Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 78223520

GI number: 78223520

Start: 2625690

End: 2626430

Strand: Reverse

Name: rnc

Synonym: Gmet_2317

Alternate gene names: 78223520

Gene position: 2626430-2625690 (Counterclockwise)

Preceding gene: 78223525

Following gene: 78223519

Centisome position: 65.7

GC content: 65.86

Gene sequence:

>741_bases
ATGGGAGAACGGGGCGTAGAGGACAAAAGCGCGGTTCAGGAGAGCGCGACTGAACTGGAGGCGGGCATCGGCTACCGCTT
CGTCAATCGGCAGTTCCTGGCTGAGGCCCTTACCCATCGTTCCTGGGTGAACGAGCGCCGCGGCGAGGAGGGGATTCGAG
ACAACGAGCGCCTGGAATTTCTGGGTGATGCGGTGCTCGGGCTCCTGGTGGGAAAGATGCTTTTTGCCCGCTTTCCCCAG
AGCCGCGAGGGGGTGCTGGCCCGGATGAAGGCGTCGCTCGTGGGGGAGGAAACTCTTGCGGCGCTGGCCTCGGCCCGCGG
CCTTGGACGACATCTGCTCCTGGGGCGGGGCGAGGAGCGGAGCGGCGGGCGGGAGCGCCGGTCGCTTCTGGCCAATACCT
ACGAGGCCCTGCTAGCAGCAGTCTACCTGGATGGCGGCCTTGGCCCCGTCGAACGGATCGTGGAGCAGGACTTCTCTCCC
CTGCTGGCCGGCATTGCTTCGGGGGCCACGGGGCGGGATTTCAAGACCGAGTTTCAGGAAATGGTTCAGACCCGATTCGG
GACGGCGCCCACCTATGAGTTAATCGCTACGGACGGCCCTCCCCATGACCGGCGCTTCACGGTAATTGCCATGGTGGCCG
GAAAACGGATGGGGGAGGGGGCTGGGAGGAGCAAGAAGGAGGCGGAGCAGGCGGCTGCCCGGCAGGTGCTCGCGCGGTTC
GCTGCCGAAGGAGAAGGATGA

Upstream 100 bases:

>100_bases
TGAATTATAGGGAAGTGGCAAGGGTAAATCAAGGCAAAAATCCCCGACAAGTCGCATAATTATTGATAAATACGGCGGAT
TCAGGTTATAGTGTTTGGTC

Downstream 100 bases:

>100_bases
AGCCGCTCATTGTCCCCTTTTTTATCTCCCACCAGGGATGTCCCCATCAGTGTGTCTTCTGCGACCAGGAGCGGATTTCC
GGCCAGCGGCCCGGGCTTCC

Product: ribonuclease III:double-stranded RNA binding

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MGERGVEDKSAVQESATELEAGIGYRFVNRQFLAEALTHRSWVNERRGEEGIRDNERLEFLGDAVLGLLVGKMLFARFPQ
SREGVLARMKASLVGEETLAALASARGLGRHLLLGRGEERSGGRERRSLLANTYEALLAAVYLDGGLGPVERIVEQDFSP
LLAGIASGATGRDFKTEFQEMVQTRFGTAPTYELIATDGPPHDRRFTVIAMVAGKRMGEGAGRSKKEAEQAAARQVLARF
AAEGEG

Sequences:

>Translated_246_residues
MGERGVEDKSAVQESATELEAGIGYRFVNRQFLAEALTHRSWVNERRGEEGIRDNERLEFLGDAVLGLLVGKMLFARFPQ
SREGVLARMKASLVGEETLAALASARGLGRHLLLGRGEERSGGRERRSLLANTYEALLAAVYLDGGLGPVERIVEQDFSP
LLAGIASGATGRDFKTEFQEMVQTRFGTAPTYELIATDGPPHDRRFTVIAMVAGKRMGEGAGRSKKEAEQAAARQVLARF
AAEGEG
>Mature_245_residues
GERGVEDKSAVQESATELEAGIGYRFVNRQFLAEALTHRSWVNERRGEEGIRDNERLEFLGDAVLGLLVGKMLFARFPQS
REGVLARMKASLVGEETLAALASARGLGRHLLLGRGEERSGGRERRSLLANTYEALLAAVYLDGGLGPVERIVEQDFSPL
LAGIASGATGRDFKTEFQEMVQTRFGTAPTYELIATDGPPHDRRFTVIAMVAGKRMGEGAGRSKKEAEQAAARQVLARFA
AEGEG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=243, Percent_Identity=31.2757201646091, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI155030236, Length=243, Percent_Identity=31.2757201646091, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1788920, Length=210, Percent_Identity=40, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17506883, Length=249, Percent_Identity=26.1044176706827, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=249, Percent_Identity=26.1044176706827, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17552834, Length=97, Percent_Identity=40.2061855670103, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=245, Percent_Identity=30.2040816326531, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_GEOMG (Q39T82)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385267.1
- ProteinModelPortal:   Q39T82
- SMR:   Q39T82
- STRING:   Q39T82
- GeneID:   3740472
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2317
- NMPDR:   fig|269799.3.peg.2561
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q39T82
- ProtClustDB:   CLSK828768
- BioCyc:   GMET269799:GMET_2317-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26724; Mature: 26592

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGERGVEDKSAVQESATELEAGIGYRFVNRQFLAEALTHRSWVNERRGEEGIRDNERLEF
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LGDAVLGLLVGKMLFARFPQSREGVLARMKASLVGEETLAALASARGLGRHLLLGRGEER
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
SGGRERRSLLANTYEALLAAVYLDGGLGPVERIVEQDFSPLLAGIASGATGRDFKTEFQE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MVQTRFGTAPTYELIATDGPPHDRRFTVIAMVAGKRMGEGAGRSKKEAEQAAARQVLARF
HHHHHCCCCCCEEEEECCCCCCCCCEEEHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHH
AAEGEG
HHCCCC
>Mature Secondary Structure 
GERGVEDKSAVQESATELEAGIGYRFVNRQFLAEALTHRSWVNERRGEEGIRDNERLEF
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LGDAVLGLLVGKMLFARFPQSREGVLARMKASLVGEETLAALASARGLGRHLLLGRGEER
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
SGGRERRSLLANTYEALLAAVYLDGGLGPVERIVEQDFSPLLAGIASGATGRDFKTEFQE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MVQTRFGTAPTYELIATDGPPHDRRFTVIAMVAGKRMGEGAGRSKKEAEQAAARQVLARF
HHHHHCCCCCCEEEEECCCCCCCCCEEEHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHH
AAEGEG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA