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The map label for this gene is mip [H]

Identifier: 78223371

GI number: 78223371

Start: 2441734

End: 2442519

Strand: Direct

Name: mip [H]

Synonym: Gmet_2164

Alternate gene names: 78223371

Gene position: 2441734-2442519 (Clockwise)

Preceding gene: 78223370

Following gene: 78223372

Centisome position: 61.08

GC content: 58.14

Gene sequence:

>786_bases
ATGAGCCGGTTTTCTCATCTGAAATGGGGTGATTACTCGCTGAAATCCCCCGAATCCGTACCAGCCTTTCCCTGCCTCAG
GGGCAATAGCCGCGGCAGGAGATGTATCCCCATAGGAATCTGGGGCTTGATCCTGTTGTTCTGTGCGGTATCCGCCGCCC
TCGGTCAGGAGATCAAGGGAGAGAATGCAAAGCTCAACTACAGCGTGGGCTACCAGGTGGGCAGTGATTTCAAGGCCCAT
GGCGTGGAACTGGACCCCGACGCACTGATGCAGGGGGTACAGGATGCCGTCAAGCAGAAAGAGCCGTCTGTGTCCAAAGA
AGAGATGAACAAGTCCCTGACGGGACTCAAACGGAAGATTGATGCCGCCGGGCAGACGAGCGCCCGGCAGAAAACCGCCG
AGTACCGCCGCGCCAGCGAGGCATTTCTGAAGGAGAACGCCCAAAAGGAAGGGGTCAAGATCCTGCCGAGCGGCGTCCAG
TACCGGGTAATCAGCGAAGGGAGCGGCAAAATGCCAACCCTCAAGGATGAGGTAAAGGTCCACTATCGCATCTCGCGGAT
AGACGGCAAGGAGTTGGGCAACACCTATGACGCCGGCATTCCGAGAACCGTCTCCGTGGCAAAAGCGATGCCGGCCCTCC
AGGAGGTGCTGCCGCTGATGGCCGAGGGGTCCAAGTGGCAGGTCGTCATCCCCACTGGCACCGCTTCGGGAAACAAGGAA
CCCCTGGATGACCAGGGAGTTTTGATCTACGACCTGGAACTGGTTTCCGTTATTCCGGCTAAATAG

Upstream 100 bases:

>100_bases
TGTCCAGGTCGCGCCTCGAGGCCGCGATCACGGCCCGTAACAGGTTTCTGCAGGAGAATGAGTGATCCGTCATATCCAAA
AATCAAGGAGGAATCAGTAC

Downstream 100 bases:

>100_bases
GCGACCTTCAACGTCTCTATAAAAACCTAGGGAAAGGTGGTGATCGGAAAGACGGCAGGGATTGCTGCAGACATCGCTGA
ACCATCTCCGGAGCGACACA

Product: FKBP-type peptidyl-prolyl isomerase-like:peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSRFSHLKWGDYSLKSPESVPAFPCLRGNSRGRRCIPIGIWGLILLFCAVSAALGQEIKGENAKLNYSVGYQVGSDFKAH
GVELDPDALMQGVQDAVKQKEPSVSKEEMNKSLTGLKRKIDAAGQTSARQKTAEYRRASEAFLKENAQKEGVKILPSGVQ
YRVISEGSGKMPTLKDEVKVHYRISRIDGKELGNTYDAGIPRTVSVAKAMPALQEVLPLMAEGSKWQVVIPTGTASGNKE
PLDDQGVLIYDLELVSVIPAK

Sequences:

>Translated_261_residues
MSRFSHLKWGDYSLKSPESVPAFPCLRGNSRGRRCIPIGIWGLILLFCAVSAALGQEIKGENAKLNYSVGYQVGSDFKAH
GVELDPDALMQGVQDAVKQKEPSVSKEEMNKSLTGLKRKIDAAGQTSARQKTAEYRRASEAFLKENAQKEGVKILPSGVQ
YRVISEGSGKMPTLKDEVKVHYRISRIDGKELGNTYDAGIPRTVSVAKAMPALQEVLPLMAEGSKWQVVIPTGTASGNKE
PLDDQGVLIYDLELVSVIPAK
>Mature_260_residues
SRFSHLKWGDYSLKSPESVPAFPCLRGNSRGRRCIPIGIWGLILLFCAVSAALGQEIKGENAKLNYSVGYQVGSDFKAHG
VELDPDALMQGVQDAVKQKEPSVSKEEMNKSLTGLKRKIDAAGQTSARQKTAEYRRASEAFLKENAQKEGVKILPSGVQY
RVISEGSGKMPTLKDEVKVHYRISRIDGKELGNTYDAGIPRTVSVAKAMPALQEVLPLMAEGSKWQVVIPTGTASGNKEP
LDDQGVLIYDLELVSVIPAK

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=201, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789745, Length=212, Percent_Identity=28.7735849056604, Blast_Score=87, Evalue=9e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28432; Mature: 28301

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFSHLKWGDYSLKSPESVPAFPCLRGNSRGRRCIPIGIWGLILLFCAVSAALGQEIKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC
ENAKLNYSVGYQVGSDFKAHGVELDPDALMQGVQDAVKQKEPSVSKEEMNKSLTGLKRKI
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DAAGQTSARQKTAEYRRASEAFLKENAQKEGVKILPSGVQYRVISEGSGKMPTLKDEVKV
HCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCEEECCCCEEEEEECCCCCCCCCHHHEEE
HYRISRIDGKELGNTYDAGIPRTVSVAKAMPALQEVLPLMAEGSKWQVVIPTGTASGNKE
EEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
PLDDQGVLIYDLELVSVIPAK
CCCCCCEEEEEEEEEHHCCCC
>Mature Secondary Structure 
SRFSHLKWGDYSLKSPESVPAFPCLRGNSRGRRCIPIGIWGLILLFCAVSAALGQEIKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC
ENAKLNYSVGYQVGSDFKAHGVELDPDALMQGVQDAVKQKEPSVSKEEMNKSLTGLKRKI
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DAAGQTSARQKTAEYRRASEAFLKENAQKEGVKILPSGVQYRVISEGSGKMPTLKDEVKV
HCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCEEECCCCEEEEEECCCCCCCCCHHHEEE
HYRISRIDGKELGNTYDAGIPRTVSVAKAMPALQEVLPLMAEGSKWQVVIPTGTASGNKE
EEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
PLDDQGVLIYDLELVSVIPAK
CCCCCCEEEEEEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7516906 [H]