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The map label for this gene is etfA [H]

Identifier: 78223469

GI number: 78223469

Start: 2566361

End: 2567329

Strand: Reverse

Name: etfA [H]

Synonym: Gmet_2265

Alternate gene names: 78223469

Gene position: 2567329-2566361 (Counterclockwise)

Preceding gene: 78223470

Following gene: 78223468

Centisome position: 64.22

GC content: 53.46

Gene sequence:

>969_bases
ATGGCGGCTCAGATCTTTGCCTATATCAAGCATAAGGGTGGTGCGGTAGATGATACCGCTTTGGAATTGATCTCCGCGGC
CAGGAATATTGATGCGTCCGCCGAACCGATAGCTCTGGTGGCAGGTTCCGGTGCTGATCTGGACCAGGCCTGCAGCCAGA
CGGCATCAACATACAAGCAGGTATGGAAGCTTGGCAACTCTGCTTTTGCCTATCCCAACGCAGAGGTTCTCAGAAAGGCG
CTTCTTGCCGTTCTCCCCACTGATGCAATCGTGCTTGTACCCCATGATGCATTTGGCATGGACCTTTCACCCGGTCTCTC
CATAAAACTCGATGCCACTTTTGTGGCGGATGTGCTTGCGCTGGAAGTATCCGGAAACGATCTTAGAGTTGTTCGCCAGG
AATATGGCGGCCAAGTAAGCTCCCATTCTCTGTGCAGGATGGATAAAGGCGCGGTGATCAATATACGGCCGGGGGCGTTC
GCTCCGGTTGAGGCCTTGGCAAGTATAGGTGAAGTTGTCGATAAATCGAGTTATGTCGCCGAAGTCTCGACCGGCAGGGA
GTTTGTTGAACTGATCGAAGCTGTGGCGGGTGATGTCGACATCACCAAGGAAGACATCCTTGTCTCCATAGGACGCGGTA
TAGGTGATGAAGAGGGTATTCAGATTGCCGAAGAACTGGCTGAGGCAATGGGAGGAGTTGTCAGCTGCAGCCGCCCCATC
GTCGATGCAAAATGGATGGATAAATCGCGGCAGGTCGGTACTTCCGGGCAGACGGTCAAACCGAAGGTCTACCTTGCCTG
TGGGATCAGTGGATCGTTTCAGCATCTGGGCGGCATCAAGGGAAACCCCTTTGTCGTGGCAATCAATAAAAATCCCAAGG
CGCCGATTTTTCAGGTTGCCGATGTGGGGATTGTTGCCGACCTGCAGGAGTTCCTGCCCGAATTGACCGAACGGATAAAC
GAGGGTTGA

Upstream 100 bases:

>100_bases
TCCCCGAATTGGGTGCCGGTGCCGAGATGCTTGATGGGAGCAACGAAGAAATAATCGATAAACTGGTCGAAATGCTCAAA
GCCAAAGGAGGGCTCAAATA

Downstream 100 bases:

>100_bases
TCGGGAACTGCTCCATGGAAGCGACGCGCGAAATATACTGGAACATCGGGCACGGGGTAGTATTACCGATGTATGTCCTG
AGCCTGGCGGCGGTGGCAAT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MAAQIFAYIKHKGGAVDDTALELISAARNIDASAEPIALVAGSGADLDQACSQTASTYKQVWKLGNSAFAYPNAEVLRKA
LLAVLPTDAIVLVPHDAFGMDLSPGLSIKLDATFVADVLALEVSGNDLRVVRQEYGGQVSSHSLCRMDKGAVINIRPGAF
APVEALASIGEVVDKSSYVAEVSTGREFVELIEAVAGDVDITKEDILVSIGRGIGDEEGIQIAEELAEAMGGVVSCSRPI
VDAKWMDKSRQVGTSGQTVKPKVYLACGISGSFQHLGGIKGNPFVVAINKNPKAPIFQVADVGIVADLQEFLPELTERIN
EG

Sequences:

>Translated_322_residues
MAAQIFAYIKHKGGAVDDTALELISAARNIDASAEPIALVAGSGADLDQACSQTASTYKQVWKLGNSAFAYPNAEVLRKA
LLAVLPTDAIVLVPHDAFGMDLSPGLSIKLDATFVADVLALEVSGNDLRVVRQEYGGQVSSHSLCRMDKGAVINIRPGAF
APVEALASIGEVVDKSSYVAEVSTGREFVELIEAVAGDVDITKEDILVSIGRGIGDEEGIQIAEELAEAMGGVVSCSRPI
VDAKWMDKSRQVGTSGQTVKPKVYLACGISGSFQHLGGIKGNPFVVAINKNPKAPIFQVADVGIVADLQEFLPELTERIN
EG
>Mature_321_residues
AAQIFAYIKHKGGAVDDTALELISAARNIDASAEPIALVAGSGADLDQACSQTASTYKQVWKLGNSAFAYPNAEVLRKAL
LAVLPTDAIVLVPHDAFGMDLSPGLSIKLDATFVADVLALEVSGNDLRVVRQEYGGQVSSHSLCRMDKGAVINIRPGAFA
PVEALASIGEVVDKSSYVAEVSTGREFVELIEAVAGDVDITKEDILVSIGRGIGDEEGIQIAEELAEAMGGVVSCSRPIV
DAKWMDKSRQVGTSGQTVKPKVYLACGISGSFQHLGGIKGNPFVVAINKNPKAPIFQVADVGIVADLQEFLPELTERINE
G

Specific function: The electron transfer flavoprotein of this bacterium serves as an electron acceptor specifically for trimethylamine dehydrogenase. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=236, Percent_Identity=36.0169491525424, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI189181759, Length=236, Percent_Identity=36.0169491525424, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786226, Length=231, Percent_Identity=36.7965367965368, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787990, Length=236, Percent_Identity=31.7796610169492, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87082157, Length=248, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17506929, Length=225, Percent_Identity=36.4444444444444, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6325261, Length=229, Percent_Identity=30.5676855895196, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136898, Length=312, Percent_Identity=32.0512820512821, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24652801, Length=312, Percent_Identity=32.0512820512821, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 33851; Mature: 33720

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQIFAYIKHKGGAVDDTALELISAARNIDASAEPIALVAGSGADLDQACSQTASTYKQ
CCHHHEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
VWKLGNSAFAYPNAEVLRKALLAVLPTDAIVLVPHDAFGMDLSPGLSIKLDATFVADVLA
HHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECHHHHEEEHE
LEVSGNDLRVVRQEYGGQVSSHSLCRMDKGAVINIRPGAFAPVEALASIGEVVDKSSYVA
EEECCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHEE
EVSTGREFVELIEAVAGDVDITKEDILVSIGRGIGDEEGIQIAEELAEAMGGVVSCSRPI
EHHCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCCC
VDAKWMDKSRQVGTSGQTVKPKVYLACGISGSFQHLGGIKGNPFVVAINKNPKAPIFQVA
CCHHHCCCCCCCCCCCCEECCEEEEEECCCCCHHHHCCCCCCCEEEEECCCCCCCEEEEC
DVGIVADLQEFLPELTERINEG
CCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAQIFAYIKHKGGAVDDTALELISAARNIDASAEPIALVAGSGADLDQACSQTASTYKQ
CHHHEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
VWKLGNSAFAYPNAEVLRKALLAVLPTDAIVLVPHDAFGMDLSPGLSIKLDATFVADVLA
HHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECHHHHEEEHE
LEVSGNDLRVVRQEYGGQVSSHSLCRMDKGAVINIRPGAFAPVEALASIGEVVDKSSYVA
EEECCCHHHHHHHHHCCCCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHEE
EVSTGREFVELIEAVAGDVDITKEDILVSIGRGIGDEEGIQIAEELAEAMGGVVSCSRPI
EHHCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCCC
VDAKWMDKSRQVGTSGQTVKPKVYLACGISGSFQHLGGIKGNPFVVAINKNPKAPIFQVA
CCHHHCCCCCCCCCCCCEECCEEEEEECCCCCHHHHCCCCCCCEEEEECCCCCCCEEEEC
DVGIVADLQEFLPELTERINEG
CCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7798207; 12567183 [H]