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The map label for this gene is tesB [H]

Identifier: 78223443

GI number: 78223443

Start: 2530752

End: 2531606

Strand: Reverse

Name: tesB [H]

Synonym: Gmet_2238

Alternate gene names: 78223443

Gene position: 2531606-2530752 (Counterclockwise)

Preceding gene: 78223444

Following gene: 78223442

Centisome position: 63.33

GC content: 51.58

Gene sequence:

>855_bases
ATGAAACAAATATTGCCAGAGATCCTTGAACTCGAACAGATTGAGGAGAACCTTTACCGGGGACTCAGTCAGAATCTTGG
CGTTAACCGAATCTATGGTGGCCAGGTTCTCGGTCAGGCCTTGGCTGCCGCAGGAAAAACTGTTATTGGACGTAAGGCTC
ATTCTTTCCACGCCTATTTTCTCCTCATGGGTGACAATAAGCTTCCGGTCATGTATGAGGTGGACCGTATTCATGAGGGT
CACAGTTTTGCGACCCGCAGAGTGGTGGCCATCCAGCGTGGGCGTGCGATCTTTGCCATGACGGCATCGTTTCAGATCGA
AGAGAAAGGACTTGAACACCAAGCTTCCATGCCCGAGGTTCCTGCCCCCGAAGAACTTCCGACCTTGGTTGAAACCTTGG
GAAAGATGGCCGCTCCCAACAGGCGCCTGCAGAACTTTTTTAATAATTTCCCTATTGAAATACGTCCCGTTAAACCCGTT
AATCCCTATGCATCTGGCATGTATCTTCCTTTTTCAAGTGTATGGCTTCGATCTACAGACCGGCTTTCCGACTGTGTCGG
GTTCCACCAAGCCGCCTTGGCCTACGCTTCTGACTATGGGTTGATTACCACGGCAGGTCTGCCGCACGATGTACCTTCCC
AAAAGGGTAAGTACCTTGAGGCGAGCCTTGACCATGCCCTGTGGTACCATCGTGATTTCCGGATGGATGAGTGGGTCCTT
TATGTCGCCGAGAGCCCGAGTGCTTCCAATGCTCGTGGTTTTTCGCAGGGGCAGTTTTTTTCCCGTGACGGCAGACTTAT
TGCTTCTGTGGCTCAGGAAGGGCTGATACGAGAGCGTCGTTTGTCAGTCGCTTGA

Upstream 100 bases:

>100_bases
GGCAGGCAACTGTTTGCAGCATGGAGTCAAAAAGATAAAGCCTGATGTTGTTGGATTACCGGACGGTAGTGCTGTAAAAC
GGAAGAAGGTGTCGCGTGAT

Downstream 100 bases:

>100_bases
TTCCTTCATGTGTAAGCGCGTAAGGGAAAGGTGTATATTTTCCATGCATCGAACGGTCGATTTATGGCGGTGTAAATGTA
ATAACTGATAGGGAGCTTAT

Product: Acyl-CoA thioesterase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKQILPEILELEQIEENLYRGLSQNLGVNRIYGGQVLGQALAAAGKTVIGRKAHSFHAYFLLMGDNKLPVMYEVDRIHEG
HSFATRRVVAIQRGRAIFAMTASFQIEEKGLEHQASMPEVPAPEELPTLVETLGKMAAPNRRLQNFFNNFPIEIRPVKPV
NPYASGMYLPFSSVWLRSTDRLSDCVGFHQAALAYASDYGLITTAGLPHDVPSQKGKYLEASLDHALWYHRDFRMDEWVL
YVAESPSASNARGFSQGQFFSRDGRLIASVAQEGLIRERRLSVA

Sequences:

>Translated_284_residues
MKQILPEILELEQIEENLYRGLSQNLGVNRIYGGQVLGQALAAAGKTVIGRKAHSFHAYFLLMGDNKLPVMYEVDRIHEG
HSFATRRVVAIQRGRAIFAMTASFQIEEKGLEHQASMPEVPAPEELPTLVETLGKMAAPNRRLQNFFNNFPIEIRPVKPV
NPYASGMYLPFSSVWLRSTDRLSDCVGFHQAALAYASDYGLITTAGLPHDVPSQKGKYLEASLDHALWYHRDFRMDEWVL
YVAESPSASNARGFSQGQFFSRDGRLIASVAQEGLIRERRLSVA
>Mature_284_residues
MKQILPEILELEQIEENLYRGLSQNLGVNRIYGGQVLGQALAAAGKTVIGRKAHSFHAYFLLMGDNKLPVMYEVDRIHEG
HSFATRRVVAIQRGRAIFAMTASFQIEEKGLEHQASMPEVPAPEELPTLVETLGKMAAPNRRLQNFFNNFPIEIRPVKPV
NPYASGMYLPFSSVWLRSTDRLSDCVGFHQAALAYASDYGLITTAGLPHDVPSQKGKYLEASLDHALWYHRDFRMDEWVL
YVAESPSASNARGFSQGQFFSRDGRLIASVAQEGLIRERRLSVA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=286, Percent_Identity=39.5104895104895, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1786657, Length=270, Percent_Identity=45.1851851851852, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71988741, Length=297, Percent_Identity=37.7104377104377, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17558508, Length=310, Percent_Identity=37.4193548387097, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI115532456, Length=270, Percent_Identity=37.4074074074074, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17531889, Length=270, Percent_Identity=37.4074074074074, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531885, Length=270, Percent_Identity=37.4074074074074, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71982224, Length=301, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI212645202, Length=283, Percent_Identity=31.095406360424, Blast_Score=117, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31838; Mature: 31838

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQILPEILELEQIEENLYRGLSQNLGVNRIYGGQVLGQALAAAGKTVIGRKAHSFHAYF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCHHHCCCCCCEEEEE
LLMGDNKLPVMYEVDRIHEGHSFATRRVVAIQRGRAIFAMTASFQIEEKGLEHQASMPEV
EEECCCCCCEEEEHHHHCCCCHHHHHEEEEEECCCEEEEEEEEEEEHHHCCHHHCCCCCC
PAPEELPTLVETLGKMAAPNRRLQNFFNNFPIEIRPVKPVNPYASGMYLPFSSVWLRSTD
CCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEECCHHHHHHCCHH
RLSDCVGFHQAALAYASDYGLITTAGLPHDVPSQKGKYLEASLDHALWYHRDFRMDEWVL
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
YVAESPSASNARGFSQGQFFSRDGRLIASVAQEGLIRERRLSVA
EEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQILPEILELEQIEENLYRGLSQNLGVNRIYGGQVLGQALAAAGKTVIGRKAHSFHAYF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCHHHCCCCCCEEEEE
LLMGDNKLPVMYEVDRIHEGHSFATRRVVAIQRGRAIFAMTASFQIEEKGLEHQASMPEV
EEECCCCCCEEEEHHHHCCCCHHHHHEEEEEECCCEEEEEEEEEEEHHHCCHHHCCCCCC
PAPEELPTLVETLGKMAAPNRRLQNFFNNFPIEIRPVKPVNPYASGMYLPFSSVWLRSTD
CCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEECCHHHHHHCCHH
RLSDCVGFHQAALAYASDYGLITTAGLPHDVPSQKGKYLEASLDHALWYHRDFRMDEWVL
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
YVAESPSASNARGFSQGQFFSRDGRLIASVAQEGLIRERRLSVA
EEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]