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The map label for this gene is menB [H]

Identifier: 78223295

GI number: 78223295

Start: 2349629

End: 2350774

Strand: Reverse

Name: menB [H]

Synonym: Gmet_2088

Alternate gene names: 78223295

Gene position: 2350774-2349629 (Counterclockwise)

Preceding gene: 78223300

Following gene: 78223294

Centisome position: 58.81

GC content: 62.04

Gene sequence:

>1146_bases
ATGGCGAGAACAGACGAGATAATCGCAAGAACCGCACCGGGGCACCTGAACGACCACAATTTGATCGACCGTGAGGTTGA
GAGCCTCTGCGACGGCATGGTGAAGTACGAGAAGCGGCCGGCAAAGCGTCATGACGGCAGTGTGGCAGAGGGGATTTACA
ACGCCTGGATCATCCTGGACAACCCCAAGCAGTACAACTCCTACACCACTGACATGGTCAAGGCAATCATCCTCGCCTTC
CGGCGGGCCTCGGTCGACCGCTCCGTGAATGCCGTGGTCTTCACCGGTGTTGGCGACAAGGCGTTCTGCACCGGCGGCAA
TACCAAGGAATACGCAGAGTACTATGCCGGTAACCCCCAAGAGTATCGCCAGTACATGCGGCTGTTCAACGACATGGTCT
CCGCCATCCTCGGCTGCGACAAGGCGGTGATCAGCCGGGTGAACGGGATGCGGATCGGCGGCGGCCAGGAAATCGGCATG
GCCTGCGACTTCTCCATCGCCCAGGACCTGGCCAACTTCGGTCAGGCCGGTCCCAAGCATGGCTCTGCCGCCATCGGCGG
GGCGACCGATTTCCTGCCGCTGATGGTCGGCTGCGAGCAGGCCATGGTGTCCGGTACGCTGTGCGAGCCGTTCTCGGCCC
ACAAGGCCGCCCGCCTGGGGATCATCTGTGACGTGGTGCCGGCCCTCAAGGTGGGTGGCAAATTCGTCGCCAACCCGACC
GTGGTCACCGACCGTTATCTGGACGAGTACGGCCGGGTCGTTCATGGCGAGTTCAAGGCCGGCGCCGCCTTCAAGGAAGG
GCAGGGGCAGATCAAGGAAGGGGAGATTGATCTCAGTCTGCTGGACGAGAAGGTTGAGTCGCTCTGCACGAAGCTGCTGG
AGACCTTCCCGGAGTGCATGACCAAGAGCCTGGAGGAGCTGCGCAAGCCGAAGCTCCATGCATGGAACCTCAACAAGGAA
AACTCCCGCGCCTGGCTGGCCCTCAACATGATGAATGAGGCCCGCACCGGCTTCCGGGCCTTCAACGAGGGGACCAAGGA
GACCGGCCGCGAGATCGACTTTGTGAAGTTGCGCCAGGGTCTGGCCAAGGGGACGCCCTGGACCGAGGAGCTGATCGAGA
GCCTCATGCCGACGGCGCAGAAGTAA

Upstream 100 bases:

>100_bases
GTAAATCGGTAATGAAGTACTAATTTACATAAATAGAGCATGAAACGTTGTTTTGAATAGTAGGGCTTGTACGAAAATAT
CCAACGGGGGAGGAAAAGCA

Downstream 100 bases:

>100_bases
CGGCAGCGCGCCCGGTGCCCTTACTCCGGTGGGGCACCGGGCGTAGGCAGCTGTAAATAGCGTTTAAAAAATGCTAATCA
AATAACGTTTGACAGTAAAA

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MARTDEIIARTAPGHLNDHNLIDREVESLCDGMVKYEKRPAKRHDGSVAEGIYNAWIILDNPKQYNSYTTDMVKAIILAF
RRASVDRSVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKAVISRVNGMRIGGGQEIGM
ACDFSIAQDLANFGQAGPKHGSAAIGGATDFLPLMVGCEQAMVSGTLCEPFSAHKAARLGIICDVVPALKVGGKFVANPT
VVTDRYLDEYGRVVHGEFKAGAAFKEGQGQIKEGEIDLSLLDEKVESLCTKLLETFPECMTKSLEELRKPKLHAWNLNKE
NSRAWLALNMMNEARTGFRAFNEGTKETGREIDFVKLRQGLAKGTPWTEELIESLMPTAQK

Sequences:

>Translated_381_residues
MARTDEIIARTAPGHLNDHNLIDREVESLCDGMVKYEKRPAKRHDGSVAEGIYNAWIILDNPKQYNSYTTDMVKAIILAF
RRASVDRSVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKAVISRVNGMRIGGGQEIGM
ACDFSIAQDLANFGQAGPKHGSAAIGGATDFLPLMVGCEQAMVSGTLCEPFSAHKAARLGIICDVVPALKVGGKFVANPT
VVTDRYLDEYGRVVHGEFKAGAAFKEGQGQIKEGEIDLSLLDEKVESLCTKLLETFPECMTKSLEELRKPKLHAWNLNKE
NSRAWLALNMMNEARTGFRAFNEGTKETGREIDFVKLRQGLAKGTPWTEELIESLMPTAQK
>Mature_380_residues
ARTDEIIARTAPGHLNDHNLIDREVESLCDGMVKYEKRPAKRHDGSVAEGIYNAWIILDNPKQYNSYTTDMVKAIILAFR
RASVDRSVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKAVISRVNGMRIGGGQEIGMA
CDFSIAQDLANFGQAGPKHGSAAIGGATDFLPLMVGCEQAMVSGTLCEPFSAHKAARLGIICDVVPALKVGGKFVANPTV
VTDRYLDEYGRVVHGEFKAGAAFKEGQGQIKEGEIDLSLLDEKVESLCTKLLETFPECMTKSLEELRKPKLHAWNLNKEN
SRAWLALNMMNEARTGFRAFNEGTKETGREIDFVKLRQGLAKGTPWTEELIESLMPTAQK

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) (Probable) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=194, Percent_Identity=29.3814432989691, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788597, Length=173, Percent_Identity=34.6820809248555, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=241, Percent_Identity=28.2157676348548, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=24.6511627906977, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129971, Length=189, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24653477, Length=189, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24654903, Length=170, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 41952; Mature: 41821

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTDEIIARTAPGHLNDHNLIDREVESLCDGMVKYEKRPAKRHDGSVAEGIYNAWIILD
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEEEE
NPKQYNSYTTDMVKAIILAFRRASVDRSVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQ
CCHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCHHHHHHHHCCCHH
EYRQYMRLFNDMVSAILGCDKAVISRVNGMRIGGGQEIGMACDFSIAQDLANFGQAGPKH
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCCCCCCCCEECHHHHHHHHHHCCCCCCC
GSAAIGGATDFLPLMVGCEQAMVSGTLCEPFSAHKAARLGIICDVVPALKVGGKFVANPT
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCC
VVTDRYLDEYGRVVHGEFKAGAAFKEGQGQIKEGEIDLSLLDEKVESLCTKLLETFPECM
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TKSLEELRKPKLHAWNLNKENSRAWLALNMMNEARTGFRAFNEGTKETGREIDFVKLRQG
HHHHHHHHCCCCEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHH
LAKGTPWTEELIESLMPTAQK
HHCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ARTDEIIARTAPGHLNDHNLIDREVESLCDGMVKYEKRPAKRHDGSVAEGIYNAWIILD
CCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEEEE
NPKQYNSYTTDMVKAIILAFRRASVDRSVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQ
CCHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCHHHHHHHHCCCHH
EYRQYMRLFNDMVSAILGCDKAVISRVNGMRIGGGQEIGMACDFSIAQDLANFGQAGPKH
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCCCCCCCCEECHHHHHHHHHHCCCCCCC
GSAAIGGATDFLPLMVGCEQAMVSGTLCEPFSAHKAARLGIICDVVPALKVGGKFVANPT
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCC
VVTDRYLDEYGRVVHGEFKAGAAFKEGQGQIKEGEIDLSLLDEKVESLCTKLLETFPECM
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TKSLEELRKPKLHAWNLNKENSRAWLALNMMNEARTGFRAFNEGTKETGREIDFVKLRQG
HHHHHHHHCCCCEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHH
LAKGTPWTEELIESLMPTAQK
HHCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA