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The map label for this gene is pgi

Identifier: 78223661

GI number: 78223661

Start: 2781173

End: 2782762

Strand: Direct

Name: pgi

Synonym: Gmet_2458

Alternate gene names: 78223661

Gene position: 2781173-2782762 (Clockwise)

Preceding gene: 78223660

Following gene: 78223663

Centisome position: 69.57

GC content: 67.67

Gene sequence:

>1590_bases
ATGGACAACACCCTCCTCTGGAACCGTTACCAATCCCACCTTTTCCACGATCCTGAGTCGGGGCTCATGCTGGACATCAG
CAGGATGAACTTCGCGGACGGATTCCTGGCGTCCATGGAGTCGGCCACCCAGAAGGCGTTCGCCGAGATGGGGGAGCTTG
AGGGAGGCGCCATCGCCAACCCCGACGAGGGGCGGATGGTGGGACACTACTGGCTGCGATCCCCGGACCTCTCCCCCACC
GATGAAATCGCCGCGGAGATTGGCGAGACCGTGCAGCGGATCAGGGAATTCGCCGCCGCCGTCCACGGCGGGAGCATCGC
GGCACCGGACGGACGCCCCTTCCGGAAACTCCTCGTGGTGGGGATCGGCGGATCGGCCCTGGGGCCCCAGTTCGTGGCCG
ACGCCCTGGGGGACGTGGACAACCCGCTCACCCCCCACTTCTTCGATAACACCGACCCCGACGGCATGGACCGGGTCCTG
GCCCAGATCGGGCCGGACCTTGCCGGGACCCTCACGGTGGTCATCTCCAAGAGCGGCGGCACCAAGGAGACCCGCAACGG
CATGCTGGAGGCCGAAATCGCCTACCGCCGGGCGGGACTCCACTTCCCCCGGTACGCCGTGGCGGTCACCGGCGAAGGGA
GCGAGCTGGACCGGACCGCCACCAGTGCCGGCTGGCTTGCCCGCTTTCCCATGTGGGACTGGGTCGGGGGTCGCACTTCT
GTAACCTCGGCCGTGGGGCTCCTTCCCGCTGCCCTCCAGGGGCTCGACATCGCCGGCATGCTGGAAGGTGCCCGGCTCTG
CGACCAACTCACCCGCCGCCCTGACACGGCCCGCAACCCGGCGGCGCTCCTGGCCCTCATGTGGCACCACGCCACCGGCG
GAAAAGGTGCCCGCGACATGGTGGTCCTCCCCTACAAGGACCGCCTCCTTCTCTTCTCCCGCTATCTGCAGCAGCTCATC
ATGGAATCCATCGGCAAGGAGCTGGACCGGGAAGGGAATGTGGTCTGCCAGGGGATTTCGGTTTACGGCAACAAGGGGTC
CACGGACCAGCACGCCTACGTGCAGCAACTTCGCGAGGGGGTGAACAACTTCTTCGTCACCTTCATCGAAGTGCTCCGGG
ACCGGCGCGGTGCGTCCCTGCCGGTGGAACCGGGGGTGACGAGCGGCGACTACCTGTCCGGCTTTCTCCAGGGAACCCGC
ACGGCCCTCGGCGAAAAGGGTCGGGAATCCCTCACCATCACCATCCCCGAGGTATCACCCCGCACCGTCGGCATGCTCAT
CGCCCTCTTCGAGCGGGCGGTGGGGCTCTACGCCTCGCTGGTGAACATCAACGCCTACCACCAGCCCGGCGTCGAGGCGG
GAAAGAAGGCGGCCGGGACGGTGCTGGCGCACCAGGCCGACATCATCGCCCACCTGCGCGGGACCGGCTCCTCTCTCACG
GCCGACGAGATTGCCGCGGCCCTCGGGCGCCCCGACGCGGCGGAGACGGTTTTCAGGACGCTGCTCCACGCCGCGGCCAA
CCCGGACCACGGCATCAGAATGGAGCCGGCGGAGTCTCTCACCGCAAGCCGCTTCTCCGTACGGGATTGA

Upstream 100 bases:

>100_bases
AGGGGCTGAACTCTTCCTGGCCCAGCACTGCTACTGCTGCACCGCCGGCGAGGGATCAAGCTGCACCGGTGCGTTGAGCT
AACAAGAAAAGGAGACCACC

Downstream 100 bases:

>100_bases
GCGGATACACAGCAGTTTGCCACCCGGCTGATACAGGCTCTTTGGGGGTAACAGCAGAGTTACTACCGCGGGGGAAGGAA
CGGCTCCAGGAGAGCCGGAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MDNTLLWNRYQSHLFHDPESGLMLDISRMNFADGFLASMESATQKAFAEMGELEGGAIANPDEGRMVGHYWLRSPDLSPT
DEIAAEIGETVQRIREFAAAVHGGSIAAPDGRPFRKLLVVGIGGSALGPQFVADALGDVDNPLTPHFFDNTDPDGMDRVL
AQIGPDLAGTLTVVISKSGGTKETRNGMLEAEIAYRRAGLHFPRYAVAVTGEGSELDRTATSAGWLARFPMWDWVGGRTS
VTSAVGLLPAALQGLDIAGMLEGARLCDQLTRRPDTARNPAALLALMWHHATGGKGARDMVVLPYKDRLLLFSRYLQQLI
MESIGKELDREGNVVCQGISVYGNKGSTDQHAYVQQLREGVNNFFVTFIEVLRDRRGASLPVEPGVTSGDYLSGFLQGTR
TALGEKGRESLTITIPEVSPRTVGMLIALFERAVGLYASLVNINAYHQPGVEAGKKAAGTVLAHQADIIAHLRGTGSSLT
ADEIAAALGRPDAAETVFRTLLHAAANPDHGIRMEPAESLTASRFSVRD

Sequences:

>Translated_529_residues
MDNTLLWNRYQSHLFHDPESGLMLDISRMNFADGFLASMESATQKAFAEMGELEGGAIANPDEGRMVGHYWLRSPDLSPT
DEIAAEIGETVQRIREFAAAVHGGSIAAPDGRPFRKLLVVGIGGSALGPQFVADALGDVDNPLTPHFFDNTDPDGMDRVL
AQIGPDLAGTLTVVISKSGGTKETRNGMLEAEIAYRRAGLHFPRYAVAVTGEGSELDRTATSAGWLARFPMWDWVGGRTS
VTSAVGLLPAALQGLDIAGMLEGARLCDQLTRRPDTARNPAALLALMWHHATGGKGARDMVVLPYKDRLLLFSRYLQQLI
MESIGKELDREGNVVCQGISVYGNKGSTDQHAYVQQLREGVNNFFVTFIEVLRDRRGASLPVEPGVTSGDYLSGFLQGTR
TALGEKGRESLTITIPEVSPRTVGMLIALFERAVGLYASLVNINAYHQPGVEAGKKAAGTVLAHQADIIAHLRGTGSSLT
ADEIAAALGRPDAAETVFRTLLHAAANPDHGIRMEPAESLTASRFSVRD
>Mature_529_residues
MDNTLLWNRYQSHLFHDPESGLMLDISRMNFADGFLASMESATQKAFAEMGELEGGAIANPDEGRMVGHYWLRSPDLSPT
DEIAAEIGETVQRIREFAAAVHGGSIAAPDGRPFRKLLVVGIGGSALGPQFVADALGDVDNPLTPHFFDNTDPDGMDRVL
AQIGPDLAGTLTVVISKSGGTKETRNGMLEAEIAYRRAGLHFPRYAVAVTGEGSELDRTATSAGWLARFPMWDWVGGRTS
VTSAVGLLPAALQGLDIAGMLEGARLCDQLTRRPDTARNPAALLALMWHHATGGKGARDMVVLPYKDRLLLFSRYLQQLI
MESIGKELDREGNVVCQGISVYGNKGSTDQHAYVQQLREGVNNFFVTFIEVLRDRRGASLPVEPGVTSGDYLSGFLQGTR
TALGEKGRESLTITIPEVSPRTVGMLIALFERAVGLYASLVNINAYHQPGVEAGKKAAGTVLAHQADIIAHLRGTGSSLT
ADEIAAALGRPDAAETVFRTLLHAAANPDHGIRMEPAESLTASRFSVRD

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=501, Percent_Identity=26.5469061876248, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI296080693, Length=499, Percent_Identity=24.4488977955912, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1790457, Length=493, Percent_Identity=27.9918864097363, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71996703, Length=495, Percent_Identity=26.8686868686869, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71996708, Length=495, Percent_Identity=26.8686868686869, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319673, Length=456, Percent_Identity=27.6315789473684, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24651916, Length=515, Percent_Identity=26.6019417475728, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24651914, Length=515, Percent_Identity=26.6019417475728, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17737445, Length=515, Percent_Identity=26.6019417475728, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_GEOMG (Q39SU1)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385408.1
- ProteinModelPortal:   Q39SU1
- SMR:   Q39SU1
- STRING:   Q39SU1
- GeneID:   3738761
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2458
- NMPDR:   fig|269799.3.peg.2626
- eggNOG:   COG0166
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- BioCyc:   GMET269799:GMET_2458-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 56858; Mature: 56858

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 322-322 ACT_SITE 351-351 ACT_SITE 455-455

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTLLWNRYQSHLFHDPESGLMLDISRMNFADGFLASMESATQKAFAEMGELEGGAIAN
CCCCEEHHHHHHHHCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PDEGRMVGHYWLRSPDLSPTDEIAAEIGETVQRIREFAAAVHGGSIAAPDGRPFRKLLVV
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEE
GIGGSALGPQFVADALGDVDNPLTPHFFDNTDPDGMDRVLAQIGPDLAGTLTVVISKSGG
ECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCC
TKETRNGMLEAEIAYRRAGLHFPRYAVAVTGEGSELDRTATSAGWLARFPMWDWVGGRTS
CCHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCHHEECCCHHCCCCCHH
VTSAVGLLPAALQGLDIAGMLEGARLCDQLTRRPDTARNPAALLALMWHHATGGKGARDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCE
VVLPYKDRLLLFSRYLQQLIMESIGKELDREGNVVCQGISVYGNKGSTDQHAYVQQLREG
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
VNNFFVTFIEVLRDRRGASLPVEPGVTSGDYLSGFLQGTRTALGEKGRESLTITIPEVSP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
RTVGMLIALFERAVGLYASLVNINAYHQPGVEAGKKAAGTVLAHQADIIAHLRGTGSSLT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCCCCC
ADEIAAALGRPDAAETVFRTLLHAAANPDHGIRMEPAESLTASRFSVRD
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHCCCCC
>Mature Secondary Structure
MDNTLLWNRYQSHLFHDPESGLMLDISRMNFADGFLASMESATQKAFAEMGELEGGAIAN
CCCCEEHHHHHHHHCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PDEGRMVGHYWLRSPDLSPTDEIAAEIGETVQRIREFAAAVHGGSIAAPDGRPFRKLLVV
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEE
GIGGSALGPQFVADALGDVDNPLTPHFFDNTDPDGMDRVLAQIGPDLAGTLTVVISKSGG
ECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCC
TKETRNGMLEAEIAYRRAGLHFPRYAVAVTGEGSELDRTATSAGWLARFPMWDWVGGRTS
CCHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCHHEECCCHHCCCCCHH
VTSAVGLLPAALQGLDIAGMLEGARLCDQLTRRPDTARNPAALLALMWHHATGGKGARDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCE
VVLPYKDRLLLFSRYLQQLIMESIGKELDREGNVVCQGISVYGNKGSTDQHAYVQQLREG
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
VNNFFVTFIEVLRDRRGASLPVEPGVTSGDYLSGFLQGTRTALGEKGRESLTITIPEVSP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
RTVGMLIALFERAVGLYASLVNINAYHQPGVEAGKKAAGTVLAHQADIIAHLRGTGSSLT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCCCCC
ADEIAAALGRPDAAETVFRTLLHAAANPDHGIRMEPAESLTASRFSVRD
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA