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The map label for this gene is sdcS [H]

Identifier: 78224053

GI number: 78224053

Start: 3235828

End: 3237276

Strand: Direct

Name: sdcS [H]

Synonym: Gmet_2857

Alternate gene names: 78224053

Gene position: 3235828-3237276 (Clockwise)

Preceding gene: 78224052

Following gene: 78224054

Centisome position: 80.95

GC content: 61.49

Gene sequence:

>1449_bases
ATGGAACGGGAACTCTTCGACAAACCGCTGAAGATCGACACCAGACCTCTCTGGCTGATCCTCATCGACCGCTCAGCACG
CTACCAGGTCTTCGCCGGGCTGATCATCGCCTGCGCTATTCTTTTCAGGCTCACACCTCCGGAGGGGCTTTCAGCGGCAG
GGTACCATGCCCTCATCGTCTTCGGAGCAACCATCTTCCTCTGGATATCGGGACTGCTCCCCATCGCCGTGACGGCGCTC
TTTTCCATGGCCTTGCTGCCGCTCCTCGGCATCATGGAAGCGAAGAAGACCTATGCCCTCTTTGGCAACGAGGCTGTCTT
CTTCATCATCGGCGCCTTTATCCTGGCGGCGGCCATGACCGGCACGGGGCTATCGGCCCGACTCGCCCGCGCCATGCTGG
CCCGGTTCGGCAAGACGCCTCGCAGCCTCGCCCTGACGGTATTCCTCCTTTCGGCGATTCTCTCGTTTTGCATGAGCGAG
CACGCCGTGGCGGCCATGATGTTCCCTGTGGTAGAGGAGATCGGTACGAGCCTCGGCCTTGAGCGCGGCAGAAGCCGCTA
CGCCAAGCTCCTTTTCATGTCCATGGCGTGGGGATGCATCATCGGAGGGATCGCCACCTTCCTCGGCGGGGCGCGTGCGC
CGCTGGCAGTGGGGATGCTCCGGGAGACGAGCGGCCTCGACTACACTTTCTTCGAGTGGACCGTTGCCGCCATCATGATC
GTCGCACCGCTGCTTGTCATCGGCTTTCTCCTGCTCCTCCTCTTCTTTCCCCCCGACATTGCGGGAGTCGACGAGGGGCT
TCGCTTCCTGAACCGCAAACGACTCGAAACGGGAAAGATGGGATACGGCGAGATGACCGTTGCCGCAGTGATGGTCGTAA
CCATCGCCTGCTGGATGGCCTTGGGCAAAGAGCTGGGCCTGGCAAACATCGCAATCCTGGCCATGGTCGCCCTCTTTGTC
TTCCGGGTGGTCTCCTGGCAGACAATCGAAGAGTACGTCAACTGGGGAATCATCCTCATGTACGGCGGTTCCATCGCACT
GGCCACCGCCCTTGAAAAGACCGGCGCCGCCCTCTGGATTGTCGAGCGGGGGCTCGGGGCCTTCTCACCGTCGCCGCTCA
TGGTGATTGCCGTCATCTCGCTGGTGTCGATCCTGCTGACCGAGTGCATCAGCCACGCTGCCGTGGTCGCCATCCTCATG
CCGATCGGCATGTCCCTGGCAAAAAGCCTCGGCATGGATCTCAAGGTGATGACGCTCGCCATTGCGCTTCCTGCAGGTCT
CGCCTACTGCCTCCCCATGGGGACGCCGGCCACGGCCATCGCCTACGCCTCGGGATACCTGCGAAGCAAGGACATCATCA
TCCCGGGTGCCTTGGTGATGGCCATTTCCTGGCTCCTCTTCATGGCTGCGGCAATCTTCATCTGGCCCCTGATTGGCCTG
AACATCTGA

Upstream 100 bases:

>100_bases
ACCGGCTCCGGGACCGGCGGCTCTTGGCTGTCTCTGACCTGCGCCGGGCTCTGCGGGTGCGGCAGGTGGAAGAGTCATTC
GAATCGGCGGGGCTCTGATT

Downstream 100 bases:

>100_bases
ACACCCTTTGCCCGGAGCGCTCACGCACTACGGACACGACCCAAAGGATCCAACATGACTGCAACCATTCAGAAAACAAT
CCCCCAACTTCCCCAGGACG

Product: Sodium/sulphate symporter

Products: NA

Alternate protein names: Na(+)/dicarboxylate symporter [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MERELFDKPLKIDTRPLWLILIDRSARYQVFAGLIIACAILFRLTPPEGLSAAGYHALIVFGATIFLWISGLLPIAVTAL
FSMALLPLLGIMEAKKTYALFGNEAVFFIIGAFILAAAMTGTGLSARLARAMLARFGKTPRSLALTVFLLSAILSFCMSE
HAVAAMMFPVVEEIGTSLGLERGRSRYAKLLFMSMAWGCIIGGIATFLGGARAPLAVGMLRETSGLDYTFFEWTVAAIMI
VAPLLVIGFLLLLLFFPPDIAGVDEGLRFLNRKRLETGKMGYGEMTVAAVMVVTIACWMALGKELGLANIAILAMVALFV
FRVVSWQTIEEYVNWGIILMYGGSIALATALEKTGAALWIVERGLGAFSPSPLMVIAVISLVSILLTECISHAAVVAILM
PIGMSLAKSLGMDLKVMTLAIALPAGLAYCLPMGTPATAIAYASGYLRSKDIIIPGALVMAISWLLFMAAAIFIWPLIGL
NI

Sequences:

>Translated_482_residues
MERELFDKPLKIDTRPLWLILIDRSARYQVFAGLIIACAILFRLTPPEGLSAAGYHALIVFGATIFLWISGLLPIAVTAL
FSMALLPLLGIMEAKKTYALFGNEAVFFIIGAFILAAAMTGTGLSARLARAMLARFGKTPRSLALTVFLLSAILSFCMSE
HAVAAMMFPVVEEIGTSLGLERGRSRYAKLLFMSMAWGCIIGGIATFLGGARAPLAVGMLRETSGLDYTFFEWTVAAIMI
VAPLLVIGFLLLLLFFPPDIAGVDEGLRFLNRKRLETGKMGYGEMTVAAVMVVTIACWMALGKELGLANIAILAMVALFV
FRVVSWQTIEEYVNWGIILMYGGSIALATALEKTGAALWIVERGLGAFSPSPLMVIAVISLVSILLTECISHAAVVAILM
PIGMSLAKSLGMDLKVMTLAIALPAGLAYCLPMGTPATAIAYASGYLRSKDIIIPGALVMAISWLLFMAAAIFIWPLIGL
NI
>Mature_482_residues
MERELFDKPLKIDTRPLWLILIDRSARYQVFAGLIIACAILFRLTPPEGLSAAGYHALIVFGATIFLWISGLLPIAVTAL
FSMALLPLLGIMEAKKTYALFGNEAVFFIIGAFILAAAMTGTGLSARLARAMLARFGKTPRSLALTVFLLSAILSFCMSE
HAVAAMMFPVVEEIGTSLGLERGRSRYAKLLFMSMAWGCIIGGIATFLGGARAPLAVGMLRETSGLDYTFFEWTVAAIMI
VAPLLVIGFLLLLLFFPPDIAGVDEGLRFLNRKRLETGKMGYGEMTVAAVMVVTIACWMALGKELGLANIAILAMVALFV
FRVVSWQTIEEYVNWGIILMYGGSIALATALEKTGAALWIVERGLGAFSPSPLMVIAVISLVSILLTECISHAAVVAILM
PIGMSLAKSLGMDLKVMTLAIALPAGLAYCLPMGTPATAIAYASGYLRSKDIIIPGALVMAISWLLFMAAAIFIWPLIGL
NI

Specific function: Mediates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane via a Na(+)- electrochemical gradient [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI225637552, Length=162, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4506979, Length=162, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI225637549, Length=162, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI31377715, Length=157, Percent_Identity=31.2101910828025, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI301069353, Length=157, Percent_Identity=31.2101910828025, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI301069346, Length=157, Percent_Identity=31.2101910828025, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI58761541, Length=157, Percent_Identity=31.2101910828025, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI301069349, Length=157, Percent_Identity=31.2101910828025, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI31795546, Length=148, Percent_Identity=27.027027027027, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786986, Length=395, Percent_Identity=24.0506329113924, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786829, Length=492, Percent_Identity=21.3414634146341, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789444, Length=369, Percent_Identity=23.0352303523035, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71988385, Length=442, Percent_Identity=24.8868778280543, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565804, Length=441, Percent_Identity=24.7165532879819, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71989118, Length=524, Percent_Identity=24.0458015267176, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17551790, Length=503, Percent_Identity=20.4771371769384, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281362116, Length=464, Percent_Identity=23.0603448275862, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362114, Length=464, Percent_Identity=22.8448275862069, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281362112, Length=464, Percent_Identity=22.8448275862069, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281366409, Length=474, Percent_Identity=23.2067510548523, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17737623, Length=474, Percent_Identity=23.2067510548523, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666468, Length=474, Percent_Identity=23.2067510548523, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45551633, Length=474, Percent_Identity=23.2067510548523, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 51723; Mature: 51723

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERELFDKPLKIDTRPLWLILIDRSARYQVFAGLIIACAILFRLTPPEGLSAAGYHALIV
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FGATIFLWISGLLPIAVTALFSMALLPLLGIMEAKKTYALFGNEAVFFIIGAFILAAAMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GTGLSARLARAMLARFGKTPRSLALTVFLLSAILSFCMSEHAVAAMMFPVVEEIGTSLGL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
ERGRSRYAKLLFMSMAWGCIIGGIATFLGGARAPLAVGMLRETSGLDYTFFEWTVAAIMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VAPLLVIGFLLLLLFFPPDIAGVDEGLRFLNRKRLETGKMGYGEMTVAAVMVVTIACWMA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LGKELGLANIAILAMVALFVFRVVSWQTIEEYVNWGIILMYGGSIALATALEKTGAALWI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCEEEE
VERGLGAFSPSPLMVIAVISLVSILLTECISHAAVVAILMPIGMSLAKSLGMDLKVMTLA
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
IALPAGLAYCLPMGTPATAIAYASGYLRSKDIIIPGALVMAISWLLFMAAAIFIWPLIGL
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHC
NI
CC
>Mature Secondary Structure
MERELFDKPLKIDTRPLWLILIDRSARYQVFAGLIIACAILFRLTPPEGLSAAGYHALIV
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FGATIFLWISGLLPIAVTALFSMALLPLLGIMEAKKTYALFGNEAVFFIIGAFILAAAMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GTGLSARLARAMLARFGKTPRSLALTVFLLSAILSFCMSEHAVAAMMFPVVEEIGTSLGL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
ERGRSRYAKLLFMSMAWGCIIGGIATFLGGARAPLAVGMLRETSGLDYTFFEWTVAAIMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VAPLLVIGFLLLLLFFPPDIAGVDEGLRFLNRKRLETGKMGYGEMTVAAVMVVTIACWMA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LGKELGLANIAILAMVALFVFRVVSWQTIEEYVNWGIILMYGGSIALATALEKTGAALWI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCEEEE
VERGLGAFSPSPLMVIAVISLVSILLTECISHAAVVAILMPIGMSLAKSLGMDLKVMTLA
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
IALPAGLAYCLPMGTPATAIAYASGYLRSKDIIIPGALVMAISWLLFMAAAIFIWPLIGL
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHC
NI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA