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The map label for this gene is cysK [H]

Identifier: 78224181

GI number: 78224181

Start: 3374570

End: 3375493

Strand: Reverse

Name: cysK [H]

Synonym: Gmet_2988

Alternate gene names: 78224181

Gene position: 3375493-3374570 (Counterclockwise)

Preceding gene: 78224182

Following gene: 78224180

Centisome position: 84.44

GC content: 66.23

Gene sequence:

>924_bases
ATGCCGGTATTTGACAGCGACAAGGTAATCGAGCAGATCGGCAACACGCCGCTGCAGCGTCTGGCGAAGCTTGAGGCGCC
CGGTTCCGCGGCCGTGTATGGCAAGGCGGAGTTCTTTAACCCGGGTGGCAGCGTGAAGGACCGCATCTGCCTGGCGATGA
TCGAGGCGGCCGAGAAAGACGGTTCCCTCAAGCCGGGGATGACCGTGGTGGAGCCCACCAGCGGCAATACCGGGATCGGC
CTCTCCATGATCTGCGCCATCAAGGGATACAAGCTCGTTCTCACCATGCCCGACACCATGACCGTGGAGCGGCGCAGGCT
CCTGGCCGCCTACGGGGCCGAACTCGTCCTGACCCCCGGGGCCCAGGGGATGCGCGGGGCCGTCCAGAAGGCCGAGGAAC
TGGCCGCCCAGCCGGGGCACATCATGATGCAGCAGTTCAAGAACGGGGCGAACCCCGAGGCGCACCGCAGGACCACCGGC
CCCGAGATCGTCAGGGCCCTCAGCGGCCAGAGCATCGACGCCTTCGTGGCCGGGGTCGGAACCGGCGGCACCATCACCGG
CGTCGGCGAGGTGCTGAAGGAACACAACGCCGCTGTGCGAATCGTGGCGGTGGAGCCCGATGCCTCTCCCATTCTCTCCG
GCGGGCAGCCCGGTCCCCACAAGATTCAGGGGATCGGTGCCGGCTTCGTCCCCGACGTGCTCAACACGAAGGTCTACGAT
GAGGTGATCCGGGTGACCAACGAGGACGCCTACGAAACCGTTCGGCGCCTGGCCCAGGAAGAAGGGGTCCTCGTGGGGAT
ATCCTCCGGCGCCAACGTCTTTGCCGCCCTCCAGGTGGCGAAAAGGCTCGGCCCCGGCAAGAACGTGGTGACGATCCTCT
GCGATACCGGGGAGCGGTACCTTTCGACGGGCGTGTTCGACTAG

Upstream 100 bases:

>100_bases
CATCACGGTGAAGGATCTGTGCGATCGGGGCCAGTCCATGGGGATCAAGCGGGAGCAGGACCACCGTTTTATGTATTTCA
TCTGAGAAAAGGAGACGGAG

Downstream 100 bases:

>100_bases
CTGTCAGCGTCGAAACTGCACGGATAATGACCAGAGAAGCCCGTTCCCCGAACGGGCTTCTCGTTTAAGGGACCACCGAT
GAACGACATTCACGATAAAT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPVFDSDKVIEQIGNTPLQRLAKLEAPGSAAVYGKAEFFNPGGSVKDRICLAMIEAAEKDGSLKPGMTVVEPTSGNTGIG
LSMICAIKGYKLVLTMPDTMTVERRRLLAAYGAELVLTPGAQGMRGAVQKAEELAAQPGHIMMQQFKNGANPEAHRRTTG
PEIVRALSGQSIDAFVAGVGTGGTITGVGEVLKEHNAAVRIVAVEPDASPILSGGQPGPHKIQGIGAGFVPDVLNTKVYD
EVIRVTNEDAYETVRRLAQEEGVLVGISSGANVFAALQVAKRLGPGKNVVTILCDTGERYLSTGVFD

Sequences:

