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The map label for this gene is hcrA [H]

Identifier: 78223343

GI number: 78223343

Start: 2402117

End: 2404423

Strand: Direct

Name: hcrA [H]

Synonym: Gmet_2136

Alternate gene names: 78223343

Gene position: 2402117-2404423 (Clockwise)

Preceding gene: 78223342

Following gene: 78223344

Centisome position: 60.09

GC content: 63.81

Gene sequence:

>2307_bases
ATGAGCGACAATCATAAAGTCATCGGCCGCAGCGTTCCCCGCATCGACGGGCCCGAGAAGGTAACCGGCGCGGCAAAGTA
TACCGGGGATCTCAAGTTCCCCAACATGCTCTACGGCAAGATCCTCACCAGCCCCCATGCCCACGCCAGGATCATCTCCA
TCGACACCTCCGAGGCGGAGAAGCTGCCGGGGGTGAAGGCGGTCATCACCCACAAGGATGTGCCGGAGCTGAAGTATGGC
CTGAGCCCGGCCCGGTGGGACGAAAACATCTTCTGCATCGACAAGGTGCGCTTCGTCGGCGACAAGGTGGCGGCGGTCGC
CTGCGTAGACGAGGATACCTGCTACCGGGCCATGAAGCTCATCAAGGTGGAATACGAAGAGCTCCCCGCAGTGCTCGATT
TCCGTCACGCCATGGACGAGGGGCAGCCTCTGGTCCACGAGGAGTACGAGCGGAACATCAACACCGAGATTCACCAGGAG
TTCGGCGACGTGGCAAAGGCCCTGGCAGAGGCCCACCATGTCCGTACCGACGTCTTCGTGGGCCAGCGGACCTATCAGGC
CCCCATCGAGCCCCACTCCGCCATCTCCATGTGGGAAGGGGAAAAACTCACCATCTATTCCAGCACCCAGTCCCCCCACT
ACTTCCAGTACTACATCGCCCGGGAGTTCGGCATGCCCATGGGGGACGTGCGGATCATCAAGCCATACCTGGGGGGAGGT
TTCGGCGGCAAGCTGGAGCCCACGGGCCTGGAGTTTGCCGGAGCGGTGCTGGCGAAGCGGACCGGCCGGCCGGTGCGGAC
CTTCTACGACCGGGCCGAAATGTTTGCCCACAACCGGGGGCGCCACGCCCAGTACATGGAGATCACCACCGGGGTGGACA
AGGACGGCAAGATCCTGGCCGCCAAGGCCAACTTCATCATGGACGGCGGCGCCTACACGAGCCTCGGGATCGCCAGCGCC
TACTACGCCGGCGCGCTCCTTCCCATGACCTACGAATTCGACAACTACCAGTTCGACATGTTCCGGGTCTACACCAACCT
CCCCGCCTGCGGCGCCCAGCGGGGCCACGGCGCTCCCCAGCCCAAGTACGCCTTCGAGAGCCATCTGGACAACGTGGCCG
CCGACCTGGGGATCGACCCCATGGACATCCGGATCCGCAATGCCCGCCGTCCCGACACCGTCACCCCCAATGACTTCCGG
GTCAACTCCTGCATGATGCGGGAGTGCCTGGAACAGGTCCGGCAGATCTCGGACTGGGACGAGAAAAAGAAAAACCTCCC
CCACGGACGCGGCATCGGCGTCGCCACCGGCAGCTTCGTCACCGGCGCGGGGTACCCCATCTACCGCACCGACCTCCCCC
ACGCCGCCGCCTTCATCAAGGTGCATGAGGACGGCACCGCAGCCACCCTCTACACCGGCTCTGTCGACATCGGCCAGGGA
TCTGATACCATTCTCTGTCAGATGGCGGCCGAGGCCATGGGGTATCGCTACGAGCAGATGAAGATCGTGGCCGCCGACAC
GGAGATCACACCGCTCGATTTCGGCGCCTACGCCAGCCGCCAGACCTACATGTCAGGGGCGGCCGTCAAGCAGGCGGGGG
AAGAGGTCAAGAAGCAGCTCCTCGACCTGGCGTCGACCATGCTTTCCCTCCCTGCCGACGACCTTGAGTGCGCGGAAGGG
GTTATTTTCTCCAAGTCGCGGGAAGGGAAGACACTGACGTTCGAGGAAGTGGCACGGAAACACTTCGTCCTCAAGGGCCC
GCTCCTGGGACGCGGCGCCTACACGCCGCCGAAACTTGGCGGAAGCTTCAAGGGGGCCGCGGTCGGCACGTCGCCCGCCT
ACAGCTTCGGCGCCCAGGTGGGAGAGGTTTCCATCGACGAGGAAACGGGAGAAATCACCGTGGTGGGCATCTGGGACGTC
CACGACTGCGGCAAGGTCATCAACCCGCGGCTGCTCCACGGCCAGGTCCACGGCGCCCTCTACATGGGGATGGGGGAATC
GGTCTGGGAAGAGGTGCTCTTCGACGACAAGGGACGGATCAAGAATGCGGAACTGGCCAATTACCGGCTCCTCACCGCCG
TGGACATGCCCCCCATCCAGTCGGAGGTGGTGAACAGCTACGAACCGACCGGGCCGTGGGGGGTGAAGGAAGTGGGCGAA
GGGGCCACCAACCCTACCCTGGGGATGTTCAGCAATGCCATCTTCGACGCCATGGGGGTCAGGGTGAACAGTCTGCCGCT
CACCTACGAGAAGGTCTGGCGGGCACTGAAGGAAAAGCGGGAGCGGGAAGAGACCAAGGCGGCATAA

Upstream 100 bases:

>100_bases
CAATCTCTGCCGCTGCACCGGCTACGTTCATATCGTCGAGGCCGTTCTGGCCGCATCCCAAGGGCGAACTGCGCCGGCCG
AGCATTAAGGAGAACAACAG

Downstream 100 bases:

>100_bases
AAACGGCAGCAGGAGTCAGCCATGTGGGACTGGATCGGAAAACTCGATGAACTGCGACGCAGCAACCAGCTGGCGGTGCT
GGTGACGGTGACGAAGAGCA

Product: xanthine dehydrogenase, molybdenum binding subunit apoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MSDNHKVIGRSVPRIDGPEKVTGAAKYTGDLKFPNMLYGKILTSPHAHARIISIDTSEAEKLPGVKAVITHKDVPELKYG
LSPARWDENIFCIDKVRFVGDKVAAVACVDEDTCYRAMKLIKVEYEELPAVLDFRHAMDEGQPLVHEEYERNINTEIHQE
FGDVAKALAEAHHVRTDVFVGQRTYQAPIEPHSAISMWEGEKLTIYSSTQSPHYFQYYIAREFGMPMGDVRIIKPYLGGG
FGGKLEPTGLEFAGAVLAKRTGRPVRTFYDRAEMFAHNRGRHAQYMEITTGVDKDGKILAAKANFIMDGGAYTSLGIASA
YYAGALLPMTYEFDNYQFDMFRVYTNLPACGAQRGHGAPQPKYAFESHLDNVAADLGIDPMDIRIRNARRPDTVTPNDFR
VNSCMMRECLEQVRQISDWDEKKKNLPHGRGIGVATGSFVTGAGYPIYRTDLPHAAAFIKVHEDGTAATLYTGSVDIGQG
SDTILCQMAAEAMGYRYEQMKIVAADTEITPLDFGAYASRQTYMSGAAVKQAGEEVKKQLLDLASTMLSLPADDLECAEG
VIFSKSREGKTLTFEEVARKHFVLKGPLLGRGAYTPPKLGGSFKGAAVGTSPAYSFGAQVGEVSIDEETGEITVVGIWDV
HDCGKVINPRLLHGQVHGALYMGMGESVWEEVLFDDKGRIKNAELANYRLLTAVDMPPIQSEVVNSYEPTGPWGVKEVGE
GATNPTLGMFSNAIFDAMGVRVNSLPLTYEKVWRALKEKREREETKAA

Sequences:

>Translated_768_residues
MSDNHKVIGRSVPRIDGPEKVTGAAKYTGDLKFPNMLYGKILTSPHAHARIISIDTSEAEKLPGVKAVITHKDVPELKYG
LSPARWDENIFCIDKVRFVGDKVAAVACVDEDTCYRAMKLIKVEYEELPAVLDFRHAMDEGQPLVHEEYERNINTEIHQE
FGDVAKALAEAHHVRTDVFVGQRTYQAPIEPHSAISMWEGEKLTIYSSTQSPHYFQYYIAREFGMPMGDVRIIKPYLGGG
FGGKLEPTGLEFAGAVLAKRTGRPVRTFYDRAEMFAHNRGRHAQYMEITTGVDKDGKILAAKANFIMDGGAYTSLGIASA
YYAGALLPMTYEFDNYQFDMFRVYTNLPACGAQRGHGAPQPKYAFESHLDNVAADLGIDPMDIRIRNARRPDTVTPNDFR
VNSCMMRECLEQVRQISDWDEKKKNLPHGRGIGVATGSFVTGAGYPIYRTDLPHAAAFIKVHEDGTAATLYTGSVDIGQG
SDTILCQMAAEAMGYRYEQMKIVAADTEITPLDFGAYASRQTYMSGAAVKQAGEEVKKQLLDLASTMLSLPADDLECAEG
VIFSKSREGKTLTFEEVARKHFVLKGPLLGRGAYTPPKLGGSFKGAAVGTSPAYSFGAQVGEVSIDEETGEITVVGIWDV
HDCGKVINPRLLHGQVHGALYMGMGESVWEEVLFDDKGRIKNAELANYRLLTAVDMPPIQSEVVNSYEPTGPWGVKEVGE
GATNPTLGMFSNAIFDAMGVRVNSLPLTYEKVWRALKEKREREETKAA
>Mature_767_residues
SDNHKVIGRSVPRIDGPEKVTGAAKYTGDLKFPNMLYGKILTSPHAHARIISIDTSEAEKLPGVKAVITHKDVPELKYGL
SPARWDENIFCIDKVRFVGDKVAAVACVDEDTCYRAMKLIKVEYEELPAVLDFRHAMDEGQPLVHEEYERNINTEIHQEF
GDVAKALAEAHHVRTDVFVGQRTYQAPIEPHSAISMWEGEKLTIYSSTQSPHYFQYYIAREFGMPMGDVRIIKPYLGGGF
GGKLEPTGLEFAGAVLAKRTGRPVRTFYDRAEMFAHNRGRHAQYMEITTGVDKDGKILAAKANFIMDGGAYTSLGIASAY
YAGALLPMTYEFDNYQFDMFRVYTNLPACGAQRGHGAPQPKYAFESHLDNVAADLGIDPMDIRIRNARRPDTVTPNDFRV
NSCMMRECLEQVRQISDWDEKKKNLPHGRGIGVATGSFVTGAGYPIYRTDLPHAAAFIKVHEDGTAATLYTGSVDIGQGS
DTILCQMAAEAMGYRYEQMKIVAADTEITPLDFGAYASRQTYMSGAAVKQAGEEVKKQLLDLASTMLSLPADDLECAEGV
IFSKSREGKTLTFEEVARKHFVLKGPLLGRGAYTPPKLGGSFKGAAVGTSPAYSFGAQVGEVSIDEETGEITVVGIWDVH
DCGKVINPRLLHGQVHGALYMGMGESVWEEVLFDDKGRIKNAELANYRLLTAVDMPPIQSEVVNSYEPTGPWGVKEVGEG
ATNPTLGMFSNAIFDAMGVRVNSLPLTYEKVWRALKEKREREETKAA

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To xanthine oxidases [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=697, Percent_Identity=26.8292682926829, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI71773480, Length=783, Percent_Identity=26.309067688378, Blast_Score=196, Evalue=7e-50,
Organism=Escherichia coli, GI1789230, Length=766, Percent_Identity=32.8981723237598, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1789246, Length=820, Percent_Identity=31.219512195122, Blast_Score=351, Evalue=8e-98,
Organism=Escherichia coli, GI1786478, Length=779, Percent_Identity=27.98459563543, Blast_Score=209, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17540638, Length=759, Percent_Identity=25.1646903820817, Blast_Score=180, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32566215, Length=781, Percent_Identity=22.9193341869398, Blast_Score=142, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17539860, Length=719, Percent_Identity=22.9485396383866, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17737937, Length=748, Percent_Identity=28.8770053475936, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24647193, Length=724, Percent_Identity=26.2430939226519, Blast_Score=146, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24647201, Length=731, Percent_Identity=25.4445964432285, Blast_Score=142, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24647199, Length=714, Percent_Identity=23.249299719888, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24647195, Length=748, Percent_Identity=22.9946524064171, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24647197, Length=739, Percent_Identity=23.1393775372125, Blast_Score=122, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017607
- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 84673; Mature: 84542

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNHKVIGRSVPRIDGPEKVTGAAKYTGDLKFPNMLYGKILTSPHAHARIISIDTSEAE
CCCCCCCCCCCCCCCCCCHHHCCCCEECCCCCCCHHHHHHHHCCCCCCEEEEEEECHHHH
KLPGVKAVITHKDVPELKYGLSPARWDENIFCIDKVRFVGDKVAAVACVDEDTCYRAMKL
HCCCCEEEEECCCCCHHHHCCCCCCCCCCEEEEEHHHHHCCCEEEEEEECCHHHHHHHHH
IKVEYEELPAVLDFRHAMDEGQPLVHEEYERNINTEIHQEFGDVAKALAEAHHVRTDVFV
HHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
GQRTYQAPIEPHSAISMWEGEKLTIYSSTQSPHYFQYYIAREFGMPMGDVRIIKPYLGGG
CCCEEECCCCCCCCEEECCCCEEEEEECCCCCCEEEEEEEHHHCCCCCCEEEEEHHHCCC
FGGKLEPTGLEFAGAVLAKRTGRPVRTFYDRAEMFAHNRGRHAQYMEITTGVDKDGKILA
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEE
AKANFIMDGGAYTSLGIASAYYAGALLPMTYEFDNYQFDMFRVYTNLPACGAQRGHGAPQ
EECCEEECCCCCHHHHHHHHHHHCEEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCC
PKYAFESHLDNVAADLGIDPMDIRIRNARRPDTVTPNDFRVNSCMMRECLEQVRQISDWD
CCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHH
EKKKNLPHGRGIGVATGSFVTGAGYPIYRTDLPHAAAFIKVHEDGTAATLYTGSVDIGQG
HHHHCCCCCCCCEEECCCEEECCCCCEEECCCCCCEEEEEEECCCCEEEEEECCEECCCC
SDTILCQMAAEAMGYRYEQMKIVAADTEITPLDFGAYASRQTYMSGAAVKQAGEEVKKQL
CCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHH
LDLASTMLSLPADDLECAEGVIFSKSREGKTLTFEEVARKHFVLKGPLLGRGAYTPPKLG
HHHHHHHHHCCCCHHHHHCCEEEECCCCCCEEEHHHHHHHHEEEECCEECCCCCCCCCCC
GSFKGAAVGTSPAYSFGAQVGEVSIDEETGEITVVGIWDVHDCGKVINPRLLHGQVHGAL
CCCCCCCCCCCCCHHHCCCCCCEEECCCCCCEEEEEEECCHHHHHHCCCEEEEEEECCEE
YMGMGESVWEEVLFDDKGRIKNAELANYRLLTAVDMPPIQSEVVNSYEPTGPWGVKEVGE
EECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCHHHHCC
GATNPTLGMFSNAIFDAMGVRVNSLPLTYEKVWRALKEKREREETKAA
CCCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDNHKVIGRSVPRIDGPEKVTGAAKYTGDLKFPNMLYGKILTSPHAHARIISIDTSEAE
CCCCCCCCCCCCCCCCCHHHCCCCEECCCCCCCHHHHHHHHCCCCCCEEEEEEECHHHH
KLPGVKAVITHKDVPELKYGLSPARWDENIFCIDKVRFVGDKVAAVACVDEDTCYRAMKL
HCCCCEEEEECCCCCHHHHCCCCCCCCCCEEEEEHHHHHCCCEEEEEEECCHHHHHHHHH
IKVEYEELPAVLDFRHAMDEGQPLVHEEYERNINTEIHQEFGDVAKALAEAHHVRTDVFV
HHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
GQRTYQAPIEPHSAISMWEGEKLTIYSSTQSPHYFQYYIAREFGMPMGDVRIIKPYLGGG
CCCEEECCCCCCCCEEECCCCEEEEEECCCCCCEEEEEEEHHHCCCCCCEEEEEHHHCCC
FGGKLEPTGLEFAGAVLAKRTGRPVRTFYDRAEMFAHNRGRHAQYMEITTGVDKDGKILA
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEE
AKANFIMDGGAYTSLGIASAYYAGALLPMTYEFDNYQFDMFRVYTNLPACGAQRGHGAPQ
EECCEEECCCCCHHHHHHHHHHHCEEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCC
PKYAFESHLDNVAADLGIDPMDIRIRNARRPDTVTPNDFRVNSCMMRECLEQVRQISDWD
CCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCHH
EKKKNLPHGRGIGVATGSFVTGAGYPIYRTDLPHAAAFIKVHEDGTAATLYTGSVDIGQG
HHHHCCCCCCCCEEECCCEEECCCCCEEECCCCCCEEEEEEECCCCEEEEEECCEECCCC
SDTILCQMAAEAMGYRYEQMKIVAADTEITPLDFGAYASRQTYMSGAAVKQAGEEVKKQL
CCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHH
LDLASTMLSLPADDLECAEGVIFSKSREGKTLTFEEVARKHFVLKGPLLGRGAYTPPKLG
HHHHHHHHHCCCCHHHHHCCEEEECCCCCCEEEHHHHHHHHEEEECCEECCCCCCCCCCC
GSFKGAAVGTSPAYSFGAQVGEVSIDEETGEITVVGIWDVHDCGKVINPRLLHGQVHGAL
CCCCCCCCCCCCCHHHCCCCCCEEECCCCCCEEEEEEECCHHHHHHCCCEEEEEEECCEE
YMGMGESVWEEVLFDDKGRIKNAELANYRLLTAVDMPPIQSEVVNSYEPTGPWGVKEVGE
EECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCHHHHCC
GATNPTLGMFSNAIFDAMGVRVNSLPLTYEKVWRALKEKREREETKAA
CCCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]