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The map label for this gene is cat2 [H]

Identifier: 78223261

GI number: 78223261

Start: 2306454

End: 2307779

Strand: Reverse

Name: cat2 [H]

Synonym: Gmet_2054

Alternate gene names: 78223261

Gene position: 2307779-2306454 (Counterclockwise)

Preceding gene: 78223262

Following gene: 78223260

Centisome position: 57.73

GC content: 58.6

Gene sequence:

>1326_bases
ATGAACGTCGTCACACTGAGCAAAAAGAATTTCCAGCAGGAATACCAGCAGAAACTCTGCACAGCGGCAGAAGCGGCATC
AATCGTGAGGTCCGGCGATCACCTCTGTTTCCCCCTCGGCGTGGGTGAGCCGACCCTCTTCGTCAGGGCACTGGCGGCGC
GCAAGCGCGAACTGGAAGGTGTGGTTGTCAACCAGCAGCATCACCTCTGTCCCGACTATTTCACCGAGGATTCGGCCCCG
CACATCAAGGTGAACGCATGGTTCACCAGCCACGTCTCCCGCGAGGCGGTCCAGAAAGGGTGGGCCGACTTCGTTCCCAA
TCACTTCAGCGAGGTCCCCAAGCTTCTGAGCATGTATTGGCCCGTCGAAGTGGCCGGAACCGTGGTTTCCCCCATGGATG
AGTATGGCTACTTCACCTGTAGCCTCTCCGTGGGCTACACCATGGAAGCGGTGAGGAAAGCGATTCAGACCGGCGGCAAG
GTGGTGGTGCAGGTGAATCCCCAGTGCCCCCGCACCCACGGCAACTGTCATATCCACATCTCCGAAGTTACCCATATCAT
CGAGTGCGACGAGCCCCTCAAGGAACTGGATATTCCCCCCATATCCCCGATAGAAGAGGCCATCGGCGGCTATATTGCGG
AAATGATCGATGACGGATCAACCGTCCAGATGGGGTGGGGCGGCATTCCCAACGCGGTCTGCCAGGCATTGCTCAAGAAG
AAGGACCTGGGAATACACACCGAACTGATTTCCAACGGCATCGTTGACCTGATGCTTGCCGGAGCGGTAAACAACTCCCG
CAAAAGCATCCACCGCGGCAAGACCGTGGGCACCTTTGCTCTGGGGACACGGAAAGTTTTCGATTTTATGAATGAAAACC
CGACGATCGAGATGCATCCGGTGGACTACGTTAACGATCCGTACGTCATCGGCCAGATGGACAACATGATCGCCATCAAC
GCCACCATCCAGGTGGATCTGTTGGGGCAGTGCTGCTCCGAATCCTTCGGCCACCTGCAGTGGAGCGGCACCGGCGGACA
GGCCGACTTTGCCCGCGGCGCCAACCGGTCCCGTGGGGGCAAGGCCTTCATCTGTACGGCGTCCACCGCCAAGAACGGAA
CGGTTTCGTGCATCGTGCCGAGCCTGATGGCCGGTTCTTCGGTCACCACCAGCAAGAACGACGTGGATCACGTGGTGACC
GAGTTCGGAGTTGCCAAACTCCGGGGCCAGACCGCCAAGCAGCGGGCCATGAACCTGATCAATGTTGCCCATCCCGATTT
CCGGGGCGAGCTCATGGAAGCAGCCAGGAGAATGAACAGAATCTGA

Upstream 100 bases:

>100_bases
GCTGAAATCGGTGCTGAAATGAAATCTCCCGTAAATCATGGGCAGGTTGCCGGAATAGCTCTTCAAACCACAGACTAAAT
TCACTATGGAGGTATCGGCC

Downstream 100 bases:

>100_bases
ACATAAACACGATTTGGCCTGGTACCCTCCCGGACTGGGACCGGCACCGTACGCCCGGAAGCAACTTTTCCTCGGCGTAC
GGTGCATTTTTTTTTCAGAA

Product: Acetyl-CoA hydrolase/transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNVVTLSKKNFQQEYQQKLCTAAEAASIVRSGDHLCFPLGVGEPTLFVRALAARKRELEGVVVNQQHHLCPDYFTEDSAP
HIKVNAWFTSHVSREAVQKGWADFVPNHFSEVPKLLSMYWPVEVAGTVVSPMDEYGYFTCSLSVGYTMEAVRKAIQTGGK
VVVQVNPQCPRTHGNCHIHISEVTHIIECDEPLKELDIPPISPIEEAIGGYIAEMIDDGSTVQMGWGGIPNAVCQALLKK
KDLGIHTELISNGIVDLMLAGAVNNSRKSIHRGKTVGTFALGTRKVFDFMNENPTIEMHPVDYVNDPYVIGQMDNMIAIN
ATIQVDLLGQCCSESFGHLQWSGTGGQADFARGANRSRGGKAFICTASTAKNGTVSCIVPSLMAGSSVTTSKNDVDHVVT
EFGVAKLRGQTAKQRAMNLINVAHPDFRGELMEAARRMNRI

Sequences:

>Translated_441_residues
MNVVTLSKKNFQQEYQQKLCTAAEAASIVRSGDHLCFPLGVGEPTLFVRALAARKRELEGVVVNQQHHLCPDYFTEDSAP
HIKVNAWFTSHVSREAVQKGWADFVPNHFSEVPKLLSMYWPVEVAGTVVSPMDEYGYFTCSLSVGYTMEAVRKAIQTGGK
VVVQVNPQCPRTHGNCHIHISEVTHIIECDEPLKELDIPPISPIEEAIGGYIAEMIDDGSTVQMGWGGIPNAVCQALLKK
KDLGIHTELISNGIVDLMLAGAVNNSRKSIHRGKTVGTFALGTRKVFDFMNENPTIEMHPVDYVNDPYVIGQMDNMIAIN
ATIQVDLLGQCCSESFGHLQWSGTGGQADFARGANRSRGGKAFICTASTAKNGTVSCIVPSLMAGSSVTTSKNDVDHVVT
EFGVAKLRGQTAKQRAMNLINVAHPDFRGELMEAARRMNRI
>Mature_441_residues
MNVVTLSKKNFQQEYQQKLCTAAEAASIVRSGDHLCFPLGVGEPTLFVRALAARKRELEGVVVNQQHHLCPDYFTEDSAP
HIKVNAWFTSHVSREAVQKGWADFVPNHFSEVPKLLSMYWPVEVAGTVVSPMDEYGYFTCSLSVGYTMEAVRKAIQTGGK
VVVQVNPQCPRTHGNCHIHISEVTHIIECDEPLKELDIPPISPIEEAIGGYIAEMIDDGSTVQMGWGGIPNAVCQALLKK
KDLGIHTELISNGIVDLMLAGAVNNSRKSIHRGKTVGTFALGTRKVFDFMNENPTIEMHPVDYVNDPYVIGQMDNMIAIN
ATIQVDLLGQCCSESFGHLQWSGTGGQADFARGANRSRGGKAFICTASTAKNGTVSCIVPSLMAGSSVTTSKNDVDHVVT
EFGVAKLRGQTAKQRAMNLINVAHPDFRGELMEAARRMNRI

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=475, Percent_Identity=24, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563853, Length=434, Percent_Identity=37.7880184331797, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17538151, Length=433, Percent_Identity=34.1801385681293, Blast_Score=236, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319456, Length=262, Percent_Identity=28.6259541984733, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358615, Length=420, Percent_Identity=40.2380952380952, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 48173; Mature: 48173

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVTLSKKNFQQEYQQKLCTAAEAASIVRSGDHLCFPLGVGEPTLFVRALAARKRELEG
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VVVNQQHHLCPDYFTEDSAPHIKVNAWFTSHVSREAVQKGWADFVPNHFSEVPKLLSMYW
EEECCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHC
PVEVAGTVVSPMDEYGYFTCSLSVGYTMEAVRKAIQTGGKVVVQVNPQCPRTHGNCHIHI
CHHHHHHHHCCHHHCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEH
SEVTHIIECDEPLKELDIPPISPIEEAIGGYIAEMIDDGSTVQMGWGGIPNAVCQALLKK
HHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
KDLGIHTELISNGIVDLMLAGAVNNSRKSIHRGKTVGTFALGTRKVFDFMNENPTIEMHP
CCCCHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCCEEEEEHHHHHHHHHHCCCCCEEECC
VDYVNDPYVIGQMDNMIAINATIQVDLLGQCCSESFGHLQWSGTGGQADFARGANRSRGG
CCCCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHCCCEEECCCCCCCHHHCCCCCCCCC
KAFICTASTAKNGTVSCIVPSLMAGSSVTTSKNDVDHVVTEFGVAKLRGQTAKQRAMNLI
CEEEEEECCCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
NVAHPDFRGELMEAARRMNRI
HHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVVTLSKKNFQQEYQQKLCTAAEAASIVRSGDHLCFPLGVGEPTLFVRALAARKRELEG
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VVVNQQHHLCPDYFTEDSAPHIKVNAWFTSHVSREAVQKGWADFVPNHFSEVPKLLSMYW
EEECCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHC
PVEVAGTVVSPMDEYGYFTCSLSVGYTMEAVRKAIQTGGKVVVQVNPQCPRTHGNCHIHI
CHHHHHHHHCCHHHCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEH
SEVTHIIECDEPLKELDIPPISPIEEAIGGYIAEMIDDGSTVQMGWGGIPNAVCQALLKK
HHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
KDLGIHTELISNGIVDLMLAGAVNNSRKSIHRGKTVGTFALGTRKVFDFMNENPTIEMHP
CCCCHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCCEEEEEHHHHHHHHHHCCCCCEEECC
VDYVNDPYVIGQMDNMIAINATIQVDLLGQCCSESFGHLQWSGTGGQADFARGANRSRGG
CCCCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHCCCEEECCCCCCCHHHCCCCCCCCC
KAFICTASTAKNGTVSCIVPSLMAGSSVTTSKNDVDHVVTEFGVAKLRGQTAKQRAMNLI
CEEEEEECCCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
NVAHPDFRGELMEAARRMNRI
HHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]