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The map label for this gene is panE [C]

Identifier: 78223840

GI number: 78223840

Start: 2993460

End: 2994368

Strand: Reverse

Name: panE [C]

Synonym: Gmet_2643

Alternate gene names: 78223840

Gene position: 2994368-2993460 (Counterclockwise)

Preceding gene: 78223847

Following gene: 78223839

Centisome position: 74.91

GC content: 63.48

Gene sequence:

>909_bases
ATGCGAATAGCAATTGTGGGCGCCGGAGCCCTGGGGCTTTACTACGGCGCTTTGCTGCAGCGGAGCGGAGAGGACGTCCA
TTTCCTCCTTCGCCGCGATTATGAGGCGATCGCCGGGAACGGCCTGAAGGTCTTTTCCATCAACGGCGATTTTACACTGC
CTCACGTGAAGGGATACCGCGCTCCCGAGGAAATCGGGCCGATGGACCTGGTGCTGGTTGGGCTGAAGACTTTTGCCAAC
AGCCGGTATGAGGAGCTGATCCGTCCGCTGGTGGAGGAGGGGACGCAGATTCTGACCCTCCAGAACGGACTGGGGAACGA
GGAGGCGCTGGCCACCCTTTTCGGGGCCGAGCGGATCATCGGCGGCGTGGCCTTTCTCTGCTCCAACAGGGGGGAGCCCG
GCGAGGTGCATCACCTGGGGGCGGGGCGGATCATCCTGGGAGAATTCCTGCCCCGCGACACGGGGCGGATCGAGGAGCTG
GCCGCCATGTTCCGCCAGGCCGGGGTGGATTGCCGGACAACCGATGACCTGAAGCGTGCCCGGTGGGAGAAGCTGGTCTG
GAACATCCCGTTCAACGGCCTGTGCGCCCTCCTGCAGCAACCGGTGAACCTGATTCTGGCGCGCGATGTGAGCCGCAAAC
TGGTGCGGGGAATTATGCTTGAAGTCATCGCCGGCGCCAATGCCCAGGGGCTTGCCACCTTCATTGCCGATGGCTACGTC
GACGACATGCTGGAATTCACCGACGCCATGGGAGAGTACAAGCCATCCATGGAGATCGACCGCGAAGAGGGGCGCCCCCT
GGAGATTGCCGCCATCTTCAGGACACCCCTTGCCTACGGTGCGCGGGAGGGGATCGCCATGCCGCGGGTTGAGATGCTGG
CGACGCTGCTGGAACAGGCCACAGGATGA

Upstream 100 bases:

>100_bases
AGGCCCGAAATCCCTCCGCACGGAGCGAAGGCCTCAGTCCCTAAACCGTCGTCAGGCCCTACCTTTTGAGGGGGGACGAC
ACTAGCGCAAGGAGACATTC

Downstream 100 bases:

>100_bases
ACGGGGATATGTTGACAGGGGCCCGTCAGACTAATCTGACGGGCTTTTCTGCGCGTGGGCACATATTGTGTAGTAATGCG
ATGTATATTGTGTGACTTGT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MRIAIVGAGALGLYYGALLQRSGEDVHFLLRRDYEAIAGNGLKVFSINGDFTLPHVKGYRAPEEIGPMDLVLVGLKTFAN
SRYEELIRPLVEEGTQILTLQNGLGNEEALATLFGAERIIGGVAFLCSNRGEPGEVHHLGAGRIILGEFLPRDTGRIEEL
AAMFRQAGVDCRTTDDLKRARWEKLVWNIPFNGLCALLQQPVNLILARDVSRKLVRGIMLEVIAGANAQGLATFIADGYV
DDMLEFTDAMGEYKPSMEIDREEGRPLEIAAIFRTPLAYGAREGIAMPRVEMLATLLEQATG

Sequences:

>Translated_302_residues
MRIAIVGAGALGLYYGALLQRSGEDVHFLLRRDYEAIAGNGLKVFSINGDFTLPHVKGYRAPEEIGPMDLVLVGLKTFAN
SRYEELIRPLVEEGTQILTLQNGLGNEEALATLFGAERIIGGVAFLCSNRGEPGEVHHLGAGRIILGEFLPRDTGRIEEL
AAMFRQAGVDCRTTDDLKRARWEKLVWNIPFNGLCALLQQPVNLILARDVSRKLVRGIMLEVIAGANAQGLATFIADGYV
DDMLEFTDAMGEYKPSMEIDREEGRPLEIAAIFRTPLAYGAREGIAMPRVEMLATLLEQATG
>Mature_302_residues
MRIAIVGAGALGLYYGALLQRSGEDVHFLLRRDYEAIAGNGLKVFSINGDFTLPHVKGYRAPEEIGPMDLVLVGLKTFAN
SRYEELIRPLVEEGTQILTLQNGLGNEEALATLFGAERIIGGVAFLCSNRGEPGEVHHLGAGRIILGEFLPRDTGRIEEL
AAMFRQAGVDCRTTDDLKRARWEKLVWNIPFNGLCALLQQPVNLILARDVSRKLVRGIMLEVIAGANAQGLATFIADGYV
DDMLEFTDAMGEYKPSMEIDREEGRPLEIAAIFRTPLAYGAREGIAMPRVEMLATLLEQATG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320057, Length=334, Percent_Identity=25.4491017964072, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33102; Mature: 33102

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAIVGAGALGLYYGALLQRSGEDVHFLLRRDYEAIAGNGLKVFSINGDFTLPHVKGYR
CEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHCHHHHCCCCEEEEEECCCEECCCCCCCC
APEEIGPMDLVLVGLKTFANSRYEELIRPLVEEGTQILTLQNGLGNEEALATLFGAERII
CHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
GGVAFLCSNRGEPGEVHHLGAGRIILGEFLPRDTGRIEELAAMFRQAGVDCRTTDDLKRA
HHHHHHHCCCCCCCCEEECCCCCEEEHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
RWEKLVWNIPFNGLCALLQQPVNLILARDVSRKLVRGIMLEVIAGANAQGLATFIADGYV
HHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
DDMLEFTDAMGEYKPSMEIDREEGRPLEIAAIFRTPLAYGAREGIAMPRVEMLATLLEQA
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TG
CC
>Mature Secondary Structure
MRIAIVGAGALGLYYGALLQRSGEDVHFLLRRDYEAIAGNGLKVFSINGDFTLPHVKGYR
CEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHCHHHHCCCCEEEEEECCCEECCCCCCCC
APEEIGPMDLVLVGLKTFANSRYEELIRPLVEEGTQILTLQNGLGNEEALATLFGAERII
CHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
GGVAFLCSNRGEPGEVHHLGAGRIILGEFLPRDTGRIEELAAMFRQAGVDCRTTDDLKRA
HHHHHHHCCCCCCCCEEECCCCCEEEHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
RWEKLVWNIPFNGLCALLQQPVNLILARDVSRKLVRGIMLEVIAGANAQGLATFIADGYV
HHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
DDMLEFTDAMGEYKPSMEIDREEGRPLEIAAIFRTPLAYGAREGIAMPRVEMLATLLEQA
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]