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The map label for this gene is lysA [H]

Identifier: 78223226

GI number: 78223226

Start: 2258867

End: 2260126

Strand: Reverse

Name: lysA [H]

Synonym: Gmet_2019

Alternate gene names: 78223226

Gene position: 2260126-2258867 (Counterclockwise)

Preceding gene: 78223227

Following gene: 78223225

Centisome position: 56.54

GC content: 62.14

Gene sequence:

>1260_bases
ATGATCCTGACGGAACAAAACGGCAAAACCTGCCTGCGGAATATCTGCTTCGAGGAGCTTGCCGCGCGCTATGGCACCCC
CTTCTACCTCTACGACCTGGACAAGGTGAAGGAGAAGTGCGCTGCCGTCCGCAAGGCCTTCGGCGACAGCCTCGAACTCC
TCTACGCCGTCAAGGCCAACCCGAACCGGGAACTCCTGGCAGCCATGCGGGGCGAAGTGGACGGCCTCGACATTGCCTCG
GCCGGCGAGCTGGAGCGCGCCCTGGAGACCGGCTATGACGCGGGGTGCATCAGCTTCGCCGGTCCGGGCAAAACCCGCGA
CGAGCTGCGCCGCTCCCTGGAGGCCGGGGTTGGCTGCATCAGCGTCGAATCGCTGCGCGAGCTTAATGACCTGCGCGATC
TGGTTCGGGCCGGTTCGCATCGGGCTTACATTTTGGTGCGGGTCAACCCCCAGCTCCTCATTAGGGACTTCGCGGTGAAG
ATGGGTGGTAAGGCTTCCCAGTTCGGTATCGACGAGGAAGAACTGCCATCGGCCCTGGACTTCATCAAGGCCAATGCCGA
TGCGTTTGACTTCAAGGGAATCCACATCTACGCCGGCACCCAGTGCCTGAACGAGGAAGCCCTGGCACAGAATCTCGCCA
ACACCCTGGCCATAGCGGCCCGGATTACCACCGACTACGGCATGGAGTGCCGGGTCATCAACATCGGCGGTGGGCTCGGG
GTCTCCTACTACGAAGAGCATCCGGGGCTCGATCTGGACAAGCTGGCCCTCCTTTTCAGGGCCGAGTTCGACCGGTACCG
CGAGGCCACGGGGACAAAACCCCGCATCCTCCTGGAGCTGGGACGGTTCCTGGTTGCCGAGGCCGGAATCTACGTAACTC
GGGTGGTGAGTGAAAAGCTGTCGCGGGGCGAGCAGTTCTATGTTCTCGACGGGGGGATGAACCACCACCTGTCGGCATCG
GGCAATCTCGGCATGACCATTAGGAAGAACTACTTGGTCCGCAACCTTTCGCGGCCCGGTGCGGAACGGATAATCTGCAC
CCTTGTCGGTCCCCTCTGCACCCCCCTTGATCTGATGGGGAAGGGGGTGACGGTGGAGGTGCCGGAGGTGGGGGATCTGG
TCGGGTTCCTGAATTCGGGGAGCTATGGGTACAGTGCGAGTCCGCTGCTCTTTTTGGGGCATGGGGAGCCGTGCGAGCTT
TTGGTTGAGGGGAAGGACGTGCGTCCCTGCCGATTGATGGGGGAAATGGGGAGTCGATGA

Upstream 100 bases:

>100_bases
CCCAGGAGATTCACTTCGAGAAGGCGTTCAGGAAAACCGCCAACGGCAAGATTGACCGCTCGGGGATCAAGAAAGAGTGG
CTGGCGGCAGGGAAGAATTG

Downstream 100 bases:

>100_bases
ACCGTGGTTGTTTTGACATAGCCGTCATAACTGATCGGGAGGCTTTTCAGGCAATCCTAGACGAGTGGAATCAGCTTGCC
GATATCAACGGCTATTACAC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MILTEQNGKTCLRNICFEELAARYGTPFYLYDLDKVKEKCAAVRKAFGDSLELLYAVKANPNRELLAAMRGEVDGLDIAS
AGELERALETGYDAGCISFAGPGKTRDELRRSLEAGVGCISVESLRELNDLRDLVRAGSHRAYILVRVNPQLLIRDFAVK
MGGKASQFGIDEEELPSALDFIKANADAFDFKGIHIYAGTQCLNEEALAQNLANTLAIAARITTDYGMECRVINIGGGLG
VSYYEEHPGLDLDKLALLFRAEFDRYREATGTKPRILLELGRFLVAEAGIYVTRVVSEKLSRGEQFYVLDGGMNHHLSAS
GNLGMTIRKNYLVRNLSRPGAERIICTLVGPLCTPLDLMGKGVTVEVPEVGDLVGFLNSGSYGYSASPLLFLGHGEPCEL
LVEGKDVRPCRLMGEMGSR

Sequences:

>Translated_419_residues
MILTEQNGKTCLRNICFEELAARYGTPFYLYDLDKVKEKCAAVRKAFGDSLELLYAVKANPNRELLAAMRGEVDGLDIAS
AGELERALETGYDAGCISFAGPGKTRDELRRSLEAGVGCISVESLRELNDLRDLVRAGSHRAYILVRVNPQLLIRDFAVK
MGGKASQFGIDEEELPSALDFIKANADAFDFKGIHIYAGTQCLNEEALAQNLANTLAIAARITTDYGMECRVINIGGGLG
VSYYEEHPGLDLDKLALLFRAEFDRYREATGTKPRILLELGRFLVAEAGIYVTRVVSEKLSRGEQFYVLDGGMNHHLSAS
GNLGMTIRKNYLVRNLSRPGAERIICTLVGPLCTPLDLMGKGVTVEVPEVGDLVGFLNSGSYGYSASPLLFLGHGEPCEL
LVEGKDVRPCRLMGEMGSR
>Mature_419_residues
MILTEQNGKTCLRNICFEELAARYGTPFYLYDLDKVKEKCAAVRKAFGDSLELLYAVKANPNRELLAAMRGEVDGLDIAS
AGELERALETGYDAGCISFAGPGKTRDELRRSLEAGVGCISVESLRELNDLRDLVRAGSHRAYILVRVNPQLLIRDFAVK
MGGKASQFGIDEEELPSALDFIKANADAFDFKGIHIYAGTQCLNEEALAQNLANTLAIAARITTDYGMECRVINIGGGLG
VSYYEEHPGLDLDKLALLFRAEFDRYREATGTKPRILLELGRFLVAEAGIYVTRVVSEKLSRGEQFYVLDGGMNHHLSAS
GNLGMTIRKNYLVRNLSRPGAERIICTLVGPLCTPLDLMGKGVTVEVPEVGDLVGFLNSGSYGYSASPLLFLGHGEPCEL
LVEGKDVRPCRLMGEMGSR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=394, Percent_Identity=23.0964467005076, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789203, Length=402, Percent_Identity=28.1094527363184, Blast_Score=118, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17562780, Length=422, Percent_Identity=22.7488151658768, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45806; Mature: 45806

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00879 ODR_DC_2_2 ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILTEQNGKTCLRNICFEELAARYGTPFYLYDLDKVKEKCAAVRKAFGDSLELLYAVKAN
CEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEECC
PNRELLAAMRGEVDGLDIASAGELERALETGYDAGCISFAGPGKTRDELRRSLEAGVGCI
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCEE
SVESLRELNDLRDLVRAGSHRAYILVRVNPQLLIRDFAVKMGGKASQFGIDEEELPSALD
EHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHH
FIKANADAFDFKGIHIYAGTQCLNEEALAQNLANTLAIAARITTDYGMECRVINIGGGLG
HHHCCCCCEECCCEEEEECCHHCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCCC
VSYYEEHPGLDLDKLALLFRAEFDRYREATGTKPRILLELGRFLVAEAGIYVTRVVSEKL
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
SRGEQFYVLDGGMNHHLSASGNLGMTIRKNYLVRNLSRPGAERIICTLVGPLCTPLDLMG
HCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHC
KGVTVEVPEVGDLVGFLNSGSYGYSASPLLFLGHGEPCELLVEGKDVRPCRLMGEMGSR
CCCEEECCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCC
>Mature Secondary Structure
MILTEQNGKTCLRNICFEELAARYGTPFYLYDLDKVKEKCAAVRKAFGDSLELLYAVKAN
CEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEECC
PNRELLAAMRGEVDGLDIASAGELERALETGYDAGCISFAGPGKTRDELRRSLEAGVGCI
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCEE
SVESLRELNDLRDLVRAGSHRAYILVRVNPQLLIRDFAVKMGGKASQFGIDEEELPSALD
EHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHH
FIKANADAFDFKGIHIYAGTQCLNEEALAQNLANTLAIAARITTDYGMECRVINIGGGLG
HHHCCCCCEECCCEEEEECCHHCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCCC
VSYYEEHPGLDLDKLALLFRAEFDRYREATGTKPRILLELGRFLVAEAGIYVTRVVSEKL
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
SRGEQFYVLDGGMNHHLSASGNLGMTIRKNYLVRNLSRPGAERIICTLVGPLCTPLDLMG
HCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHC
KGVTVEVPEVGDLVGFLNSGSYGYSASPLLFLGHGEPCELLVEGKDVRPCRLMGEMGSR
CCCEEECCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA