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The map label for this gene is phoR [H]

Identifier: 78223890

GI number: 78223890

Start: 3041232

End: 3043001

Strand: Direct

Name: phoR [H]

Synonym: Gmet_2694

Alternate gene names: 78223890

Gene position: 3041232-3043001 (Clockwise)

Preceding gene: 78223889

Following gene: 78223896

Centisome position: 76.08

GC content: 63.11

Gene sequence:

>1770_bases
GTGAGATTCACCATCCAGTGGAAGCTCATGGCTTCCTACCTCCTTCTCGTGCTCTTCATCGGCGGGGTCTTCTTCGCCTA
CCTGAACCACACCCTGAACCAGCACCTGACGGCGGAGATCCGGCAAAACCTCGCCACTGAGGCCCGGCTGACCCGGATGA
TCGCCCACCGCGACATCGGCAGAATGAAGGACGATGCCCCGGCAGTGGCTGCCGCAATCTCGCGGGAGACGAGGGCGCGG
GTGACCATCATCCTCGCCGGCGGCGAGGTGGTCGGGGATTCGGAGATTGCTCCCGGCCAGTTGAAGGAACTTGAGAACCA
CCTGAATCGACCGGAGGTCCAGCAGGCGCTGAAGAGCGGCAGTGGGGAATCAATCCGCTACTCGGCGACGATCAAGACCC
CCATGCTCTACGTGGCGGTTCCGCTGCAGACCGCCGGCGGCGAAGAGGGATTTGTCCGGCTCTCCCTTCCCCTCACCGCC
CTGGAAAAGGCAGAGGGGAGCATCAGAACACTCCTGGGGGCATCCCTGGCGGTCTCACTCCTCGTTGCCCTCGTTCTGAG
CTACATCCTCTCCCGGGTGACGTCCCGGTCACTGCGCACCATCACGGCGCTGGCGAAACAGATCGGCAAGGGAAACTTCA
ACAGGAGGATCCCGGTCCCGACCCGCGACGAGGTGGGGGAGCTGGCCCGGGTGATGAACGACATGGCGGCCCGGATAGAG
CAGCAGCTGGAGCGAACCTCGGCAGAGAAAAACCGGCTCGACACCATCCTGCGGGGGATGGGGGAAGGGCTTATGGTAAC
GGATGCCAACGGTCTGATCACCCTGGTCAATCCAGCCTTTCTCGGCCTCTTCTCCCTGAATGAAAGCGTGGAAGGAAGAC
ACATCATCGAGATCGCGCGGCATCCGGTCCTCAACGATGCCTTCAAGGCCATCGTCGCCTCCGGGGACGAACGGGTCGAG
AAGATGACTCTCACCATGGGGGAGGAGAAGCATGTCCTGACCCACTGGGTGCCCCTTGTGGACAACGGGGAGTTGCAGGG
GGTCGTGGCGGTCTTCCATGACATCACCGATCTGACGCGGCTGGAAAACATCCGGCGGGATTTCGTGGCCAACGTCTCCC
ATGAGCTGAGAACGCCGGTTACCGTCATCAAGGGGTATGCCGAGGCGCTCATCGACGGCGCCATGGAAACCGATCCCGAG
CGGGCGCGAAAGTTTGTCGGGATCATCCTCAGCCACTCGGAGCGGCTCGCCGCCCTGATCGGCGACCTCCTCACCCTCTC
CCAGCTGGAGGCGGGGAGCATGAACCTTGAGAAGACGACGGTCAGACCGGAGCAGGTGGCAAAGCGTGCCATGGAGCTTT
TACAGCCGAAGGCTGCCCGGAAGGGGATTACCATCGACTGCTCGGGGTTGAGCGGGGCGCAGTCGGTGCTGGCCGATCCG
GGCCGGCTCGAACAGGTGCTGGTCAACCTCCTCGACAACGCCATCAAATATACCCCGGAGGGGGGGGCAATCTCGTTTTC
CGCCGCAGTCAAGGAGAATATGGTCCGCATCGGCGTAAAGGATACCGGCGTCGGCATCCCTCCCAAGGACCTCCCCCGGA
TCTTCGAGCGGTTCTACCGGGTGGACACGGCCCGCAGCCGCGATGAAGGGGGGACCGGCCTCGGGCTCTCCATCGTGAAG
CACATCGTCCAGCTCCATGGCGGCGCCGTGGGGGTGGAGAGCGAGCCCGGCAAGGGATCGGAATTCTGGTTTACCATCAA
GAAGGCCTGA

Upstream 100 bases:

>100_bases
GCACGGTTGACACGCACATCACTCGTCTGCGCACGAAGCTGGGCCCGGCCGGCGACCTGATCAAGACAGTTCGCGGTTTC
GGCTACAAGATGGAGGAGCC

Downstream 100 bases:

>100_bases
TGCCGAGGCGGGGCTGGTCCGCTGCCGTCACCGTCCCCCGGCCAGCCACGGGCCATTCACCACATTGATCGGCGAACCGG
CCAGAAACGCAGCCACATTG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MRFTIQWKLMASYLLLVLFIGGVFFAYLNHTLNQHLTAEIRQNLATEARLTRMIAHRDIGRMKDDAPAVAAAISRETRAR
VTIILAGGEVVGDSEIAPGQLKELENHLNRPEVQQALKSGSGESIRYSATIKTPMLYVAVPLQTAGGEEGFVRLSLPLTA
LEKAEGSIRTLLGASLAVSLLVALVLSYILSRVTSRSLRTITALAKQIGKGNFNRRIPVPTRDEVGELARVMNDMAARIE
QQLERTSAEKNRLDTILRGMGEGLMVTDANGLITLVNPAFLGLFSLNESVEGRHIIEIARHPVLNDAFKAIVASGDERVE
KMTLTMGEEKHVLTHWVPLVDNGELQGVVAVFHDITDLTRLENIRRDFVANVSHELRTPVTVIKGYAEALIDGAMETDPE
RARKFVGIILSHSERLAALIGDLLTLSQLEAGSMNLEKTTVRPEQVAKRAMELLQPKAARKGITIDCSGLSGAQSVLADP
GRLEQVLVNLLDNAIKYTPEGGAISFSAAVKENMVRIGVKDTGVGIPPKDLPRIFERFYRVDTARSRDEGGTGLGLSIVK
HIVQLHGGAVGVESEPGKGSEFWFTIKKA

Sequences:

>Translated_589_residues
MRFTIQWKLMASYLLLVLFIGGVFFAYLNHTLNQHLTAEIRQNLATEARLTRMIAHRDIGRMKDDAPAVAAAISRETRAR
VTIILAGGEVVGDSEIAPGQLKELENHLNRPEVQQALKSGSGESIRYSATIKTPMLYVAVPLQTAGGEEGFVRLSLPLTA
LEKAEGSIRTLLGASLAVSLLVALVLSYILSRVTSRSLRTITALAKQIGKGNFNRRIPVPTRDEVGELARVMNDMAARIE
QQLERTSAEKNRLDTILRGMGEGLMVTDANGLITLVNPAFLGLFSLNESVEGRHIIEIARHPVLNDAFKAIVASGDERVE
KMTLTMGEEKHVLTHWVPLVDNGELQGVVAVFHDITDLTRLENIRRDFVANVSHELRTPVTVIKGYAEALIDGAMETDPE
RARKFVGIILSHSERLAALIGDLLTLSQLEAGSMNLEKTTVRPEQVAKRAMELLQPKAARKGITIDCSGLSGAQSVLADP
GRLEQVLVNLLDNAIKYTPEGGAISFSAAVKENMVRIGVKDTGVGIPPKDLPRIFERFYRVDTARSRDEGGTGLGLSIVK
HIVQLHGGAVGVESEPGKGSEFWFTIKKA
>Mature_589_residues
MRFTIQWKLMASYLLLVLFIGGVFFAYLNHTLNQHLTAEIRQNLATEARLTRMIAHRDIGRMKDDAPAVAAAISRETRAR
VTIILAGGEVVGDSEIAPGQLKELENHLNRPEVQQALKSGSGESIRYSATIKTPMLYVAVPLQTAGGEEGFVRLSLPLTA
LEKAEGSIRTLLGASLAVSLLVALVLSYILSRVTSRSLRTITALAKQIGKGNFNRRIPVPTRDEVGELARVMNDMAARIE
QQLERTSAEKNRLDTILRGMGEGLMVTDANGLITLVNPAFLGLFSLNESVEGRHIIEIARHPVLNDAFKAIVASGDERVE
KMTLTMGEEKHVLTHWVPLVDNGELQGVVAVFHDITDLTRLENIRRDFVANVSHELRTPVTVIKGYAEALIDGAMETDPE
RARKFVGIILSHSERLAALIGDLLTLSQLEAGSMNLEKTTVRPEQVAKRAMELLQPKAARKGITIDCSGLSGAQSVLADP
GRLEQVLVNLLDNAIKYTPEGGAISFSAAVKENMVRIGVKDTGVGIPPKDLPRIFERFYRVDTARSRDEGGTGLGLSIVK
HIVQLHGGAVGVESEPGKGSEFWFTIKKA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=376, Percent_Identity=31.9148936170213, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=36.9565217391304, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788393, Length=222, Percent_Identity=34.6846846846847, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI145693157, Length=216, Percent_Identity=36.1111111111111, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786783, Length=249, Percent_Identity=30.9236947791165, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790861, Length=236, Percent_Identity=36.4406779661017, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI48994928, Length=260, Percent_Identity=31.1538461538462, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788713, Length=352, Percent_Identity=26.1363636363636, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=33.7719298245614, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=31.3559322033898, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI87081816, Length=225, Percent_Identity=32.4444444444444, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=31.6742081447964, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=30.5309734513274, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=399, Percent_Identity=25.5639097744361, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=28.5067873303167, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=206, Percent_Identity=32.5242718446602, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788279, Length=216, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790300, Length=239, Percent_Identity=30.9623430962343, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=260, Percent_Identity=27.3076923076923, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790567, Length=347, Percent_Identity=24.7838616714697, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=236, Percent_Identity=29.2372881355932, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1787374, Length=207, Percent_Identity=28.0193236714976, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64240; Mature: 64240

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFTIQWKLMASYLLLVLFIGGVFFAYLNHTLNQHLTAEIRQNLATEARLTRMIAHRDIG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMKDDAPAVAAAISRETRARVTIILAGGEVVGDSEIAPGQLKELENHLNRPEVQQALKSG
CCCCCCHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCC
SGESIRYSATIKTPMLYVAVPLQTAGGEEGFVRLSLPLTALEKAEGSIRTLLGASLAVSL
CCCCEEEEEEECCCEEEEEEEEECCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHH
LVALVLSYILSRVTSRSLRTITALAKQIGKGNFNRRIPVPTRDEVGELARVMNDMAARIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QQLERTSAEKNRLDTILRGMGEGLMVTDANGLITLVNPAFLGLFSLNESVEGRHIIEIAR
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHH
HPVLNDAFKAIVASGDERVEKMTLTMGEEKHVLTHWVPLVDNGELQGVVAVFHDITDLTR
CCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHH
LENIRRDFVANVSHELRTPVTVIKGYAEALIDGAMETDPERARKFVGIILSHSERLAALI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHH
GDLLTLSQLEAGSMNLEKTTVRPEQVAKRAMELLQPKAARKGITIDCSGLSGAQSVLADP
HHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHCCHHHHCCCEEEECCCCCHHHHHCCC
GRLEQVLVNLLDNAIKYTPEGGAISFSAAVKENMVRIGVKDTGVGIPPKDLPRIFERFYR
HHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHH
VDTARSRDEGGTGLGLSIVKHIVQLHGGAVGVESEPGKGSEFWFTIKKA
HHCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRFTIQWKLMASYLLLVLFIGGVFFAYLNHTLNQHLTAEIRQNLATEARLTRMIAHRDIG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMKDDAPAVAAAISRETRARVTIILAGGEVVGDSEIAPGQLKELENHLNRPEVQQALKSG
CCCCCCHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCC
SGESIRYSATIKTPMLYVAVPLQTAGGEEGFVRLSLPLTALEKAEGSIRTLLGASLAVSL
CCCCEEEEEEECCCEEEEEEEEECCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHH
LVALVLSYILSRVTSRSLRTITALAKQIGKGNFNRRIPVPTRDEVGELARVMNDMAARIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QQLERTSAEKNRLDTILRGMGEGLMVTDANGLITLVNPAFLGLFSLNESVEGRHIIEIAR
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHH
HPVLNDAFKAIVASGDERVEKMTLTMGEEKHVLTHWVPLVDNGELQGVVAVFHDITDLTR
CCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHH
LENIRRDFVANVSHELRTPVTVIKGYAEALIDGAMETDPERARKFVGIILSHSERLAALI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHH
GDLLTLSQLEAGSMNLEKTTVRPEQVAKRAMELLQPKAARKGITIDCSGLSGAQSVLADP
HHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHCCHHHHCCCEEEECCCCCHHHHHCCC
GRLEQVLVNLLDNAIKYTPEGGAISFSAAVKENMVRIGVKDTGVGIPPKDLPRIFERFYR
HHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHH
VDTARSRDEGGTGLGLSIVKHIVQLHGGAVGVESEPGKGSEFWFTIKKA
HHCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]