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The map label for this gene is folP [H]

Identifier: 78223096

GI number: 78223096

Start: 2103196

End: 2104068

Strand: Reverse

Name: folP [H]

Synonym: Gmet_1889

Alternate gene names: 78223096

Gene position: 2104068-2103196 (Counterclockwise)

Preceding gene: 78223097

Following gene: 78223095

Centisome position: 52.64

GC content: 58.88

Gene sequence:

>873_bases
ATGGGAAAATCCGATGAAATCGTGGTTCCGTCTTTCTGGAGGCTAGCGAAGCGGTCTCTTGACCTCTCCCGGCGTCCCTG
CATCATGGGGATCCTGAACGTAACCCCTGACTCCTTTTCCGACGGCAGCCGCTACCTTGATCTTGACCGTGCGGAAGAGC
GCGCTCACCAAATGGTTGAACAGGGGGCGGACATCGTCGATATCGGGGGGGAGAGCACCCGCCCCAATATTGCACCGGTG
GATGCCGATGAGGAACTTCGGCGGGTCATTCCTCTGGTCGAACGGCTTGCAGGACGCATTCCGGTGCCGATTTCGGTGGA
TACCTACAAGGCTGTTGTGGCTCGTGAGGCGCTCCGCGTCGGCGCCGAAATCGTGAACGACATAAGCGGCCTTACCTTTG
ACCCGGCCATGGCTGCCACAGTGGCGGAAGCCGATGCCGGGCTGGTGGTGATGCATACCCGCGGCAGACCCGACACCATG
CAAAGGGATACCGCTTATGGCAACCTGATCGCCGAGGTGATTGATTTCCTTCGTCAGTCCGTGTTGATTGCGGAAGCCGC
TGGAGTTTCCAAGGAACGGATTGTTGTTGATCCGGGAATTGGCTTCGCCAAGAGCGTTCAGGGCAACCTCGAGATACTGA
GGCAACTTCGGGATGTTGCCAGTCTCCAACTCCCCATACTTGTGGGAACCTCTCGCAAGTCGTTTATCGGTACCATTCTC
GGCCGCAACGTGGATGAACGCCTGTTCGGCACAGCGGCAACGGTGGCCCTTGCAGTCGCCAACGGTGCCTCCATCATTCG
GGTCCACGAAGTACGTGAGATGCGCGACGTGGCGGATATGGCCCATGCCGTGCTTCACCCCCACGCGTATTGA

Upstream 100 bases:

>100_bases
AGCTTATTGAGAAGGAAAACCTGACTGGCGACGAAGTGGAGCAGATCGTCAGGTCCGTCAGGGGAACGGTTCCGGCTTCC
GAGGAAATTCCTGCCTCCTG

Downstream 100 bases:

>100_bases
TTCACTGAACGAGCTTTCCGTGTTTGTAACGCCGCCGAACTTCCAGCGGCCTGGTGCCTACGATGCCCGATTCCCTTCAG
CTTTTCGGGTGGCGAGATCT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MGKSDEIVVPSFWRLAKRSLDLSRRPCIMGILNVTPDSFSDGSRYLDLDRAEERAHQMVEQGADIVDIGGESTRPNIAPV
DADEELRRVIPLVERLAGRIPVPISVDTYKAVVAREALRVGAEIVNDISGLTFDPAMAATVAEADAGLVVMHTRGRPDTM
QRDTAYGNLIAEVIDFLRQSVLIAEAAGVSKERIVVDPGIGFAKSVQGNLEILRQLRDVASLQLPILVGTSRKSFIGTIL
GRNVDERLFGTAATVALAVANGASIIRVHEVREMRDVADMAHAVLHPHAY

Sequences:

>Translated_290_residues
MGKSDEIVVPSFWRLAKRSLDLSRRPCIMGILNVTPDSFSDGSRYLDLDRAEERAHQMVEQGADIVDIGGESTRPNIAPV
DADEELRRVIPLVERLAGRIPVPISVDTYKAVVAREALRVGAEIVNDISGLTFDPAMAATVAEADAGLVVMHTRGRPDTM
QRDTAYGNLIAEVIDFLRQSVLIAEAAGVSKERIVVDPGIGFAKSVQGNLEILRQLRDVASLQLPILVGTSRKSFIGTIL
GRNVDERLFGTAATVALAVANGASIIRVHEVREMRDVADMAHAVLHPHAY
>Mature_289_residues
GKSDEIVVPSFWRLAKRSLDLSRRPCIMGILNVTPDSFSDGSRYLDLDRAEERAHQMVEQGADIVDIGGESTRPNIAPVD
ADEELRRVIPLVERLAGRIPVPISVDTYKAVVAREALRVGAEIVNDISGLTFDPAMAATVAEADAGLVVMHTRGRPDTMQ
RDTAYGNLIAEVIDFLRQSVLIAEAAGVSKERIVVDPGIGFAKSVQGNLEILRQLRDVASLQLPILVGTSRKSFIGTILG
RNVDERLFGTAATVALAVANGASIIRVHEVREMRDVADMAHAVLHPHAY

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=267, Percent_Identity=46.0674157303371, Blast_Score=226, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=34.2767295597484, Blast_Score=161, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31463; Mature: 31331

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKSDEIVVPSFWRLAKRSLDLSRRPCIMGILNVTPDSFSDGSRYLDLDRAEERAHQMVE
CCCCCCEECHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHH
QGADIVDIGGESTRPNIAPVDADEELRRVIPLVERLAGRIPVPISVDTYKAVVAREALRV
CCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHH
GAEIVNDISGLTFDPAMAATVAEADAGLVVMHTRGRPDTMQRDTAYGNLIAEVIDFLRQS
HHHHHHHHCCCEECHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
VLIAEAAGVSKERIVVDPGIGFAKSVQGNLEILRQLRDVASLQLPILVGTSRKSFIGTIL
HHHHHHCCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
GRNVDERLFGTAATVALAVANGASIIRVHEVREMRDVADMAHAVLHPHAY
CCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GKSDEIVVPSFWRLAKRSLDLSRRPCIMGILNVTPDSFSDGSRYLDLDRAEERAHQMVE
CCCCCEECHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHH
QGADIVDIGGESTRPNIAPVDADEELRRVIPLVERLAGRIPVPISVDTYKAVVAREALRV
CCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHH
GAEIVNDISGLTFDPAMAATVAEADAGLVVMHTRGRPDTMQRDTAYGNLIAEVIDFLRQS
HHHHHHHHCCCEECHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
VLIAEAAGVSKERIVVDPGIGFAKSVQGNLEILRQLRDVASLQLPILVGTSRKSFIGTIL
HHHHHHCCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
GRNVDERLFGTAATVALAVANGASIIRVHEVREMRDVADMAHAVLHPHAY
CCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]