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The map label for this gene is lpxA [H]

Identifier: 78223764

GI number: 78223764

Start: 2914883

End: 2915692

Strand: Reverse

Name: lpxA [H]

Synonym: Gmet_2567

Alternate gene names: 78223764

Gene position: 2915692-2914883 (Counterclockwise)

Preceding gene: 78223765

Following gene: 78223763

Centisome position: 72.94

GC content: 61.23

Gene sequence:

>810_bases
ATGACTACTAGCATCCATCCTTCAGCACAGATAAGCCCCTCCGCCACCATCGCCGACGGCGTTGAGATCGGCGCCAACGT
CATCGTGGGGGACCATTCCTCCATCGGCGCCGGCACGAAGGTGATGGCCAACGCCGTCATCGGCCCCTGGACGAAGATCG
GCGAGAACAACACGATCCATTACGGAGCCATCGTTGGCCATGACCCCCAGGACTTCGGCTACAAAGGGGAGGAGAGCTGG
ACCATCATCGGCAACGGCAACATCATCCGCGAGGGTGCCACCATCCACCGGGGGAACCGGCCCGGGACGAACACGGTGGT
CGGCGACAACAACTTCTTCATGGTCAACTCCCACGTGGGGCACAACTGCGTGCTGGGGAACAATATCATCCTGGTGAACG
GGGTGCTCCTGGCCGGCCACGTGGTGGTGGAGGACCGGGCCATCGTCTCCGGCAACTGCGTGGTGCATCAGTTCTGCCGG
ATCGGAAAATTTGCCATGATGCGGGGGCTTTCCCGCACCTCCCGCGACGTGCCCCCCTTCTGCATCATGGACGACACCCA
CACGGTTAAGGCTCTGAACCTCGTGGGACTGCGCCGCAACGGCTTTGACCAGGCCCGCATCCGCGCCATCAAGAATGCCT
TCAAACTCCTCTTCCTTTCGGGGCTCAATATGCAAAACGCCCTGGCCGAGGCGGAGCGCACTCTCACCATTACCGACGAT
GTCCGCTACCTTCTGGACTTCATCAAGAGCGCCAAGCGGGGGGTCTGCTTCGGACACGGCGTGATCGTGGACGTGGAAGA
GAAAGACTAA

Upstream 100 bases:

>100_bases
GCCGAGATCATCATCGGCAAGCAGCGTAACGGCCCCATCGGAACGGTAAAGCTCCTGTTCAACGGCCAGTACACCAAGTT
CGAAAACCTGGAGAAACGTC

Downstream 100 bases:

>100_bases
AAAGAGGAGTTTCCCCAATGACCCAATACAATCCTTTGAAACAGATTCCTGCGACCGCCGGTTATGGTAAGGGCGACGTC
TTCGTCCTATTCGGCGAACT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTTSIHPSAQISPSATIADGVEIGANVIVGDHSSIGAGTKVMANAVIGPWTKIGENNTIHYGAIVGHDPQDFGYKGEESW
TIIGNGNIIREGATIHRGNRPGTNTVVGDNNFFMVNSHVGHNCVLGNNIILVNGVLLAGHVVVEDRAIVSGNCVVHQFCR
IGKFAMMRGLSRTSRDVPPFCIMDDTHTVKALNLVGLRRNGFDQARIRAIKNAFKLLFLSGLNMQNALAEAERTLTITDD
VRYLLDFIKSAKRGVCFGHGVIVDVEEKD

Sequences:

>Translated_269_residues
MTTSIHPSAQISPSATIADGVEIGANVIVGDHSSIGAGTKVMANAVIGPWTKIGENNTIHYGAIVGHDPQDFGYKGEESW
TIIGNGNIIREGATIHRGNRPGTNTVVGDNNFFMVNSHVGHNCVLGNNIILVNGVLLAGHVVVEDRAIVSGNCVVHQFCR
IGKFAMMRGLSRTSRDVPPFCIMDDTHTVKALNLVGLRRNGFDQARIRAIKNAFKLLFLSGLNMQNALAEAERTLTITDD
VRYLLDFIKSAKRGVCFGHGVIVDVEEKD
>Mature_268_residues
TTSIHPSAQISPSATIADGVEIGANVIVGDHSSIGAGTKVMANAVIGPWTKIGENNTIHYGAIVGHDPQDFGYKGEESWT
IIGNGNIIREGATIHRGNRPGTNTVVGDNNFFMVNSHVGHNCVLGNNIILVNGVLLAGHVVVEDRAIVSGNCVVHQFCRI
GKFAMMRGLSRTSRDVPPFCIMDDTHTVKALNLVGLRRNGFDQARIRAIKNAFKLLFLSGLNMQNALAEAERTLTITDDV
RYLLDFIKSAKRGVCFGHGVIVDVEEKD

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=253, Percent_Identity=40.7114624505929, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1786376, Length=191, Percent_Identity=29.8429319371728, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 29000; Mature: 28868

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSIHPSAQISPSATIADGVEIGANVIVGDHSSIGAGTKVMANAVIGPWTKIGENNTIH
CCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHCCCCCEEE
YGAIVGHDPQDFGYKGEESWTIIGNGNIIREGATIHRGNRPGTNTVVGDNNFFMVNSHVG
EEEEECCCCHHCCCCCCCCEEEEECCCEEECCCEEECCCCCCCCEEECCCCEEEEECCCC
HNCVLGNNIILVNGVLLAGHVVVEDRAIVSGNCVVHQFCRIGKFAMMRGLSRTSRDVPPF
CEEEECCCEEEEEEEEEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCE
CIMDDTHTVKALNLVGLRRNGFDQARIRAIKNAFKLLFLSGLNMQNALAEAERTLTITDD
EEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEEHHH
VRYLLDFIKSAKRGVCFGHGVIVDVEEKD
HHHHHHHHHHHCCCEEEECCEEEEEECCC
>Mature Secondary Structure 
TTSIHPSAQISPSATIADGVEIGANVIVGDHSSIGAGTKVMANAVIGPWTKIGENNTIH
CCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHCCCCCEEE
YGAIVGHDPQDFGYKGEESWTIIGNGNIIREGATIHRGNRPGTNTVVGDNNFFMVNSHVG
EEEEECCCCHHCCCCCCCCEEEEECCCEEECCCEEECCCCCCCCEEECCCCEEEEECCCC
HNCVLGNNIILVNGVLLAGHVVVEDRAIVSGNCVVHQFCRIGKFAMMRGLSRTSRDVPPF
CEEEECCCEEEEEEEEEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCE
CIMDDTHTVKALNLVGLRRNGFDQARIRAIKNAFKLLFLSGLNMQNALAEAERTLTITDD
EEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEEHHH
VRYLLDFIKSAKRGVCFGHGVIVDVEEKD
HHHHHHHHHHHCCCEEEECCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA