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The map label for this gene is mutB [H]

Identifier: 78223413

GI number: 78223413

Start: 2498486

End: 2498893

Strand: Reverse

Name: mutB [H]

Synonym: Gmet_2208

Alternate gene names: 78223413

Gene position: 2498893-2498486 (Counterclockwise)

Preceding gene: 78223414

Following gene: 78223412

Centisome position: 62.51

GC content: 51.72

Gene sequence:

>408_bases
ATGTCCAATCAACACATAAAAGTACTATTGGCAAAGAAAAAAATCGACGTCCATGGTCGCGCTAGCAAGCTGATCGCGCG
AGAACTGCGGGATGCGGGCATGGAGGTGGTCTATTTCCGCTTCGGCACGGTTGACGACATCGTCACGGCGGCGATCCAGG
AAGATGTTAACGTGATTGCGCTCAGCATCATGACGAGCGGACACATGCTGATTGCCAAGAAGCTGATCCCTGCTCTCAAG
GCAAACGGTATGACTGATGTCCTGGTGATAATCGGTGGCATTATCCCCGAGGTGGATTTCGAAGAACTGGAGAAGATCGG
CATTCACAAATGCTTCATTTCCGGCCTGCCGGGAGAAACCGTTGCCGAATACATCAAGGAAAATGTGGGCAAGGTCAGCT
TGCGCTAG

Upstream 100 bases:

>100_bases
CGGTTGGGTAGTGACGGAATAGGCTGGTTCTGTCGGTAACAGGGATTGTGCGCGCAGAGTCTACTACTTCAATGAAGATT
GATAATTCGAGGTGAATGGT

Downstream 100 bases:

>100_bases
TGCCGTAGCAGCATAAACAAAACAACTGGTCGAAAGGTGAATCCCATGTCTTTTGAGACTATCATTCTGGACAAGAAAGA
TGGCATTGCCACCATAACGT

Product: methylmalonyl-CoA mutase-like

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MSNQHIKVLLAKKKIDVHGRASKLIARELRDAGMEVVYFRFGTVDDIVTAAIQEDVNVIALSIMTSGHMLIAKKLIPALK
ANGMTDVLVIIGGIIPEVDFEELEKIGIHKCFISGLPGETVAEYIKENVGKVSLR

Sequences:

>Translated_135_residues
MSNQHIKVLLAKKKIDVHGRASKLIARELRDAGMEVVYFRFGTVDDIVTAAIQEDVNVIALSIMTSGHMLIAKKLIPALK
ANGMTDVLVIIGGIIPEVDFEELEKIGIHKCFISGLPGETVAEYIKENVGKVSLR
>Mature_134_residues
SNQHIKVLLAKKKIDVHGRASKLIARELRDAGMEVVYFRFGTVDDIVTAAIQEDVNVIALSIMTSGHMLIAKKLIPALKA
NGMTDVLVIIGGIIPEVDFEELEKIGIHKCFISGLPGETVAEYIKENVGKVSLR

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=110, Percent_Identity=33.6363636363636, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789284, Length=112, Percent_Identity=33.9285714285714, Blast_Score=70, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25144500, Length=124, Percent_Identity=34.6774193548387, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 14768; Mature: 14637

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQHIKVLLAKKKIDVHGRASKLIARELRDAGMEVVYFRFGTVDDIVTAAIQEDVNVIA
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHEEE
LSIMTSGHMLIAKKLIPALKANGMTDVLVIIGGIIPEVDFEELEKIGIHKCFISGLPGET
EEEHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHH
VAEYIKENVGKVSLR
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNQHIKVLLAKKKIDVHGRASKLIARELRDAGMEVVYFRFGTVDDIVTAAIQEDVNVIA
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHEEE
LSIMTSGHMLIAKKLIPALKANGMTDVLVIIGGIIPEVDFEELEKIGIHKCFISGLPGET
EEEHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHH
VAEYIKENVGKVSLR
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2569861; 2569860; 8805541; 9655823 [H]