGGCGGGGCGCTATCTGAAGCTGCAGGTGGTGCTGGACGACATTCCCGGTTCCCTGGCGGGGCTGGCCACGGAGGTGGC
TGCTGTCCGGGCCAACATCTTCCTCATCAACCACGAGCGCCGCTCCCTGGACCTTCCCCTCGGCAAGACCGAGGTCCTTC
TGGAACTGGAGACCCGGGGCTACGAACACATCCAGGAGATCATCGGCCACCTGGGGCGACGGGGCTATGAGGTGGATGTC
GTAAAATGA

Upstream 100 bases:

>100_bases
CCACGACCATCACGGCCACGACCATGGGCACGGCCATGACCACCACGGGCACGACCACGACCACTGCCACCATGACCACT
AGCAACCCCACGGAGAACCG

Downstream 100 bases:

>100_bases
ACTCCCTCGTGAGGGGAGCGCCGTTGCCCGGATCCACCAACTCCGGCCGCAGGAGGTCGGCGGCCGTGTCAACATCATGC
CACACCGGCAGGAGCGCCGT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLPYTLIQEASDRLKKRVRRTELIHSHHFSERFGFPLLFKCENLQRTGAFKIRGALNFMTSQPREALTKGVITASAGNHA
QGVAFSADLLGAQATVFMPESTPPQKVQATKEYGADVVLTGRNFDEAYAAAVQAQKETGALFVHPFDDPLVMAGQGTIGL
EILDELPDVSAILVPIGGGGLIAGIATAVKETHPHVRIIGIESKAAPSMHFSLKKGKIVEAPLTVTLADGIAVKKVGRNT
FPIIRELVDDVVLVEEEEIALAIVGLLERTKLLVEGAGAVTLAALLNGKAGKLPGKTVCVLSGGNIDVKTISTVVERGLV
AAGRYLKLQVVLDDIPGSLAGLATEVAAVRANIFLINHERRSLDLPLGKTEVLLELETRGYEHIQEIIGHLGRRGYEVDV
VK

Sequences:

>Translated_402_residues
MLPYTLIQEASDRLKKRVRRTELIHSHHFSERFGFPLLFKCENLQRTGAFKIRGALNFMTSQPREALTKGVITASAGNHA
QGVAFSADLLGAQATVFMPESTPPQKVQATKEYGADVVLTGRNFDEAYAAAVQAQKETGALFVHPFDDPLVMAGQGTIGL
EILDELPDVSAILVPIGGGGLIAGIATAVKETHPHVRIIGIESKAAPSMHFSLKKGKIVEAPLTVTLADGIAVKKVGRNT
FPIIRELVDDVVLVEEEEIALAIVGLLERTKLLVEGAGAVTLAALLNGKAGKLPGKTVCVLSGGNIDVKTISTVVERGLV
AAGRYLKLQVVLDDIPGSLAGLATEVAAVRANIFLINHERRSLDLPLGKTEVLLELETRGYEHIQEIIGHLGRRGYEVDV
VK
>Mature_402_residues
MLPYTLIQEASDRLKKRVRRTELIHSHHFSERFGFPLLFKCENLQRTGAFKIRGALNFMTSQPREALTKGVITASAGNHA
QGVAFSADLLGAQATVFMPESTPPQKVQATKEYGADVVLTGRNFDEAYAAAVQAQKETGALFVHPFDDPLVMAGQGTIGL
EILDELPDVSAILVPIGGGGLIAGIATAVKETHPHVRIIGIESKAAPSMHFSLKKGKIVEAPLTVTLADGIAVKKVGRNT
FPIIRELVDDVVLVEEEEIALAIVGLLERTKLLVEGAGAVTLAALLNGKAGKLPGKTVCVLSGGNIDVKTISTVVERGLV
AAGRYLKLQVVLDDIPGSLAGLATEVAAVRANIFLINHERRSLDLPLGKTEVLLELETRGYEHIQEIIGHLGRRGYEVDV
VK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=319, Percent_Identity=38.871473354232, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI19923959, Length=306, Percent_Identity=31.6993464052288, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=29.5819935691318, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1789505, Length=310, Percent_Identity=48.0645161290323, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1790207, Length=384, Percent_Identity=35.4166666666667, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71991565, Length=387, Percent_Identity=44.1860465116279, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17537387, Length=384, Percent_Identity=36.9791666666667, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17508781, Length=311, Percent_Identity=27.9742765273312, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320930, Length=386, Percent_Identity=34.9740932642487, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=40.7643312101911, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6319788, Length=273, Percent_Identity=24.5421245421245, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355833, Length=365, Percent_Identity=42.4657534246575, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24645328, Length=297, Percent_Identity=42.7609427609428, Blast_Score=172, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43056; Mature: 43056

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPYTLIQEASDRLKKRVRRTELIHSHHFSERFGFPLLFKCENLQRTGAFKIRGALNFMT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCEEEEEEHHHHC
SQPREALTKGVITASAGNHAQGVAFSADLLGAQATVFMPESTPPQKVQATKEYGADVVLT
CCCHHHHHHCEEEECCCCCCCCEEEEHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEE
GRNFDEAYAAAVQAQKETGALFVHPFDDPLVMAGQGTIGLEILDELPDVSAILVPIGGGG
CCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHCCCCCEEEEEEECCCH
LIAGIATAVKETHPHVRIIGIESKAAPSMHFSLKKGKIVEAPLTVTLADGIAVKKVGRNT
HHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEECCEEEEEECCEEEECCCCCH
FPIIRELVDDVVLVEEEEIALAIVGLLERTKLLVEGAGAVTLAALLNGKAGKLPGKTVCV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHEEECCCHHEEHHHHCCCCCCCCCCEEEE
LSGGNIDVKTISTVVERGLVAAGRYLKLQVVLDDIPGSLAGLATEVAAVRANIFLINHER
EECCCEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHEEEEEEEEEECCC
RSLDLPLGKTEVLLELETRGYEHIQEIIGHLGRRGYEVDVVK
CEECCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MLPYTLIQEASDRLKKRVRRTELIHSHHFSERFGFPLLFKCENLQRTGAFKIRGALNFMT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCCCCCCEEEEEEHHHHC
SQPREALTKGVITASAGNHAQGVAFSADLLGAQATVFMPESTPPQKVQATKEYGADVVLT
CCCHHHHHHCEEEECCCCCCCCEEEEHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEE
GRNFDEAYAAAVQAQKETGALFVHPFDDPLVMAGQGTIGLEILDELPDVSAILVPIGGGG
CCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHCCCCCEEEEEEECCCH
LIAGIATAVKETHPHVRIIGIESKAAPSMHFSLKKGKIVEAPLTVTLADGIAVKKVGRNT
HHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEECCEEEEEECCEEEECCCCCH
FPIIRELVDDVVLVEEEEIALAIVGLLERTKLLVEGAGAVTLAALLNGKAGKLPGKTVCV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHEEECCCHHEEHHHHCCCCCCCCCCEEEE
LSGGNIDVKTISTVVERGLVAAGRYLKLQVVLDDIPGSLAGLATEVAAVRANIFLINHER
EECCCEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHEEEEEEEEEECCC
RSLDLPLGKTEVLLELETRGYEHIQEIIGHLGRRGYEVDVVK
CEECCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA