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The map label for this gene is fbp

Identifier: 78223128

GI number: 78223128

Start: 2146675

End: 2147619

Strand: Reverse

Name: fbp

Synonym: Gmet_1921

Alternate gene names: 78223128

Gene position: 2147619-2146675 (Counterclockwise)

Preceding gene: 78223133

Following gene: 78223127

Centisome position: 53.73

GC content: 54.07

Gene sequence:

>945_bases
ATGCCGTTCAGTGAACCGGGCAAGACGAAATTCCAGGTAGATTTGCGCCGTCATCTCCGTAATCAAGGGATCTGCGACAA
CCTCGTCCACCTCATCTGCGAGATTGCCGAGGCGAGCAAGTATGTGATCAACGCTGTTCGTACCGGTGATCTGGGCGTGG
CGGGTACCTCCAACCTTTACGGCGAAGAGCAGCTTGCCCTGGACGTCCTTTCGGACAGGATTATCAAGAAACGGCTCATT
CACTCCGGCGTTGTCTGTAACATTGCTTCCGAGGAAATGGATGAAATCTTCCAGGCCCAGGCCGATGCAGATGGCCTTTA
CTCGGTGGCCTATGATCCCCTCGACGGTTCGTCGCTCGTGGATGTGAATCTGGCGGTTGGCACCATCGTCTCCATCTATG
AGGGGTGCAATCTGCTCCAGAAAGGGCGCAACCAGGTCGCGGCCTTGTACATCCTCTATGGCCCACGGGTCTCTATGGTC
TACTCCGTCGGCAGAGGGGTGCATGAATTCACCATGAACCATCTGATGGAGTTCACTCTTTCGCGCGAAAACATTGTCAT
GCAGGAAGAGGGAAATATTTATGCTCCTGGTGGCCTGCGCAACAAATATCAAGAGGGGACTGAACAGTTCGTTCGTTATT
TGGAGGAGAAGGGGGCCAAACTCCGGTACTCGGGCGGTTTTGTGCCGGACATCAACCAGGTTATCATGAAAGGGAAGGGC
ATTTTTATGTATCCGGCCCTTAACGGATCCCCTAACGGCAAACTGAGACTCCTCTTCGAGCTTAACGCCATGGCATATCT
GGTTGAAAACGCCGGTGGGGCAGCCACTGACGGGAAACAGCCGATTCTTGACCTGGAACCCCACTCCCTCGACCAACGCG
CCCCTGTTTACATCGGTTGCAAGGCTGACGTGGTGAAGGCGATGGAATTTGTCAGTCGCAATTGA

Upstream 100 bases:

>100_bases
ACCTCTGAACACTGGGTTGACGCTACTTTTCGCTTGATTTGCCTTACCTCTTTACATTAATCTTTAAGGGATTTTACTAT
TTTATGCACAGGAGGGATGC

Downstream 100 bases:

>100_bases
CAGTGATTTCGATTAACTACGAGGCTTTCATGGAAGAAAATGCGAAACAGCAACGACTTTGCACCGAGATCCAACTCTTT
GATCTGTGCGACAAGGGACC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MPFSEPGKTKFQVDLRRHLRNQGICDNLVHLICEIAEASKYVINAVRTGDLGVAGTSNLYGEEQLALDVLSDRIIKKRLI
HSGVVCNIASEEMDEIFQAQADADGLYSVAYDPLDGSSLVDVNLAVGTIVSIYEGCNLLQKGRNQVAALYILYGPRVSMV
YSVGRGVHEFTMNHLMEFTLSRENIVMQEEGNIYAPGGLRNKYQEGTEQFVRYLEEKGAKLRYSGGFVPDINQVIMKGKG
IFMYPALNGSPNGKLRLLFELNAMAYLVENAGGAATDGKQPILDLEPHSLDQRAPVYIGCKADVVKAMEFVSRN

Sequences:

>Translated_314_residues
MPFSEPGKTKFQVDLRRHLRNQGICDNLVHLICEIAEASKYVINAVRTGDLGVAGTSNLYGEEQLALDVLSDRIIKKRLI
HSGVVCNIASEEMDEIFQAQADADGLYSVAYDPLDGSSLVDVNLAVGTIVSIYEGCNLLQKGRNQVAALYILYGPRVSMV
YSVGRGVHEFTMNHLMEFTLSRENIVMQEEGNIYAPGGLRNKYQEGTEQFVRYLEEKGAKLRYSGGFVPDINQVIMKGKG
IFMYPALNGSPNGKLRLLFELNAMAYLVENAGGAATDGKQPILDLEPHSLDQRAPVYIGCKADVVKAMEFVSRN
>Mature_313_residues
PFSEPGKTKFQVDLRRHLRNQGICDNLVHLICEIAEASKYVINAVRTGDLGVAGTSNLYGEEQLALDVLSDRIIKKRLIH
SGVVCNIASEEMDEIFQAQADADGLYSVAYDPLDGSSLVDVNLAVGTIVSIYEGCNLLQKGRNQVAALYILYGPRVSMVY
SVGRGVHEFTMNHLMEFTLSRENIVMQEEGNIYAPGGLRNKYQEGTEQFVRYLEEKGAKLRYSGGFVPDINQVIMKGKGI
FMYPALNGSPNGKLRLLFELNAMAYLVENAGGAATDGKQPILDLEPHSLDQRAPVYIGCKADVVKAMEFVSRN

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI22907028, Length=325, Percent_Identity=35.6923076923077, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI189083692, Length=325, Percent_Identity=35.0769230769231, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI16579888, Length=325, Percent_Identity=35.0769230769231, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1790679, Length=267, Percent_Identity=40.0749063670412, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17508131, Length=317, Percent_Identity=38.4858044164038, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323409, Length=327, Percent_Identity=31.1926605504587, Blast_Score=156, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45550998, Length=321, Percent_Identity=35.5140186915888, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI19921562, Length=321, Percent_Identity=35.5140186915888, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_GEOMG (Q39UC4)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384875.1
- HSSP:   P0A993
- ProteinModelPortal:   Q39UC4
- SMR:   Q39UC4
- STRING:   Q39UC4
- GeneID:   3738105
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1921
- NMPDR:   fig|269799.3.peg.2184
- eggNOG:   COG0158
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- PhylomeDB:   Q39UC4
- ProtClustDB:   PRK09293
- BioCyc:   GMET269799:GMET_1921-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR023079
- PANTHER:   PTHR11556
- PRINTS:   PR01958

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 34634; Mature: 34503

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00124 FBPASE

Important sites: BINDING 223-223 BINDING 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFSEPGKTKFQVDLRRHLRNQGICDNLVHLICEIAEASKYVINAVRTGDLGVAGTSNLY
CCCCCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCC
GEEQLALDVLSDRIIKKRLIHSGVVCNIASEEMDEIFQAQADADGLYSVAYDPLDGSSLV
CCHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCCCCCEEEEEECCCCCCCEE
DVNLAVGTIVSIYEGCNLLQKGRNQVAALYILYGPRVSMVYSVGRGVHEFTMNHLMEFTL
EEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHC
SRENIVMQEEGNIYAPGGLRNKYQEGTEQFVRYLEEKGAKLRYSGGFVPDINQVIMKGKG
CCCCEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCC
IFMYPALNGSPNGKLRLLFELNAMAYLVENAGGAATDGKQPILDLEPHSLDQRAPVYIGC
EEEEECCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCEEEEC
KADVVKAMEFVSRN
HHHHHHHHHHHHCC
>Mature Secondary Structure 
PFSEPGKTKFQVDLRRHLRNQGICDNLVHLICEIAEASKYVINAVRTGDLGVAGTSNLY
CCCCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCC
GEEQLALDVLSDRIIKKRLIHSGVVCNIASEEMDEIFQAQADADGLYSVAYDPLDGSSLV
CCHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCCCCCEEEEEECCCCCCCEE
DVNLAVGTIVSIYEGCNLLQKGRNQVAALYILYGPRVSMVYSVGRGVHEFTMNHLMEFTL
EEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHC
SRENIVMQEEGNIYAPGGLRNKYQEGTEQFVRYLEEKGAKLRYSGGFVPDINQVIMKGKG
CCCCEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCC
IFMYPALNGSPNGKLRLLFELNAMAYLVENAGGAATDGKQPILDLEPHSLDQRAPVYIGC
EEEEECCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCEEEEC
KADVVKAMEFVSRN
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA