Click here to switch to the map view.

The map label for this gene is zraR [H]

Identifier: 78224120

GI number: 78224120

Start: 3312141

End: 3313553

Strand: Reverse

Name: zraR [H]

Synonym: Gmet_2924

Alternate gene names: 78224120

Gene position: 3313553-3312141 (Counterclockwise)

Preceding gene: 78224135

Following gene: 78224118

Centisome position: 82.89

GC content: 57.96

Gene sequence:

>1413_bases
ATGGAAAACATTGATGTTCTTGTGGTGGACGATGAAGCGGTTATTCGCGAGGGACTGCGGCGCATCCTGGAGAAGGAGGG
ATTCCATGTGGAGACCTCGGCCAGCGGGCAGATTGCCCTCGAACGGATGCAGGAGGAAAACTTCAGTCTTGTGATTACCG
ACCTGAAGATGCCCGGCATGAGCGGCATGGAGGTTCTCAAGGCAATCAAGGTTCTGCAGCCGGAAGTTCCGGTTATCATC
ATTACCGGCTTCTCAACCGTCGACACCGCTGTGGAGGCCATGAAGAACGGTGCCTTCGACTACATCGCCAAACCCTTTAC
CCCCGAGCAGATTACGGAGAAAGTGAGGAAAGCTCTCGATCAGCGTGCAGTCCTGATTGAGAACATCTTTCTGAAGAAGG
AGCTGGGAGAGCACCACGGCTTCGATCTCTTCGTGGGGGAGAGCAAGGAAATCCAGAAGGTCTACCGGCGCATCATCCAG
GTTGCCCCCACCGACAGCACCGTTCTCATCACCGGCGAGAGCGGTACCGGGAAGGAGCTGGTTGCCCGGGCCATCCACAA
CCACAGCAACCGCCGCGAAAATCCCTTTGTTGCCGTCGACTGTACGTCCCTGGCCGAGAACCTCCTGGAAAGCGAATTGT
TCGGCCACGTGAAAGGATCGTTCACCGGTGCGATCCAGACGAAAACCGGACTCTTCAAGGTGGCTGACGGCGGCACCCTC
TTCTTGGACGAGATATCCAACATAAGCCTCACCACCCAGGCGAAGCTCCTGCGGGTTCTTCAGGAGCGGGAGATCACCCC
CATCGGCGGCACCCAGCCGGTCCCCATCGACATCCGCCTCGTGGCTGCCACCAACAAGAACCTCCGGACCCTGGTCCCCC
AGGGGACCTTCCGGGAAGACCTCTTCTTCCGCCTGAACATTATTCCCATAGACCTTCCTCCCCTGCGTGAGCGCAAGGGG
GATCTGCCGCTCCTCATCGCCTTCTTCCTCAAGAAGTTTTCCGAGGAGATGGGGCGGGAAATCCGGGGACTGGCGCCTGA
CGCCATGGCACTCCTGGAGGATTACACGTTTCCCGGCAACGTACGGGAGTTGGAGAACATCATCGAGCGGGCCGTGGTCC
TTGCCGAGGAGGATTTGATCCAGAAGGAAGATCTGGAACTGCGTCTCTCCGGAAGCGAGGGGACCGGAGTTGCGGCCTAT
GTCCCCCAGAACGTCGAGGAGTTGAAGGAGACCAAGCGGCAGATTCGGGAGCGAGCCGTGGAACCCATCGAAAAGGCCTT
TGTCCTCCAGGCCCTCAAACGCAACAACTGGAACATTACCCGGGCTGCTGAGGAAACGGGTATGCTTCGGCCCAACTTCC
AGGCGTTGCTTAAAAAACTGCGGATCTCAGTGCGAAGTCAGATGAACAATTGA

Upstream 100 bases:

>100_bases
GTTGATGTAATTTAGAAACTACTAATCGTCTGTTGCTTTGTCGCCGGTCTGTTATGAATGAGTAACCCACCCGTATGGGG
GATGAAAAGGGAAGGTGGCG

Downstream 100 bases:

>100_bases
CGCGAAGCCGCTGCTGCGGGGCGATTGAAACGAAAAAGGGGGCCACAATCCGTGGACCCCTTTTCTTATGCCGATGAAAG
CGGATGGAGAGTCAGGAGGA

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MENIDVLVVDDEAVIREGLRRILEKEGFHVETSASGQIALERMQEENFSLVITDLKMPGMSGMEVLKAIKVLQPEVPVII
ITGFSTVDTAVEAMKNGAFDYIAKPFTPEQITEKVRKALDQRAVLIENIFLKKELGEHHGFDLFVGESKEIQKVYRRIIQ
VAPTDSTVLITGESGTGKELVARAIHNHSNRRENPFVAVDCTSLAENLLESELFGHVKGSFTGAIQTKTGLFKVADGGTL
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPVPIDIRLVAATNKNLRTLVPQGTFREDLFFRLNIIPIDLPPLRERKG
DLPLLIAFFLKKFSEEMGREIRGLAPDAMALLEDYTFPGNVRELENIIERAVVLAEEDLIQKEDLELRLSGSEGTGVAAY
VPQNVEELKETKRQIRERAVEPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRSQMNN

Sequences:

>Translated_470_residues
MENIDVLVVDDEAVIREGLRRILEKEGFHVETSASGQIALERMQEENFSLVITDLKMPGMSGMEVLKAIKVLQPEVPVII
ITGFSTVDTAVEAMKNGAFDYIAKPFTPEQITEKVRKALDQRAVLIENIFLKKELGEHHGFDLFVGESKEIQKVYRRIIQ
VAPTDSTVLITGESGTGKELVARAIHNHSNRRENPFVAVDCTSLAENLLESELFGHVKGSFTGAIQTKTGLFKVADGGTL
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPVPIDIRLVAATNKNLRTLVPQGTFREDLFFRLNIIPIDLPPLRERKG
DLPLLIAFFLKKFSEEMGREIRGLAPDAMALLEDYTFPGNVRELENIIERAVVLAEEDLIQKEDLELRLSGSEGTGVAAY
VPQNVEELKETKRQIRERAVEPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRSQMNN
>Mature_470_residues
MENIDVLVVDDEAVIREGLRRILEKEGFHVETSASGQIALERMQEENFSLVITDLKMPGMSGMEVLKAIKVLQPEVPVII
ITGFSTVDTAVEAMKNGAFDYIAKPFTPEQITEKVRKALDQRAVLIENIFLKKELGEHHGFDLFVGESKEIQKVYRRIIQ
VAPTDSTVLITGESGTGKELVARAIHNHSNRRENPFVAVDCTSLAENLLESELFGHVKGSFTGAIQTKTGLFKVADGGTL
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPVPIDIRLVAATNKNLRTLVPQGTFREDLFFRLNIIPIDLPPLRERKG
DLPLLIAFFLKKFSEEMGREIRGLAPDAMALLEDYTFPGNVRELENIIERAVVLAEEDLIQKEDLELRLSGSEGTGVAAY
VPQNVEELKETKRQIRERAVEPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRSQMNN

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=458, Percent_Identity=43.2314410480349, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=41.7943107221007, Blast_Score=351, Evalue=5e-98,
Organism=Escherichia coli, GI1790299, Length=380, Percent_Identity=43.9473684210526, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1788905, Length=454, Percent_Identity=37.2246696035242, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI87082117, Length=362, Percent_Identity=41.4364640883978, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789233, Length=310, Percent_Identity=45.1612903225806, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1789087, Length=326, Percent_Identity=40.7975460122699, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87082152, Length=318, Percent_Identity=43.7106918238994, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87081872, Length=336, Percent_Identity=39.2857142857143, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1786524, Length=392, Percent_Identity=39.2857142857143, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1787583, Length=249, Percent_Identity=40.5622489959839, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1789828, Length=289, Percent_Identity=32.5259515570934, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI87081858, Length=234, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=31.1475409836066, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=34.7457627118644, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790860, Length=119, Percent_Identity=32.7731092436975, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082012, Length=120, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786599, Length=116, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790552, Length=116, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790863, Length=121, Percent_Identity=31.404958677686, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789402, Length=102, Percent_Identity=32.3529411764706, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788222, Length=136, Percent_Identity=28.6764705882353, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786784, Length=126, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52690; Mature: 52690

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIDVLVVDDEAVIREGLRRILEKEGFHVETSASGQIALERMQEENFSLVITDLKMPGM
CCCCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEEECCCCCC
SGMEVLKAIKVLQPEVPVIIITGFSTVDTAVEAMKNGAFDYIAKPFTPEQITEKVRKALD
CHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
QRAVLIENIFLKKELGEHHGFDLFVGESKEIQKVYRRIIQVAPTDSTVLITGESGTGKEL
HHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
VARAIHNHSNRRENPFVAVDCTSLAENLLESELFGHVKGSFTGAIQTKTGLFKVADGGTL
HHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCEE
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPVPIDIRLVAATNKNLRTLVPQGTFRED
EEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCC
LFFRLNIIPIDLPPLRERKGDLPLLIAFFLKKFSEEMGREIRGLAPDAMALLEDYTFPGN
EEEEEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
VRELENIIERAVVLAEEDLIQKEDLELRLSGSEGTGVAAYVPQNVEELKETKRQIRERAV
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHH
EPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRSQMNN
HHHHHHHHHHHHHCCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENIDVLVVDDEAVIREGLRRILEKEGFHVETSASGQIALERMQEENFSLVITDLKMPGM
CCCCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEEECCCCCC
SGMEVLKAIKVLQPEVPVIIITGFSTVDTAVEAMKNGAFDYIAKPFTPEQITEKVRKALD
CHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
QRAVLIENIFLKKELGEHHGFDLFVGESKEIQKVYRRIIQVAPTDSTVLITGESGTGKEL
HHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
VARAIHNHSNRRENPFVAVDCTSLAENLLESELFGHVKGSFTGAIQTKTGLFKVADGGTL
HHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCEE
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPVPIDIRLVAATNKNLRTLVPQGTFRED
EEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCC
LFFRLNIIPIDLPPLRERKGDLPLLIAFFLKKFSEEMGREIRGLAPDAMALLEDYTFPGN
EEEEEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
VRELENIIERAVVLAEEDLIQKEDLELRLSGSEGTGVAAYVPQNVEELKETKRQIRERAV
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHH
EPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRSQMNN
HHHHHHHHHHHHHCCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]