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The map label for this gene is nadC [H]

Identifier: 78223195

GI number: 78223195

Start: 2217824

End: 2218654

Strand: Reverse

Name: nadC [H]

Synonym: Gmet_1988

Alternate gene names: 78223195

Gene position: 2218654-2217824 (Counterclockwise)

Preceding gene: 78223199

Following gene: 78223194

Centisome position: 55.5

GC content: 62.45

Gene sequence:

>831_bases
ATGACCGGCATAGACAAGATCATCGAAAACGCCCTCATGGAGGATATTCATACCGGGGATATCACGACTCTGGCGGTGGT
TCCCGGGAGCCGTCCGGCCCGCGCCCGACTCATCGCCAAGGAGCCCCTGATTCTGGCTGGCATTGACGTGGCGGCCCGGG
TCTTCACGTTCCTTGACGCGTCGGTCTGTTTTGAGGCACGACATGGGGACGGAGCGCGGCTAGCTGCCGGCGATCTGATT
GCCGAGCTTACCGGCGACTCCGCTCTCCTCCTCCAGGGTGAGCGGGTGGCTCTCAACCTGCTTCAGCGCATGTGCGGCAC
CGCGACCCTTACGGCCAGGTATGTGGAGGCCGTGGCGGGAACGCGGGCTCGCATCGTTGATACGCGGAAGACAACTCCGG
GGCTCCGGGTCCTGGAGAAATACGCCGTTCGGGTTGGCGGGGGAATCAACCACCGCACCGGCCTCTATGACGGTGTCCTC
ATCAAGGAGAACCACATCGCCGCCGCGGGCGGCATCAGCCGGGCCGTAAGCCGGGCACGGTCCTACATCCCCCATACCCT
GAAAATTGAGGTGGAGACCGAATCCATCGCGGAGGTGACCGAAGCACTTGAGGCCGGTGCCGATATCATCATGCTCGACA
ATATGGATCTGCCGACGATGACTGAGGCGGTGGCCCTCATTGGTGGCCGTGCCCTGGTGGAAGCCTCGGGGGGGGTAAAC
CTCGAAACAGTCAGAGGAATTGCCGAGGCAGGGGTTGACATCATTTCCGTGGGGGCGCTTACCCATTCTGCCCGAGCCAT
GGACATCTCGATGCTTCTGGAGGCTGAGTGA

Upstream 100 bases:

>100_bases
GAAATGCAAGGGGGGAAGCCCGAGCCGCGCCCTCTTTGCGGTTGCGGCTTCCCGTCTCCTGTGCTATATAGAGGCTTAAT
TTTTCTGATGCGGAGAGCCC

Downstream 100 bases:

>100_bases
GCGGAGAGTTGCCACGCCCCGACGCAATCGGCAGCAAGGAGATCGACCGGAAGATTCTGGAAATCTTCAGGAGCCGTGAC
GGGGGCGTTGTTTCCGGCGA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTGIDKIIENALMEDIHTGDITTLAVVPGSRPARARLIAKEPLILAGIDVAARVFTFLDASVCFEARHGDGARLAAGDLI
AELTGDSALLLQGERVALNLLQRMCGTATLTARYVEAVAGTRARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGVL
IKENHIAAAGGISRAVSRARSYIPHTLKIEVETESIAEVTEALEAGADIIMLDNMDLPTMTEAVALIGGRALVEASGGVN
LETVRGIAEAGVDIISVGALTHSARAMDISMLLEAE

Sequences:

>Translated_276_residues
MTGIDKIIENALMEDIHTGDITTLAVVPGSRPARARLIAKEPLILAGIDVAARVFTFLDASVCFEARHGDGARLAAGDLI
AELTGDSALLLQGERVALNLLQRMCGTATLTARYVEAVAGTRARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGVL
IKENHIAAAGGISRAVSRARSYIPHTLKIEVETESIAEVTEALEAGADIIMLDNMDLPTMTEAVALIGGRALVEASGGVN
LETVRGIAEAGVDIISVGALTHSARAMDISMLLEAE
>Mature_275_residues
TGIDKIIENALMEDIHTGDITTLAVVPGSRPARARLIAKEPLILAGIDVAARVFTFLDASVCFEARHGDGARLAAGDLIA
ELTGDSALLLQGERVALNLLQRMCGTATLTARYVEAVAGTRARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGVLI
KENHIAAAGGISRAVSRARSYIPHTLKIEVETESIAEVTEALEAGADIIMLDNMDLPTMTEAVALIGGRALVEASGGVNL
ETVRGIAEAGVDIISVGALTHSARAMDISMLLEAE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=276, Percent_Identity=39.4927536231884, Blast_Score=165, Evalue=4e-41,
Organism=Escherichia coli, GI1786299, Length=272, Percent_Identity=44.4852941176471, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321162, Length=278, Percent_Identity=35.6115107913669, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29029; Mature: 28898

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGIDKIIENALMEDIHTGDITTLAVVPGSRPARARLIAKEPLILAGIDVAARVFTFLDA
CCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCEEEECHHHHHHHHHHHHH
SVCFEARHGDGARLAAGDLIAELTGDSALLLQGERVALNLLQRMCGTATLTARYVEAVAG
HHEEEECCCCCCEEEHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHC
TRARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGVLIKENHIAAAGGISRAVSRAR
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEECCHHHHHHHHHH
SYIPHTLKIEVETESIAEVTEALEAGADIIMLDNMDLPTMTEAVALIGGRALVEASGGVN
HHCCCEEEEEECHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCCCCC
LETVRGIAEAGVDIISVGALTHSARAMDISMLLEAE
HHHHHHHHHCCCCEEEECHHHCCCHHEEEEEEEECC
>Mature Secondary Structure 
TGIDKIIENALMEDIHTGDITTLAVVPGSRPARARLIAKEPLILAGIDVAARVFTFLDA
CCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCEEEECHHHHHHHHHHHHH
SVCFEARHGDGARLAAGDLIAELTGDSALLLQGERVALNLLQRMCGTATLTARYVEAVAG
HHEEEECCCCCCEEEHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHC
TRARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGVLIKENHIAAAGGISRAVSRAR
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEECCHHHHHHHHHH
SYIPHTLKIEVETESIAEVTEALEAGADIIMLDNMDLPTMTEAVALIGGRALVEASGGVN
HHCCCEEEEEECHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCCCCC
LETVRGIAEAGVDIISVGALTHSARAMDISMLLEAE
HHHHHHHHHCCCCEEEECHHHCCCHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]