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The map label for this gene is pdhA [H]

Identifier: 78223709

GI number: 78223709

Start: 2849294

End: 2850352

Strand: Direct

Name: pdhA [H]

Synonym: Gmet_2509

Alternate gene names: 78223709

Gene position: 2849294-2850352 (Clockwise)

Preceding gene: 78223708

Following gene: 78223710

Centisome position: 71.28

GC content: 66.48

Gene sequence:

>1059_bases
ATGCCCGAATCGATCCTCGCCACTTTCACTGTCAAGCGCCTGGAGATCATCGCCCCGGACGGGACCGCCGACGAGGACCT
CGTCCCGGGCCTCTCGGGGGACGAACTGCGGCGCATCTACTACCTGCTCCTCCTCACCCGCGCCTACGACGGCCGCGCCC
TGGCCCTCCAGCGGGAGGGGCGGCTCGGCACCTACCCGTCGGTCCTGGGGCAGGAGGCGGCCCAGGTGGGGAGCGCCTTC
GCCATCCACGAGCGGGACTGGGTCTTCCCCTCCTTCCGGGAGATGGGGGTCCACCTCACCCTCGGCTATCCGGCCCACCA
GCTCTTTCAGTACTGGGGAGGTGACGAGCGGGGGATGCGAACTCCTGACGGCATGAACATCTTCCCCATCTCCGTCTCCG
TGGGAACCCACATCCCCCACGCCGCCGGCGCGGCCCTGGCCGCGAAACTCCGGGGTGACCCGATCGCTGTGATCGCCTAT
TTTGGCGACGGCGGCACCTCAAAGGGTGATTTCCATGAGGGGTTCAACCTGGCAGGAGTCATGGGGCTCCCGACGGTTTT
TATCTGCCAGAACAACCAATGGGCCATCTCGGTGCCCCTGTCGGCCCAGACTGCCTCCCGATCCCTTGCCCAGAAGGCCC
TTGCCTACGGTTTCGACGGCATCCAGGTGGACGGCAACGACGTCCTGGCCGTCTACCGGGCCACCCGCGAGGCCCTGGAG
AAGGCCCGAAGCGGCGGCGGACCCACCTTCATCGAATGCCTCACCTACCGGATGTCCGACCACACCACGTCCGACGACGC
GAGCCGGTACCGTTCCCCCGAAGAAATGGAACAATGGCGGGAGCGGGACCCGATCCTGCGCTACGAGCGGTTCCTGGCGA
AGCGGGGACTCTGGAACGAGGACTATGCCGCCGAGATGAAGGGAAAGGCGGGAGGAGAGATCGACGAGGCGGTGCGGCGC
TACGAATCGGTGCCGCCGCCAGCGCCGGGGGAGATGTTCAATTTCGTGAGTGGGGAGTTGTCGGCGAGGCTGCGGCGACA
GCGGGAAACATCTACTTGA

Upstream 100 bases:

>100_bases
GCTGCGGCTGGCAACCGAAGAGGCCGATGCGGCGCTCATGCGGAACGGCAACAACGGCCCGCCCCCTTGACTCCGGGCCG
CTTCCCGCTACCCTTTACCC

Downstream 100 bases:

>100_bases
ATAACACGGAGAGACGGAGAACACGGAGTAAAATCAAGCTGTTATTCTTCAGCAACAATTTGATTCAGTACTCCTTCTTG
GCTCAAAATAAATAAATGGT

Product: dehydrogenase, E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPESILATFTVKRLEIIAPDGTADEDLVPGLSGDELRRIYYLLLLTRAYDGRALALQREGRLGTYPSVLGQEAAQVGSAF
AIHERDWVFPSFREMGVHLTLGYPAHQLFQYWGGDERGMRTPDGMNIFPISVSVGTHIPHAAGAALAAKLRGDPIAVIAY
FGDGGTSKGDFHEGFNLAGVMGLPTVFICQNNQWAISVPLSAQTASRSLAQKALAYGFDGIQVDGNDVLAVYRATREALE
KARSGGGPTFIECLTYRMSDHTTSDDASRYRSPEEMEQWRERDPILRYERFLAKRGLWNEDYAAEMKGKAGGEIDEAVRR
YESVPPPAPGEMFNFVSGELSARLRRQRETST

Sequences:

>Translated_352_residues
MPESILATFTVKRLEIIAPDGTADEDLVPGLSGDELRRIYYLLLLTRAYDGRALALQREGRLGTYPSVLGQEAAQVGSAF
AIHERDWVFPSFREMGVHLTLGYPAHQLFQYWGGDERGMRTPDGMNIFPISVSVGTHIPHAAGAALAAKLRGDPIAVIAY
FGDGGTSKGDFHEGFNLAGVMGLPTVFICQNNQWAISVPLSAQTASRSLAQKALAYGFDGIQVDGNDVLAVYRATREALE
KARSGGGPTFIECLTYRMSDHTTSDDASRYRSPEEMEQWRERDPILRYERFLAKRGLWNEDYAAEMKGKAGGEIDEAVRR
YESVPPPAPGEMFNFVSGELSARLRRQRETST
>Mature_351_residues
PESILATFTVKRLEIIAPDGTADEDLVPGLSGDELRRIYYLLLLTRAYDGRALALQREGRLGTYPSVLGQEAAQVGSAFA
IHERDWVFPSFREMGVHLTLGYPAHQLFQYWGGDERGMRTPDGMNIFPISVSVGTHIPHAAGAALAAKLRGDPIAVIAYF
GDGGTSKGDFHEGFNLAGVMGLPTVFICQNNQWAISVPLSAQTASRSLAQKALAYGFDGIQVDGNDVLAVYRATREALEK
ARSGGGPTFIECLTYRMSDHTTSDDASRYRSPEEMEQWRERDPILRYERFLAKRGLWNEDYAAEMKGKAGGEIDEAVRRY
ESVPPPAPGEMFNFVSGELSARLRRQRETST

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=347, Percent_Identity=38.328530259366, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI258645172, Length=347, Percent_Identity=38.328530259366, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4885543, Length=335, Percent_Identity=29.8507462686567, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4505685, Length=340, Percent_Identity=27.6470588235294, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI291084742, Length=340, Percent_Identity=27.6470588235294, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI291084744, Length=272, Percent_Identity=29.4117647058824, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI291084757, Length=176, Percent_Identity=30.6818181818182, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563357, Length=370, Percent_Identity=35.1351351351351, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI86563355, Length=370, Percent_Identity=35.1351351351351, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI32564172, Length=313, Percent_Identity=30.6709265175719, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17536047, Length=313, Percent_Identity=30.6709265175719, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=311, Percent_Identity=27.9742765273312, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21355903, Length=346, Percent_Identity=33.5260115606936, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24639744, Length=299, Percent_Identity=30.7692307692308, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28571106, Length=299, Percent_Identity=30.7692307692308, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24639740, Length=299, Percent_Identity=30.7692307692308, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24639746, Length=288, Percent_Identity=31.5972222222222, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639748, Length=299, Percent_Identity=27.4247491638796, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38846; Mature: 38715

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESILATFTVKRLEIIAPDGTADEDLVPGLSGDELRRIYYLLLLTRAYDGRALALQREG
CCCHHHHHEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
RLGTYPSVLGQEAAQVGSAFAIHERDWVFPSFREMGVHLTLGYPAHQLFQYWGGDERGMR
CCCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCEEEEECCCHHHHHHHHCCCCCCCC
TPDGMNIFPISVSVGTHIPHAAGAALAAKLRGDPIAVIAYFGDGGTSKGDFHEGFNLAGV
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEE
MGLPTVFICQNNQWAISVPLSAQTASRSLAQKALAYGFDGIQVDGNDVLAVYRATREALE
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHH
KARSGGGPTFIECLTYRMSDHTTSDDASRYRSPEEMEQWRERDPILRYERFLAKRGLWNE
HHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCC
DYAAEMKGKAGGEIDEAVRRYESVPPPAPGEMFNFVSGELSARLRRQRETST
CHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PESILATFTVKRLEIIAPDGTADEDLVPGLSGDELRRIYYLLLLTRAYDGRALALQREG
CCHHHHHEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
RLGTYPSVLGQEAAQVGSAFAIHERDWVFPSFREMGVHLTLGYPAHQLFQYWGGDERGMR
CCCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCEEEEECCCHHHHHHHHCCCCCCCC
TPDGMNIFPISVSVGTHIPHAAGAALAAKLRGDPIAVIAYFGDGGTSKGDFHEGFNLAGV
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEE
MGLPTVFICQNNQWAISVPLSAQTASRSLAQKALAYGFDGIQVDGNDVLAVYRATREALE
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHH
KARSGGGPTFIECLTYRMSDHTTSDDASRYRSPEEMEQWRERDPILRYERFLAKRGLWNE
HHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCC
DYAAEMKGKAGGEIDEAVRRYESVPPPAPGEMFNFVSGELSARLRRQRETST
CHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]