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The map label for this gene is trpE [H]

Identifier: 78224203

GI number: 78224203

Start: 3393941

End: 3395701

Strand: Direct

Name: trpE [H]

Synonym: Gmet_3010

Alternate gene names: 78224203

Gene position: 3393941-3395701 (Clockwise)

Preceding gene: 78224202

Following gene: 78224204

Centisome position: 84.9

GC content: 67.52

Gene sequence:

>1761_bases
ATGAGCGGGACGCCGACGGTCACCCTGTTATCCCTGGCGCCGGAGCACCATCCGGCCTCGTTCCGCTTCGACGGATTCGT
GGAGGAGATCACGGCCCGCACCCCCGAGGAGGTCATCCCTGCCCTGAAGAGGGTTGAGGAGGCGGCTGCCCAGGGGCTCC
ACGCGGCGGGGTTCGTCTCCTACGAAGCGGCGGCGGGGCTCGGCACCGGCCTCGCCACGCACTCCCCCGGCCCCCTCCCC
CTTGTCTGGTTCGGCGTGTTCGAGAACCGCCTCGGCATTGCCCCACGCCTCCCCAGCGCCGCGGAATGCGGGGTGGCCTG
CGGAACCTCCGGCTGGGAGACCACCCTCTCGCCCGAGGCCTACCAGGGGGCCGTCGAGCGGACCAAGGAATACATCGCCG
CCGGCGACACCTACCAGGTGAACTTCACCTTCAGCCAGCGTTTCGCCTTCACGGGGAATCCCGCTGCCTATTTCGGCGAC
CTCTGCCGGGCCCAGAATGCCCCGTTCTGTGCCCATCTGGACACGGGACGCTTCCAGATTCTGTCGGCATCCCCCGAACT
CTTTTTCGAACTGCGCCACGGCGTCCTCACCTGCCGTCCCATGAAGGGGACCGCTACGCGGGGCCGCTGGCGGAGCGAGG
ACGAGCAGATCAAGGCGCGCCTGGCCGAGAGCGAGAAGGAGCGGGCCGAGAACCTGATGATCACCGATCTTCTGCGCAAC
GACCTGGGGATGGTGGCGAAGACCGGCTCAGTGCAGGTGGACGGGCTTTTTGCGGTGGAGACCCTGGAGACGGTCCACCA
GATGACCTCCACCATCACGGCCCGGCAGCGGGAGGGGGTAGACCTGCCGGAGCTCTTTCGGGCCCTCTTCCCCTGCGGCT
CCGTGACCGGCGCCCCCAAGAAGCGGAGCATGGAGATCATCCGTGAGCTGGAGGACTCCCCCCGGGGGGTCTACACCGGC
TGCATCGGCCACGTATCCCCCGGCGGGGAGATGACCTTCAGCGTAGCCATCCGCACCGTGGTCGTCGACACTGAGACGGG
AAGGGGTGAACTGGGAATCGGAAGCGGCGTCACCATCGGCTCCCAGGCAGAGGACGAGTACCAGGAGTGCCTCGCCAAGG
CCCGCTTTGCCCGGGAGCGCATGCCCGACTTCCAGCTCGTGGAGACCATGCTCCACGAGGAGGACAAGGGGTGCTTCCTT
CTCGACCGGCACCTGGCGCGGCTTTTCCGCTCCGCCGCCTACTTCGGCTTCACCGTGCGCCTCGGCACCATCACCATGGT
CCTCGCCCACCGCACCGGTAGCCTTGAAGGAAAGCACAAGGTGCGGCTCCTCCTGAACCGCCGGGGGGCCTTCACCATCG
AGACCGAGCCGCTCCCGCCGACGGAAGGCGTTGAGACGATGATTACCTGCTTCGCCTCGGAGGCCGTCGAGTCCGCAGAC
CCGTTCCTCTACCACAAGACGACCCATCGCCCCCTCTACATGCGGGAGCGGGAGAGGCATCCCGATTGCGACGATGTCAT
CTTCGTCAACGAGCGGGGAGAGGTGACCGAGGCGACCACCGCCAACGTGGTGGCCCGGATCGGCGGCACCCTCGTGACCC
CTCCCCTTCCCTGCGGGCTTCTTCCCGGCACCTTCCGGGAGGAAATCCTGGCCCTGGGCCAGGTGCGGGAGCGGGTCATC
ACCCGGGAGGAACTGGAAGGGGCCGAGGACATCTACCTCGTCAACTCGGTTCGGCAGTGGCGCTGGGCGCGGCTGACTTG
A

Upstream 100 bases:

>100_bases
TTCCCCTCTGCCACCTGGGAATCTCGGAGGGGTGCGACGGCACGGTGCAGCCCCTCTGCCGCCAATGCCCGGTGGTGGAG
CTCTGTGGGGCGGGTGCGCC

Downstream 100 bases:

>100_bases
AAAGGAAACGGAGGTAATCCATGCAGAAATTCGGTTTCATCGGCCTCGGCATCATGGGAAGCGCCATGGCTAAGAACCTT
GTGAAAGCGGGCTGTTCGGT

Product: Para-aminobenzoate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MSGTPTVTLLSLAPEHHPASFRFDGFVEEITARTPEEVIPALKRVEEAAAQGLHAAGFVSYEAAAGLGTGLATHSPGPLP
LVWFGVFENRLGIAPRLPSAAECGVACGTSGWETTLSPEAYQGAVERTKEYIAAGDTYQVNFTFSQRFAFTGNPAAYFGD
LCRAQNAPFCAHLDTGRFQILSASPELFFELRHGVLTCRPMKGTATRGRWRSEDEQIKARLAESEKERAENLMITDLLRN
DLGMVAKTGSVQVDGLFAVETLETVHQMTSTITARQREGVDLPELFRALFPCGSVTGAPKKRSMEIIRELEDSPRGVYTG
CIGHVSPGGEMTFSVAIRTVVVDTETGRGELGIGSGVTIGSQAEDEYQECLAKARFARERMPDFQLVETMLHEEDKGCFL
LDRHLARLFRSAAYFGFTVRLGTITMVLAHRTGSLEGKHKVRLLLNRRGAFTIETEPLPPTEGVETMITCFASEAVESAD
PFLYHKTTHRPLYMRERERHPDCDDVIFVNERGEVTEATTANVVARIGGTLVTPPLPCGLLPGTFREEILALGQVRERVI
TREELEGAEDIYLVNSVRQWRWARLT

Sequences:

>Translated_586_residues
MSGTPTVTLLSLAPEHHPASFRFDGFVEEITARTPEEVIPALKRVEEAAAQGLHAAGFVSYEAAAGLGTGLATHSPGPLP
LVWFGVFENRLGIAPRLPSAAECGVACGTSGWETTLSPEAYQGAVERTKEYIAAGDTYQVNFTFSQRFAFTGNPAAYFGD
LCRAQNAPFCAHLDTGRFQILSASPELFFELRHGVLTCRPMKGTATRGRWRSEDEQIKARLAESEKERAENLMITDLLRN
DLGMVAKTGSVQVDGLFAVETLETVHQMTSTITARQREGVDLPELFRALFPCGSVTGAPKKRSMEIIRELEDSPRGVYTG
CIGHVSPGGEMTFSVAIRTVVVDTETGRGELGIGSGVTIGSQAEDEYQECLAKARFARERMPDFQLVETMLHEEDKGCFL
LDRHLARLFRSAAYFGFTVRLGTITMVLAHRTGSLEGKHKVRLLLNRRGAFTIETEPLPPTEGVETMITCFASEAVESAD
PFLYHKTTHRPLYMRERERHPDCDDVIFVNERGEVTEATTANVVARIGGTLVTPPLPCGLLPGTFREEILALGQVRERVI
TREELEGAEDIYLVNSVRQWRWARLT
>Mature_585_residues
SGTPTVTLLSLAPEHHPASFRFDGFVEEITARTPEEVIPALKRVEEAAAQGLHAAGFVSYEAAAGLGTGLATHSPGPLPL
VWFGVFENRLGIAPRLPSAAECGVACGTSGWETTLSPEAYQGAVERTKEYIAAGDTYQVNFTFSQRFAFTGNPAAYFGDL
CRAQNAPFCAHLDTGRFQILSASPELFFELRHGVLTCRPMKGTATRGRWRSEDEQIKARLAESEKERAENLMITDLLRND
LGMVAKTGSVQVDGLFAVETLETVHQMTSTITARQREGVDLPELFRALFPCGSVTGAPKKRSMEIIRELEDSPRGVYTGC
IGHVSPGGEMTFSVAIRTVVVDTETGRGELGIGSGVTIGSQAEDEYQECLAKARFARERMPDFQLVETMLHEEDKGCFLL
DRHLARLFRSAAYFGFTVRLGTITMVLAHRTGSLEGKHKVRLLLNRRGAFTIETEPLPPTEGVETMITCFASEAVESADP
FLYHKTTHRPLYMRERERHPDCDDVIFVNERGEVTEATTANVVARIGGTLVTPPLPCGLLPGTFREEILALGQVRERVIT
REELEGAEDIYLVNSVRQWRWARLT

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=267, Percent_Identity=43.8202247191011, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1787518, Length=291, Percent_Identity=30.5841924398625, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320935, Length=267, Percent_Identity=34.8314606741573, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324361, Length=284, Percent_Identity=27.4647887323944, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 64546; Mature: 64415

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTPTVTLLSLAPEHHPASFRFDGFVEEITARTPEEVIPALKRVEEAAAQGLHAAGFVS
CCCCCCEEEEEECCCCCCCCEEECHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCEEE
YEAAAGLGTGLATHSPGPLPLVWFGVFENRLGIAPRLPSAAECGVACGTSGWETTLSPEA
HHHHCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHH
YQGAVERTKEYIAAGDTYQVNFTFSQRFAFTGNPAAYFGDLCRAQNAPFCAHLDTGRFQI
HHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCEEE
LSASPELFFELRHGVLTCRPMKGTATRGRWRSEDEQIKARLAESEKERAENLMITDLLRN
EECCHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLGMVAKTGSVQVDGLFAVETLETVHQMTSTITARQREGVDLPELFRALFPCGSVTGAPK
CHHHEEECCCEEECCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
KRSMEIIRELEDSPRGVYTGCIGHVSPGGEMTFSVAIRTVVVDTETGRGELGIGSGVTIG
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCC
SQAEDEYQECLAKARFARERMPDFQLVETMLHEEDKGCFLLDRHLARLFRSAAYFGFTVR
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHEEEEE
LGTITMVLAHRTGSLEGKHKVRLLLNRRGAFTIETEPLPPTEGVETMITCFASEAVESAD
HHHEEEEEEECCCCCCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
PFLYHKTTHRPLYMRERERHPDCDDVIFVNERGEVTEATTANVVARIGGTLVTPPLPCGL
CEEEECCCCCCHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCC
LPGTFREEILALGQVRERVITREELEGAEDIYLVNSVRQWRWARLT
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCC
>Mature Secondary Structure 
SGTPTVTLLSLAPEHHPASFRFDGFVEEITARTPEEVIPALKRVEEAAAQGLHAAGFVS
CCCCCEEEEEECCCCCCCCEEECHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCEEE
YEAAAGLGTGLATHSPGPLPLVWFGVFENRLGIAPRLPSAAECGVACGTSGWETTLSPEA
HHHHCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHH
YQGAVERTKEYIAAGDTYQVNFTFSQRFAFTGNPAAYFGDLCRAQNAPFCAHLDTGRFQI
HHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCEEE
LSASPELFFELRHGVLTCRPMKGTATRGRWRSEDEQIKARLAESEKERAENLMITDLLRN
EECCHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLGMVAKTGSVQVDGLFAVETLETVHQMTSTITARQREGVDLPELFRALFPCGSVTGAPK
CHHHEEECCCEEECCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
KRSMEIIRELEDSPRGVYTGCIGHVSPGGEMTFSVAIRTVVVDTETGRGELGIGSGVTIG
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCC
SQAEDEYQECLAKARFARERMPDFQLVETMLHEEDKGCFLLDRHLARLFRSAAYFGFTVR
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHEEEEE
LGTITMVLAHRTGSLEGKHKVRLLLNRRGAFTIETEPLPPTEGVETMITCFASEAVESAD
HHHEEEEEEECCCCCCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
PFLYHKTTHRPLYMRERERHPDCDDVIFVNERGEVTEATTANVVARIGGTLVTPPLPCGL
CEEEECCCCCCHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCC
LPGTFREEILALGQVRERVITREELEGAEDIYLVNSVRQWRWARLT
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]