>Translated_307_residues
MPVFDSDKVIEQIGNTPLQRLAKLEAPGSAAVYGKAEFFNPGGSVKDRICLAMIEAAEKDGSLKPGMTVVEPTSGNTGIG
LSMICAIKGYKLVLTMPDTMTVERRRLLAAYGAELVLTPGAQGMRGAVQKAEELAAQPGHIMMQQFKNGANPEAHRRTTG
PEIVRALSGQSIDAFVAGVGTGGTITGVGEVLKEHNAAVRIVAVEPDASPILSGGQPGPHKIQGIGAGFVPDVLNTKVYD
EVIRVTNEDAYETVRRLAQEEGVLVGISSGANVFAALQVAKRLGPGKNVVTILCDTGERYLSTGVFD
>Mature_306_residues
PVFDSDKVIEQIGNTPLQRLAKLEAPGSAAVYGKAEFFNPGGSVKDRICLAMIEAAEKDGSLKPGMTVVEPTSGNTGIGL
SMICAIKGYKLVLTMPDTMTVERRRLLAAYGAELVLTPGAQGMRGAVQKAEELAAQPGHIMMQQFKNGANPEAHRRTTGP
EIVRALSGQSIDAFVAGVGTGGTITGVGEVLKEHNAAVRIVAVEPDASPILSGGQPGPHKIQGIGAGFVPDVLNTKVYDE
VIRVTNEDAYETVRRLAQEEGVLVGISSGANVFAALQVAKRLGPGKNVVTILCDTGERYLSTGVFD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=40, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=40, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=40, Blast_Score=223, Evalue=1e-58,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=52.6984126984127, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=45.945945945946, Blast_Score=244, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=51.1705685618729, Blast_Score=286, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=55.8528428093645, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=48.8294314381271, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=49.6598639455782, Blast_Score=263, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=47.1571906354515, Blast_Score=227, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=48.8262910798122, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=38.125, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=37.1428571428571, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=45.6896551724138, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=327, Percent_Identity=26.9113149847095, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=40.3125, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=36.697247706422, Blast_Score=155, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=39.6774193548387, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=39.6774193548387, Blast_Score=201, Evalue=4e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32180; Mature: 32049

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFDSDKVIEQIGNTPLQRLAKLEAPGSAAVYGKAEFFNPGGSVKDRICLAMIEAAEKD
CCCCCHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHCC
GSLKPGMTVVEPTSGNTGIGLSMICAIKGYKLVLTMPDTMTVERRRLLAAYGAELVLTPG
CCCCCCCEEEECCCCCCCCCHHHHEEECCCEEEEECCCCHHHHHHHHHHHHCCCEEECCC
AQGMRGAVQKAEELAAQPGHIMMQQFKNGANPEAHRRTTGPEIVRALSGQSIDAFVAGVG
CCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHCCCCCHHHHHHHCCCCCEEEEEECC
TGGTITGVGEVLKEHNAAVRIVAVEPDASPILSGGQPGPHKIQGIGAGFVPDVLNTKVYD
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHH
EVIRVTNEDAYETVRRLAQEEGVLVGISSGANVFAALQVAKRLGPGKNVVTILCDTGERY
HHHHHCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHH
LSTGVFD
HHCCCCC
>Mature Secondary Structure 
PVFDSDKVIEQIGNTPLQRLAKLEAPGSAAVYGKAEFFNPGGSVKDRICLAMIEAAEKD
CCCCHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHCC
GSLKPGMTVVEPTSGNTGIGLSMICAIKGYKLVLTMPDTMTVERRRLLAAYGAELVLTPG
CCCCCCCEEEECCCCCCCCCHHHHEEECCCEEEEECCCCHHHHHHHHHHHHCCCEEECCC
AQGMRGAVQKAEELAAQPGHIMMQQFKNGANPEAHRRTTGPEIVRALSGQSIDAFVAGVG
CCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHCCCCCHHHHHHHCCCCCEEEEEECC
TGGTITGVGEVLKEHNAAVRIVAVEPDASPILSGGQPGPHKIQGIGAGFVPDVLNTKVYD
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHH
EVIRVTNEDAYETVRRLAQEEGVLVGISSGANVFAALQVAKRLGPGKNVVTILCDTGERY
HHHHHCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHH
LSTGVFD
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA