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The map label for this gene is algA [H]

Identifier: 78223674

GI number: 78223674

Start: 2810956

End: 2811336

Strand: Reverse

Name: algA [H]

Synonym: Gmet_2471

Alternate gene names: 78223674

Gene position: 2811336-2810956 (Counterclockwise)

Preceding gene: 78223675

Following gene: 78223673

Centisome position: 70.33

GC content: 58.53

Gene sequence:

>381_bases
GTGTTGGAACGAGGAGAACGCCCCTGGGGGACCTACACGGTCCTTGAGGAAAACACCAGTTACAAGATCAAGCGGATCGA
AGTGAATCCGGGGCAGCGGCTGTCGCTCCAGATGCACCACCACCGGAGCGAGCACTGGATCGTGGTTTCCGGCACTGCCA
GGGTGACCTGCGGTGATGAGGAGTATGTGGTCAACGTGAACGAGTCCACCTTCATTCCCATCGGCCGGAACCACCGGCTG
GAGAACCCCGGCAAGATCCCCCTTGTCATCATCGAGGTACAGAGCGGCGAGTATCTGGGCGAAGACGACATTGTCCGCTT
CGACGACGACTACAATCGCTGTGAGCCGGGAACGGAGACTTTCTCCGGAGAAACTGATTAG

Upstream 100 bases:

>100_bases
CCATGATGCGGGGCTTGAGTTGGAGGACTGGCGCGAGGCCCTTAAAAACTATCTGGAAAGGCGTCAGCCGGCAGTAAGAA
GCTGACGGGAGGGAGACCCT

Downstream 100 bases:

>100_bases
GCGACAACGGCGTCTCCTCGCCAGGACGGTAGCCGCATAGTATCGACCGGTTGAAGGACGGGGCGTCGCTCCCCCCAGCG
ACATGTATCCCAAGGGAAAA

Product: mannose-6-phosphate isomerase, type II:cupin region

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MLERGERPWGTYTVLEENTSYKIKRIEVNPGQRLSLQMHHHRSEHWIVVSGTARVTCGDEEYVVNVNESTFIPIGRNHRL
ENPGKIPLVIIEVQSGEYLGEDDIVRFDDDYNRCEPGTETFSGETD

Sequences:

>Translated_126_residues
MLERGERPWGTYTVLEENTSYKIKRIEVNPGQRLSLQMHHHRSEHWIVVSGTARVTCGDEEYVVNVNESTFIPIGRNHRL
ENPGKIPLVIIEVQSGEYLGEDDIVRFDDDYNRCEPGTETFSGETD
>Mature_126_residues
MLERGERPWGTYTVLEENTSYKIKRIEVNPGQRLSLQMHHHRSEHWIVVSGTARVTCGDEEYVVNVNESTFIPIGRNHRL
ENPGKIPLVIIEVQSGEYLGEDDIVRFDDDYNRCEPGTETFSGETD

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0662

COG function: function code G; Mannose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=107, Percent_Identity=57.9439252336449, Blast_Score=138, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 14505; Mature: 14505

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERGERPWGTYTVLEENTSYKIKRIEVNPGQRLSLQMHHHRSEHWIVVSGTARVTCGDE
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCCEEEEECCEEEEECCC
EYVVNVNESTFIPIGRNHRLENPGKIPLVIIEVQSGEYLGEDDIVRFDDDYNRCEPGTET
EEEEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCEEEECCCCCCCCCCCCC
FSGETD
CCCCCC
>Mature Secondary Structure
MLERGERPWGTYTVLEENTSYKIKRIEVNPGQRLSLQMHHHRSEHWIVVSGTARVTCGDE
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCCEEEEECCEEEEECCC
EYVVNVNESTFIPIGRNHRLENPGKIPLVIIEVQSGEYLGEDDIVRFDDDYNRCEPGTET
EEEEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCEECCCCEEEECCCCCCCCCCCCC
FSGETD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]