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The map label for this gene is nrdZ [H]

Identifier: 78223117

GI number: 78223117

Start: 2130608

End: 2131447

Strand: Reverse

Name: nrdZ [H]

Synonym: Gmet_1910

Alternate gene names: 78223117

Gene position: 2131447-2130608 (Counterclockwise)

Preceding gene: 78223118

Following gene: 78223115

Centisome position: 53.32

GC content: 56.07

Gene sequence:

>840_bases
GTGGCACGATACCTCAAGGATCCGGGAATAGATTTTCCCTCCCTGGCTGAAGATATCAAAACTGCCGTGCGGTTCCTCGA
CGATACCATCGATGCCAACATTTATCCCTTGCCGGCCATCGAGCTGATGCACAAGGGAAACCGCAAGATCGGCCTCGGCG
TCATGGGGTGGGCGGACCTGCTCCTGCGGCTCGGGCTTCCGTACAATCATCCGCAATCCTTCGCCCTGGCCCGATCGCTG
ATGAAGTTCGTCAGGGACACCTCGCGGAAGGCGTCGGCAGAGCTTGCCGAAGAGCGGGGCGTCTTCCCTAATTTTGCAGG
GTCGGTCTATGATGCTCCCGACCGTCCGCGGGTACGCAATGCTACCACTACAACCATTGCACCCACGGGGACCCTGGCGA
CCATCGCGGACTGTTCCAGCGGCATCGAACCGCTTTTTGCCCTTGCCTATAAGAGGAATGTTCTGGGTACCGAGCTTACG
GAAATCAATGGGTATTTCTTGAACGTCGCCAAGGAACGGGGTTTGTTCTCAGACGAACTCATGCAGAAGGTTATGGAGCA
GGGTAATCTGCGCGGTATAACCGGCATTCCAGCCGATATCAGAAGGCTCTTCAAGACCGCCCTGGAGATACCCGCAGCAG
ATCACATCGAGATGCAGGCTGCCTTCCAGGAGTACACGGACAATGCCGTTTCCAAGACGGTCAATCTCCCCGCCAGGGCG
ACACGGGGAGATGTGGCCAAAGCTTTCCTTCTTGCCTATGAGAAGGGGGTAAAAGGGATAACCGTTTTCAGGTACGGGAG
TAAGAAAGGGACTCTGGTGAAATTCGTCGATACCGATTGA

Upstream 100 bases:

>100_bases
CGCAAATCCTACCCCTCATATCGGCTCATTCGAGAGCACAAACCCCTGCGGCGAGCAACCACTCCTGCCTTATGAGGCAT
GCGTCCTCGGCTCCCTGAAC

Downstream 100 bases:

>100_bases
GCATCCGGCAGGCTACATTGGCTTGTCGGTATGCACACCCACCGAGAACGTGAGGATTGCCCCAACCCTGACTTCGAGGC
GAGACGCAACTTGCGGCATC

Product: ribonucleotide reductase large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MARYLKDPGIDFPSLAEDIKTAVRFLDDTIDANIYPLPAIELMHKGNRKIGLGVMGWADLLLRLGLPYNHPQSFALARSL
MKFVRDTSRKASAELAEERGVFPNFAGSVYDAPDRPRVRNATTTTIAPTGTLATIADCSSGIEPLFALAYKRNVLGTELT
EINGYFLNVAKERGLFSDELMQKVMEQGNLRGITGIPADIRRLFKTALEIPAADHIEMQAAFQEYTDNAVSKTVNLPARA
TRGDVAKAFLLAYEKGVKGITVFRYGSKKGTLVKFVDTD

Sequences:

>Translated_279_residues
MARYLKDPGIDFPSLAEDIKTAVRFLDDTIDANIYPLPAIELMHKGNRKIGLGVMGWADLLLRLGLPYNHPQSFALARSL
MKFVRDTSRKASAELAEERGVFPNFAGSVYDAPDRPRVRNATTTTIAPTGTLATIADCSSGIEPLFALAYKRNVLGTELT
EINGYFLNVAKERGLFSDELMQKVMEQGNLRGITGIPADIRRLFKTALEIPAADHIEMQAAFQEYTDNAVSKTVNLPARA
TRGDVAKAFLLAYEKGVKGITVFRYGSKKGTLVKFVDTD
>Mature_278_residues
ARYLKDPGIDFPSLAEDIKTAVRFLDDTIDANIYPLPAIELMHKGNRKIGLGVMGWADLLLRLGLPYNHPQSFALARSLM
KFVRDTSRKASAELAEERGVFPNFAGSVYDAPDRPRVRNATTTTIAPTGTLATIADCSSGIEPLFALAYKRNVLGTELTE
INGYFLNVAKERGLFSDELMQKVMEQGNLRGITGIPADIRRLFKTALEIPAADHIEMQAAFQEYTDNAVSKTVNLPARAT
RGDVAKAFLLAYEKGVKGITVFRYGSKKGTLVKFVDTD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=273, Percent_Identity=27.8388278388278, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17555242, Length=284, Percent_Identity=28.5211267605634, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6322123, Length=279, Percent_Identity=26.8817204301075, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6320914, Length=274, Percent_Identity=28.4671532846715, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17352481, Length=273, Percent_Identity=26.3736263736264, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 30708; Mature: 30576

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYLKDPGIDFPSLAEDIKTAVRFLDDTIDANIYPLPAIELMHKGNRKIGLGVMGWADL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEHHHHHHH
LLRLGLPYNHPQSFALARSLMKFVRDTSRKASAELAEERGVFPNFAGSVYDAPDRPRVRN
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
ATTTTIAPTGTLATIADCSSGIEPLFALAYKRNVLGTELTEINGYFLNVAKERGLFSDEL
CCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHCCCCEEEEHHHCCCCHHHH
MQKVMEQGNLRGITGIPADIRRLFKTALEIPAADHIEMQAAFQEYTDNAVSKTVNLPARA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
TRGDVAKAFLLAYEKGVKGITVFRYGSKKGTLVKFVDTD
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECC
>Mature Secondary Structure 
ARYLKDPGIDFPSLAEDIKTAVRFLDDTIDANIYPLPAIELMHKGNRKIGLGVMGWADL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEHHHHHHH
LLRLGLPYNHPQSFALARSLMKFVRDTSRKASAELAEERGVFPNFAGSVYDAPDRPRVRN
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
ATTTTIAPTGTLATIADCSSGIEPLFALAYKRNVLGTELTEINGYFLNVAKERGLFSDEL
CCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHCCCCEEEEHHHCCCCHHHH
MQKVMEQGNLRGITGIPADIRRLFKTALEIPAADHIEMQAAFQEYTDNAVSKTVNLPARA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
TRGDVAKAFLLAYEKGVKGITVFRYGSKKGTLVKFVDTD
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]