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The map label for this gene is gluP [H]

Identifier: 78223588

GI number: 78223588

Start: 2695691

End: 2696542

Strand: Reverse

Name: gluP [H]

Synonym: Gmet_2385

Alternate gene names: 78223588

Gene position: 2696542-2695691 (Counterclockwise)

Preceding gene: 78223592

Following gene: 78223586

Centisome position: 67.46

GC content: 63.03

Gene sequence:

>852_bases
ATGACAACTCCCGAGCGCCGCTCGATCCTCTGCCCAAACTGCGGCAGGCTCATCAGTCGCGACGAGCCTTCTTGCCCCTG
GTGCGGCACCTCCCATCCCGGTTCGTGGCTGAAGAACAACCCCCTCACCCGGAGCGTGGGGAGCGCCGACCAGCTCGTCA
CCATCATCATCACGGTTAACATGGTGATGTACCTCGTGTCGCTGCTGATCAGCAATCACTCTCCCGGCCACGGGGGACTC
TTCTCTGCGCTCTCGCCCGATCAGGGGAGCCTCTTGGCCCTAGGGGCCACTGGCGTTGTCCCCATCGATCGCTACGGCCG
TTTCTGGTCGCTCCTTTCCGCCAACTACCTCCATGGGGGGCCGCTCCACATCTTCTTCAACATGATGGCCCTGCGCCAGC
TTCTGCCGCTGGTGGCCCAGGAGTACGGTACCTCGCGGATGCTCACCATCTATACCCTCGGAGGAGTTTGCGGCTACGTG
CTGTCATACCTGGCGGGGGTCGGTTACACCATCGGCGCTTCAGCGGCCCTCTGCGGCCTCATTGGCTCCCTGCTTTACTA
CGGCAAGAGCCGGGGCGGGGTCTACGGGCAGGCGGTCTTCAAGGAAGTATGGGGTTGGGTGGTGGGGCTTTTCTTCTTTG
GCCTCATCGTGCCAGGGATCAATAACTGGGGGCACGGCGGCGGCGTTGTGGGGGGGATCGTCCTGGGGTTCCTGCTTGGT
TACCGGGAGCGGCGGGCTGAGAATCTCTTCCACAAGTTCCTGGCCGGAGGGTGCATCCTGGCGACGGCCGTAGCGCTGGC
TCTGGGGCTCCTTTCGGCCTTTATCACGTTTGCGGGGAGATCTTTGCACTGA

Upstream 100 bases:

>100_bases
ATATCGTGAGGTTTCTTGCACCGGCAAGCTCTCCGCGGTAGGATGCAGAAACGTCTGAGACATATCGACGAGCCGATAGC
CATTCTACCATGAGGTCACC

Downstream 100 bases:

>100_bases
ACCGCGCGTGTTCCTTACCCCCGTAGCTGTCTTCTGTCAATTCACTAACCGCCACTGCCGGGCATCGAGAAACTCCTCCA
GTTCCCGGCGTCCGGCGGTG

Product: rhomboid-like protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTTPERRSILCPNCGRLISRDEPSCPWCGTSHPGSWLKNNPLTRSVGSADQLVTIIITVNMVMYLVSLLISNHSPGHGGL
FSALSPDQGSLLALGATGVVPIDRYGRFWSLLSANYLHGGPLHIFFNMMALRQLLPLVAQEYGTSRMLTIYTLGGVCGYV
LSYLAGVGYTIGASAALCGLIGSLLYYGKSRGGVYGQAVFKEVWGWVVGLFFFGLIVPGINNWGHGGGVVGGIVLGFLLG
YRERRAENLFHKFLAGGCILATAVALALGLLSAFITFAGRSLH

Sequences:

>Translated_283_residues
MTTPERRSILCPNCGRLISRDEPSCPWCGTSHPGSWLKNNPLTRSVGSADQLVTIIITVNMVMYLVSLLISNHSPGHGGL
FSALSPDQGSLLALGATGVVPIDRYGRFWSLLSANYLHGGPLHIFFNMMALRQLLPLVAQEYGTSRMLTIYTLGGVCGYV
LSYLAGVGYTIGASAALCGLIGSLLYYGKSRGGVYGQAVFKEVWGWVVGLFFFGLIVPGINNWGHGGGVVGGIVLGFLLG
YRERRAENLFHKFLAGGCILATAVALALGLLSAFITFAGRSLH
>Mature_282_residues
TTPERRSILCPNCGRLISRDEPSCPWCGTSHPGSWLKNNPLTRSVGSADQLVTIIITVNMVMYLVSLLISNHSPGHGGLF
SALSPDQGSLLALGATGVVPIDRYGRFWSLLSANYLHGGPLHIFFNMMALRQLLPLVAQEYGTSRMLTIYTLGGVCGYVL
SYLAGVGYTIGASAALCGLIGSLLYYGKSRGGVYGQAVFKEVWGWVVGLFFFGLIVPGINNWGHGGGVVGGIVLGFLLGY
RERRAENLFHKFLAGGCILATAVALALGLLSAFITFAGRSLH

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 30188; Mature: 30057

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPERRSILCPNCGRLISRDEPSCPWCGTSHPGSWLKNNPLTRSVGSADQLVTIIITVN
CCCCCCCCEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
MVMYLVSLLISNHSPGHGGLFSALSPDQGSLLALGATGVVPIDRYGRFWSLLSANYLHGG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCC
PLHIFFNMMALRQLLPLVAQEYGTSRMLTIYTLGGVCGYVLSYLAGVGYTIGASAALCGL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IGSLLYYGKSRGGVYGQAVFKEVWGWVVGLFFFGLIVPGINNWGHGGGVVGGIVLGFLLG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
YRERRAENLFHKFLAGGCILATAVALALGLLSAFITFAGRSLH
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTPERRSILCPNCGRLISRDEPSCPWCGTSHPGSWLKNNPLTRSVGSADQLVTIIITVN
CCCCCCCEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
MVMYLVSLLISNHSPGHGGLFSALSPDQGSLLALGATGVVPIDRYGRFWSLLSANYLHGG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCC
PLHIFFNMMALRQLLPLVAQEYGTSRMLTIYTLGGVCGYVLSYLAGVGYTIGASAALCGL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IGSLLYYGKSRGGVYGQAVFKEVWGWVVGLFFFGLIVPGINNWGHGGGVVGGIVLGFLLG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
YRERRAENLFHKFLAGGCILATAVALALGLLSAFITFAGRSLH
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]