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The map label for this gene is asnC

Identifier: 78223615

GI number: 78223615

Start: 2725889

End: 2727274

Strand: Reverse

Name: asnC

Synonym: Gmet_2412

Alternate gene names: 78223615

Gene position: 2727274-2725889 (Counterclockwise)

Preceding gene: 78223617

Following gene: 78223614

Centisome position: 68.23

GC content: 64.14

Gene sequence:

>1386_bases
ATGAGCGCACGCATACGTATCCGGAACGCCCTGGCCGGCGAAGGGCTGGGGAATGAGATAATGGTAAAAGGGTGGGTGAG
GACCATCCGGACAGGGAAAGAGGTCGCCTTCCTGGCCCTGAACGACGGCTCCTGCTTCGCCAATCTCCAGGTGGTGGCCG
AGCCAGGGCTTGCCACTTTTGCCGATGTCTGCGCCATTGGCACCGGCGCCGCCGTGGCGGTCCGGGGGCGTCTCGTGGAT
TCGCCGGCCAGCGGCCAGTGCTATGAGCTCCACGCCGATGAGGTGGCGGTGATCGGCCTCGCCGACGAGAGCTATCCCCT
CCAGAAAAAGCGTCACTCCTTCGAGTACCTGCGGAGTATCGCCCACCTCCGCCCCCGTTCCAACACCTTCGGGGCGGTTT
TCCGGGTCCGCTCCTCCGTGGCCCAGGCGGTGCACCGCTTCTTTGCCGAGCGGGGATTCCTCTATGTCCACACCCCCATC
ATCACCACCAGTGACTGCGAGGGGGCAGGGGAGATGTTTCGGGTCACCACCCTTGATCCGGCCGCTCCACCGCTTCTGGA
GGGGGAGGTTGACTTCAGCCGCGACTTCTTCGCCGCCCAGGCGGGGCTCACCGTGAGCGGCCAGCTTGAGGGGGAGCTTT
TCGCCCAGGCCTTCAGCGATATTTATACCTTTGGCCCCACCTTCCGGGCCGAGAACTCCAACACCCCCCGCCACGCCGCC
GAGTTCTGGATGATCGAGCCCGAGATGGCCTTTGCCGATCTCATGGCTGACGCAGCCCTGGCCGAGGAGTTCTTCCGCTA
CCTCTGCCGCCATGTCCTTGACGCCTGCGGGGAGGATATGGCGTTCTTCAACGACCACATCGACAAGGGACTCATTGCCC
GGGTGGAGCAGGTGGCGAACTCCTCCTTCGCCATCATGGAGTACGGCGAGGCCATCGAGCGCCTCAAGAAGGCGACCGTG
ACATTCGAGTACCCCGTGGAGTGGGGGCTCGACCTCCAGACCGAGCATGAGCGCTATCTCACCGAGCAGGTGGTGGGGGG
ACCGGTCTTTGTTATCAACTACCCCAAGCACATCAAGGCGTTCTACATGCGGGTGAACGACGACAACAAGACCGTGGCCG
CCATGGATCTTCTCGTCCCCAAGGTGGGTGAGATCATCGGCGGGAGCCAGCGGGAGGAACGGCTCCCTGTCCTCGAAGGG
CGCATGGCCGAGGTGGGGGTCAATCCCGAGGGGCTCTGGTGGTATCTCGACTCCCGCCGCTGGGGCTCCACCCCCCACGC
CGGTTTCGGTCTCGGCTTCGAGCGGCTCATCATGTACCTCACCGGCATGGAGAACATCCGCGACGTGATTCCGTTCCCCC
GCACCCCTCGCCACGCGGAATTTTGA

Upstream 100 bases:

>100_bases
TTCATGACTCGGTTCTCCTTTGCTGTACAATTGGGCTGTCGCCTTTTCTGAACTATACCGGAGAGGCGCGCCAAGTCAAA
TATCCACGGGGAGCAGCACC

Downstream 100 bases:

>100_bases
AAACGAAGAAATCCTCGTTGTTTGTTTTTGGAGCATGCACATGTTCGTCTTCTCCGCCCGCTTCCACATCTTTCTGCCGA
CCGATTCCCTCAAGGGAAAG

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSARIRIRNALAGEGLGNEIMVKGWVRTIRTGKEVAFLALNDGSCFANLQVVAEPGLATFADVCAIGTGAAVAVRGRLVD
SPASGQCYELHADEVAVIGLADESYPLQKKRHSFEYLRSIAHLRPRSNTFGAVFRVRSSVAQAVHRFFAERGFLYVHTPI
ITTSDCEGAGEMFRVTTLDPAAPPLLEGEVDFSRDFFAAQAGLTVSGQLEGELFAQAFSDIYTFGPTFRAENSNTPRHAA
EFWMIEPEMAFADLMADAALAEEFFRYLCRHVLDACGEDMAFFNDHIDKGLIARVEQVANSSFAIMEYGEAIERLKKATV
TFEYPVEWGLDLQTEHERYLTEQVVGGPVFVINYPKHIKAFYMRVNDDNKTVAAMDLLVPKVGEIIGGSQREERLPVLEG
RMAEVGVNPEGLWWYLDSRRWGSTPHAGFGLGFERLIMYLTGMENIRDVIPFPRTPRHAEF

Sequences:

>Translated_461_residues
MSARIRIRNALAGEGLGNEIMVKGWVRTIRTGKEVAFLALNDGSCFANLQVVAEPGLATFADVCAIGTGAAVAVRGRLVD
SPASGQCYELHADEVAVIGLADESYPLQKKRHSFEYLRSIAHLRPRSNTFGAVFRVRSSVAQAVHRFFAERGFLYVHTPI
ITTSDCEGAGEMFRVTTLDPAAPPLLEGEVDFSRDFFAAQAGLTVSGQLEGELFAQAFSDIYTFGPTFRAENSNTPRHAA
EFWMIEPEMAFADLMADAALAEEFFRYLCRHVLDACGEDMAFFNDHIDKGLIARVEQVANSSFAIMEYGEAIERLKKATV
TFEYPVEWGLDLQTEHERYLTEQVVGGPVFVINYPKHIKAFYMRVNDDNKTVAAMDLLVPKVGEIIGGSQREERLPVLEG
RMAEVGVNPEGLWWYLDSRRWGSTPHAGFGLGFERLIMYLTGMENIRDVIPFPRTPRHAEF
>Mature_460_residues
SARIRIRNALAGEGLGNEIMVKGWVRTIRTGKEVAFLALNDGSCFANLQVVAEPGLATFADVCAIGTGAAVAVRGRLVDS
PASGQCYELHADEVAVIGLADESYPLQKKRHSFEYLRSIAHLRPRSNTFGAVFRVRSSVAQAVHRFFAERGFLYVHTPII
TTSDCEGAGEMFRVTTLDPAAPPLLEGEVDFSRDFFAAQAGLTVSGQLEGELFAQAFSDIYTFGPTFRAENSNTPRHAAE
FWMIEPEMAFADLMADAALAEEFFRYLCRHVLDACGEDMAFFNDHIDKGLIARVEQVANSSFAIMEYGEAIERLKKATVT
FEYPVEWGLDLQTEHERYLTEQVVGGPVFVINYPKHIKAFYMRVNDDNKTVAAMDLLVPKVGEIIGGSQREERLPVLEGR
MAEVGVNPEGLWWYLDSRRWGSTPHAGFGLGFERLIMYLTGMENIRDVIPFPRTPRHAEF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI226491502, Length=461, Percent_Identity=47.0715835140998, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI4758762, Length=454, Percent_Identity=30.3964757709251, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI45439306, Length=501, Percent_Identity=27.1457085828343, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1787161, Length=452, Percent_Identity=56.4159292035398, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1788173, Length=105, Percent_Identity=35.2380952380952, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71984122, Length=447, Percent_Identity=31.5436241610738, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556372, Length=426, Percent_Identity=30.7511737089202, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551876, Length=489, Percent_Identity=25.7668711656442, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319872, Length=470, Percent_Identity=37.0212765957447, Blast_Score=288, Evalue=8e-79,
Organism=Saccharomyces cerevisiae, GI6321807, Length=468, Percent_Identity=27.991452991453, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=503, Percent_Identity=26.8389662027833, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922416, Length=460, Percent_Identity=35.4347826086957, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI19921528, Length=464, Percent_Identity=28.8793103448276, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI17136276, Length=487, Percent_Identity=26.0780287474333, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYN_GEOMG (Q39SY7)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385362.1
- HSSP:   O57980
- ProteinModelPortal:   Q39SY7
- SMR:   Q39SY7
- STRING:   Q39SY7
- GeneID:   3740450
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2412
- NMPDR:   fig|269799.3.peg.2853
- eggNOG:   COG0017
- HOGENOM:   HBG745843
- OMA:   EPEMAFC
- PhylomeDB:   Q39SY7
- ProtClustDB:   PRK03932
- BioCyc:   GMET269799:GMET_2412-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00534
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00457

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.22

Molecular weight: Translated: 51328; Mature: 51197

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARIRIRNALAGEGLGNEIMVKGWVRTIRTGKEVAFLALNDGSCFANLQVVAEPGLATF
CCCEEEEEHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEECCCHHHH
ADVCAIGTGAAVAVRGRLVDSPASGQCYELHADEVAVIGLADESYPLQKKRHSFEYLRSI
HHHHHCCCCCEEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHH
AHLRPRSNTFGAVFRVRSSVAQAVHRFFAERGFLYVHTPIITTSDCEGAGEMFRVTTLDP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECEEEECCCCCCCCEEEEEECCC
AAPPLLEGEVDFSRDFFAAQAGLTVSGQLEGELFAQAFSDIYTFGPTFRAENSNTPRHAA
CCCCCCCCCCCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHH
EFWMIEPEMAFADLMADAALAEEFFRYLCRHVLDACGEDMAFFNDHIDKGLIARVEQVAN
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCC
SSFAIMEYGEAIERLKKATVTFEYPVEWGLDLQTEHERYLTEQVVGGPVFVINYPKHIKA
CCEEEHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHEEE
FYMRVNDDNKTVAAMDLLVPKVGEIIGGSQREERLPVLEGRMAEVGVNPEGLWWYLDSRR
EEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHCCCHHCCCHHCCCCCCCCEEEEEECCC
WGSTPHAGFGLGFERLIMYLTGMENIRDVIPFPRTPRHAEF
CCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SARIRIRNALAGEGLGNEIMVKGWVRTIRTGKEVAFLALNDGSCFANLQVVAEPGLATF
CCEEEEEHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEECCCHHHH
ADVCAIGTGAAVAVRGRLVDSPASGQCYELHADEVAVIGLADESYPLQKKRHSFEYLRSI
HHHHHCCCCCEEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHH
AHLRPRSNTFGAVFRVRSSVAQAVHRFFAERGFLYVHTPIITTSDCEGAGEMFRVTTLDP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECEEEECCCCCCCCEEEEEECCC
AAPPLLEGEVDFSRDFFAAQAGLTVSGQLEGELFAQAFSDIYTFGPTFRAENSNTPRHAA
CCCCCCCCCCCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHH
EFWMIEPEMAFADLMADAALAEEFFRYLCRHVLDACGEDMAFFNDHIDKGLIARVEQVAN
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCC
SSFAIMEYGEAIERLKKATVTFEYPVEWGLDLQTEHERYLTEQVVGGPVFVINYPKHIKA
CCEEEHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHEEE
FYMRVNDDNKTVAAMDLLVPKVGEIIGGSQREERLPVLEGRMAEVGVNPEGLWWYLDSRR
EEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHCCCHHCCCHHCCCCCCCCEEEEEECCC
WGSTPHAGFGLGFERLIMYLTGMENIRDVIPFPRTPRHAEF
CCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA